Article
Pharmacology & Pharmacy
Fang-Ling Zhao, Qing Zhang, Shuang-Hu Wang, Yun Hong, Shan Zhou, Quan Zhou, Pei-Wu Geng, Qing-Feng Luo, Jie-Fu Yang, Hao Chen, Jian-Ping Cai, Da-Peng Dai
Summary: Cytochrome 2C9 (CYP2C9), an important drug metabolic enzyme in the human hepatic P450 superfamily, has high genetic polymorphism. This study identified four new variants of CYP2C9 in the Chinese Han population, which exhibited reduced enzyme activity compared to the wild-type enzyme.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Weiwei Gui, Julong Liang, Xihua Lin, Nanjing Shi, Yiyi Zhu, Bowen Tan, Hong Li
Summary: The study found that IGF2-related genes, including H19, IGF2, IGF2BP2, and IGF2R, may play crucial roles in the development of MetS. The different genotypes in patients of different genders were associated with the risk of developing metabolic syndrome and various biochemical indicators.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Infectious Diseases
Shishi Xing, Yuhe Wang, Xue He, Wei Yang, Qunying Hu, Yongjun He, Dongya Yuan, Tianbo Jin
Summary: The study revealed that CYP2C8 and CYP2E1 gene polymorphisms are associated with an increased risk of tuberculosis in the Northwest Chinese Han population, especially in females. This provides important insights for defining new therapeutic strategies for chemoprevention.
INFECTION GENETICS AND EVOLUTION
(2021)
Review
Oncology
Michael Xu, Latese Evans, Candice L. Bizzaro, Fabio Quaglia, Cecilia E. Verrillo, Li Li, Julia Stieglmaier, Matthew J. Schiewer, Lucia R. Languino, William K. Kelly
Summary: Despite therapeutic advances in prostate cancer treatment, metastatic castration-resistant prostate cancer remains a challenge. Highly expressed proteins STEAP1-4 have been identified as significant drivers of prostate cancer aggressiveness and metastasis. However, their other biological functions and understanding of heterotrimers and homotrimers are limited. This review highlights the importance of further research on the role of STEAP1-4 in prostate cancer and their potential clinical applications.
Article
Oncology
Ze-Xuan Fang, Chun-Lan Li, Wen-Jia Chen, Hua-Tao Wu, Jing Liu
Summary: This study analyzed the expression of STEAP family members in CRC. Among different STEAP family members, STEAP4 plays a different role in CRC compared to STEAPs 1-3. In CRC, the expression of STEAP4 is not only lower than that in normal tissues, but it is also positively correlated with immune infiltration and immune-related biomarkers. These findings suggest that STEAP4 may be a potential biomarker for predicting CRC immune infiltration status.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Xun Wang, Dongni Wang, Qiwei Wang, Weiming Huang, Meimei Dongye, Xulin Zhang, Duoru Lin, Zhuoling Lin, Jing Li, Weiling Hu, Xiaoyan Li, Xiaoshan Lin, Qiuping Zhong, Weirong Chen, Haotian Lin
Summary: This study broadens the mutation and phenotype spectrum of the GJA8 and CHMP4B genes in a cohort of Chinese patients with congenital cataracts. Patients carrying mutations in the same gene exhibit similar cataract phenotypes at a young age.
FRONTIERS IN MEDICINE
(2021)
Article
Pediatrics
Fang Zhang, Gulbanur Amat, Yanjing Tang, Ru Chen, Xin Tian, Wenting Hu, Changcheng Chen, Shuhong Shen, Yangyang Xie
Summary: This study reveals the NUDT15 gene polymorphism in Chinese children of Han, Uighur, Kirghiz, and Dai nationalities, providing effective detection recommendations for different ethnic groups to predict thiopurine-related toxicity.
FRONTIERS IN PEDIATRICS
(2022)
Article
Genetics & Heredity
Xuehui Yu, Lamei Yuan, Sheng Deng, Hong Xia, Xiaolong Tu, Xiong Deng, Xiangjun Huang, Xiao Cao, Hao Deng
Summary: This study identified a possible association between DNAH17 gene variants and left-right asymmetry disorders, expanding the variant spectrum of this gene in human disorders. This provides insights into the potential pathogenesis of ciliary/flagellar disorders and offers supplementary explanation for genetic counseling.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Hui-Hui Fan, Lei Cui, Xiao-Xia Jiang, Ya-Dan Song, Shu-Shu Liu, Ke-Yun Wu, Hao-Jia Dong, Miao Mao, Begench Ovlyakulov, Hong-Mei Wu, Jian-Hong Zhu, Xiong Zhang
Summary: This study found that genetic variants of CLEC16A are associated with an increased risk of Parkinson's disease (PD) in the Han Chinese population. Specifically, the rs6498169 and rs7200786 variants were significantly associated with PD susceptibility, and rs6498169 was also associated with a specific subtype of PD. Functional annotation analysis suggested that rs6498169 may affect transcription factor binding and target gene expression. These findings highlight the pleiotropic role of CLEC16A and strengthen the association between PD and autoimmune diseases.
FRONTIERS IN GENETICS
(2022)
Article
Psychiatry
Xiaorong Wang, Guofu Zhang, Weihong Lu, Yi Zhang, Weixing Fan, Wei Tang, Chen Zhang
Summary: This study identified a novel BD risk SNP rs10932201 in Han Chinese, which may be a risk factor for cognitive dysfunction in patients with BD. The G allele of rs10932201 was associated with a higher frequency in BD patients compared to control subjects, and carriers of this allele had significantly lower levels of CREB1 expression in intralobular white matter.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Qing Zhang, Yuying Qi, Shuanghu Wang, Fangling Zhao, Lili Zou, Quan Zhou, Peiwu Geng, Yun Hong, Hang Yang, Qingfeng Luo, Jianping Cai, Hualan Wu, Dongxu Wang, Hao Chen, Jiefu Yang, Dapeng Dai
Summary: This study investigated the distribution pattern of CYP2C9 gene variants in a Chinese Han population and assessed their impact on drug metabolic activities. A total of 26 allelic variants of CYP2C9 were detected, including 16 previously reported alleles and 10 newly identified non-synonymous variants. The newly detected variants showed comparable protein expression levels to the wild type in yeast cells, except for a few. Most variants exhibited significantly elevated activities for drug metabolism, while three variants almost lost their catalytic activities.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Hui Yang, Huijun Li, Qingyao Xia, Wencheng Dai, Xin Li, Yan Liu, Jie Nie, Fei Yang, Yunfeng Sun, Lei Feng, Liye Yang
Summary: This study investigated the correlation between UGT1A1 variant and neonatal hyperbilirubinemia in Chinese Uighur and Han populations. The results suggest that UGT1A1 promoter polymorphism may be an important genetic modulator of plasma bilirubin level and risk of neonatal hyperbilirubinemia within ethnic groups.
Article
Medical Laboratory Technology
Shimeng Chen, Xiaolu Deng, Juan Xiong, Fang He, Lifen Yang, Baiyu Chen, Chen Chen, Ciliu Zhang, Li Yang, Jing Peng, Fei Yin
Summary: This study explored the clinical and genetic characteristics of Chinese patients with de novo DEAF1 variants. The patients exhibited intellectual disability, language delay, and behavior problems. Interestingly, the DEAF1-related epilepsy in Eastern-Asian individuals was found to be completely treatable. The study expanded the knowledge of DEAF1-related neurodevelopmental disorder and the de novo variant database of DEAF1.
CLINICA CHIMICA ACTA
(2021)
Article
Fisheries
Jiying Li, Ke Zhao, Hao Li, Kaimin Zhou, Qun Wang, Weiwei Li
Summary: The study revealed that the Dscam gene in the Chinese mitten crab has different variants that play a role in immune regulation, with significant increase in expression levels after bacterial stimulation. The two variants also differ in their regulation of antimicrobial peptides, proportion of carried exons, and bacterial phagocytosis.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Lijuan Huang, Jiajia Peng, Yan Xie, Yunyu Zhou, Xiaolin Wang, Hui Wang, Jingang Gui, Ningdong Li
Summary: This study aims to describe the diversity of clinical features caused by PAX6 pathogenic variants in Han Chinese patients. Genetic testing identified 20 pathogenic variations, 12 of which were previously reported and 8 were novel. The clinical phenotypes varied among patients, even those with the same variants. Genetic testing is helpful for differential diagnosis.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Guang Shi, Hong Zhang, Qiong Yu, Hui Jin, Chun-Mei Hu, Shu-Chun Li, You-Bo Ji
JOURNAL OF CELLULAR BIOCHEMISTRY
(2018)
Article
Endocrinology & Metabolism
Qiong Yu, Dong Li, Dan Wang, Chun-Mei Hu, Yan Sun, Yan Tang, Guang Shi
JOURNAL OF BONE AND MINERAL METABOLISM
(2019)
Review
Pharmacology & Pharmacy
Yan Zheng, Wei Feng, Yu-Juan Wang, Yan Sun, Guang Shi, Qiong Yu
EUROPEAN JOURNAL OF PHARMACOLOGY
(2019)
Article
Clinical Neurology
Wen-Wang Rao, Ming-Jia Yang, Bo-Nan Cao, Yue-Yue You, Yang-Yu Zhang, Ying-Yu Liu, Changgui Kou, Yaqin Yu, Ryan M. Cassidy, Qiong Yu, Xiang Yang Zhang
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Article
Polymer Science
Chun-Mei Hu, Wei Zhong, Yan Tang, Qiong Yu, Guang Shi
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2019)
Article
Biotechnology & Applied Microbiology
Xiaojing Zhu, Rixin Li, Guojun Kang, Qi Kang, Wenwang Rao, Mingjia Yang, Bonan Cao, Mingyuan Zhang, Yaoyao Sun, Yueying Wang, Xin Chen, Yaqin Yu, Qiong Yu
Article
Oncology
Yujie He, Lot D. de Witte, Lotte C. Houtepen, Danny M. Nispeling, Zhida Xu, Qiong Yu, Yaqin Yu, Elly M. Hol, Rene S. Kahn, Marco P. Boks
CLINICAL EPIGENETICS
(2019)
Review
Medicine, Research & Experimental
Liang Cong, Qiwei Yang, Chunmei Hu, Qiong Yu, Shuhong Hao, Dongfu Li
MEDICAL SCIENCE MONITOR
(2019)
Article
Biochemistry & Molecular Biology
Yaoyao Sun, Guojun Kang, Xiaojing Zhu, Rixin Li, Qi Kang, Mingyuan Zhang, Yueying Wang, Xin Chen, Yaqin Yu, Qiong Yu
Review
Medicine, General & Internal
Li-Jia Wen, Jun-Hong Chen, Hong-Ji Xu, Qiong Yu, Kai Liu
Article
Medicine, General & Internal
Yueying Wang, Shuai Liu, Zhao Wang, Yusi Fan, Jingxuan Huang, Lan Huang, Zhijun Li, Xinwei Li, Mengdi Jin, Qiong Yu, Fengfeng Zhou
Summary: The study found that the survival rate of women with primary lung cancer is often higher than that of men, and machine learning algorithms perform well in survival prediction. Surgical removal plays an important role in one-year survival prediction. Male patients may have more complex factors in lung cancer, highlighting the need for developing gender-specific diagnosis and prognosis models.
MEDICINA-LITHUANIA
(2021)
Article
Medicine, General & Internal
Quewang Liu, Yueying Wang, Meiyu Duan, Yusi Fan, Xingyuan Pan, Shuai Liu, Qiong Yu, Lan Huang, Fengfeng Zhou
Summary: The study found that sex-specific models outperformed sex-independent models in detecting early-stage lung cancers, and Venn plots indicated that females and males shared only a few transcriptomic biomarkers of early-stage lung cancers. Therefore, sex information plays an important role in optimizing disease diagnosis models.
Review
Biochemistry & Molecular Biology
Qiong Yu, Fengyu Xue, Zhijun Li, Xinwei Li, Lizhe Ai, Mengdi Jin, Mengtong Xie, Yaqin Yu
Summary: Through a meta-analysis of multiple studies, it was found that the intake of total carotenoids, beta-carotene, alpha-carotene, lycopene, and/or corn xanthin was significantly inversely associated with depressive symptoms, while beta-cryptoxanthin showed no significant correlation. The results suggest that carotenoids may act as protective factors for depressive symptoms, and dietary intake may help reduce the risk of depressive symptoms.
Article
Psychiatry
M. P. Boks, L. C. Houtepen, Z. Xu, Y. He, G. Ursini, A. X. Maihofer, P. Rajarajan, Q. Yu, H. Xu, Y. Wu, S. Wang, J. P. Shi, H. E. Hulshoff Pol, E. Strengman, B. P. F. Rutten, A. E. Jaffe, J. E. Kleinman, D. G. Baker, E. M. Hol, S. Akbarian, C. M. Nievergelt, L. D. De Witte, C. H. Vinkers, D. R. Weinberger, J. Yu, R. S. Kahn
Article
Endocrinology & Metabolism
G. Shi, C-M. Hu, Q. Yu, N. Yang, Z-S. Xue, B. Zhao, M. Guo, Y. Zheng
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2018)