Article
Oncology
Ashley Schlafstein, Yuan Liu, Subir Goyal, Shannon Kahn, Karen Godette, Jolinta Lin, Mylin A. Torres, Trevor J. Royce, Sagar A. Patel
Summary: The addition of regional nodal irradiation (RNI) may not provide long-term survival benefits for breast cancer patients who convert to pathologically node negative after neoadjuvant chemotherapy (NAC) and breast conserving surgery with sentinel lymph node biopsy (SLNB) alone.
CLINICAL BREAST CANCER
(2022)
Article
Oncology
Andrea Barrio, Giacomo Montagna, Anita Mamtani, Varadan Sevilimedu, Marcia Edelweiss, Deborah Capko, Hiram S. Cody, Mahmoud El-Tamer, Mary L. Gemignani, Alexandra Heerdt, Laurie Kirstein, Tracy-Ann Moo, Melissa Pilewskie, George Plitas, Virgilio Sacchini, Lisa Sclafani, Audree Tadros, Kimberly J. Van Zee, Monica Morrow
Summary: This study examined nodal recurrence rates in patients with clinically node-positive cancer treated with sentinel lymph node biopsy after neoadjuvant chemotherapy, showing low rates of axillary failure at a median follow-up of 40 months, supporting potential omission of axillary lymph node dissection in patients achieving nodal pathologic complete response with SLNB alone.
Article
Oncology
Daegan Sit, Nafisha Lalani, Elisa Chan, Eric Tran, Caroline Speers, Lovedeep Gondara, Stephen Chia, Karen Gelmon, Caroline Lohrisch, Alan Nichol
Summary: This study aimed to investigate whether regional nodal irradiation (RNI) improves breast cancer recurrence-free interval (BCRFI) in women with biologically low-risk N1 breast cancer. The population-based study found that RNI was not associated with improved BCRFI for this specific population.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Giacomo Montagna, Minna K. Lee, Varadan Sevilimedu, Andrea Barrio, Monica Morrow
Summary: In cN1 patients rendered cN0 with neoadjuvant chemotherapy, when >= 3 sentinel lymph nodes (SLNs) are removed, the clipped node is an SLN in the majority of cases. Failure to retrieve the clipped node should not be an indication for axillary lymph node dissection (ALND).
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Li Zhang, Jun Liu, Jinli Ma, Xin Mei, Xingxing Chen, Miao Mo, Xiaofang Wang, Jin Meng, Wei Shi, Jose G. Bazan, Zhimin Shao, Zhen Zhang, Xiaoli Yu, Xiaomao Guo, Zhaozhi Yang
Summary: This study aimed to examine whether the inclusion of the posterolateral supraclavicular node (SCL) region to the standard medial SCL target volume improves SCL control and survival outcomes in high-risk node-positive breast cancer patients. Retrospective analysis of 544 patients treated with post-operative radiation therapy was conducted, and the results showed that irradiating the posterolateral SCL region did not significantly improve SCL control and survival outcomes.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Sue Zann Lim, Tae-Kyung Yoo, Sae Byul Lee, Jisun Kim, Il Yong Chung, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Sei-Hyun Ahn, Seonok Kim, Hee Jeong Kim
Summary: This study suggests that patients who had complete disappearance of lymph nodes following neoadjuvant chemotherapy can be safely treated with SLNB alone, and have better survival rates compared to those who underwent ALND.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Surgery
Alexandra M. Zaborowski, Katie Doogan, Siobhan Clifford, Gavin Dowling, Farah Kazi, Karina Delaney, Himanshu Yadav, Aaron Brady, James Geraghty, Denis Evoy, Jane Rothwell, Damian Mccartan, Anna Heeney, Mitchel Barry, Siun M. Walsh, Maurice Stokes, Malcolm R. Kell, Michael Allen, Colm Power, Arnold D. K. Hill, Elizabeth Connolly, Dhafir Alazawi, Terence Boyle, Mark Corrigan, Peter O'Leary, Ruth S. Prichard
Summary: There is a debate about the necessity of performing a sentinel lymph node biopsy in patients with clinically and radiologically node-negative breast cancer after neoadjuvant chemotherapy. This study found that the rate of sentinel lymph node positivity is exceptionally low in patients who achieve a radiological complete response in the breast.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Oncology
Won Kyung Cho, Jee Suk Chang, Seung Gyu Park, Nalee Kim, Doo Ho Choi, Haeyoung Kim, Yong Bae Kim, Won Park, Chang Ok Suh
Summary: In node-positive breast cancer patients treated with mastectomy, post-mastectomy RT, and taxane-based chemotherapy, IMNI is associated with improved disease-free survival (DFS) and overall survival (OS), despite a low rate of locoregional recurrence.
Review
Oncology
Dan Moldoveanu, Tanya L. Hoskin, Courtney N. Day, Amy K. Schulze, Matthew P. Goetz, Judy C. Boughey
Summary: This study aimed to evaluate the effectiveness of neoadjuvant chemotherapy in treating node-positive ER+/HER2- breast cancer. The results showed a high rate of pathological complete response in the lymph nodes, which was associated with patient age and Ki67 levels. Pathological complete response in the lymph nodes was positively correlated with overall survival.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Surgery
Gray B. Peery, Joyce Pak, Laura Burkbauer, Chris B. Agala, Julia M. Selfridge, Kristalyn K. Gallagher, Philip M. Spanheimer
Summary: The study aimed to investigate the omission of axillary lymph node dissection (ALND) in patients with ypN + breast cancer after neoadjuvant systemic therapy (NST). The results showed that despite guidelines recommending ALND, omission of ALND is common in these patients and has been increasing over time.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Oncology
Maria Cristina Leonardi, Camilla Arrobbio, Sara Gandini, Stefania Volpe, Francesca Colombo, Eliana La Rocca, Viviana Galimberti, Sabrina Kahler-Ribeiro-Fontana, Cristiana Fodor, Samantha Dicuonzo, Damaris Patricia Rojas, Maria Alessia Zerella, Anna Morra, Emilia Montagna, Marco Colleoni, Giovanni Mazzarol, Laura Lavinia Travaini, Mattia Zaffaroni, Paolo Veronesi, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
Summary: This study aimed to evaluate the rate of positive non-sentinel lymph nodes in breast cancer patients after neoadjuvant systemic therapy following positive sentinel lymph node biopsy. Positive non-SLNs were found in 62.3% of cases and were significantly associated with older age, clinically positive lymph nodes, SLN extracapsular extension, and a higher ratio of positive SLNs/total SLNs. ECE and higher nodal ratio were independent predictors of III axillary level positivity.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Sungchan Gwark, Woo Chul Noh, Sei Hyun Ahn, Eun Sook Lee, Yongsik Jung, Lee Su Kim, Wonshik Han, Seok Jin Nam, Gyungyub Gong, Seon-Ok Kim, Hee Jeong Kim
Summary: This study evaluated ALND rates and prognosis in ER+/HER2-, LN-positive, premenopausal breast cancer patients after NCT and NET treatment. The NCT group had a lower ALND rate, higher axillary pCR rate, but there was no significant difference in survival rates compared to the NET group.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Sabine R. de Wild, Janine M. Simons, Marie-Jeanne T. F. D. Vrancken Peeters, Marjolein L. Smidt, Linetta B. Koppert
Summary: There is a trend towards de-escalating axillary staging and treatment in breast cancer patients by using less invasive procedures. However, it is unclear which procedure is the most accurate, and long-term oncologic safety data are missing.
Article
Oncology
Angelena Crown, Mithat Gonen, Tiana Le, Monica Morrow
Summary: The study suggests that node-negative, hormone receptor-positive/human epidermal growth factor receptor 2-negative patients have a lower risk of locoregional recurrence, while node-negative, triple-negative patients may have a risk as high as 10% at 3 years, indicating a possible benefit from postmastectomy radiation/regional nodal irradiation. Additional research with more patients is needed for definitive conclusions.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Jung Whan Chun, Jisun Kim, Il Yong Chung, Beom Seok Ko, Hee Jeong Kim, Jong Won Lee, Byung Ho Son, Sei-Hyun Ahn, Sae Byul Lee
Summary: This study analyzed the long-term outcomes of patients with residual N1 nodal disease following neoadjuvant chemotherapy for breast cancer and found that omission of axillary lymph node dissection using propensity score matching was oncologically safe. No significant differences in axillary recurrence-free survival, distant metastasis-free survival, overall survival, and breast cancer-free survival were observed between SLNB only group and ALND group after propensity score matching.
SCIENTIFIC REPORTS
(2021)
Letter
Oncology
Wendy A. Woodward, Naoto T. Ueno, Henry M. Kuerer, Anthony Lucci, Yu Shen
Article
Oncology
Naoko Matsuda, Xiaoping Wang, Bora Lim, Savitri Krishnamurthy, Ricardo H. Alvarez, Jie S. Willey, Charla A. Parker, Juhee Song, Yu Shen, Jianhua Hu, Wenhui Wu, Nan Li, Gildy V. Babiera, James L. Murray, Banu K. Arun, Abenaa M. Brewster, James M. Reuben, Michael C. Stauder, Chad M. Barnett, Wendy A. Woodward, H. T. Carisa Le-Petross, Anthony Lucci, Sarah M. DeSnyder, Debu Tripathy, Vicente Valero, Naoto T. Ueno
Article
Oncology
Aaron J. Grossberg, Xiudong Lei, Ting Xu, Simona F. Shaitelman, Karen E. Hoffman, Elizabeth S. Bloom, Michael C. Stauder, Welela Tereffe, Pamela J. Schlembach, Wendy A. Woodward, Thomas A. Buchholz, Benjamin D. Smith
Article
Biotechnology & Applied Microbiology
Manasa Gadde, Caleb Phillips, Neda Ghousifam, Anna G. Sorace, Enoch Wong, Savitri Krishnamurthy, Anum Syed, Omar Rahal, Thomas E. Yankeelov, Wendy A. Woodward, Marissa N. Rylander
BIOTECHNOLOGY AND BIOENGINEERING
(2020)
Article
Oncology
Priyanka Chakraborty, Jason T. George, Wendy A. Woodward, Herbert Levine, Mohit Kumar Jolly
Summary: The study compared various gene lists proposed as molecular footprints of IBC and found little overlap between them. However, single-sample gene set enrichment analysis improved the accuracy of identifying IBC samples. Additionally, IBC samples displayed higher variability in EMT scores, suggesting a potential useful biomarker.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Beryl McCormick, Kathryn A. Winter, Wendy Woodward, Henry M. Kuerer, Nour Sneige, Eileen Rakovitch, Barbara L. Smith, Isabelle Germain, Alan C. Hartford, Mark A. O'Rourke, Eleanor M. Walker, Eric A. Strom, Judith O. Hopkins, Lori J. Pierce, Anthony T. Pu, Kenneth N. M. Sumida, Danny Vesprini, Jennifer Moughan, Julia R. White
Summary: NRG/RTOG 9804 is the only randomized trial assessing the impact of whole breast irradiation versus observation in women with good-risk ductal carcinoma in situ (DCIS) following lumpectomy. The study found that whole breast irradiation significantly reduced the risk of ipsilateral breast recurrence for DCIS with durable effects at 15 years.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
D. Boyce-Fappiano, I Bedrosian, Y. Shen, H. Lin, O. Gjyshi, A. Yoder, S. F. Shaitelman, W. A. Woodward
Summary: Surgery remains the mainstay of curative therapy for non-metastatic breast cancer, but a small percentage of patients do not undergo surgery. Factors associated with lack of surgery include black race, older age, lower income, and lack of insurance or public insurance. Patients who did not undergo surgery had higher disease stage and more aggressive disease biology, with only a small portion receiving radiation therapy. Age, race, income, insurance status, disease stage, tumor subtype, treatment facility type and location, and receipt of radiation therapy were associated with overall survival in non-surgical breast cancer patients. Subgroup analysis showed that chemotherapy improved survival in certain subgroups, while radiation therapy was beneficial for others. This study highlights the importance of considering alternative therapies for patients who do not undergo surgery for breast cancer.
Editorial Material
Oncology
Mikhail G. Kolonin, Wendy A. Woodward
Summary: Chemotherapy is effective in treating nonmetastatic cancer, but some high-risk patients may develop chemoresistance and progress to an incurable metastatic stage. A study suggests that the interaction between the immune system and extracellular matrix remodeling plays a role in this process, and lysyl oxidase secreted by CD8(+) T cells may be a potential target to enhance the efficacy of chemotherapy agents.
Article
Oncology
Charlotte Rypens, Francois Bertucci, Pascal Finetti, Fredika Robertson, Sandra Fernandez, Naoto Ueno, Wendy A. Woodward, Kenneth Van Golen, Peter Vermeulen, Luc Dirix, Patrice Viens, Daniel Birnbaum, Gayathri R. Devi, Massimo Cristofanilli, Steven Van Laere
Summary: In this study, the transcriptome of a series of inflammatory breast cancer (IBC) preclinical models was evaluated and compared to patient samples. It was found that the IBC preclinical models are predominantly estrogen receptor-negative and of the basal-like subtype, which is similar to the molecular characteristics observed in patients. The study also revealed important roles for cell proliferation, MYC transcriptional activity, and TNF alpha/NF kappa B in IBC biology.
Letter
Oncology
Steven J. Chmura, Wendy A. Woodward, Julia R. White
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Wendy A. Woodward, Melissa P. Mitchell
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Medicine, General & Internal
Alshaimaa Tarek, Hossam Taha Mohamed, Aya Ali El-Sharkawy, Shrouk Khalaf El-Sayed, Jon Mark Hirshon, Wendy A. Woodward, Mohamed El-Shinawi, Mona Mostafa Mohamed
Summary: By comparing the gene expression profiles of matrisome and adhesome in non-IBC and IBC tissues, as well as the secretory inflammatory mediators in patient-derived explants, we found that these genes and cytokines play a significant role in the metastasis of inflammatory breast cancer.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Oncology
Manasa Gadde, Melika Mehrabi-Dehdezi, Bisrat G. Debeb, Wendy A. Woodward, Marissa Nichole Rylander
Summary: Macrophages, specifically tumor-associated macrophages (TAMs), play a vital role in the progression of inflammatory breast cancer (IBC). This study presents a 3D in vitro microfluidic IBC platform that incorporates TAMs, IBC cells, and endothelial cells. The inclusion of TAMs in the platform led to an increase in the formation of new blood vessel sprouts and enhanced permeability of the endothelium. Interestingly, platforms containing THP-1 M1 or M2 macrophages exhibited significantly greater porosity in the extracellular matrix compared to platforms containing THP-1 M0 and MDA-IBC3 cells alone. Cytokine analysis revealed selective increases in IL-8 and MMP9 secretion when macrophages were cultured in the platforms. Notably, intravasation of tumor cells into the vessels was observed exclusively in the platform containing MDA-IBC3 and M0 macrophages.
Article
Oncology
Shane R. Stecklein, Simona F. Shaitelman, Gildy V. Babiera, Isabelle Bedrosian, Dalliah M. Black, Matthew T. Ballo, Isadora Arzu, Eric A. Strom, Valerie K. Reed, Tomas Dvorak, Benjamin D. Smith, Wendy A. Woodward, Karen E. Hoffman, Pamela J. Schlembach, Steve M. Kirsner, Christopher L. Nelson, Jinzhong Yang, William Guerra, Shiva Dibaj, Elizabeth S. Bloom
PRACTICAL RADIATION ONCOLOGY
(2019)
Review
Oncology
Bora Lim, Wendy A. Woodward, Xiaoping Wang, James M. Reuben, Naoto T. Ueno
NATURE REVIEWS CANCER
(2018)