Article
Biochemistry & Molecular Biology
Iason Psilopatis, Jule Ida Schaefer, Dimitrios Arsenakis, Dimitrios Bolovis, Georgia Levidou
Summary: This study provides preliminary evidence suggesting that overexpression of SOX11 might promote EMT in metastatic serous ovarian cancer, thereby enhancing tumor metastasis.
Article
Reproductive Biology
Qiao Ping Xu, Kui Deng, Zhen Zhang, Hongkai Shang
Summary: Ovarian cancer is a growing global disease, and there is an urgent need for chemotherapy and targeted therapy. SLFN5 plays an important role in malignancy, but its specific function in ovarian cancer cells is still unclear. This study suggests that SLFN5 expression is related to the progression and malignancy of ovarian cancer, and its silencing has a significant inhibitory effect on the invasion and metastasis ability of ovarian cancer cells. Therefore, SLFN5 may serve as a potential target for future drug development in the treatment of ovarian cancer.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Medicine, Research & Experimental
Dilys Leung, Zoe K. Price, Noor A. Lokman, Wanqi Wang, Lizamarie Goonetilleke, Elif Kadife, Martin K. Oehler, Carmela Ricciardelli, George Kannourakis, Nuzhat Ahmed
Summary: The study identified novel EMT-related markers in platinum-resistant ovarian cancer cells, indicating a potential link between EMT and chemotherapy resistance. Proteomic analysis revealed enhanced cell migration and reduced proliferation, glycolysis, and oxidative phosphorylation in resistant cell lines.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hadil Onallah, Sheethal Thomas Mannully, Ben Davidson, Reuven Reich
Summary: The study demonstrates the important role of PLD isoenzymes in regulating migration, invasion, metastasis, and EMT in HGSC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
Article
Biochemistry & Molecular Biology
Long Xu, Jian Wang, Buhan Liu, Jiaying Fu, Yuanxin Zhao, Sihang Yu, Luyan Shen, Xiaoyu Yan, Jing Su
Summary: Epithelial ovarian cancer has the highest mortality rate among gynecological malignant tumors, largely due to metastasis. This study found that HDAC9 plays different roles in different histological subtypes of ovarian cancer and may be a potential target for personalized treatment.
Article
Biotechnology & Applied Microbiology
Lanqing Gong, Liqiong Cai, Guodong Li, Jing Cai, Xiaoqing Yi
Summary: In epithelial ovarian cancer, overexpression of GADD45B leads to shorter survival and poor outcomes, and is associated with metastasis. Downregulation of GADD45B decreases cell migration and affects the EMT pathway.
ONCOTARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Tania Velletri, Carlo Emanuele Villa, Domenica Cilli, Bianca Barzaghi, Pietro Lo Riso, Michela Lupia, Raffaele Luongo, Alejandro Lopez-Tobon, Marco De Simone, Raoul J. P. Bonnal, Luca Marelli, Stefano Piccolo, Nicoletta Colombo, Massimiliano Pagani, Ugo Cavallaro, Saverio Minucci, Giuseppe Testa
Summary: This study introduces a new method for isolating and growing single cells from patients' metastatic ascites to establish 3D cultures referred to as sMOCS. By using single cell RNA sequencing, researchers were able to define the cellular composition of metastatic ascites and reproduce features of the original metastasis that cannot be observed in traditional 2D culture. This method provides a powerful tool for precision oncology in ovarian cancer by enriching informative cell subpopulations and analyzing their diversity at the functional and molecular level.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Environmental Sciences
Tingting Xie, Minghua Tan, Yang Gao, Hong Yang
Summary: The study reveals that upregulation of CRABP2 contributes to ovarian cancer progression through promoting EZH2 expression and regulating TRIM16 promoter methylation, as well as modulating the expression of EMT marker proteins. These findings provide insights into the potential roles of CRABP2, EZH2, and TRIM16 in ovarian cancer development.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Xiaoyan Xie, Mu Xu, Hangjing Gao, Xianjing Chen, Liangzhi Cai
Summary: This study found that exosome-derived miR21 enhanced the proliferation, migration, and invasion of EOC cells while inhibiting apoptosis. This suggests that exosomal miR21 may be a tumor promoter for ovarian cancer.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Genetics & Heredity
Narges Maleki, Negar Yavari, Maryam Ebrahimi, Ahmad Faisal Faiz, Roya Khosh Ravesh, Aysan Sharbati, Mohammad Panji, Keivan Lorian, Abdollah Gravand, Mojtaba Abbasi, Omid Abazari, Mehdi Shafiee Mehr, Yasin Eskandari
Summary: Silibinin exhibits strong inhibitory effects on ovarian cancer by suppressing cell viability, migration, and invasion, and promoting apoptosis. It also reverses epithelial-mesenchymal transition mechanism and ameliorates tumor growth.
Article
Biochemistry & Molecular Biology
Zhiyang Zhou, Li Jin, Jian Shen, Weihui Shi, Yue Xu, Longyun Ye, Junxi Liu, Jiexue Pan
Summary: A novel synthetic agent, COM33, is developed to relieve chemoresistance caused by carboplatin in ovarian cancer. The combination of COM33 and carboplatin enhances the inhibitory effects on cancer cells and suppresses tumor growth. COM33 also inhibits carboplatin-induced epithelial-mesenchymal transition by inhibiting the ERK signaling pathway.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Miao Zou, Xirui Yin, Xuan Zhou, Xinhui Niu, Manman Su, Yi Wang
Summary: Salinomycin-loaded high-density lipoprotein (S-HDL) has strong anti-ovarian cancer effects and has the potential to be a future treatment for ovarian cancer.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biology
Valentina Cutano, Jessica Marianne Ferreira Mendes, Sara Escudeiro-Lopes, Susana Machado, Judith Vinaixa Forner, Juan M. Gonzales-Morena, Martin Prevorovsky, Viacheslav Zemlianski, Yuxiong Feng, Petra Kralova Viziova, Andrea Hartmanova, Beata Malcekova, Pavel Jakoube, Sonia Iyer, Zuzana Keckesova
Summary: This study demonstrates the tumor suppressor properties of mitochondrial protein LACTB in ovarian cancer, showing its ability to inhibit cancer cell growth and migration through the regulation of cell differentiation and stemness properties. By targeting the EMT program and Snail2/Slug transcription factor, LACTB presents a new therapeutic approach for ovarian cancer.
LIFE SCIENCE ALLIANCE
(2022)
Article
Engineering, Civil
Weiren Zhang, Fan Yang, Siyuan Zhang, Yijie Bian, Peng Wang, S. A. Meguid
Summary: This paper presents a new multicellular design for effective energy absorption. Extensive experiments, simulations, and analysis were conducted to evaluate the performance of this design. The results show that a face centered square layout with an appropriately selected taper angle has excellent energy absorption and crashworthiness properties.
INTERNATIONAL JOURNAL OF STRUCTURAL STABILITY AND DYNAMICS
(2023)
Article
Oncology
Thomas Behrens, Calvin Ge, Roel Vermeulen, Benjamin Kendzia, Ann Olsson, Joachim Schuez, Hans Kromhout, Beate Pesch, Susan Peters, Luetzen Portengen, Per Gustavsson, Dario Mirabelli, Pascal Guenel, Daniele Luce, Dario Consonni, Neil E. Caporaso, Maria Teresa Landi, John K. Field, Stefan Karrasch, Heinz-Erich Wichmann, Jack Siemiatycki, Marie-Elise Parent, Lorenzo Richiardi, Lorenzo Simonato, Karl-Heinz Joeckel, Wolfgang Ahrens, Hermann Pohlabeln, Guillermo Fernandez-Tardon, David Zaridze, John R. McLaughlin, Paul A. Demers, Beata Swiatkowska, Jolanta Lissowska, Tamas Pandics, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Paolo Boffetta, Bas Bueno-de-Mesquita, Francesco Forastiere, Kurt Straif, Thomas Bruening
Summary: Limited evidence exists regarding the exposure-effect relationship between lung-cancer risk and hexavalent chromium (Cr(VI)) or nickel. This study found that occupational exposure to Cr(VI) and nickel was associated with lung-cancer risks, particularly in men. In men, the highest quartile of cumulative exposure to CR(VI) and nickel were both significantly associated with increased odds ratios for lung cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Letter
Oncology
Bradley J. Monk, Keiichi Fujiwara, David M. O'Malley, Robert L. Coleman, Iain A. McNeish, Kevin K. Lin, Stephanie Hume, Rebecca S. Kristeleit
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Rheumatology
Ai Yaku, Yuki Ishikawa, Takeshi Iwasaki, Ryosuke Hiwa, Keitaro Matsuo, Hiroh Saji, Kimiko Yurugi, Yasuo Miura, Moritoshi Furu, Hiromu Ito, Takao Fujii, Taira Maekawa, Motomu Hashimoto, Koichiro Ohmura, Tsuneyo Mimori, Chikashi Terao
Summary: Objective HLA-DRB1 alleles, particularly the shared epitope (SE) alleles, are strongly associated with RA. Different genetic structures underlie the production of the various autoantibodies in RA. However, the genetic architecture underlying IgG-RF, which is associated with rheumatoid vasculitis, is not well understood.
Article
Oncology
Eun-Young Kang, Ashley Weir, Nicola S. Meagher, Kyo Farrington, Gregg S. Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J. Riggan, Adelyn Bolithon, Gordana Popovic, Betty Leung, Katrina Tang, Neil Lambie, Joshua Millstein, Jennifer Alsop, Michael S. Anglesio, Beyhan Ataseven, Ellen Barlow, Matthias W. Beckmann, Jessica Berger, Christiani Bisinotto, Hans Boesmueller, Jessica Boros, Alison H. Brand, Angela Brooks-Wilson, Sara Y. Brucker, Michael E. Carney, Yovanni Casablanca, Alicia Cazorla-Jimenez, Paul A. Cohen, Thomas P. Conrads, Linda S. Cook, Penny Coulson, Madeleine Courtney-Brooks, Daniel W. Cramer, Philip Crowe, Julie M. Cunningham, Cezary Cybulski, Kathleen M. Darcy, Mona A. El-Bahrawy, Esther Elishaev, Ramona Erber, Rhonda Farrell, Sian Fereday, Anna Fischer, Maria J. Garcia, Simon A. Gayther, Aleksandra Gentry-Maharaj, C. Blake Gilks, Marcel Grube, Paul R. Harnett, Shariska Petersen Harrington, Philipp Harter, Arndt Hartmann, Jonathan L. Hecht, Sebastian Heikaus, Alexander Hein, Florian Heitz, Joy Hendley, Brenda Y. Hernandez, Susanna Hernando Polo, Sabine Heublein, Akira Hirasawa, Estrid Hogdall, Claus K. Hogdall, Hugo M. Horlings, David G. Huntsman, Tomasz Huzarski, Andrea Jewell, Mercedes Jimenez-Linan, Michael E. Jones, Scott H. Kaufmann, Catherine J. Kennedy, Dineo Khabele, Felix K. F. Kommoss, Roy F. P. M. Kruitwagen, Diether Lambrechts, Nhu D. Le, Marcin Lener, Jenny Lester, Yee Leung, Anna Linder, Liselore Loverix, Jan Lubinski, Rashna Madan, G. Larry Maxwell, Francesmary Modugno, Susan L. Neuhausen, Alexander Olawaiye, Siel Olbrecht, Sandra Orsulic, Jose Palacios, Celeste Leigh Pearce, Malcolm C. Pike, Carmel M. Quinn, Ganendra Raj Mohan, Cristina Rodriguez-Antona, Matthias Ruebner, Andy Ryan, Stuart G. Salfinger, Naoko Sasamoto, Joellen M. Schildkraut, Minouk J. Schoemaker, Mitul Shah, Raghwa Sharma, Yurii B. Shvetsov, Naveena Singh, Gabe S. Sonke, Linda Steele, Colin J. R. Stewart, Karin Sundfeldt, Anthony J. Swerdlow, Aline Talhouk, Adeline Tan, Sarah E. Taylor, Kathryn L. Terry, Aleksandra Toloczko, Nadia Traficante, Koen K. Van de Vijver, Maaike A. van der Aa, Toon Van Gorp, Els Van Nieuwenhuysen, Lilian Van-Wagensveld, Ignace Vergote, Robert A. Vierkant, Chen Wang, Lynne R. Wilkens, Stacey J. Winham, Anna H. Wu, Javier Benitez, Andrew Berchuck, Francisco J. Candido Dos Reis, Anna DeFazio, Peter A. Fasching, Ellen L. Goode, Marc T. Goodman, Jacek Gronwald, Beth Y. Karlan, Stefan Kommoss, Usha Menon, Hans-Peter Sinn, Annette Staebler, James D. Brenton, David D. Bowtell, Paul D. P. Pharoah, Susan J. Ramus, Martin Kobel
Summary: This study validates that high-level amplification of CCNE1 is associated with shorter survival in tubo-ovarian high-grade serous carcinoma (HGSC), supporting its use as a prognostic biomarker in this disease.
Article
Oncology
Nikoletta Vidra, Ivy Beeren, Moniek van Zutphen, Katja K. Aben, Ellen Kampman, J. Alfred Witjes, Antoine G. van Der Heijden, Lambertus A. Kiemeney, Alina Vrieling
Summary: Although the evidence is limited, adherence to the WCRF/AICR lifestyle recommendations is associated with improved health-related quality of life in patients with NMIBC.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Zhuxuan Fu, Maria Mori Brooks, Sarah Irvin, Susan Jordan, Katja K. H. Aben, Hoda Anton-Culver, Elisa Bandera, Matthias W. Beckmann, Andrew Berchuck, Angela Brooks-Wilson, Jenny Chang-Claude, Linda S. Cook, Daniel W. Cramer, Kara L. Cushing-Haugen, Jennifer A. Doherty, Arif B. Ekici, Peter A. Fasching, Renee T. Fortner, Simon A. Gayther, Aleksandra Gentry-Maharaj, Graham G. Giles, Ellen L. Goode, Marc T. Goodman, Holly R. Harris, Alexander Hein, Rudolf Kaaks, Lambertus A. Kiemeney, Martin Koebel, Joanne Kotsopoulos, Nhu D. Le, Alice W. Lee, Keitaro Matsuo, Valerie McGuire, John R. McLaughlin, Usha Menon, Roger L. Milne, Kirsten B. Moysich, Celeste Leigh Pearce, Malcolm C. Pike, Bo Qin, Susan J. Ramus, Marjorie J. Riggan, Joseph H. Rothstein, Joellen M. Schildkraut, Weiva Sieh, Rebecca Sutphen, Kathryn L. Terry, Pamela J. Thompson, Linda Titus, Anne M. van Altena, Emily White, Alice S. Whittemore, Anna H. Wu, Wei Zheng, Argyrios Ziogas, Sarah E. Taylor, Lu Tang, Thomas Songer, Nicolas Wentzensen, Penelope M. Webb, Harvey A. Risch, Francesmary Modugno
Summary: The lifetime ovulatory years (LOY) are positively associated with nonmucinous epithelial ovarian cancer (EOC) risk, implicating factors beyond ovulation in the development of EOC. The protective effects of parity and oral contraceptive use may not solely depend on anovulation.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Genetics & Heredity
Margaret A. Park, Thinzar Zaw, Sean J. Yoder, Maria Gomez, Maria Genilo-Delgado, Toni Basinski, Esther Katende, Aamir Dam, Shaffer R. S. Mok, Alvaro Monteiro, Amir Mohammadi, Daniel K. Jeong, Kun Jiang, Barbara A. Centeno, Pamela Hodul, Mokenge Malafa, Jason Fleming, Dung-Tsa Chen, Qianxing Mo, Jamie K. Teer, Jennifer B. Permuth
Summary: This study aimed to determine the frequency and type of DNA mutations in surgically resected IPMN and investigate if these mutations can be detected in paired plasma samples. The results showed that common driver mutations were found in IPMN tissue, but not in plasma samples. Therefore, although blood-based biopsies are attractive noninvasive methods, the sensitivity of the method used in this study was not sufficient for detecting driver mutations in IPMN tissue using plasma samples.
G3-GENES GENOMES GENETICS
(2023)
Article
Oncology
Xiaoyin Li, Siddhartha Roy, Jennifer Damonte, Hyun Y. Park, Aasha I. Hoogland, Kala Jamison, Khaled R. Komrokji, Chang Dong Yeo, Youngchul Kim, Jasreman Dhillon, Lisa M. Gudenkauf, Laura B. Oswald, Heather S. L. Jim, Kosj Yamoah, Julio M. Pow-Sang, Peter A. Kanetsky, Clement K. Gwede, Jong Y. Park, Brian D. Gonzalez
Summary: This study aimed to establish a state-wide biobank of African American prostate cancer survivors in Florida to identify biological bases for health disparities. African American men diagnosed with prostate cancer between 2013 and 2017 were identified through the State of Florida's cancer registry. Of the eligible and reachable individuals, a low overall consent rate of 10% was observed. Existing challenges limit the consent and participation in biospecimen research.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Medical Laboratory Technology
Julia R. Naso, Jackie Chan, Janani Reisenauer, Eric S. Edell, Katherine Stackhouse, Aaron O. Bungum, Robert A. Vierkant, Karlyn Pierson, Andrew Seidl, Charles D. Sturgis, Chady Meroueh, Yajue Huang, Christopher P. Hartley
Summary: The use of a remote-controlled robotic microscope improved the ease of adequacy assessment compared to non-robotic telecytology and enabled expediently rendered strongly concordant diagnoses. This study provides evidence that modern robotic telecytology is a feasible and user-friendly method for remotely and potentially intraoperatively rendering adequacy assessments and diagnoses on bronchoscopic cytology specimens.
DIAGNOSTIC CYTOPATHOLOGY
(2023)
Article
Engineering, Environmental
Jian Chen, Barry P. Rosen
Summary: In this study, the broad diversity of structural domains in ArsMs was revealed through comparative analysis. The differences in the ArsM structure lead to variations in methylation efficiency and substrate selectivity. The C-terminal domain was found to play a role in modulating the rate of catalysis. Additionally, the relationship between arsenite efflux systems and methylation was examined.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Yang Wang, Jing Ma, Shiaw-Yih Lin, Huan Xie, Dong Liang
Summary: A stability indicating LC-MS/MS assay was developed and validated for quantification of R14 in plasma and blood. The method involved the rapid conversion of R14 to a stable bisulfite adduct, which provided a suitable way of quantitating R14 concentrations.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Oncology
Laura B. Oswald, Lisa M. Gudenkauf, Xiaoyin Li, Gabriel De Avila, Lauren C. Peres, Kedar Kirtane, Brian D. Gonzalez, Aasha I. Hoogland, Oanh Nguyen, Yvelise Rodriguez, Rachid C. Baz, Kenneth H. Shain, Melissa Alsina, Frederick L. Locke, Ciara Freeman, Omar Castaneda Puglianini, Taiga Nishihori, Hien Liu, Brandon Blue, Ariel Grajales-Cruz, Heather S. L. Jim, Doris K. Hansen
Summary: This study aimed to evaluate patient-reported outcomes among patients with relapsed/refractory multiple myeloma treated with idecabtagene vicleucel (ide-cel) therapy. The findings showed that most patients reported significant and meaningful improvements in health-related quality of life and physical well-being after CAR T treatment.
Meeting Abstract
Oncology
Brett M. Reid, Ann Chen, Zhihua Chen, Florian A. Karreth, Peter Kanetsky, Jennifer B. Permuth, Ozlen Saglam, Jamie Teer, Xiaoqing Yu, Simon Gayther, Ellen Goode, Paul Pharoah, Thomas A. Sellers, Kate Lawrenson
Article
Obstetrics & Gynecology
Michael O. Schneider, Jutta Pretscher, Tamme W. Goecke, Lothar Haeberle, Anne Engel, Johannes Kornhuber, Anna Eichler, Arif B. Ekici, Matthias W. Beckmann, Peter A. Fasching, Eva Schwenke
Summary: This study did not find any association between the candidate haplotypes analyzed in PGR and CYP19A1 genes, as well as single SNPs in ESR1 and COMT genes, with depression scores assessed by EPDS in a cohort of healthy unselected pregnant women.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)