Article
Materials Science, Ceramics
P. Navarrete-Segado, M. Tourbin, D. Grossin, C. Frances
Summary: This research focuses on using stirred bead milling process to control the size of hydroxyapatite particles. The study found the optimal parameters to obtain desired particulate suspensions. The research confirmed the efficient and stable dispersion of hydroxyapatite-filled slurries using this method.
CERAMICS INTERNATIONAL
(2022)
Article
Crystallography
Bwalya A. Witika, Vincent J. Smith, Roderick B. Walker
Summary: A wet media milling top-down approach was used to develop and produce nano co-crystals of Lamivudine (3TC) and zidovudine (AZT) for managing HIV/AIDS infection. Optimization was achieved through design of experiments (DoE) and response surface methodology (RSM) to ensure the final product exhibited the target critical quality attributes (CQA).
Article
Biochemistry & Molecular Biology
Chiara Bellomo, Cristina Pavan, Gianluca Fiore, Guillermo Escolano-Casado, Lorenzo Mino, Francesco Turci
Summary: Occupational exposure to quartz dust is associated with fatal diseases. The contribution of nanometric particles to the toxicity of quartz is still largely unknown. In this study, a top-down milling procedure was used to obtain a nanometric quartz with similar surface properties to fractured quartz, providing a novel material for toxicological investigations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Sergio Alcala-Alcala, Jose Eduardo Casarrubias-Anacleto, Maximiliano Mondragon-Guillen, Carlos Alberto Tavira-Montalvan, Marcos Bonilla-Hernandez, Diana Lizbeth Gomez-Galicia, Guillermo Gosset, Angelica Meneses-Acosta
Summary: A preformed recombinant melanin (PRM) was used as the polymeric raw material to generate recombinant melanin nanoparticles (RMNPs) through bottom-up and top-down manufacturing approaches. The properties of RMNPs, including size, stability, morphology, and solid-state characteristics, were evaluated. The results showed that RMNPs exhibited high stability and resistance to sterilization. Cytotoxicity assays confirmed the safety of RMNPs at concentrations up to 100 μg/mL. These findings pave the way for potential applications of melanin nanoparticles in drug delivery, tissue engineering, diagnosis, and sun protection.
Article
Chemistry, Physical
Narayanan Ramaswamy, Venkatachalam Gopalan, Tae Yub Kwon
Summary: Nano-crystalline hydroxyapatite (HA) coatings were electrochemically deposited on Ti6Al4V substrates, and cathodic HA coatings were obtained by stirring the electrolyte using ultrasonic vibration. The coating obtained at a current density of 50 mA/cm(2) showed good corrosion resistance.
Article
Engineering, Chemical
Gulenay Guner, Dogacan Yilmaz, Dmitry Eskin, Ecevit Bilgili
Summary: In this study, wet-milling kinetics of a drug in a stirred mill were investigated using a microhydrodynamic model. The breakage rate constant k was determined by fitting an nth-order kinetics model to the experimental data. Microhydrodynamic parameters were calculated using three different radial distribution functions (RDFs). Multiple linear regression models (MLRMs) were used to predict k based on the microhydrodynamic parameters or process-bead parameters. The MLRM based on the Lun RDF showed the best fitting-prediction performance among the models tested, outperforming the empirical MLRMs.
Article
Chemistry, Applied
Zhanmei Jiang, Sinan Mu, Chenglong Ma, Yue Liu, Yue Ma, Minghan Zhang, Hongyu Li, Xianqi Liu, Juncai Hou, Bo Tian
Summary: The combined treatment of ball milling and high-pressure homogenization had significant effects on the structure, physical and chemical properties, and rheological characteristics of citrus fiber, leading to reductions in particle size and increases in porosity. This treatment also resulted in improved water and oil holding capacities, water swelling capacity, antioxidant properties, and apparent viscosity of the citrus fiber, providing a theoretical basis for obtaining high-quality citrus fibers in the food industry.
FOOD HYDROCOLLOIDS
(2022)
Article
Pharmacology & Pharmacy
Rita Ambrus, Areen Alshweiat, Piroska Szabo-Revesz, Csilla Bartos, Ildiko Csoka
Summary: Nanocrystals of meloxicam (MLX) were prepared using the bead mill method and high-pressure homogenization. Different drying methods and cryoprotectants were applied to obtain dry nanocrystals. The results showed that freeze-dried samples had the smallest particle size, mannitol-based samples had the highest crystallinity index, and trehalose-based samples had the lowest crystallinity index. These factors explained the differences in dissolution among the samples.
Article
Chemistry, Multidisciplinary
Jan Leipert, Philipp T. Kaulich, Max K. Steinbach, Britta Steer, Konrad Winkels, Christine Blurton, Matthias Leippe, Andreas Tholey
Summary: Researchers have developed a sample preparation method based on protein aggregation and acidic elution, allowing for sensitive protein identification analysis of single nematodes on a digital microfluidics device. Compared to in-tube sample preparation, this method increases proteoform identifications by 46%. Label-free quantification also reveals changes in proteoform abundance that cannot be distinguished by bottom-up proteomics. This workflow facilitates proteoform-focused analysis on limited availability samples.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Nanoscience & Nanotechnology
Jianyu Zhang, Hosop Shin, Wei Lu
Summary: This study demonstrates the top-down synthesis approach for mass-producing phosphorene-graphene nanosheet composites with superior performance. The hybrid material exhibits high reversible capacities at high current densities and maintains structural robustness for long-term cyclability. This scalable synthesis method opens up possibilities for practical applications of phosphorene-graphene materials in batteries.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Food Science & Technology
Annachiara Pirozzi, Roberta Capuano, Roberto Avolio, Gennaro Gentile, Giovanna Ferrari, Francesco Donsi
Summary: Cellulosic nanomaterials obtained through high-pressure homogenization showed better emulsion stabilization capability compared to those obtained through ball milling, forming a 3D network structure that prevents coalescence and gravitational separation of oil droplets.
Article
Chemistry, Applied
Ana Gonzalez, Ya-Jane Wang
Summary: High pressure processing (HPP) is a method of starch modification that is typically conducted in water, but little is known about how the changes induced by pressure differ in different mediums. This study examined the effects of water versus sodium sulfate on corn, potato, and pea starches subjected to HPP at 690 MPa. The results showed that HPP in both media reduced gelatinization enthalpy and crystallinity for all starches. HPP in sodium sulfate had a greater impact on the crystallites of common corn and potato starches, leading to changes in their properties such as pasting temperatures, peak viscosities, breakdowns, and alpha-amylase susceptibility. The competition between sodium sulfate and water molecules affected the properties of HPP starches with different crystalline structures.
Article
Materials Science, Multidisciplinary
Christoph Peppersack, Karsten Wermbter, Arno Kwade, Georg Garnweitner, Sandra Breitung-Faes
Summary: This study presents a simple and effective process for producing transparent coatings on glass substrates. The use of a low surface tension liquid medium in the coating process creates stable suspensions with small particle size, resulting in increased transparency. Dip coating with small particles allows for the production of highly transparent coatings with controlled thickness. Additionally, the drying temperature can be adjusted to alter the film color without affecting transparency.
Article
Food Science & Technology
Xue Li, Zhifei He, Jingbing Xu, Chang Su, Xu Xiao, Ling Zhang, Huanhuan Zhang, Hongjun Li
Summary: High-pressure homogenization (HPH) can improve the particle size, stability, and calcium solubility of rabbit bone aqueous suspensions (RBAS) mainly by improving the protein solubility through changes in protein conformation. However, excessive HPH treatment may negatively affect the quality of the suspensions.
Article
Physics, Multidisciplinary
Deepa Yadav, Neha Bura, Ankit Bhoriya, Jasveer Singh, Velaga Srihari, Himanshu K. Poswal, Nita Dilawar Sharma
Summary: High-pressure investigations were conducted on nano-crystalline Scandium Oxide (Sc2O3) using the synchrotron angle dispersive x-ray diffraction technique. The sample showed crystallographic parameter changes under external pressure while maintaining phase stability up to 35.4 GPa. The compressible nature of the crystal structure was revealed through a significant decrease in lattice parameters and unit cell volume with increasing pressure.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
