Article
Biochemistry & Molecular Biology
Tomasz Wolkowicz, Katarzyna Zacharczuk, Rafal Gierczynski, Magdalena Nowakowska, Katarzyna Piekarska
Summary: The majority of S. Kentucky isolates from humans in Poland belonged to ST198 and exhibited high-level resistance to ampicillin and quinolones, with multiple resistant determinants found in some strains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Sazia Sultana, Md. Sahadat Hossain, Monika Mahmud, Mashrafi Bin Mobarak, Md Humayun Kabir, Nahid Sharmin, Samina Ahmed
Summary: The study successfully synthesized hydroxyapatite from eggshells using a UV-mediated solid-state method without thermal treatment, demonstrating good bioactivity and drug release response. The results suggest the potential of UV-Hap as a biomaterial in biomedical applications.
Article
Engineering, Biomedical
Liz Hannah George, Aswin Arakkal, Prathapan Sreedharan, G. S. Sailaja
Summary: An injectable osteoconductive polyelectrolyte complex (PEC)-hydroxyapatite (HAP) formulation capable of controlled delivery of ciprofloxacin has been developed for the treatment of osteomyelitis. The formulation combines the functionalities of HAP and PEC, allowing better control over swelling and degradation kinetics. It has been shown to be cytocompatible and promote early biomimetic mineralization. The antibacterial efficacy of the formulation has also been evaluated.
BIOMEDICAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xiulin Dong, Yi Sun, Yuanyuan Li, Xiaoyu Ma, Shuiquan Zhang, Yuan Yuan, Joachim Kohn, Changsheng Liu, Jiangchao Qian
Summary: This study demonstrates the potential of bioactive nanoparticles in overcoming multidrug resistance in cancer chemotherapy. By utilizing the synergistic effects of HAPNs and DOX, the efficacy of drug treatment for breast cancer was significantly improved, possibly due to the multiple action mechanisms of HAPNs.
Article
Immunology
Radhika Gharpure, Cindy R. Friedman, Veronica Fialkowski, Jennifer P. Collins, Jonathan Strysko, Zachary A. Marsh, Jessica C. Chen, Elizabeth H. Meservey, Azizat A. Adediran, Morgan N. Schroeder, Ashutosh Wadhwa, Kathleen E. Fullerton, Louise Francois Watkins
Summary: A study investigated a multi-drug resistant Shigella outbreak where 4 patients were treated with azithromycin, all of whom experienced treatment failure, with 2 also showing microbiologic failure; 2 patients who received ciprofloxacin treatment also failed. The findings underscore the importance of identifying alternative treatment options for resistant strains.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Materials Science, Ceramics
R. Saranya, B. Aruna Devi, N. Meenakshi Sundaram
Summary: This study aims to develop a cost-effective composite material for the treatment of osteomyelitis by reducing the dosage of antibiotics. Hydroxyapatite extracted from oyster shell is used to improve the biocompatibility of the composite, while the recycling of waste shell reduces environmental pollution. The synthesized composite, consisting of ciprofloxacin-loaded hydroxyapatite and chitosan, exhibits good biocompatibility and sustained drug release in vitro. The characterization of the composite material confirms the presence of hydroxyapatite and its stability at higher temperatures.
JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
(2023)
Article
Pharmacology & Pharmacy
Nasser H. Alotaibi, Muhammad Usman Munir, Nabil K. Alruwaili, Khalid Saad Alharbi, Ayesha Ihsan, Alanood S. Almurshedi, Ikram Ullah Khan, Syed Nasir Abbas Bukhari, Mubashar Rehman, Naveed Ahmad
Summary: The increasing bacterial resistance poses a great challenge in bone infection treatment. This study presents the use of citrate-functionalized mesoporous hydroxyapatite nanocarriers (Ctr-mpHANCs) as drug carriers and treatment options for bone infections caused by bacteria.
Article
Materials Science, Ceramics
Ke Ma, Yuli Gao, Jianjun Yi, Meng Cui, Haijun Hao, Qinghong Xu
Summary: A new kind of mesoporous hydroxyapatite (mesoHA) with an average pore diameter of about 2.4 nm was successfully prepared by depositing Ca2+ and H2PO4- ions on the inner channel surface of Si-MCM-41 and dissolving the Si-MCM-41 in alkali soluble. The porous material was used as a pH-responsive platform for adsorption and release of ciprofloxacin molecules. About 88.5% of ciprofloxacin was released from the platform when the environmental pH value was approximately 4.8, providing a new method for efficient utilization of antibiotics due to the host mesoHA being compatible with the human body.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2023)
Article
Medicine, General & Internal
Karlis Racenis, Dace Rezevska, Monta Madelane, Ervins Lavrinovics, Sarah Djebara, Aivars Petersons, Juta Kroica
Summary: Pseudomonas aeruginosa is a significant pathogen in osteomyelitis infections, and the combination of bacteriophages with antibiotics shows potential in treating biofilm-associated infections, demonstrating additive effects in difficult-to-treat bone and soft tissue infections.
FRONTIERS IN MEDICINE
(2022)
Article
Materials Science, Biomaterials
Yue Ding, Yuxuan Ma, Lvming Zhu, Yue Xu, Chenwei Wang, Bing Lu, Yang Wang, Chang Du, Yong Yao
Summary: A supramolecular polypeptide nanomedicine was constructed to co-deliver doxorubicin and indocyanine green for drug resistance reversal. The generation of NO upon NIR irradiation down-regulated P-gp expression level and enhanced the tumoricidal potential through photothermal therapy. This nanomedicine provides an effective strategy to overcome multidrug resistance.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Xiaoxia Wu, Jinghui Yang, Jie Xing, Yonglei Lyu, Ruifen Zou, Xin Wang, Junlie Yao, Dinghu Zhang, Dawei Qi, Guoliang Shao, Aiguo Wu, Jianwei Li
Summary: Researchers have developed a nano delivery system that combines photodynamic therapy (PDT) and chemotherapy (CHT), showing promise in safe and effective cancer treatment. The system utilizes engineered interfacial interactions between Ag2S quantum dots to deliver anti-cancer drugs and photosensitizers. Smart drug release under acidic microenvironments and high-efficiency drug delivery to tumor sites were achieved, demonstrating significant treatment efficacy in in vitro and in vivo studies.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
William Ndugire, Dang Truong, N. G. Hasitha Raviranga, Jingzhe Lao, Olof Ramstrom, Mingdi Yan
Summary: The addition of thiourea (TU) enhances the broad-spectrum antimicrobial activity of D-maltose-capped gold nanoclusters (AuNC-Mal). AuNC-Mal/TU exhibits effective inhibition against multidrug-resistant Pseudomonas aeruginosa with low cytotoxicity. The antimicrobial activity is attributed to the generation of [Au(TU)(2)](+) and smaller AuNCs, increased accumulation of Au in bacteria, and inhibition of thioredoxin reductase.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Gastroenterology & Hepatology
Karina Frahm Kirk, Jeppe Boel, Hans Linde Nielsen
Summary: This case report describes a rare case of osteomyelitis caused by C. jejuni. The patient presented with lower back pain, fever, and diarrhea, and was diagnosed with osteomyelitis through MRI. After surgery and targeted antibiotic treatment, the patient recovered well. The study suggests that C. jejuni should be considered as a possible cause of vertebral osteomyelitis, especially when diarrhea symptoms are present.
Article
Chemistry, Applied
Hanan Farouk Youssef, Abeer M. El-Kady, Manar M. Ahmed, Hanan Hassan Abo-almaged
Summary: This study aimed to design novel bio-composite materials based on microwave-prepared AuNPs-loaded Zeolite-A and nano-hydroxyapatite for potential treatment of osteomyelitis with Ciprofloxacin. The bio-composites showed improved drug release profiles compared to their parent constituents and were found to be safe and non-toxic. The application of the Higuchi square root model indicated a diffusion-controlled drug elution for both bio-composites, showing high efficiency as a controlled drug delivery system for Ciprofloxacin.
JOURNAL OF POROUS MATERIALS
(2021)
Article
Chemistry, Applied
Qiang Chen, Chaochao Jia, Yingran Xu, Zhuanzhuan Jiang, Ting Hu, Conghu Li, Xu Cheng
Summary: Efficient dual-pH responsive chitosan nanoparticles were fabricated to treat MDR tumors, showing high toxicity and strong antitumor efficiency in vivo.
CARBOHYDRATE POLYMERS
(2022)
Article
Immunology
Sania Aslam, Waqas Younis, Muhammad Nasir Hayat Malik, Shah Jahan, Alamgeer, Ambreen Malik Uttra, Muhammad Usman Munir, Muhammad Roman
Summary: This study investigated the effect of terpinen-4-ol on arthritis using in vitro and in vivo models. It was found that terpinen-4-ol has a significant anti-inflammatory and antioxidant effect, inhibits joint swelling, and improves related parameters.
INFLAMMOPHARMACOLOGY
(2022)
Article
Chemistry, Physical
Farhan Arshad, Akhtar Munir, Aleena Tahir, Syed Zajif Hussain, Asim Jilani, Aamir Hussain, Najeeb Ullah, Falak Sher, Irshad Hussain
Summary: In this study, a core-shell nanostructured electrocatalyst, NiFe LDH@CuxO, was designed and synthesized by decorating vertically oriented NiFe LDH ultra-thin nanosheets on CuxO support via a microwave-assisted hydrothermal reaction. The NiFe LDH@CuxO catalyst demonstrated promising electrocatalytic performance for the oxygen evolution reaction (OER), with an onset potential of 1.43 V and an overpotential of 270 mV at 10 mA cm-2. It outperformed pristine NiFe LDH and iridium oxide (IrO2) in terms of electrocatalytic activity, durability, and Faradaic efficiency. The unique core-shell 3D structure effectively prevented aggregation and restacking of the NiFe LDH nanosheets, enhancing the electrochemical stability.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Chemistry, Physical
Irfan Ullah, Tanveer ul Haq, Aqeel Aslam Khan, Abid Inayat, Muhammad Shoaib, Ali Haider, Murtaza Saleem, Syed Mustansar Abbas, Michael A. Pope, Irshad Hussain
Summary: This study presents the development of a hierarchically nanostructured cathode material by encapsulating sodium decavanadate Na6V10O28 in the scaffold of manganese-based metal-organic framework. The uniform distribution of NaDV in the pores of Mn-BTC enables multielectron redox properties, while the diverse 3D diffusion channels and flexible architecture of Mn-BTC ensure high intercalation capacity. The NaDV@Mn-BTC cathode material exhibits a high reversible capacity of 137 mAh/g at 1 C rate, suggesting its potential as a high-energy cathode material for aqueous batteries.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Medicinal
Syed Nasir Abbas Bukhari, Mohamed Abdelwahab Abdelgawad, Muhammad Wahab Amjad, Muhammad Usman Munir, Fatima Akbar Sheikh
Summary: This study synthesized a series of novel oxime derivatives and tested their inhibitory activity against COX-1, COX-2, and LOX-5 enzymes. Results showed that these oxime derivatives effectively inhibited the activity of COX-1 and COX-2, with compounds containing methoxymethoxy or hydroxy substituents exhibiting the strongest effects, while compounds with a long alkyl chain ether group showed the strongest inhibition against 5-LOX. Furthermore, these derivatives demonstrated the ability to inhibit nitric oxide generation and LPS-induced inflammatory factor production in macrophages. Molecular docking studies revealed the inhibitory mechanism of these compounds and the importance of various interactions.
MEDICINAL CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Aleena Tahir, Farhan Arshad, Tanveer ul Haq, Irshad Hussain, Syed Zajif Hussain, Habib ur Rehman
Summary: This review discusses the role of transition metal oxides as active and supported sites for electrochemical water splitting. Different perspectives for the rational design of TMO-based electrode materials are proposed, including electronic state modulation, modification of surface structure, acceleration of charge and mass transport, and stability in harsh environments. The relationship among catalytic activity, challenges, research directions, and perspectives of OER and HER electrocatalysis is systematically discussed.
ACS APPLIED NANO MATERIALS
(2023)
Review
Medicine, Research & Experimental
Hassan Yousaf, Malik Ihsan Ullah Khan, Iftikhar Ali, Muhammad Usman Munir, Ka Yiu Lee
Summary: In the past three decades, research studies on animal models have provided a wealth of evidence showing the central role of macrophages in diseases, especially in non-infectious diseases, where they are often referred to as double-edged swords. Macrophages, as the most versatile immunocytes, play a key role in both health and diseases. The conventional paradigms of macrophages, such as the M1/M2 dichotomy, have been challenged by various experimental models, revealing a complex characterization of macrophages in disease immunology. In human diseases, macrophages demonstrate a complex web of mechanisms, with pro-inflammatory roles (mediated by cytokines such as IL-1, IL-6, IL-12, IL-23, and tumor necrosis factor) and anti-inflammatory roles (including CCl-17, CCl-22, CCL-2, transforming growth factor (TGF), and interleukin-10), which are involved in wound healing and pathogen-suppression. The conventional division of macrophages into M1 and M2 is based on their opposing functions, with M1 being involved in tissue damage and pro-inflammatory roles, and M2 promoting cell proliferation and inflammation resolution. These pathways mutually down-regulate each other in diseases through a variety of enzymatic and cytokine mediators.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Applied
Aleena Tahir, Tanveer ul-Haq, Usman Zubair, Faria Rafique, Akhtar Munir, Yousef Haik, Irshad Hussain, Habib Ur Rehman
Summary: Electrochemical water splitting for hydrogen production has gained significant attention due to its potential in cost-effective solutions for energy crises. This study presents a scalable method for developing a thin film of Au@TiO2 on FTO, which efficiently catalyzes both oxygen and hydrogen evolution reactions. By sensitizing mesoporous TiO2 with a minimal amount of Au, the catalyst exhibits sustainable behavior for over 60 hours with low overpotential. This facile and scalable approach provides insights for designing more efficient electrode materials for electrochemical water splitting processes with minimal use of precious metals.
Article
Multidisciplinary Sciences
Wei-Wei Fang, Gui-Yu Yang, Zi-Hui Fan, Zi-Chao Chen, Xun-Liang Hu, Zhen Zhan, Irshad Hussain, Yang Lu, Tao He, Bi-En Tan
Summary: This study develops a phosphine-based conjugated hypercrosslinked polymer (PPh3-CHCP) photocatalyst for efficient large-scale photoinduced copper-catalyzed atom transfer radical polymerization (Cu-ATRP). The photocatalyst enables near-quantitative conversions of monomers including acrylates and methyl acrylates under a wide range of radiations or sunlight directly. It can be easily recycled and shows great potential for industrial applications.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Muhammad Ikram Ullah, Ayman Ali Mohammed Alameen, Ziad H. Al-Oanzi, Lienda Bashier Eltayeb, Muhammad Atif, Muhammad Usman Munir, Hasan Ejaz
Summary: Liver cirrhosis is a complication of persistent chronic liver disease and is associated with mechanisms such as hypoalbuminemia, impaired amino acid turnover, and micronutrient deficiencies. Zinc, an essential micronutrient, plays a critical role in cellular metabolism and is involved in various biological processes. Abnormalities in liver function can lead to zinc deficiency, which affects cellular, endocrine, immune, sensory, and skin functions.
Article
Materials Science, Multidisciplinary
Huang Ouyang, Kunpeng Song, Irshad Hussain, Bien Tan
Summary: CO2 cycloaddition with epoxides is an important process for CO2 conversion to generate cyclic carbonates. However, the catalytic efficiency of porous organic polymers (POPs) for this process is typically low and requires severe conditions or prolonged reaction time. In this study, amine-impregnated porous organic polymers (HCP-TPP-Co-EDA-10 and HCP-TPP-Co-PEI-5) were developed to enhance the interaction with CO2 and improve catalytic efficiency. These catalysts exhibited strong binding affinity with CO2 and high catalytic yield under mild conditions. The turnover number (TON) and turnover frequency (TOF) achieved were among the highest reported so far. Additionally, the catalysts showed excellent recyclability and stability for CO2 conversion. The use of amines as chemisorption sites for CO2 provides a simple strategy for designing highly efficient functionalized hyper-cross-linked polymers (HCPs) for CO2 capture and chemical conversion.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Physical
Irfan Ullah, Roheen Saeed, Abid Inayat, Muhammad Zubair, Xianyong Wu, Hatice Duran, Ali Haider, Irshad Hussain
Summary: This study presents an in-situ integration of ultra-small PBAs cubes into carbon-doped manganese oxide nanorods, forming a continuous conductive architecture. The hierarchical configuration effectively buffers the lattice expansion and improves the structural stability of NiCoPBA. The developed composite shows promising performance in both aqueous and non-aqueous electrolytes.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Biochemistry & Molecular Biology
Sania Munir, Rizwan Hafeez, Waqas Younis, Muhammad Nasir Hayat Malik, Muhammad Usman Munir, Wajiha Manzoor, Muryam Abdul Razzaq, Luciane Barbosa Pessoa, Katiana Simoes Lopes, Francislaine Aparecida dos Reis Livero, Arquimedes Gasparotto Jr
Summary: Citronellol has potential cardioprotective effects in preventing doxorubicin-induced cardiotoxicity by reducing pro-inflammatory cytokine expression and increasing expression of anti-inflammatory cytokines.
Article
Chemistry, Medicinal
Rui Zhang, Cui Feng, Dandan Luo, Ruibo Zhao, Perumal Ramesh Kannan, Yuebang Yin, Muhammad Zubair Iqbal, Yeting Hu, Xiangdong Kong
Summary: Metformin hydrochloride can inhibit rotavirus replication and mitigate the lesions caused by rotavirus infection. This study also confirms the reliability of organoids as an in vitro virus model.
Article
Chemistry, Multidisciplinary
Arshad Ali, Muhammad Tahir Haseeb, Muhammad Ajaz Hussain, Ume Ruqia Tulain, Gulzar Muhammad, Irfan Azhar, Syed Zajif Hussain, Irshad Hussain, Naveed Ahmad
Summary: A drug delivery system (SSH-co-MAA) based on the mucilage from seeds of Salvia spinosa (SSH) and methacrylic acid (MAA) was developed for controlled release of venlafaxine HCl. The structure of SSH-co-MAA was confirmed through Fourier transform infrared and solid-state CP/MAS C-13-NMR spectroscopy. The concentration of SSH, MAA, and MBA influenced the gel conversion, porosity, and drug release of SSH-co-MAA.
Article
Materials Science, Multidisciplinary
Hunza Hayat, Fazli Rabbi Awan, Ammara Aziz, Romana Schirhagl, Adeel Afzal, Adnan Mujahid, Arifa Jamil, Tayyaba Asim, Waheed S. Khan, Sadia Z. Bajwa
Summary: Molecularly imprinted polymers (MIP) based on biomimetic approaches have been shown to create highly specific receptor materials. We developed a biosensor based on MIP for the selective detection of cholesterol and tested it in synthetic media as well as in human blood sera. The biosensor demonstrated a good linear relationship with cholesterol concentration, low detection limit, and promising clinical recovery rate.
JOURNAL OF MATERIALS RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
