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Oncology
Yuki Ohkawa, Pu Zhang, Hiroyuki Momota, Akira Kato, Noboru Hashimoto, Yuhsuke Ohmi, Robiul H. Bhuiyan, Yesmin Farhana, Atsushi Natsume, Toshihiko Wakabayashi, Keiko Furukawa, Koichi Furukawa
Summary: This study revealed that deficiency of GD3 synthase attenuated the progression of gliomas in a mouse model, leading to prolonged lifespan and low-grade pathology in generated gliomas. It also showed that GD3S enhances glioma progression through the Ap2 alpha-MMP9 axis, with associated alterations in gene expression levels.
Article
Medical Laboratory Technology
Elena Porcu, Francesca Maule, Lorenzo Manfreda, Elena Mariotto, Silvia Bresolin, Alice Cani, Roberta Bortolozzi, Alessandro Della Puppa, Diana Corallo, Giampietro Viola, Elena Rampazzo, Luca Persano
Summary: We found that ANXA2 is a key mediator of the pro-oncogenic features of GBM tumors, involved in stemness, proliferation and invasion, thus affecting patient prognosis. Using the QUADrATiC bioinformatic tool, we identified Homoharringtonine (HHT) as a potent inhibitor of GBM cell motility and proliferation. HHT inhibits a transcriptional program involved in cell migration and invasion by impairing PDGFRα-dependent signaling through STAT3 and RhoA axes. This suggests that HHT could be an effective treatment option for GBM by targeting its hallmarks.
TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Physical
Xiaoxiao Yang, Hai Yu, Xiaohong Yang, Anoopjit Singh Kooner, Yue Yuan, Bryant Luu, Xi Chen
Summary: Human sialyltransferase ST3GAL II was expressed in E. coli as a soluble fusion protein and utilized in a multienzyme sialylation system for high-yield production of ganglioside glycans. The lower glycosylation activity of recombinant hST3GAL II simplifies enzymatic reactions and has potential for use in automated chemoenzymatic synthetic processes in the future.
Article
Multidisciplinary Sciences
Jialin Wang, Zhendong Liu, Cheng Zhang, Hongbo Wang, Ang Li, Binfeng Liu, Xiaoyu Lian, Zhishuai Ren, Wang Zhang, Yanbiao Wang, Bo Zhang, Bo Pang, Yanzheng Gao
Summary: High expression of HOXD11 is significantly associated with survival and clinical characteristics of glioma patients, serving as a potential biomarker for targeted therapy and prognostic assessment. Knockout of HOXD11 can inhibit proliferation and invasion of glioma cells, altering cell behavior.
Article
Biochemistry & Molecular Biology
Yuxue Sun, Haiyan Huang, Zhixin Zhan, Haijun Gao, Chaochao Zhang, Jiacheng Lai, Junguo Cao, Chaoyue Li, Yong Chen, Ziqiang Liu
Summary: In this study, it was found that berberine inhibits the migration and invasion of glioma cells by suppressing the TGF-beta 1/COL11A1 pathway and altering actin cytoskeleton arrangement. These findings suggest that berberine could be a promising candidate for the development of anti-glioma drugs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Min Kyeong Lee, Xianglan Zhang, Hyung Jun Kim, Young Sun Hwang
Summary: This study provides evidence that Prx5's role in removing excess ROS may contribute to cancer invasion and progression.
Article
Immunology
Min Chao, Nan Liu, Zhichuan Sun, Yongli Jiang, Tongtong Jiang, Meng Xv, Lintao Jia, Yanyang Tu, Liang Wang
Summary: Sox9, an upregulated transcription factor in clinical gliomas associated with poor prognosis, promotes migration and invasion of glioma cells and in vivo tumor development. It functions downstream of the TGF-beta pathway, where TGF-beta signaling prevents proteasomal degradation of Sox9 protein in glioma cells. These findings provide new insights into the interaction between TGF-beta signaling and oncogenic transcription factors, with implications for targeted therapy and prognostic assessment of gliomas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Lin Zhao, Mingchao Shang, Xiaofang Hu, Jun Li, Jun Tian, Lianjie Li, Bangqing Yuan
Summary: This study investigated the role and mechanism of LINC01578 in glioma. The results showed that LINC01578 was highly expressed in glioma tissues and cells. Overexpression of LINC01578 promoted the proliferation, invasion, and migration abilities of glioma cells, while inhibiting apoptosis and inducing epithelial-mesenchymal transition. In contrast, inhibition of LINC01578 weakened the survival of glioma cells and increased apoptosis. Therefore, LINC01578 plays an important role in the development of glioma.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biotechnology & Applied Microbiology
Nitai C. Hait, Aparna Maiti, Rongrong Wu, Valerie L. Andersen, Chang-Chieh Hsu, Yun Wu, Digantkumar G. Chapla, Kazuaki Takabe, Michael E. Rusiniak, Wiam Bshara, Jianmin Zhang, Kelley W. Moremen, Joseph T. Y. Lau
Summary: Our study found that extracellular ST6GAL1 can compensate for insufficient cellular ST6GAL1, promoting cancer cell proliferation and invasiveness. Moreover, we identified novel cofactors in the exosome-like particles that amplify the action of extrinsic ST6GAL1. Overall, this study reveals the importance of ST6GAL1 in tumor pathobiology.
CANCER GENE THERAPY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Shicong Xie, Jan M. Skotheim
Summary: Cell growth drives progression into the cell cycle by diluting a diverse set of cell-cycle inhibitors in yeast, animal, and plant cells. New research shows that plant cells include specific degradation and chromatin-partitioning components in these inhibitor dilution mechanisms. These mechanisms help implement cell-size control in cases where large and small cells inherit a similar number of inhibitor molecules.
Article
Cell Biology
Yujie Lei, Yunchao Huang, Jianbin Lin, Shihui Sun, Keda Che, Junting Shen, Jun Liao, Yangming Chen, Kai Chen, Zhaoxian Lin, Xing Lin
Summary: The study aims to investigate the role and molecular mechanism of MAX interactor 1 (Mxi1) in the pathogenesis of lung cancer. The results show that Mxi1 inhibits the progression of lung cancer by suppressing the expression of miR-300 and regulating the expression of KLF9 and GADD34. These findings reveal a potential target for the treatment of lung cancer.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Deshuai Ren, Xiaoyu Zhuang, Yanxin Lv, Yun Zhang, Jiazhi Xu, Fengquan Gao, Dagang Chen, Yu Wang
Summary: This study found that FAM84B is highly expressed in glioma tissues and inhibits the proliferation of glioma cells through regulating the cell cycle pathways.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Integrative & Complementary Medicine
Lei Chen, Shu Zhu, He Wang, Xingyi Pang, Xuepeng Wang
Summary: mir-601 was found to be significantly upregulated in GBM primary tumors and cell lines, suppressing cell proliferation through inhibition of the potential target gene TINP1.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2022)
Article
Oncology
Chunhong Wang, Haiyang Su, Rui Cheng, Hongming Ji
Summary: The study demonstrated that high expression of SPAG5 in glioma patients is associated with poor prognosis. Knockdown of SPAG5 can inhibit proliferation, migration, and invasion of glioma cells, promote apoptosis, and is associated with the expression of CDH2.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Erino Araki, Masaya Hane, Rina Hatanaka, Ryota Kimura, Kana Tsuda, Miku Konishi, Naoko Komura, Hiromune Ando, Ken Kitajima, Chihiro Sato
Summary: This study analyzed the features of three isoforms of St8sia5 and found that St8sia5-L is localized in the Golgi, while St8sia5-M and -S are localized in the ER. Furthermore, only cells expressing St8sia5-L showed an increase in the incorporation of exogenous GD3. These findings indicate that the localization of St8sia5 is crucial for its enzymatic activity.
GLYCOCONJUGATE JOURNAL
(2022)