Article
Oncology
Chenghai Li, Hua Zhao, Bin Wang
Summary: While a large body of research has shown the dual role of MSCs in tumor growth and inhibition, studies on the contribution of MSCs to tumorigenesis are rare. MSCs can increase cancer stem cell population, generate cancer precursors, and induce epithelial-mesenchymal transition. Understanding the developmental origin and tissue-resident native MSCs is crucial for grasping MSCs' contribution to cancer cell origin.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Cell Biology
Xiaobo Li, Qijing Huang, Xiangxiang Zhang, Changfeng Xie, Muyun Liu, Yueming Yuan, Jianjia Feng, Haoyu Xing, Li Ru, Zheng Yuan, Zhiyong Xu, YaoXiang Yang, Yan Long, Chengfeng Xing, Jianping Song, Xiang Hu, Qin Xu
Summary: The study evaluated the effects of intravenous injection of hUC-MSCs on reproduction and development in rats, finding no significant adverse effects within a certain dosage range, but high doses may lead to mortality in pregnant female rats, highlighting the importance of cautious use.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sepideh Saghati, cigir Biray Avci, Ayla Hassani, Sajed Nazifkerdar, Hassan Amini, Solmaz Saghebasl, Mahdi Mahdipour, Behnaz Banimohamad-Shotorbani, Atieh Rezaei Namjoo, Fateme Nazary Abrbekoh, Reza Rahbarghazi, Hamid Tayefi Nasrabadi, Ali Baradar Khoshfetrat
Summary: This study investigated the osteogenic properties of phenolated alginate hydrogel containing collagen and nano-hydroxyapatite on human mesenchymal stem cells. The results showed that the combination of alginate/collagen/nano-hydroxyapatite had suitable mechanical features and promoted cell viability, osteoblast differentiation, and new bone formation through involving the Wnt signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell Biology
Ying-Hao Han, Ying-Ying Mao, Kyung Ho Lee, Hee Jun Cho, Nan-Nan Yu, Xiao-Ya Xing, Ai-Guo Wang, Mei-Hua Jin, Kwan Soo Hong, Hu-Nan Sun, Taeho Kwon
Summary: Our study investigated the role of Prx II in regulating exosome secretion from DMSCs and elucidated the underlying molecular mechanisms. We found that depletion of Prx II significantly decreased exosome secretion from DMSCs and increased the number of intracellular MVBs. Mechanistically, Prx II regulates the ISGylation switch that controls MVB degradation and impairs exosome secretion. These findings provide important insights into the molecular mechanisms governing exosome secretion from DMSCs and highlight the critical role of Prx II in controlling this process.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Medicine, Research & Experimental
Nesrine Ebrahim, Heba Elsayed Abd El-Halim, Omayma Kamel Helal, Nahla El-Eraky El-Azab, Omnia A. M. Badr, Amira Hassouna, Hajir A. Al Saihati, Nashwa Hassan Aborayah, Hanan Tawfeek Emam, Hend S. El-wakeel, Mohammad Aljasir, Mohamed El-Sherbiny, Naglaa A. S. Sarg, Gehan Ahmed Shaker, Ola Mostafa, Dina Sabry, Marwa Abdel Kader Fouly, Nicholas Robert Forsyth, Nehal M. Elsherbiny, Rabab F. Salim
Summary: The study indicated that BM-MSCs-Ex reduced oxidative stress, inflammation, and angiogenesis in diabetic retinas by inhibiting the Wnt/β-catenin signaling pathway, ultimately improving DR features.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Obstetrics & Gynecology
Jing Li, Yongdong Dai, Chao Li, Yanling Zhang, Haiyan Zhu, Xiaoying Jin, Xiang Lin, Jianmin Chen, Lijuan Zhao, Songying Zhang
Summary: This study evaluated the effect of seminal plasma on the growth of endometrial mesenchymal stem cells and found that it can promote their proliferation and cell cycle progression. These effects may be mediated through the activation of TGF-beta 1 signaling pathway.
REPRODUCTIVE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ruohao Xu, Miao Wu, Yawen Wang, Chao Li, Lingji Zeng, Yulian Wang, Maozhi Xiao, Xiaomei Chen, Suxia Geng, Peilong Lai, Xin Du, Jianyu Weng
Summary: Myofibroblasts (MFB), derived from the fibroblast to myofibroblast transition (FMT), play a crucial role in pathologic fibrosis. Although MFBs were considered terminally differentiated cells, recent studies have shown their potential for de-differentiation, which could be therapeutically valuable for treating fibrotic diseases. This study investigated the MSC-mediated regulation of FMT and found that MSCs can reversibly de-differentiate MFBs into a group of fibroblast-like cells by inhibiting the TGF-beta-SMAD2/3 signaling pathway. These de-differentiated cells remain sensitive to TGF-beta 1 and may contribute to the progression of fibrotic diseases unless the pro-fibrotic microenvironment is corrected.
MOLECULAR MEDICINE
(2023)
Article
Cell & Tissue Engineering
Belle Yu-Hsuan Wang, Allen Wei-Ting Hsiao, Hoi Ting Shiu, Nicodemus Wong, Amanda Yu-Fan Wang, Chien-Wei Lee, Oscar Kuang-Sheng Lee, Wayne Yuk-Wai Lee
Summary: This study investigated the therapeutic efficacy of adipose-derived mesenchymal stem cells (ADSCs) in attenuating dexamethasone (Dex)-induced muscle atrophy. The results showed that ADSC treatment increased the number of type I fibers, improved muscle strength, accelerated recovery rate, and enhanced anti-fatigue ability via the ERK1/2 signaling pathway. The inhibition of muscle atrophy-associated genes by ADSCs offers a potential intervention option for muscle-associated diseases.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Hongwei Gao, Hui Dong, Jiachun Zheng, Xufeng Jiang, Mingzhi Gong, Le Hu, Jinshan He, Yongxiang Wang
Summary: The study identified LINC01119 as a negative regulator of osteogenic differentiation in MSCs, with its knockdown promoting calcification and osteogenic differentiation. It was revealed that LINC01119 negatively regulates osteogenesis through the Wnt pathway by targeting FZD4, with transcription factor EBF3 directly binding to LINC01119's promoter region.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Fengyun Zhang, Fei Gao, Kun Wang, Xiaohong Liu, Zhuoqi Zhang
Summary: This study found that miR-34a is significantly increased under chronic hyperglycemia exposure, leading to impaired MSCs viability, exacerbated senescence, and disrupted paracrine capacity. The mechanism involves the activation of the SIRT1/FoxO3a autophagy pathway by miR-34a in MSCs exposed to high glucose, resulting in deterioration of cell function. Inhibiting miR-34a may hold therapeutic promise for MSC-based therapies in diabetic patients with myocardial infarction.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Lina N. Zaripova, Angela Midgley, Stephen E. Christmas, Michael W. Beresford, Clare Pain, Eileen M. Baildam, Rachel A. Oldershaw
Summary: Mesenchymal stem cells (MSCs) have potential as immunosuppressants for treating autoimmune and autoinflammatory diseases. They can reduce inflammation and promote tissue regeneration. However, during the inflammatory process, MSCs become impaired and lose their immunomodulatory activity. Despite challenges and risks, MSCs show promise in the treatment of severe diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Guoqiang Yang, Jiraporn Kantapan, Maryam Mazhar, Xue Bai, Yuanxia Zou, Honglian Wang, Bingfeng Huang, Sijing Yang, Nathupakorn Dechsupa, Li Wang
Summary: It has been found that the combination of MSCs with IronQ can improve the survival and viability of MSCs and exhibit an anti-inflammatory effect. The combined treatment of MSCs with IronQ can alleviate the inflammatory response caused by intracerebral hemorrhage (ICH) by regulating the Mincle/syk signaling pathway, thus improving neurologic deficits and brain edema.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell Biology
Mengdong Liu, Yunshu Yang, Bin Zhao, Yuefan Yang, Jing Wang, Kuo Shen, Xuekang Yang, Dahai Hu, Guoxu Zheng, Juntao Han
Summary: The study showed that ADMSC-Exos reduced oxidative stress, inflammation, and microglial infiltration by activating the SIRT1 pathway, providing protective effects against radiation-induced brain injury.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Yin Yuan, Shuo Ni, Aoxiang Zhuge, Lanjuan Li, Bo Li
Summary: A study found that adipose-derived mesenchymal stem cells (ADMSCs) can alleviate ulcerative colitis (UC) by reducing the infiltration of pro-inflammatory macrophages (M1 macrophages) and reprogramming the glycolytic pathway. Additionally, the secretion of succinate by M1 macrophages triggers ADMSCs to secrete PGE2, which can shift macrophages from the pro-inflammatory phenotype to the anti-inflammatory phenotype. This research demonstrates the immunomodulatory effect of ADMSCs and provides a new perspective for UC therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zhihui Zhang, Yulin Kuang, Kui Ma, Yan Li, Xiaoming Liu, Yuru Shi, Xu Wu
Summary: This study investigates the therapeutic effects of bone marrow mesenchymal stem cells (BMSCs) overexpressing GCLc on acute lung injury (ALI). The results show that overexpression of GCLc in BMSCs can reduce oxidative stress, improve cell survival, and inhibit apoptosis. The anti-apoptotic effects of GCLc are mediated through the PI3K/AKT/Foxo1 pathway. In an ALI mouse model, GCLc-overexpressing BMSCs improve lung inflammation and pulmonary edema.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mariya S. Balashova, Inna G. Tuluzanovskaya, Oleg S. Glotov, Andrey S. Glotov, Yury A. Barbitoff, Mikhail A. Fedyakov, Diana A. Alaverdian, Tatiana E. Ivashchenko, Olga V. Romanova, Andrey M. Sarana, Sergey G. Scherbak, Vladislav S. Baranov, Marat I. Filimonov, Anatoly V. Skalny, Natalya A. Zhuchenko, Tatiana M. Ignatova, Aliy Y. Asanov
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2020)
Review
Medicine, General & Internal
Ally Murji, Kutay Biberoglu, Jinhua Leng, Michael D. Mueller, Thomas Roemer, Michele Vignali, Maria Yarmolinskaya
CURRENT MEDICAL RESEARCH AND OPINION
(2020)
Article
Endocrinology & Metabolism
Maria Yarmolinskaya, Elena Suslova, Natalia Tkachenko, Arseniy Molotkov, Igor Kogan
GYNECOLOGICAL ENDOCRINOLOGY
(2020)
Article
Cell Biology
Alla S. Koltsova, Olga A. Efimova, Anna A. Pendina, Olga G. Chiryaeva, Natalia S. Osinovskaya, Natalia Y. Shved, Maria Yarmolinskaya, Nikolai Polenov, Vladislava V. Kunitsa, Yanina M. Sagurova, Tatyana G. Tral, Gulrukhsor K. Tolibova, Vladislav S. Baranov
Summary: The study revealed that uterine leiomyomas (ULs) with normal karyotypes consist of both normal and abnormal cells, suggesting that the presence of minor cell subpopulations with numerical chromosome abnormalities may be a characteristic of UL tumorigenesis. The differences in frequencies of heteroploid cells in vivo and in vitro indicate their dependency on microenvironmental conditions, which could play a role in UL pathogenesis.
CYTOGENETIC AND GENOME RESEARCH
(2021)
Article
Obstetrics & Gynecology
Gennady T. Sukhikh, Leila Adamyan, Svetlana O. Dubrovina, Igor I. Baranov, Vitaly F. Bezhenar, Andrey Kozachenko, Viktor E. Radzinsky, Mekan R. Orazov, Maria Yarmolinskaya, Jan Olofsson
Summary: The study compared two different treatment regimens of dydrogesterone for endometriosis-related chronic pelvic pain, finding that both prolonged cyclical and continuous regimens led to significant and similar reductions in pain severity and improvements in quality of life and sexual well-being.
FERTILITY AND STERILITY
(2021)
Article
Endocrinology & Metabolism
Maria Yarmolinskaya, Olga Bulgakova, Elena Abashova, Valentina Borodina, Tatyana Tral
Summary: This study aimed to evaluate the potential effectiveness of resveratrol in treating PCOS, with results showing its ability to restore normal ovarian tissue morphology, normalize estrous cycle regularity, and decrease body weight in rats with PCOS.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Maria Yarmolinskaya, Alexandra Denisova, Natalia Tkachenko, Tatyna Ivashenko, Olesya Bespalova, Gulrukhsor Tolibova, Tatyana Tral
Summary: Genital endometriosis (GE) is a multifactorial disease, and studying the role of vitamin D in its pathogenesis has shown promising results. Lower levels of 25(OH)D were found in patients with GE, and certain VDR gene polymorphisms were associated with increased risk of GE. Vitamin D deficiency plays a significant role in GE pathogenesis, and targeted therapy with vitamin D may be effective in treating GE.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alla S. Koltsova, Olga A. Efimova, Olga V. Malysheva, Natalia S. Osinovskaya, Thomas Liehr, Ahmed Al-Rikabi, Natalia Yu. Shved, Iskender Yu. Sultanov, Olga G. Chiryaeva, Maria I. Yarmolinskaya, Nikolai I. Polenov, Vladislava V. Kunitsa, Maka I. Kakhiani, Tatyana G. Tral, Gulrukhsor Kh. Tolibova, Olesya N. Bespalova, Igor Yu. Kogan, Andrey S. Glotov, Vladislav S. Baranov, Anna A. Pendina
Summary: Uterine leiomyomas (ULs) exhibit both inter- and intratumor genetic heterogeneity. Regardless of the MED12 status, a tumor may consist of clones with and without chromosomal abnormalities. Under in vitro conditions, the clonal frequency of cells shifts up or down, possibly due to variations in the ability of cells with different genetic aberrations to survive outside the body.
Article
Obstetrics & Gynecology
Alyona Tiselko, Roman Kapustin, Yuliya P. Milyutina, Natalia Borovik, Elena Abashova, Maria Yarmolinskaya
Summary: This study analyzed glucose variability and its relationship with the development of preeclampsia in pregnant women with type 1 diabetes mellitus (T1DM). The results showed that the severity of preeclampsia was linked to the duration of T1DM as well as the level of HbA1c before and during pregnancy. Pregnant women using continuous subcutaneous insulin infusion (CSII) had a lower rate of preeclampsia compared to those using multiple daily insulin injections (MDI). Pathological glucose variability was negatively correlated with gestational age when preeclampsia occurred, and with the time for the detection of preeclampsia. The study highlights the correlation between preeclampsia and glucose variability, and suggests the benefits of CSII in achieving glycemic targets and reducing glucose variability in pregnant women with T1DM to decrease the frequency of preeclampsia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Genetics & Heredity
Yulia A. Nasykhova, Yury A. Barbitoff, Ziravard N. Tonyan, Maria M. Danilova, Ivan A. Nevzorov, Tatiana M. Komandresova, Anastasiia A. Mikhailova, Tatiana V. Vasilieva, Olga B. Glavnova, Maria Yarmolinskaya, Evgenia Sluchanko, Andrey S. Glotov
Summary: This study analyzed the genetic and phenotypic characteristics in relation to the response to metformin therapy in patients with type 2 diabetes mellitus (T2DM). The rs12208357 variant in the SLC22A1 gene was found to have a significant impact on metformin response. A machine learning model incorporating gender, rs12208357 genotype, familial T2DM background, and waist-hip ratio (WHR) showed the highest accuracy in predicting the response to metformin therapy in T2DM patients.
Article
Genetics & Heredity
Olga E. E. Talantova, Alla S. S. Koltsova, Andrei V. V. Tikhonov, Anna A. A. Pendina, Olga V. V. Malysheva, Olga A. A. Tarasenko, Elena S. S. Vashukova, Elena S. S. Shabanova, Arina V. V. Golubeva, Olga G. G. Chiryaeva, Andrey S. S. Glotov, Olesya N. N. Bespalova, Olga A. A. Efimova
Summary: A 29-year-old woman refused chorionic villus sampling and chose non-invasive prenatal testing (NIPT), which showed low risk for common aneuploidies. Subsequent ultrasound examinations revealed various abnormalities, and the patient decided to terminate the pregnancy.
Article
Genetics & Heredity
M. A. Ishchuk, O. Malysheva, E. M. Komarova, I. D. Mekina, E. A. Lesik, A. M. Gzgzyan, I. Yu Kogan, V. S. Baranov
Summary: The study evaluated the relationship between transcripts of protamines 1 and 2 in sperm and fertility status of patients, finding that abnormal sperm protamine ratio was associated with poor semen quality and DNA fragmentation. Such sperm-quality markers could help in understanding male infertility causes and improving male reproductive health.
RUSSIAN JOURNAL OF GENETICS
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
N. S. Osinovskaya, N. Y. Shved, O. V. Malysheva, M. I. Yarmolinskaya, V. S. Baranov
EUROPEAN JOURNAL OF HUMAN GENETICS
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
M. A. Ishchuk, E. M. Komarova, O. V. Malysheva, I. D. Mekina, E. A. Lesik, A. M. Gzgzyan, V. S. Baranov, I. Y. Kogan
EUROPEAN JOURNAL OF HUMAN GENETICS
(2020)
Article
Neurosciences
N. E. Ordyan, O. V. Malysheva, V. K. Akulova, S. G. Pivina, G. I. Kholova
NEUROCHEMICAL JOURNAL
(2020)