Article
Biochemistry & Molecular Biology
Borja Herrero de la Parte, Mikel Rodeno-Casado, Sira Iturrizaga Correcher, Carmen Mar Medina, Ignacio Garcia-Alonso
Summary: Curcumin has demonstrated an anti-tumor effect against liver implants from colorectal cancer by reducing cell proliferation and migration capacity, both in vitro and in vivo.
Review
Food Science & Technology
Lynne Howells, Rushad Malhotra Mukhtyar, Despoina Theofanous, Coral Pepper, Anne Thomas, Karen Brown, Sameena Khan
Summary: While there is extensive pre-clinical evidence supporting the utility of curcuminoids across many diseases, especially in cancer prevention, there remains a lack of clinical evidence. The study found that, although some research shows positive effects of curcuminoids on certain diseases, there are relatively few RCTs conducted in the prevention setting.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Chemistry, Applied
Surangna Jain, Scott Lenaghan, Vermont Dia, Qixin Zhong
Summary: The physicochemical properties and cytotoxicity of curcumin and quercetin encapsulated in shellac nanocapsules were investigated in this study. The nanocapsules with a curcumin and quercetin mass ratio of 4:1 showed the highest antioxidant properties and cytotoxicity for colorectal cancer cells. After simulated digestions, the encapsulated polyphenols showed bioaccessibility and retained their cytotoxicity. This study provides insights into the potential use of multiple polyphenols as anti-cancer agents.
Review
Chemistry, Medicinal
Solmaz Maleki Dizaj, Mahdieh Alipour, Elaheh Dalir Abdolahinia, Elham Ahmadian, Aziz Eftekhari, Haleh Forouhandeh, Yalda Rahbar Saadat, Simin Sharifi, Sepideh Zununi Vahed
Summary: Curcumin, a phytochemical derived from turmeric, is widely used for cancer treatment. However, its efficacy is limited due to issues like rapid metabolism, low bioavailability, and toxicity. Scientists have explored novel drug delivery systems to overcome these problems.
PHYTOTHERAPY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Vasiliki Zoi, Vasiliki Galani, Georgios D. Lianos, Spyridon Voulgaris, Athanasios P. Kyritsis, George A. Alexiou
Summary: Curcumin, a polyphenol extracted from turmeric, has anti-inflammatory and anticancer properties by regulating immune modulators and signaling pathways. Clinical trials have shown its effectiveness in various types of cancer.
Article
Oncology
Natalie S. Joe, Ines Godet, Nubaira Milki, Noor U. I. Ain, Harsh H. Oza, Gregory J. Riggins, Daniele M. Gilkes
Summary: This study found that the orally available drug mebendazole (MBZ) can inhibit the proliferation of triple-negative breast cancer cells and slow down disease progression by reducing the size of primary tumors and preventing metastasis. In addition, MBZ can also reduce the properties of cancer stem cells. These findings contribute to the potential use of MBZ as a therapeutic to slow tumor progression and prevent metastasis.
BREAST CANCER RESEARCH
(2022)
Article
Sport Sciences
Mireia Pelaez, Martijn M. Stuiver, Marike Broekman, Kathryn H. Schmitz, Eva M. Zopf, Dorothea Clauss, Yvonne Wengstroem, Friederike Rosenberger, Karen Steindorf, Ander Urruticoechea, Anne M. May
Summary: Around 25% of mBC patients develop brain metastases, and regular MRI screening is not recommended unless patients have CNS-related symptoms.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Review
Food Science & Technology
Fatemeh Sadoughi, Parisa Maleki Dana, Zatollah Asemi, Bahman Yousefi
Summary: Curcumin, as a beneficial plant compound, has the ability to modulate miRNA expression and have impacts on cancer hallmarks. MiRNAs are capable of regulating gene expression and signaling, as well as modulating cell differentiation and cell cycle, making them great candidates for personalized cancer treatment.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Leila Farhoudi, Prashant Kesharwani, Muhammed Majeed, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Natural compounds, such as curcumin, have potential benefits in cancer therapy, but their low bioavailability limits their application. Nanotechnology-based drug delivery systems have shown promise in improving the delivery and efficacy of curcumin.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Oncology
Silpita Paul, Gaurisankar Sa
Summary: The immune system components are crucial in combating tumors, but tumor cells can cleverly escape immune surveillance by adopting evasion mechanisms. Curcumin, a potential anti-cancer molecule, may be used in conjunction with immunotherapies to open up new avenues for treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Vicenc Ruiz de Porras, Laura Layos, Eva Martinez-Balibrea
Summary: Colorectal cancer is the second leading cause of cancer death globally, and is mainly treated with combinations of cytotoxic chemotherapy plus anti-EGFR or anti-VEGF drugs. Curcumin, a natural product with proven anticancer properties and low toxicity, is being studied as a potential treatment for CRC. Despite its poor bioavailability, new formulations are showing promising results in increasing its effectiveness in clinical settings.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sourour Idoudi, Takwa Bedhiafi, Fairooz Sahir, Yousef Hijji, Shahab Uddin, Maysaloun Merhi, Said Dermime, Nashiru Billa
Summary: This study evaluated the anti-cancer activity of curcumin nanoparticles (CUR-NPs) and succinylated curcumin nanoparticles (CUR.SA-NPs) on colon cancer cell lines. The nanoparticles showed dose and time-dependent cytotoxicity, inducing apoptosis through activation of Caspase signaling. Based on their promising attributes and in vitro results, further investigation into the role of these nanoparticle formulations in CRC management is warranted.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Narissara Namwan, Gulsiri Senawong, Chanokbhorn Phaosiri, Pakit Kumboonma, La-Or Somsakeesit, Arunta Samankul, Chadaporn Leerat, Thanaset Senawong
Summary: The curcumin derivative CU17 shows potential in inhibiting the growth of lung cancer cells, while exhibiting less toxicity to non-cancer cells. CU17 inhibits HDAC activity, induces cell cycle arrest and apoptosis, and down-regulates expression of certain proteins associated with cancer growth in lung cancer cells.
Review
Biochemistry & Molecular Biology
Daniel-Clement Osei-Bordom, Sivesh Kamarajah, Niki Christou
Summary: In the clinical management of liver metastasis of colorectal cancer, surgeons and oncologists categorize the metastasis into resectable and non-resectable groups to initiate tailored therapeutics. The combination of targeted therapies and biotherapies around these two entities is being actively explored to determine the ideal conditions for their application to improve patient survival and quality of life.
Review
Biochemistry & Molecular Biology
Hilda Amekyeh, Enas Alkhader, Rayan Sabra, Nashiru Billa
Summary: This review discusses the potential use of CUR-NPs in cancer treatment. CUR incorporation into nanoparticles enhances its pharmaceutical and therapeutic significance, improving solubility, absorption, bioavailability, stability, plasma half-life, targeted delivery, and anticancer effect. Promising anticancer activity suggests the potential application of CUR-NPs, but clinical reports are limited. Further clinical trials are needed to ensure effective translation into clinical applications.
Article
Oncology
Adriana Amaro, Giovanna Angelini, Valentina Mirisola, Alessia Isabella Esposito, Daniele Reverberi, Serena Matis, Massimo Maffei, Walter Giaretti, Maurizio Viale, Rosaria Gangemi, Laura Emionite, Simonetta Astigiano, Michele Cilli, Beatrice E. Bachmeier, Peter H. Killian, Adriana Albini, Ulrich Pfeffer
Article
Oncology
Peter H. Killian, Emanuel Kronski, Katharina M. Michalik, Ottavia Barbieri, Simonetta Astigiano, Christian P. Sommerhoff, Ulrich Pfeffer, Andreas G. Nerlich, Beatrice E. Bachmeier
Article
Oncology
Emanuel Kronski, Micol E. Fiori, Ottavia Barbieri, Simonetta Astigiano, Valentina Mirisola, Peter H. Killian, Antonino Bruno, Arianna Pagani, Francesca Rovera, Ulrich Pfeffer, Christian P. Sommerhoff, Douglas M. Noonan, Andreas G. Nerlich, Laura Fontana, Beatrice E. Bachmeier
MOLECULAR ONCOLOGY
(2014)
Article
Multidisciplinary Sciences
Stephanie Panzer, Oliver Peschel, Brigitte Haas-Gebhard, Beatrice E. Bachmeier, Carsten M. Pusch, Andreas G. Nerlich
Article
Oncology
Andreas G. Nerlich, Beatrice E. Bachmeier
Editorial Material
Biochemistry & Molecular Biology
Beatrice E. Bachmeier, Dieter Melchart
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Medicine, General & Internal
Dieter Melchart, Volker Fischer, Jingzhang Dai, Stefan Hager, Lisa Dersch, Beatrice E. Bachmeier
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Oncology
Jochen Rutz, Sebastian Maxeiner, Saira Justin, Beatrice Bachmeier, August Bernd, Stefan Kippenberger, Nadja Zoeller, Felix K-H Chun, Roman A. Blaheta
Article
Multidisciplinary Sciences
Andreas G. Nerlich, Sonja M. Kirchhoff, Stephanie Panzer, Christine Lehn, Beatrice E. Bachmeier, Birgit Bayer, Katja Anslinger, Pascale Roecker, Oliver K. Peschel
Summary: A multidisciplinary study of a well-preserved mummy from Napoleonic times revealed evidence of long-standing but terminally inactive pulmonary tuberculosis and other diseases. Despite the presence of tuberculosis infection, it was not the cause of death for the mummy with excellent living conditions correlating well with his diet.
Article
Biochemistry & Molecular Biology
Mohamed E. M. Saeed, Rumeysa Yuecer, Mona Dawood, Mohamed-Elamir F. Hegazy, Assia Drif, Edna Ooko, Onat Kadioglu, Ean-Jeong Seo, Fadhil S. Kamounah, Salam J. Titinchi, Beatrice Bachmeier, Thomas Efferth
Summary: This study evaluated the binding affinities of 50 curcumin derivatives to cancer-related target proteins EGFR and NF-kappa B using a molecular docking approach. The results showed similar binding affinities of the curcumin compounds for both target proteins. In silico results were validated using microscale thermophoresis, and bioactivity was further investigated through various assays. The study suggests that the derivatization of curcumin may be a promising strategy to develop more effective targeted curcumin-based drugs for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Beatrice E. Bachmeier, Roman Blaheta
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Beatrice E. Bachmeier, Salome Hoelzle, Mohamed Gasser, Marjan van den Akker
Summary: This study aimed to describe how German general practitioners (GPs) manage patients with ongoing complaints after a SARS-CoV-2 infection. The most commonly described symptoms were ongoing fatigue, dyspnea, chest tightness, and a decrease in physical capacity. There is a lack of comprehensive guidelines for diagnosing and treating Long-/Post-COVID, and current treatments focus on symptom relief with both pharmacological and non-pharmacological interventions.
Article
Medicine, Research & Experimental
Ulrich Pfeffer, Adriana Amaro, Beatrice Bachmeier, Giovanna Angelini
NEW HORIZONS IN TRANSLATIONAL MEDICINE
(2014)
Letter
Immunology
Andreas G. Nerlich, Raffaella Bianucci, Anna Trisciuoglio, Gabriele Schoenian, Markus Ball, Valentina Giuffra, Beatrice Bachmeier, Carsten M. Pusch, Ezio Ferroglio, Gino Fornaciari
EMERGING INFECTIOUS DISEASES
(2012)