The Role of Extracellular Vesicles in Bone Metastasis

The key role of extracellular vesicles in the metastatic process

(2018) Hongyun Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A

(2018) Kyoko Hashimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic cells loaded with tumor derived exosomes for cancer immunotherapy

(2017) Hongyu Liu et al.   Oncotarget

Exosomal miR-141-3p regulates osteoblast activity to promote the osteoblastic metastasis of prostate cancer

(2017) Yun Ye et al.   Oncotarget

Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway

(2017) Simona Taverna et al.   Scientific Reports

Mesenchymal Stem Cell–Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow

(2016) Sarah A. Bliss et al.   CANCER RESEARCH

The roles of bone-derived exosomes and exosomal microRNAs in regulating bone remodelling

(2016) Yong Xie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Characterization of Regulatory Extracellular Vesicles from Osteoclasts

(2016) N. Huynh et al.   JOURNAL OF DENTAL RESEARCH

Exosomes in tumor microenvironment: novel transporters and biomarkers

(2016) Zhen Wang et al.   Journal of Translational Medicine

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

(2016) Defang Li et al.   Nature Communications

Antagonizing miR-218-5p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells

(2016) Hanna Taipaleenmäki et al.   Oncotarget

Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity

(2016) Weijia Sun et al.   Cell Discovery

Tumor Cell-Derived Exosomes from the Prostate Cancer Cell Line TRAMP-C1 Impair Osteoclast Formation and Differentiation

(2016) Terese Karlsson et al.   PLoS One

Bone marrow stromal/stem cell-derived extracellular vesicles regulate osteoblast activity and differentiation in vitro and promote bone regeneration in vivo

(2016) Yunhao Qin et al.   Scientific Reports

Identification and proteomic analysis of osteoblast-derived exosomes

(2015) Min Ge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Osteoblast-derived microvesicles: A novel mechanism for communication between osteoblasts and osteoclasts

(2015) Lili Deng et al.   BONE

Immunoregulatory Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles on T Lymphocytes

(2015) Andrea Del Fattore et al.   CELL TRANSPLANTATION

Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth

(2015) Jess Morhayim et al.   FASEB JOURNAL

Exosomes derived from mineralizing osteoblasts promote ST2 cell osteogenic differentiation by alteration of microRNA expression

(2015) Yazhou Cui et al.   FEBS LETTERS

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

(2015) Donald G. Phinney et al.   Nature Communications

Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites

(2015) Krishna C. Vallabhaneni et al.   Oncotarget

Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation

(2015) Lavinia Raimondi et al.   Oncotarget

Differential effects of extracellular vesicles secreted by mesenchymal stem cells from different sources on glioblastoma cells

(2014) Andrea Del Fattore et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

miR-140-5p suppresses BMP2-mediated osteogenesis in undifferentiated human mesenchymal stem cells

(2014) Supyong Hwang et al.   FEBS LETTERS

Tartrate-resistant acid phosphatase (TRAP) co-localizes with receptor activator of NF-KB ligand (RANKL) and osteoprotegerin (OPG) in lysosomal-associated membrane protein 1 (LAMP1)-positive vesicles in rat osteoblasts and osteocytes

(2014) L. B. Solberg et al.   HISTOCHEMISTRY AND CELL BIOLOGY

miRNA cargo within exosome-like vesicle transfer influences metastatic bone colonization

(2014) Karmele Valencia et al.   Molecular Oncology

Active caspase-3 is removed from cells by release of caspase-3-enriched vesicles

(2013) A.N. Böing et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

MiR-503 Regulates Osteoclastogenesis via Targeting RANK

(2013) Chao Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Monocyte Exosomes Stimulate the Osteogenic Gene Expression of Mesenchymal Stem Cells

(2013) Karin Ekström et al.   PLoS One

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Microvesicles Derived from Human Bone Marrow Mesenchymal Stem Cells Inhibit Tumor Growth

(2012) Stefania Bruno et al.   STEM CELLS AND DEVELOPMENT

Bone cell interactions through Eph/ephrin

(2012) Koichi Matsuo et al.   Cell Adhesion & Migration

Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis

(2011) Rebecca A. Dragovic et al.   Nanomedicine-Nanotechnology Biology and Medicine

Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2

(2010) Atsushi Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Denosumab Compared With Zoledronic Acid for the Treatment of Bone Metastases in Patients With Advanced Breast Cancer: A Randomized, Double-Blind Study

(2010) Alison T. Stopeck et al.   JOURNAL OF CLINICAL ONCOLOGY

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes

(2010) Jung Eun Park et al.   MOLECULAR & CELLULAR PROTEOMICS

RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis

(2010) Eva Gonzalez-Suarez et al.   NATURE

New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK/RANKL axis

(2010) J. C. Crockett et al.   OSTEOPOROSIS INTERNATIONAL

The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent procoagulant activity and demonstrate greater expression of glycoprotein Ib

(2010) Thomas Exner et al.   THROMBOSIS AND HAEMOSTASIS

Human Placenta Expresses and Secretes NKG2D Ligands via Exosomes that Down-Modulate the Cognate Receptor Expression: Evidence for Immunosuppressive Function

(2009) M. Hedlund et al.   JOURNAL OF IMMUNOLOGY

ExoCarta: A compendium of exosomal proteins and RNA

(2009) Suresh Mathivanan et al.   PROTEOMICS

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY