Present Status and Future Challenges of New Therapeutic Targets in Preclinical Models of Stroke in Aged Animals with/without Comorbidities

Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery

(2018) Peiying Li et al.   NEUROPHARMACOLOGY

Analysis of long non-coding RNA expression profiles following focal cerebral ischemia in mice

(2018) Cuiying Liu et al.   NEUROSCIENCE LETTERS

Stem cell therapies in preclinical models of stroke. Is the aged brain microenvironment refractory to cell therapy?

(2017) Raluca Elena Sandu et al.   EXPERIMENTAL GERONTOLOGY

Association of ZFHX3 gene variation with atrial fibrillation, cerebral infarction, and lung thromboembolism: An autopsy study

(2017) Khin Thet Thet Zaw et al.   Journal of Cardiology

Association of CYP2J2 gene polymorphisms with ischemic stroke and stroke subtypes in Chinese population

(2017) Si-Yang Wang et al.   MEDICINE

Neurogenesis upregulation on the healthy hemisphere after stroke enhances compensation for age-dependent decrease of basal neurogenesis

(2017) Joanna Adamczak et al.   NEUROBIOLOGY OF DISEASE

Association of CD147 genetic polymorphisms with carotid atherosclerotic plaques in a Han Chinese population with cerebral infarction

(2017) Tongtian Ni et al.   THROMBOSIS RESEARCH

Genome Editing for the Study of Cardiovascular Diseases

(2017) Alexandra C. Chadwick et al.   Current Cardiology Reports

CRISPR-Cas9 Genome Editing for Treatment of Atherogenic Dyslipidemia

(2017) Alexandra C. Chadwick et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Phosphodiesterase Inhibitors in Vascular Ischemia: A Case Report and Review of Their Use in Ischemic Conditions

(2017) Wendy Ky Ng et al.   Canadian Journal of Plastic Surgery

Magnetic resonance imaging of local and remote vascular remodelling after experimental stroke

(2016) Pavel Yanev et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Altered white matter integrity and functional connectivity of hyperacute-stage cerebral ischemia in a rat model

(2016) Jihoon Cha et al.   MAGNETIC RESONANCE IMAGING

Post-stroke gaseous hypothermia increases vascular density but not neurogenesis in the ischemic penumbra of aged rats

(2016) Raluca Elena Sandu et al.   RESTORATIVE NEUROLOGY AND NEUROSCIENCE

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability

(2016) Christina Wayman et al.   Jove-Journal of Visualized Experiments

Inflammatory cause of metabolic syndrome via brain stress and NF-κB

(2016) Dongsheng Cai et al.   Aging-US

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

(2015) Brendan A.I. Payne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Fluoxetine Enhances Neurogenesis in Aged Rats with Cortical Infarcts, but This is not Reflected in a Behavioral Recovery

(2015) Xiaoyu Sun et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Peripheral Frequency of CD4+ CD28− Cells in Acute Ischemic Stroke

(2015) Antonino Tuttolomondo et al.   MEDICINE

High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain

(2015) Ákos Menyhárt et al.   NEUROBIOLOGY OF AGING

Forced limb-use enhanced neurogenesis and behavioral recovery after stroke in the aged rats

(2015) H.L. Qu et al.   NEUROSCIENCE

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

(2015) Thorsten R. Doeppner et al.   Stem Cells Translational Medicine

Present status and future challenges of electroencephalography- and magnetic resonance imaging-based monitoring in preclinical models of focal cerebral ischemia

(2014) Slavianka G. Moyanova et al.   BRAIN RESEARCH BULLETIN

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

The late phase of post-stroke neurorepair in aged rats is reflected by MRI-based measures

(2014) E.M. Titova et al.   NEUROSCIENCE

Stem cell therapies in preclinical models of stroke associated with aging

(2014) Aurel Popa-Wagner et al.   Frontiers in Cellular Neuroscience

Transcriptomics of Post-Stroke Angiogenesis in the Aged Brain

(2014) Ana Maria Buga et al.   Frontiers in Aging Neuroscience

Intrafamilial phenotypic variability in four families with Anderson-Fabry disease

(2013) M. Rigoldi et al.   CLINICAL GENETICS

Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised

(2013) Stefano Salvioli et al.   CURRENT PHARMACEUTICAL DESIGN

Non-invasive imaging of transplanted human neural stem cells and ECM scaffold remodeling in the stroke-damaged rat brain by 19F- and diffusion-MRI

(2012) Ellen Bible et al.   BIOMATERIALS

Imaging Neuroinflammation after Stroke: Current Status of Cellular and Molecular MRI Strategies

(2012) Lisette H. Deddens et al.   CEREBROVASCULAR DISEASES

Prolonged Gaseous Hypothermia Prevents the Upregulation of Phagocytosis-Specific Protein Annexin 1 and Causes Low-Amplitude EEG Activity in the Aged Rat Brain after Cerebral Ischemia

(2012) Christy Joseph et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Identification of New Therapeutic Targets by Genome-Wide Analysis of Gene Expression in the Ipsilateral Cortex of Aged Rats after Stroke

(2012) Ana-Maria Buga et al.   PLoS One

Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death

(2011) J. J. Neher et al.   JOURNAL OF IMMUNOLOGY

The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease

(2011) Jens P Dreier   NATURE MEDICINE

Targeted Delivery of Neural Stem Cells to the Brain Using MRI-Guided Focused Ultrasound to Disrupt the Blood-Brain Barrier

(2011) Alison Burgess et al.   PLoS One

Cognitive dysfunction with aging and the role of inflammation

(2011) Arthur A. Simen et al.   Therapeutic Advances in Chronic Disease

Mechanistic Insight into DNA Damage and Repair in Ischemic Stroke: Exploiting the Base Excision Repair Pathway as a Model of Neuroprotection

(2010) Peiying Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Chronic brain tissue remodeling after stroke in rat: A 1-year multiparametric magnetic resonance imaging study

(2010) Kishor Karki et al.   BRAIN RESEARCH

Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population

(2010) Cong Li et al.   HUMAN GENETICS

Fractalkine Attenuates Excito-neurotoxicity via Microglial Clearance of Damaged Neurons and Antioxidant Enzyme Heme Oxygenase-1 Expression

(2010) Mariko Noda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inducing Stroke in Aged, Hypertensive, Diabetic Rats

(2010) Sarah SJ Rewell et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mosaic aging

(2010) Lary C. Walker et al.   MEDICAL HYPOTHESES

Neural mechanisms of ageing and cognitive decline

(2010) Nicholas A. Bishop et al.   NATURE

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

(2010) Martin Fuhrmann et al.   NATURE NEUROSCIENCE

Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys

(2010) A.A. Willette et al.   NEUROIMAGE

Mechanisms and targets for angiogenic therapy after stroke

(2010) Deepti Navaratna et al.   Cell Adhesion & Migration

Autologous Bone Marrow Mononuclear Cells Enhance Recovery after Acute Ischemic Stroke in Young and Middle-Aged Rats

(2009) Miranda Brenneman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CONGENITAL MUSCULAR DYSTROPHY WITH DEFECTIVE  -DYSTROGLYCAN, CEREBELLAR HYPOPLASIA, AND EPILEPSY

(2009) S. Messina et al.   NEUROLOGY

Magnetic nanoparticles in MR imaging and drug delivery☆

(2008) C SUN et al.   ADVANCED DRUG DELIVERY REVIEWS

Spreading depolarizations occur in human ischemic stroke with high incidence

(2008) Christian Dohmen et al.   ANNALS OF NEUROLOGY

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

(2008) L. A. Truman et al.   BLOOD

Mannitol enhances delivery of marrow stromal cells to the brain after experimental intracerebral hemorrhage

(2008) Donald M. Seyfried et al.   BRAIN RESEARCH

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Identification and molecular characterization of six novel mutations in the UDP-N-acetylglucosamine-1-phosphotransferase gamma subunit (GNPTG) gene in patients with mucolipidosis III gamma

(2008) Emanuele Persichetti et al.   HUMAN MUTATION

The genomic response of the ipsilateral and contralateral cortex to stroke in aged rats

(2008) A.-M. Buga et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Predictors of outcome in acute ischemic cerebrovascular syndromes: The GIFA study

(2007) Antonino Tuttolomondo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Early disruptions of the blood–brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats

(2007) Vincent A. DiNapoli et al.   NEUROBIOLOGY OF AGING