Article
Polymer Science
Kheira Zanoune Dellali, Mohammed Dellali, Delia Mihaela Rata, Anca Niculina Cadinoiu, Leonard Ionut Atanase, Marcel Popa, Mihaela-Claudia Spataru, Carmen Solcan
Summary: Drug delivery is a critical aspect of nanomedicine, aimed at targeting specific active substances to desired sites of action. This study focuses on the synthesis of nanocapsules using chitosan and poly(N-vinyl pyrrolidone-alt-itaconic anhydride) and investigates their behavior and properties. In vivo experiments demonstrate the biocompatibility of nanocapsules and their ability to stimulate the monocytic macrophage system without causing inflammation. The study also emphasizes the importance of the administration route and the interaction with organ cells in determining the behavior of nanocapsules.
Article
Polymer Science
Htet Htet Moe San, Khent Primo Alcantara, Bryan Paul I. Bulatao, Waraluck Chaichompoo, Nonthaneth Nalinratana, Apichart Suksamrarn, Opa Vajragupta, Pranee Rojsitthisak, Pornchai Rojsitthisak
Summary: The encapsulation of turmeric oil in chitosan/alginate nanocapsules improved its physicochemical characteristics and enhanced its cytotoxicity against breast cancer cells, suggesting its potential as a candidate for in vivo anticancer activity evaluation.
Review
Polymer Science
Md. Harun-Or-Rashid, Most. Nazmin Aktar, Md. Sabbir Hossain, Nadia Sarkar, Md. Rezaul Islam, Md. Easin Arafat, Shukanta Bhowmik, Shin-ichi Yusa
Summary: Polymeric drug delivery technology has advanced significantly in recent decades, allowing medicinal ingredients to enter cells more easily. Natural and synthetic polymers are used in drug delivery systems, and combining synthetic and biological approaches can result in revolutionary drug and gene delivery devices.
Review
Pharmacology & Pharmacy
Tomasz Osmalek, Anna Froelich, Barbara Jadach, Adam Tatarek, Piotr Gadzinski, Aleksandra Falana, Kinga Gralinska, Michal Ekert, Vinam Puri, Joanna Wrotynska-Barczynska, Bozena Michniak-Kohn
Summary: The vagina has long been considered as a potential drug administration route, with most formulations made of natural or synthetic polymers serving different functions. In addition to topical applications, the anatomical and physiological features of the vagina make it suitable for systemic drug absorption. Research shows that intravaginal products continue to attract scientific attention, with ongoing exploration of novel polymers and formulations.
Article
Materials Science, Multidisciplinary
Shiyi Zhao, Chi Huang, Xuan Yue, Xuebo Li, Ping Zhou, Anxin Wu, Chonghao Chen, Yan Qu, Chen Zhang
Summary: Micro/nanoparticles-based drug delivery system has significantly influenced the pharma industry. The development of cost-effective and scalable production methods is crucial for clinical translation. Electrospray technology can quickly obtain uniform and stable micro/nanoparticles as drug carriers. The micro/nanoparticles carriers can change drug solubility and bioavailability, reducing toxicity. Electrospray has wide applications in different drug delivery routes and diseases.
MATERIALS & DESIGN
(2022)
Article
Materials Science, Biomaterials
Marina Machtakova, Sebastian Wirsching, Stephan Gehring, Katharina Landfester, Heloise Therien-Aubin
Summary: Nanocapsules are a promising platform for delivering macromolecular payloads, but the challenge lies in controlling the release of these molecules. By varying the crosslinking density of the nanoshell, the release of model macromolecules from degradable protein nanocapsules can be controlled. These optimized protein nanocapsules have successfully delivered and released a bioactive macromolecular vaccine adjuvant in vitro, demonstrating their potential as efficient platforms for nanovaccine design.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Hongda Zhou, Haowei Huang, Mounib Bahri, Nigel D. Browning, James Smith, Michael Graham, Dmitry Shchukin
Summary: This study demonstrated communication assemblies between biomimetic nanocapsules in a 3D closed system with self-regulating and self-organization functionalities. The nanocapsules have clear core-shell structures with different average diameters and massive pore structures, displaying high encapsulation capabilities. Through the communication assemblies, an autonomic three-stage release process and internal modulation of self-controlled release efficiency were achieved, with the overweight ratio of capsules influencing the communication-release interaction.
Article
Polymer Science
Xiaotao Wang, Wei Hu, Yebin Yang, Yonggui Liao, Wing-Cheung Law, Chak-Yin Tang
Summary: Multifunctional composite nanoparticles with monodispersity and uniform particle size can be synthesized by distillation precipitation polymerization, which were used as core-shell structure and emit visible light under 980nm near-infrared light for developing imaging. These composite nanoparticles have a certain hollow structure after etch of HF and can load DOX with a drug loading rate of 6.23%. The release rate of the drug can reach up to 85.13% under the stimulation of pH = 4 and UV light. The composite nanoparticles show lower cytotoxicity and stable drug release behavior in human breast cancer cells (MCF-7).
EUROPEAN POLYMER JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Zhenyang Ji, Jinrong Yao, Zhengzhong Shao, Xin Chen
Summary: This study developed zein/chitosan composite nanospheres as carriers for controlled release of cinnamaldehyde (CA) in cosmetics industry. The structure of the nanospheres was influenced by the zein/chitosan mass ratio. The interaction between CA and zein, as well as the formation of Schiff base between CA and chitosan, effectively reduced the volatilization rate of CA and prolonged its release time.
Article
Chemistry, Multidisciplinary
Bradley P. Hambly, Chandler K. Sears, Marcin Guzinski, Felio Perez, Rose-Marie Latonen, Johan Bobacka, Bradford D. Pendley, Erno Lindner
Summary: The feasibility of using reagent-loaded porous polymeric nanocapsules for sensor design was evaluated by decorating the nanocapsule surfaces with EDOT moieties. Two electrochemical deposition methods were investigated for attaching acrylate-based porous nanocapsules with EDOT moieties to an existing PEDOT film, with different distribution observed in the resulting films.
Review
Pharmacology & Pharmacy
Daniel Andres Real, Karen Bolanos, Josefina Priotti, Nicolas Yutronic, Marcelo J. Kogan, Rodrigo Sierpe, Orlando Donoso-Gonzalez
Summary: This review focuses on the application of CD-modified or CD-based nanomaterials in drug delivery, highlighting their potential in formulating new systems and achieving controlled drug release and increased bioavailability in in vivo studies.
Article
Chemistry, Physical
Ronaldo Badenhorst, Evgeny Katz, Oleh Smutok
Summary: In this study, bovine serum albumin (BSA) was immobilized on a buckypaper electrode using covalent bonds. By controlling the local pH, BSA release was achieved. Blocking the formation of affinity bonds was crucial for protein release.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Polymer Science
Elena Simona Bacaita, Delia Mihaela Rata, Anca Niculina Cadinoiu, Vlad Ghizdovat, Maricel Agop, Alina-Costina Luca
Summary: The present study examines the drug release process from nanoparticles and its inclusion in cream-type formulations. The cream allows for targeted delivery of the drug to tumor epithelial cells, reducing side effects and improving treatment effectiveness. The process of obtaining these formulations is simple and reproducible. The theoretical model considers the system as complex, utilizing multifractal dimensions and functions to analyze microscopic characteristics and system complexity.
Article
Materials Science, Biomaterials
Arjaree Jobdeedamrong, Man Theerasilp, Norased Nasongkla, Daniel Crespy
Summary: In this study, silica nanocapsules (SiO2NCs) stabilized with a reactive surfactant were synthesized to prevent leaching during dialysis, showing superior stability and biocompatibility compared with SiO2NCs prepared with conventional surfactants. These SiO2NCs can be used in self-healing materials, smart agriculture, and biomedical applications.
BIOMATERIALS SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Zhijuan Sun, Lei Yang, Chenchen Xu, Chenxin Cai, Li Li
Summary: In this study, stable core-shell zwitterionic nanocapsules with dual pH- and thermal-responsiveness were successfully synthesized. These nanocapsules can effectively encapsulate drugs and control drug release. Experimental results showed that the nanocapsules had an average particle size ranging from 178 to 142 nm when the temperature changed from 25°C to 40°C. Sustained release experiments using bovine serum albumin (BSA) as the payload demonstrated the capability of the nanocapsules to achieve controlled drug release, with different release profiles at different temperatures. In vitro cytotoxicity tests also confirmed the feasibility of their biomedical application. These dual pH- and thermal-responsive nanocapsules hold promising potential for drug-controlled release.
Article
Medicine, General & Internal
Paulina Cortes-Acevedo, Susana E. Mendoza-Elvira, Rainer Doffinger, Gabriela Barcenas-Morales
Summary: Anti-cytokine autoantibodies (ACAA) are an important cause of secondary immunodeficiencies, and high titers of these autoantibodies can lead to susceptibility to life-threatening infectious diseases. Various types of autoantibodies have been associated with specific infections, such as IFN gamma autoantibodies with mycobacterial infections and IL-6 autoantibodies with subcutaneous abscesses. Detection of ACAA is crucial for the diagnosis and treatment of patients, especially those with late-onset diseases.
GACETA MEDICA DE MEXICO
(2023)
Article
Polymer Science
Claudia I. Garcia-Betanzos, Humberto Hernandez-Sanchez, Sergio A. Ojeda-Piedra, Araceli Ulloa-Saavedra, David Quintanar-Guerrero, Maria L. Zambrano-Zaragoza
Summary: Solid lipid nanoparticles (SLN) based on candelilla wax were prepared using the hot homogenization technique. The resulting suspension had monomodal behavior with a particle size of 809-885 nm; polydispersity index < 0.31, and zeta potential of -3.5 mV 5 weeks after monitoring. The effects of temperature, film composition, and relative humidity on the microstructural, thermal, mechanical, and optical properties, as well as the water vapor barrier, were evaluated. Films with 20 g/L of SLN, 30 g/L of glycerol, and 3 g/L of xanthan gum (XG) showed the most appropriate physical properties for packaging and prolonging the shelf-life of fresh foods.
Review
Pharmacology & Pharmacy
Sheila I. Pena-Corona, Hector Hernandez-Parra, Sergio A. Bernal-Chavez, Nestor Mendoza-Munoz, Alejandra Romero-Montero, Maria Luisa Del Prado-Audelo, Hernan Cortes, Dilek Arslan Atessahin, Solomon Habtemariam, Zainab M. Almarhoon, Ahmad Faizal Abdull Razis, Babagana Modu, Javad Sharifi-Rad, Gerardo Leyva-Gomez
Summary: Cancer is a major cause of death worldwide and poses significant clinical, social, and financial burdens. Traditional cancer chemotherapies have limitations, and there is a need for bioactive anticancer compounds. Neopeltolide, a macrolide derived from deep-water sponges, shows promise as a novel drug for cancer therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemical Research Methods
Sergio A. Bernal-Chavez, Alejandra Romero-Montero, Hector Hernandez-Parra, Sheila I. Pena-Corona, Maria L. Del Prado-Audelo, Sergio Alcala-Alcala, Hernan Cortes, Lashyn Kiyekbayeva, Javad Sharifi-Rad, Gerardo Leyva-Gomez
Summary: The freeze-thaw method is commonly used in the processing and handling of drugs to enhance their stability and obtain pharmaceutical applications. However, the use of this method is limited by certain characteristics and requires optimization of process conditions and variables. Current research focuses on enhancing formulations, process optimization, and the use of freeze-thaw methods. This review discusses the impact of the freeze-thaw process on the physical, mechanical, and chemical properties of pharmaceutical applications, along with challenges and opportunities in development.
JOURNAL OF BIOLOGICAL ENGINEERING
(2023)
Review
Biochemical Research Methods
Samanta Castaneda-Rodriguez, Maykel Gonzalez-Torres, Rosa Maria Ribas-Aparicio, Maria Luisa Del Prado-Audelo, Gerardo Leyva-Gomez, Eda Soenmez Gurer, Javad Sharifi-Rad
Summary: Tissue engineering and regenerative medicine aim to develop materials that can replace, restore, or enhance organs or tissues, and improve cellular capacity for proliferation, migration, and differentiation. Renewable resources have been utilized to produce environmentally friendly biomaterials, including the biodegradable polymer poly(lactic acid) (PLA). In combination with other polymers, PLA can be modified to create biomaterials with suitable properties for tissue engineering applications. This review focuses on the advancements in modified PLA as tissue engineering materials, highlighting efforts to overcome limitations such as biological inertness, low cell adhesion, and slow degradation rate, and develop enhanced alternative biomaterials.
JOURNAL OF BIOLOGICAL ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Isaac H. Caballero-Floran, Hernan Cortes, Fabiola V. Borbolla-Jimenez, Carla D. Floran-Hernandez, Maria L. Del Prado-Audelo, Jonathan J. Magana, Benjamin Floran, Gerardo Leyva-Gomez
Summary: This study proposes the use of polyethylene glycol 400 (PEG) and trehalose as a surface modification technique to improve PLGA-based nanoparticles as drug carriers for neurons. The combination of PEG and trehalose enhances the hydrophilicity of the nanoparticles and promotes their cellular internalization. Through optimization using central composite design, PLGA nanoparticles with diameters smaller than 200 nm were produced, and the coating process did not significantly increase their size. The nanoparticles showed high curcumin entrapment efficiency and a controlled release profile.
Article
Pharmacology & Pharmacy
Ramon Andres Pineda-Alvarez, Carolina Flores-Avila, Luis Medina-Torres, Jesus Gracia-Mora, Jose Juan Escobar-Chavez, Gerardo Leyva-Gomez, Mohammad-Ali Shahbazi, Maria Josefa Bernad-Bernad
Summary: This study evaluates the performance of Laponite in lecithin/gelatin composites and maltodextrin/sodium ascorbate mixtures. Nanoparticles were prepared using the gelatin desolvation method and turned into films via the solvent-casting method. The optimal composites were developed with 8.8 mg of Laponite, reducing particle size and avoiding agglomeration. Drug release in LGL MAS was fitted to first-order and Korsmeyer-Peppas models.
Review
Biology
Edgar Yebran Villegas-Vazquez, Laura Itzel Quintas-Granados, Hernan Cortes, Manuel Gonzalez-Del Carmen, Gerardo Leyva-Gomez, Miguel Rodriguez-Morales, Lilia Patricia Bustamante-Montes, Daniela Silva-Adaya, Carlos Perez-Plasencia, Nadia Jacobo-Herrera, Octavio Daniel Reyes-Hernandez, Gabriela Figueroa-Gonzalez
Summary: Lithium, an anti-cancer agent, shows potential in inducing apoptosis, autophagy, and inhibiting tumor growth. It also plays a role in tumor regulation and synergizes with standard cancer therapies. Additionally, lithium has neuroprotective effects and enhances anti-tumor activities in nano-sized form. However, its therapeutic activities depend on various factors. This review emphasizes the importance of repurposing lithium as a therapeutic agent and highlights its molecular mechanisms.
Article
Biochemistry & Molecular Biology
Jose E. Aguilar-Toala, Abraham Vidal-Limon, Andrea M. Liceaga, Maria L. Zambrano-Zaragoza, David Quintanar-Guerrero
Summary: This study demonstrates the potential of canary seed peptides (CSP) in inhibiting skin-aging factors, such as elastase and tyrosinase. Through analysis methods like fractionalization and molecular dynamics-ensemble docking, favorable peptides for passive insertion into skin membranes were identified, suggesting a promising application of CSP in skin-aging treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Moises Job Galindo-Perez, Lizbeth Martinez-Acevedo, Gustavo Vidal-Romero, Luis Eduardo Serrano-Mora, Maria de la Luz Zambrano-Zaragoza
Summary: This study aimed to preserve fresh-cut papaya using lemon oil and curcumin nanocapsules. The nanoparticles were stable and had a size smaller than 120 nm. They effectively reduced the respiration rate, maintained pH and acidity levels, improved color and texture, and preserved total phenolic compounds in the fruit. Lemon oil/EC nanocapsules showed better color retention. The findings highlight the effectiveness of these nanocapsules in preserving fresh-cut 'Maradol' papaya.
Review
Chemistry, Applied
Nestor Mendoza-Munoz, Gerardo Leyva-Gomez, Elizabeth Pinon-Segundo, Maria L. Zambrano-Zaragoza, David Quintanar-Guerrero, Maria Luisa Del Prado Audelo, Zaida Urban-Morlan
Summary: The term biopolymer refers to materials obtained by chemically modifying natural biological substances or producing them through biotechnological processes. They are biodegradable, biocompatible and non-toxic. Due to these advantages, biopolymers have wide applications in cosmetic formulations and have emerged as essential ingredients with various functions.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2023)
Article
Biochemical Research Methods
Sergio Alberto Bernal-Chavez, Sergio Alcala-Alcala, Zainab M. Almarhoon, Aknur Turgumbayeva, Eda Sonmez Gurer, Ma. de los Dolores Campos-Echeverria, Hernan Cortes, Alejandra Romero-Montero, Maria Luisa Del Prado-Audelo, Javad Sharifi-Rad, Gerardo Leyva-Gomez
Summary: In this study, an ultra-stretchable and self-healing hydrogel was developed by adding PolyOX to cationic guar gum hydrogels. The optimized hydrogel exhibited semi-crystalline structure, high stretchability, and excellent self-healing properties, making it suitable for various applications in tissue engineering, drug delivery, and food storage.
JOURNAL OF BIOLOGICAL ENGINEERING
(2023)
Review
Pharmacology & Pharmacy
Fabiola V. Borbolla-Jimenez, Sheila I. Pena-Corona, Sonia J. Farah, Maria Teresa Jimenez-Valdes, Emiliano Pineda-Perez, Alejandra Romero-Montero, Maria Luisa Del Prado-Audelo, Sergio Alberto Bernal-Chavez, Jonathan J. Magana, Gerardo Leyva-Gomez
Summary: Wound healing is a complex process involving four phases: hemostasis, inflammation, proliferation, and remodeling. Polymeric films have been widely used as wound dressings due to their biocompatibility, low immunogenicity, ease of application, and gas exchange capabilities. Among various methods for designing polymeric films, solvent casting is a reliable and cost-effective technique. This review focuses on polymeric dressings obtained using solvent casting, discussing the manufacturing factors necessary for effective wound dressing performance.
Review
Polymer Science
Rosy G. Cruz-Monterrosa, Adolfo A. Rayas-Amor, Ricardo M. Gonzalez-Reza, Maria L. Zambrano-Zaragoza, Jose E. Aguilar-Toala, Andrea M. Liceaga
Summary: Polysaccharide-based edible coatings can improve the quality parameters and extend the shelf life of foods, while also providing antioxidant and antimicrobial properties.
