Article
Oncology
Katherine K. Clifton, Cynthia X. Ma, Luigi Fontana, Lindsay L. Peterson
Summary: Intermittent fasting (IF) has gained popularity as a potential anticarcinogenic strategy, but its effects on cancer patients remain unclear without high-quality randomized clinical trials. More research is needed to determine the risks and benefits of IF for cancer patients before it can be recommended outside of clinical trials.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Review
Oncology
Ezzeldin M. Ibrahim, Meteb H. Al-Foheidi, Mubarak M. Al-Mansour
Summary: Dietary interventions have a significant impact on body metabolism and can hinder cancer growth and progression while enhancing the efficacy of chemotherapy and radiation therapy. Although current clinical trials have small sample sizes, they have shown clinical benefits for cancer patients.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Nutrition & Dietetics
Mehdi Sadeghian, Sepideh Rahmani, Saman Khalesi, Ehsan Hejazi
Summary: Fasting may improve the response of tumor cells to chemotherapy through multiple mechanisms, protect normal cells, and enhance the effectiveness of chemotherapy. However, with limited human trials, more human studies with sufficient sample size and follow-ups are needed to confirm these findings.
CLINICAL NUTRITION
(2021)
Article
Oncology
Mona Alidadi, Maciej Banach, Paul C. Guest, Simona Bo, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: Caloric restriction (CR) and fasting have shown potential anticancer effects by reducing tumor progression, enhancing death of cancer cells, and elevating the effectiveness and tolerability of chemo- and radiotherapies. However, clinical studies on the potential of CR and fasting in cancer treatment are scarce and inconsistent, requiring further investigation to clarify their impact.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Medicine, General & Internal
Carla Serra, Alessandro Sestu, Veronica Murru, Giulia Greco, Matteo Vacca, Angelo Scuteri
Summary: According to this study, alterations in heart rate variability (HRV) are associated with arterial aging. Lower sympathetic and parasympathetic activity in women are significantly associated with arterial stiffening, while there is no significant association in men.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Baptiste Gramont, Martin Killian, Elodie Bernard, Laure Martinez, Sebastien Bruel, Bogdan Galusca, Nathalie Barth, Thomas Celarier
Summary: This study investigated the knowledge, practices, and acceptability of therapeutic fasting in subjects aged 65 years and over. The results showed that a majority of elderly individuals are interested in and willing to try therapeutic fasting if it is proven beneficial, particularly in terms of reducing the burden of chronic diseases. These findings lay the groundwork for future clinical trials evaluating therapeutic fasting in elderly subjects.
Article
Cell Biology
Xiaoping Zhang, Yong Zhong, Lin Liu, Chengyou Jia, Haidong Cai, Jianshe Yang, Bo Wu, Zhongwei Lv
Summary: The study found that fasting can inhibit glycolysis and mitochondrial function in papillary thyroid carcinoma (PTC). Fasting significantly increases the expression of lncRNA PRKCQ-AS1 in PTC cells, which leads to suppression of glycolysis and reduced mitochondrial function. PRKCQ-AS1 interacts with IGF2BPs and enhances the expression of PRMT7 mRNA, thereby regulating glycolysis and mitochondrial function in PTC and inhibiting tumor growth.
CELL DEATH & DISEASE
(2023)
Article
Health Care Sciences & Services
Ludek Kalfirt, Chia-Ting Su, Chung-Pei Fu, Shin-Da Lee, Ai-Lun Yang
Summary: The prevalence of autism spectrum disorder (ASD) among children is increasing. This study investigates the differences in motor skills, heart rate variability (HRV), and arterial stiffness between children with ASD and typically developing children. The results show motor skill deficits and autonomic dysregulation in children with ASD.
Editorial Material
Endocrinology & Metabolism
Raghu Vemuganti, Thiruma Arumugam
Summary: A proper diet is crucial for health and longevity. Intermittent fasting shows benefits in mitigating metabolic disorders and reducing the risk of age-related diseases like heart attack, stroke and dementia through altered epigenetic and transcriptional programming.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Geriatrics & Gerontology
Jonas R. Schaarup, Martin S. Christensen, Adam Hulman, Christian S. Hansen, Dorte Vistisen, Adam G. Tabak, Daniel R. Witte, Lasse Bjerg
Summary: This study examines the association between autonomic nervous function and arterial stiffness. The autonomic nervous function was evaluated using heart rate variability (HRV) indices and resting heart rate (rHR), while arterial stiffness was measured using carotid-femoral pulse wave velocity (PWV). The results show that a decrease in HRV and unchanged rHR are associated with higher levels of PWV, especially in younger individuals.
Review
Oncology
Olga Blazevits, Maira Di Tano, Valter D. Longo
Summary: Fasting mimicking diets (FMDs) have emerged as effective dietary interventions to improve healthspan and decrease the incidence of cancer and other age-related diseases. FMD cycles provide safer and less challenging options for cancer patients by increasing protection in healthy cells and sensitizing cancer cells to therapies. Recent data show that FMD cycles enhance the efficacy of different cancer drugs in mice by stimulating antitumor immunity. This article reports on the effects of FMD cycles on cancer prevention and treatment and the underlying mechanisms.
Article
Nutrition & Dietetics
Alda Attina, Claudia Leggeri, Rita Paroni, Francesca Pivari, Michele Dei Cas, Alessandra Mingione, Maria Dri, Marco Marchetti, Laura Di Renzo
Summary: Fasting is a key topic in the Nutritional Era, involving catabolism of lipids, proteins, and carbohydrates to maintain blood glucose levels and promote longevity. While studies show benefits, there is a lack of safe fasting protocols for physicians to prescribe. Research needs to focus on specific guidelines to enhance effectiveness and improve body composition.
Review
Sport Sciences
Alberto Calleja-Romero, German Vicente-Rodriguez, Nuria Garatachea
Summary: Running a long-distance race has a considerable acute effect on the autonomic nervous system, hemodynamics, and vascular properties, with a decrease in markers of parasympathetic activity, blood pressure, and arterial stiffness.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Oncology
Claudia Matlakala Ntsapi, Ben Loos
Summary: Alzheimer's disease is a devastating neurodegenerative condition with significant socio-economic impact, exacerbated by rapid population aging. Accumulation of the Aβ peptide, driven by the amyloid precursor protein processing, plays a key role in synaptic dysfunction and neuronal cell loss associated with AD pathogenesis. Modulation of autophagy for enhanced Aβ clearance has shown promising therapeutic potential in neuronal protection.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Toshifumi Muneyasu, Harutoyo Hirano, Akira Furui, Zu Soh, Ryuji Nakamura, Noboru Saeki, Yoshiyuki Okada, Masashi Kawamoto, Masao Yoshizumi, Atsuo Yoshino, Takafumi Sasaoka, Shigeto Yamawaki, Toshio Tsuji
Summary: This study aimed to investigate the features of peripheral arterial stiffness to determine whether it inherits the features of muscle sympathetic nerve activity (MSNA) for non-invasive evaluation. Results showed that peripheral arterial stiffness beta exhibits similar features to MSNA, making it an effective non-invasive substitute for MSNA measurement.
SCIENTIFIC REPORTS
(2021)