The Target of Rapamycin and Mechanisms of Cell Growth

La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region

(2017) Lucas Philippe et al.   NUCLEIC ACIDS RESEARCH

La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

(2017) Roni M Lahr et al.   eLife

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Sestrin regulation of TORC1: Is Sestrin a leucine sensor?

(2016) Jun Hee Lee et al.   Science Signaling

TORC2 Structure and Function

(2016) Christl Gaubitz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

(2016) Bernadette Carroll et al.   eLife

Sestrin regulation of TORC1: Is Sestrin a leucine sensor?

(2016) Jun Hee Lee et al.   Science Signaling

Signalling to eIF4E in cancer

(2015) N. Siddiqui et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)

(2015) Bruno D. Fonseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

(2014) E.A. Dunlop et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Hepatoprotective role of Sestrin2 against chronic ER stress

(2014) Hwan-Woo Park et al.   Nature Communications

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

(2014) Lynne Chantranupong et al.   Cell Reports

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

(2014) Anita Parmigiani et al.   Cell Reports

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program

(2013) C Chauvin et al.   ONCOGENE

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

(2013) I. Ben-Sahra et al.   SCIENCE

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

(2012) Jun Hee Lee et al.   Cell Metabolism

Organ Size Control by Hippo and TOR Pathways

(2012) Karen Tumaneng et al.   CURRENT BIOLOGY

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

Emerging Treatments in the Management of Tuberous Sclerosis Complex

(2012) Michael H. Kohrman   PEDIATRIC NEUROLOGY

mTOR binds to the promoters of RNA polymerase I- and III-transcribed genes

(2011) Chi Kwan Tsang et al.   CELL CYCLE

Relieving Autophagy and 4EBP1 from Rapamycin Resistance

(2011) B. Nyfeler et al.   MOLECULAR AND CELLULAR BIOLOGY

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Biosynthesis of rapamycin and its regulation: past achievements and recent progress

(2010) Sung Ryeol Park et al.   JOURNAL OF ANTIBIOTICS

Requirement of the mTOR Kinase for the Regulation of Maf1 Phosphorylation and Control of RNA Polymerase III-dependent Transcription in Cancer Cells

(2010) Boris Shor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly

(2010) Takeshi Kaizuka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

Rapamycin inhibits mTORC1, but not completely

(2009) Carson C. Thoreen et al.   Autophagy

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms

(2009) E.A. Dunlop et al.   CELLULAR SIGNALLING

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

(2008) A. Y. Choo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE