Article
Pharmacology & Pharmacy
Etienne E. Muller, Dumisile Maseko, Ranmini S. Kularatne
Summary: This study conducted phenotypic and genotypic surveillance on ACV resistance in HSV-2 derived from genital ulcer samples collected in a primary healthcare facility in South Africa. The results revealed no resistance-associated mutations, but identified several known natural polymorphisms and amino acid changes of unknown significance. All cultivable HSV-2 isolates showed susceptibility to ACV.
ANTIVIRAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Narayan Bashyal, Tae-Young Lee, Da-Young Chang, Jin-Hwa Jung, Min Gyeong Kim, Rakshya Acharya, Sung-Soo Kim, Il-Hoan Oh, Haeyoung Suh-Kim
Summary: Research has shown that MSC-TK(A168H) cells modified with the HSV-TK(A168H) gene exhibit safety in pre-clinical trials, making them suitable for therapeutic use. This genetic modification makes allogeneic MSC-based ex vivo therapy safer by eliminating transplanted cells during SAEs such as uncontrolled cell proliferation.
MOLECULES AND CELLS
(2022)
Review
Cell Biology
Mohamad Mahjoor, Arshia Fakouri, Simin Farokhi, Hojjatollah Nazari, Hamed Afkhami, Fatemeh Heidari
Summary: The skin is essential for the innate and adaptive immune systems, but skin lesions can have undesirable consequences. Mesenchymal stromal cells (MSCs) are being increasingly used for skin wound treatment due to their advantages in promoting healing. The oxygen concentration has an impact on MSC biology, and expanding MSCs in a hypoxic environment can enhance their effectiveness.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mehmet Hakan Taskin, Hanne Nur Kurucay, Hamza Kadi, Cuneyt Tamer, Emre Ozan, Bahadir Muftuoglu, Harun Albayrak, Semra Gumusova, Mahir Igde, Ahmed Eisa Elhag, Zafer Yazici
Summary: Two pandemics in the first two decades of the 21st century have highlighted the lack of effective antivirals against viruses with epidemic and pandemic potentials. This study investigated the antiviral effects of the base analogue 5-fluorouracil (FU) on herpes simplex virus type 1 (HSV-1) replication and identified drug resistance mutations.
Article
Biotechnology & Applied Microbiology
Darshini Kuruppu, Deepak Bhere, Christian T. Farrar, Khalid Shah, Anna-Liisa Brownell, Umar Mahmood Umar Mahmood, Kenneth K. Tanabe
Summary: This study investigates the therapeutic efficacy of oncolytic Herpes simplex virus 1 (HSV1) on different stages of breast cancer leptomeningeal metastases growth. The results show that targeting the lag and intermediate phases of the disease can inhibit tumor growth, delay symptoms onset, and extend survival.
CANCER GENE THERAPY
(2023)
Article
Immunology
Cooper K. Hayes, Christopher K. Villota, Fiona B. McEnany, Stacey Ceron, Sita Awasthi, Moriah L. Szpara, Harvey M. Friedman, David A. Leib, Richard Longnecker, Matthew D. Weitzman, Lisa N. Akhtar
Summary: Clinical HSV-2 isolates collected from neonates with encephalitis are more neurovirulent in human neuronal cell culture and murine models as compared to isolates from neonates with skin-limited disease, suggesting that viral factors contribute to neurologic outcome following human neonatal infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Ruth F. Itzhaki
Summary: The research suggests that HSV1 may play a significant role in Alzheimer's disease in APOE-ε4 carriers, and further investigation into disease prevention through vaccination or prolonged antiviral treatment of HSV1 infection in APOE-ε4 carriers is warranted.
Article
Pharmacology & Pharmacy
J. Giorgi, B. Simon, G. Destras, Q. Semanas, C. Ginevra, T. Boyer, H. Regue, G. Billaud, S. Ducastelle, F. Ader, F. Morfin, L. Josset, E. Frobert
Summary: This study reports the identification of novel UL23 and UL30 substitutions in immunocompromised patients with HSV1 and HSV2, which contributes to the completion of the HSV1 and HSV2 substitution database and enhances accurate diagnosis of related diseases.
ANTIVIRAL RESEARCH
(2023)
Correction
Multidisciplinary Sciences
Rosamaria Pennisi, Maria Musarra-Pizzo, Zhixiang Lei, Grace Guoying Zhou, Maria Teresa Sciortino
Summary: The paper has been amended and the revised version can be accessed through a link at the top of the paper.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Kevin Danastas, Gerry Guo, Jessica Merjane, Nathan Hong, Ava Larsen, Monica Miranda-Saksena, Anthony L. Cunningham
Summary: This study explores the effects of interferons (IFNs) on herpes simplex virus-1 (HSV-1) and reveals that IFNs have the potential to block virus release from nerve endings, thereby preventing transmission into the skin. The study also highlights the potential wider antiviral effects of IFN-γ in neurons, suggesting its role in HSV-1 reactivation. These findings identify new targets for the development of immunotherapies to impede HSV-1 spread from nerves to the skin.
Article
Virology
Mashidur Rana, Mizumi Setia, Pratima K. Suvas, Anish Chakraborty, Susmit Suvas
Summary: Reactive oxygen species (ROS) play a crucial role in herpes stromal keratitis (HSK), with neutrophils being the primary cells responsible for ROS generation. NOX2 is involved in ROS production in neutrophils. However, manipulating ROS levels in neutrophils may help alleviate the severity of HSK, and NOX2 is not the main contributor to ROS generation in neutrophils.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Joanne Kite, Tiffany Russell, Juliet Jones, Gillian Elliott
Summary: Although nectin1 is required for extracellular entry into the majority of human keratinocytes, it is dispensable for direct cell-to-cell transmission.
Article
Biochemistry & Molecular Biology
Bishajit Sarkar, Md. Asad Ullah, Yusha Araf, Sowmen Das, Md. Hasanur Rahman, Abu Tayab Moin
Summary: HSV is a highly infectious virus with two types, HSV-1 and HSV-2, infecting millions worldwide. This study designed three polyvalent subunit vaccines targeting multiple strains of HSV, which showed stability and potential effectiveness through molecular docking and simulation studies. Validation of these vaccines in wet lab-based studies is still needed.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Review
Pharmacology & Pharmacy
Yiwei Huang, Yuyun Song, Jichen Li, Changning Lv, Zhe-Sheng Chen, Zhijun Liu
Summary: Human herpes simplex viruses use cell surface receptors such as heparan sulfate, herpesvirus entry mediator, and nectin-1/-2, 3-O-sulfated heparan sulfate to enter host cells. No vaccine or curative treatment is currently available for HSV infections.
DRUG DISCOVERY TODAY
(2022)
Review
Microbiology
Rohini Krishnan, Patrick M. Stuart
Summary: Herpes simplex virus is a common viral infection that requires the development of new methods for prevention and management. While some vaccines have been developed in the past, there are currently no approved vaccines available. Various promising vaccine candidates are currently being studied and developed.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biology
Vidya Sankarapandian, Balu Alagar Venmathi Maran, Ramya Lakshmi Rajendran, Manasi P. Jogalekar, Sridharan Gurunagarajan, Rajapandiyan Krishnamoorthy, Prakash Gangadaran, Byeong-Cheol Ahn
Summary: Probiotics play a significant role in the prevention and treatment of cancer by enhancing the epithelial barrier and stimulating the production of anti-inflammatory, antioxidant, and anticarcinogenic compounds.
Review
Medicine, Research & Experimental
Anand Krishnan, Prakash Gangadaran, Vivek P. Chavda, Manasi P. Jogalekar, Ramesh Muthusamy, Disha Valu, Chithravel Vadivalagan, Prasanna Ramani, Alexey Laishevtcev, Naresh Kumar Katari, Byeong-Cheol Ahn
Summary: COVID-19, caused by the spread of SARS-CoV-2, has impacted society greatly, with misdiagnoses and inaccurate test results being common. A more specific, selective, and reliable diagnostic tool is needed, and convalescent serum-derived exosomes show potential in this regard.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Balu Alagar Venmathi Maran, Mohammad Iqbal, Prakash Gangadaran, Byeong-Cheol Ahn, Pasupuleti Visweswara Rao, Muhammad Dawood Shah
Summary: Medicinal plants, such as Andrographis paniculata, Bauhinia purpurea, Commelina nudiflora, Dillenia suffruticosa, Elaeis guineensis, Lygodium microphyllum, and Nephrolepis biserrata, have been reported to have hepatoprotective properties due to their phytochemical composition. These plants contain various compounds, including alkaloids, saponins, flavonoids, tannins, terpenoids, steroids, polyphenols, and diterpenoid lactones, which contribute to their antioxidant, anti-inflammatory, immunomodulatory, and hepatoprotective effects.
Article
Oncology
Ji Min Oh, Ramya Lakshmi Rajendran, Prakash Gangadaran, Chae Moon Hong, Ju Hye Jeong, Jaetae Lee, Byeong-Cheol Ahn
Summary: In this study, the researchers found that reversing iodine non-avid thyroid cancers to iodine avid cancers can make the cancers sensitive to radioactive-iodine therapy again. They demonstrated that GLI1 knockdown increased expression of thyroid-specific proteins, restoring iodine avidity and improving the efficacy of radioactive-iodine therapy. Targeting GLI1 could be a potential strategy for redifferentiation in dedifferentiated thyroid cancers.
Article
Cell Biology
Ramya Lakshmi Rajendran, Prakash Gangadaran, Mi Hee Kwack, Ji Min Oh, Chae Moon Hong, Madhan Jeyaraman, Young Kwan Sung, Jaetae Lee, Byeong-Cheol Ahn
Summary: The study suggests that engineered nanovesicles (eNVs) have therapeutic potential for alopecia, as they can enhance the proliferation and migration of hair follicle cells and increase the size of human hair follicles.
Review
Biotechnology & Applied Microbiology
Ragunanthan Narayanaswamy, Bishnu Prasad Patro, Naveen Jeyaraman, Prakash Gangadaran, Ramya Lakshmi Rajendran, Arulkumar Nallakumarasamy, Madhan Jeyaraman, Prasanna Ramani, Byeong-Cheol Ahn
Summary: Various forms of platelet concentrates have evolved over the past few decades, with newer generation products such as leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) showing superior biological properties in musculoskeletal regeneration compared to the first-generation concentrates. These newer platelet concentrates have a complete matrix of physiological fibrin and facilitate intercellular signaling and migration, promoting angiogenic, chondrogenic, and osteogenic activities. A-PRF, with higher leukocyte inclusion, also possesses antimicrobial activity and can replicate various physiological and immunological factors of wound healing. Its applications have expanded to include the management of musculoskeletal conditions, reconstructive cosmetic surgery, wound healing in diabetic patients, and maxillofacial surgeries.
BIOENGINEERING-BASEL
(2023)
Review
Biotechnology & Applied Microbiology
Bushu Harna, Vijay Gupta, Shivali Arya, Naveen Jeyaraman, Ramya Lakshmi Rajendran, Madhan Jeyaraman, Prakash Gangadaran, Manish Khanna, Chae Moon Hong, Byeong-Cheol Ahn
Summary: Adhesive capsulitis shoulder is a common problem, and this study evaluated the efficacy of intra-articular injections of platelet-rich plasma (PRP) in the treatment. The results showed that PRP injections improved clinical and functional outcomes in patients with adhesive capsulitis shoulder, and no major side effects were observed.
BIOENGINEERING-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Prakash Gangadaran, Eun Jung Oh, Ramya Lakshmi Rajendran, Ji Min Oh, Hyun Mi Kim, Suin Kwak, Ho Yun Chung, Jaetae Lee, Byeong-Cheol Ahn, Chae Moon Hong
Summary: Cultured MSCs exhibit different effects on their secretomes depending on whether they are grown as 2D monolayers or 3D spheroids. The secretomes of 3D-MSCs contain higher levels of proangiogenic factors compared to 2D-MCs. The secretomes of 3D-MSCs promote proliferation, migration, and tube formation of ECs, and show enhanced wound healing in a burn injury mouse model.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Vidya Sankarapandian, Kirubakaran Nitharsan, Kavitha Parangusadoss, Prakash Gangadaran, Prasanna Ramani, Balu Alagar Venmathi Maran, Manasi P. P. Jogalekar
Summary: The study aimed to develop prebiotic products from Spirulina and analyzed the biological properties. Various value-added products were prepared to meet the nutritional needs of vulnerable populations.
Article
Biotechnology & Applied Microbiology
Sathish Muthu, Madhan Jeyaraman, Moinuddin Basha Kotner, Naveen Jeyaraman, Ramya Lakshmi Rajendran, Shilpa Sharma, Manish Khanna, Sree Naga Sowndary Rajendran, Ji Min Oh, Prakash Gangadaran, Byeong-Cheol Ahn
Summary: Stem cells have the ability to self-renew and differentiate into various cell lineages, making them valuable for regenerative therapies. Stem cell therapy is a rapidly advancing branch of medicine that offers potential treatments for severe diseases. The development of international standards for advanced therapeutic medicinal products aims to facilitate global information exchange.
BIOENGINEERING-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Madhan Jeyaraman, Shiva Kumar Bingi, Sathish Muthu, Naveen Jeyaraman, Rathinavelpandian Perunchezhian Packkyarathinam, Rajni Ranjan, Shilpa Sharma, Saurabh Kumar Jha, Manish Khanna, Sree Naga Sowndary Rajendran, Ramya Lakshmi Rajendran, Prakash Gangadaran
Summary: Human bone marrow is a promising source of mesenchymal stromal cells (MSCs) for regenerative procedures involving cartilage and bone. However, the low proportion of MSCs in the bone marrow requires careful harvesting and processing techniques. There is currently a lack of consensus regarding the variables in the harvesting and processing technique of bone marrow aspiration concentrate (BMAC) and their impact on MSC yield.
BIOENGINEERING-BASEL
(2022)