Emerging Roles of Tumor Necrosis Factor-Stimulated Gene-6 in the Pathophysiology and Treatment of Atherosclerosis

Intraarticularly-Injected Mesenchymal Stem Cells Stimulate Anti-Inflammatory Molecules and Inhibit Pain Related Protein and Chondrolytic Enzymes in a Monoiodoacetate-Induced Rat Arthritis Model

(2018) Toru Ichiseki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanical Activation of Adipose Tissue and Derived Mesenchymal Stem Cells: Novel Anti-Inflammatory Properties

(2018) Stephana Carelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mesenchymal Stromal Cells Inhibit Inflammatory Lymphangiogenesis in the Cornea by Suppressing Macrophage in a TSG-6-Dependent Manner

(2018) Hyun Beom Song et al.   MOLECULAR THERAPY

Catestatin Prevents Macrophage-Driven Atherosclerosis but Not Arterial Injury–Induced Neointimal Hyperplasia

(2018) Miho Kojima et al.   THROMBOSIS AND HAEMOSTASIS

Tumor necrosis factor alpha-stimulated gene-6 (TSG-6) inhibits the inflammatory response by inhibiting the activation of P38 and JNK signaling pathway and decreases the restenosis of vein grafts in rats

(2017) Chengxin Zhang et al.   HEART AND VESSELS

TSG-6 is highly expressed in human abdominal aortic aneurysms

(2017) S. Keisin Wang et al.   JOURNAL OF SURGICAL RESEARCH

TSG-6 Secreted by Human Adipose Tissue-derived Mesenchymal Stem Cells Ameliorates DSS-induced colitis by Inducing M2 Macrophage Polarization in Mice

(2017) Woo-Jin Song et al.   Scientific Reports

Lipid-based nanocarriers for oral peptide delivery

(2016) Zhigao Niu et al.   ADVANCED DRUG DELIVERY REVIEWS

Counteractive effects of omentin-1 against atherogenesis

(2016) Kaho Watanabe et al.   CARDIOVASCULAR RESEARCH

Contrasting effects of stanniocalcin-related polypeptides on macrophage foam cell formation and vascular smooth muscle cell migration

(2016) Keigo Yamamoto et al.   PEPTIDES

Scalable Production of a Multifunctional Protein (TSG-6) That Aggregates with Itself and the CHO Cells That Synthesize It

(2016) Dong-Ki Kim et al.   PLoS One

Global Overview of the Epidemiology of Atherosclerotic Cardiovascular Disease

(2015) Simon Barquera et al.   ARCHIVES OF MEDICAL RESEARCH

Mesenchymal Stem Cells Stabilize Atherosclerotic Vulnerable Plaque by Anti-Inflammatory Properties

(2015) Shuang-shuang Wang et al.   PLoS One

TSG-6 Inhibits Neutrophil Migration via Direct Interaction with the Chemokine CXCL8

(2014) D. P. Dyer et al.   JOURNAL OF IMMUNOLOGY

A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods

(2014) Marialaura Madrigal et al.   Journal of Translational Medicine

Vasoprotective Effects of Urocortin 1 against Atherosclerosis In Vitro and In Vivo

(2014) Akinori Hasegawa et al.   PLoS One

Mesenchymal stem cells transplantation suppresses inflammatory responses in global cerebral ischemia: contribution of TNF-α-induced protein 6

(2013) Qing-ming Lin et al.   ACTA PHARMACOLOGICA SINICA

TSG-6 Produced by hMSCs Delays the Onset of Autoimmune Diabetes by Suppressing Th1 Development and Enhancing Tolerogenicity

(2013) D. J. Kota et al.   DIABETES

Administration of TSG-6 improves memory after traumatic brain injury in mice

(2013) Jun Watanabe et al.   NEUROBIOLOGY OF DISEASE

Long Pentraxin 3/Tumor Necrosis Factor-Stimulated Gene-6 Interaction

(2012) Daria Leali et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Amplifies Hyaluronan Synthesis by Airway Smooth Muscle Cells

(2012) Mark E. Lauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocyte-to-Macrophage Differentiation

(2012) Mary Y. Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transplantation of Placenta-Derived Mesenchymal Stem Cells in the EAE Mouse Model of MS

(2012) Yonit Fisher-Shoval et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mesenchymal Stem Cells Attenuate Peritoneal Injury through Secretion of TSG-6

(2012) Nan Wang et al.   PLoS One

Novel mechanism for mesenchymal stem cells in attenuating peritoneal adhesion: accumulating in the lung and secreting tumor necrosis factor α-stimulating gene-6

(2012) Nan Wang et al.   Stem Cell Research & Therapy

Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF- B signaling in resident macrophages

(2011) H. Choi et al.   BLOOD

Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice

(2011) M. Nagashima et al.   DIABETOLOGIA

TSG-6 Protein, a Negative Regulator of Inflammatory Arthritis, Forms a Ternary Complex with Murine Mast Cell Tryptases and Heparin

(2011) Gyorgy Nagyeri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury

(2010) J. Y. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6

(2009) Ryang Hwa Lee et al.   Cell Stem Cell

Preventive Effects of Heregulin-β 1 on Macrophage Foam Cell Formation and Atherosclerosis

(2009) Gang Xu et al.   CIRCULATION RESEARCH

Coregulation in human leukocytes of the long pentraxin PTX3 and TSG-6

(2009) Virginia Maina et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Impact of Salusin-α and -β on Human Macrophage Foam Cell Formation and Coronary Atherosclerosis

(2008) Takuya Watanabe et al.   CIRCULATION