Article
Immunology
Yunxing Fu, Zhen Yang, Hongjuan Zhang, Yu Liu, Baocheng Hao, Ruofeng Shang
Summary: The study showed that DPTM effectively inhibited MRSA Hla, reduced inflammatory gene expressions, and protected cells from MRSA-induced damage.
MICROBIAL PATHOGENESIS
(2021)
Article
Immunology
Chaogui Tang, Qianhui Li, Tao Lin
Summary: The study showed that Lycopene protected cells from S. aureus USA300-induced damage and reduced the severity of acute lung inflammation by inhibiting the expression of inflammatory factors induced by S. aureus USA300.
MICROBES AND INFECTION
(2021)
Article
Biotechnology & Applied Microbiology
Vijayakumar Karuppiah, Muhilvannan Seralathan
Summary: This study demonstrates the anti-quorum sensing and anti-biofilm potential of vaccenic acid against Chromobacterium violaceum and methicillin-resistant Staphylococcus aureus (MRSA). Vaccenic acid at sub-MIC concentrations significantly inhibits pigment production and biofilm formation, and reduces the virulence production of C. violaceum and MRSA.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2022)
Article
Microbiology
Shriram Patel, Abel A. Vlasblom, Koen M. Verstappen, Aldert L. Zomer, Ad C. Fluit, Malbert R. C. Rogers, Jaap A. Wagenaar, Marcus J. Claesson, Birgitta Duim
Summary: This study investigated the dynamics of the nasal microbiome of piglets over time, revealing an increase in richness and diversity as well as identifying coabundant groups of species strongly correlated with MRSA and S. aureus colonization.
Article
Pharmacology & Pharmacy
Xingye Wang, Lin Wei, Li Wang, Xiaoyu Chen, Xiangri Kong, Yanhe Luan, Jiyu Guan, Xuerui Guo, Yan Shi, Tiedong Wang, Bingmei Wang, Wu Song, Yicheng Zhao
Summary: Research has shown that scutellarin exerts dual inhibition effects on Sortase A and caseinolytic peptidase P, important virulence factors of MRSA. Scutellarin not only directly inhibits the activity of Sortase A, but also inhibits the hemolytic activity of Staphylococcus aureus by inhibiting the expression of Hla through ClpP inhibition. Combined with vancomycin, scutellarin can effectively inhibit the growth of MRSA and improve survival and lung pathology in pneumonia mice.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Microbiology
Xinran Ren, Xuerui Guo, Chang Liu, Shisong Jing, Tiedong Wang, Li Wang, Jiyu Guan, Wu Song, Yicheng Zhao, Yan Shi
Summary: Hispidulin effectively inhibits the expression of the virulence factor alpha-hemolysin in Staphylococcus aureus without affecting bacterial growth.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Hematology
Kristin Jahn, Stefan Handtke, Raghavendra Palankar, Thomas P. Kohler, Jan Wesche, Martina Wolff, Janina Bayer, Christiane Wolz, Andreas Greinacher, Sven Hammerschmidt
Summary: This study investigated the effects of Staphylococcus aureus and Streptococcus pneumoniae toxins on human platelets. The results showed that alpha-hemolysin of S. aureus had a significant impact on platelet activation and thrombus formation, while other toxins had little effect. These findings may have clinical relevance for the treatment of S. aureus-induced endocarditis.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Agriculture, Dairy & Animal Science
Vanessa Silva, Sofia I. Gabriel, Sofia B. Borrego, Maria Teresa Tejedor-Junco, Vera Manageiro, Eugenia Ferreira, Ligia Reis, Manuela Canica, Jose L. Capelo, Gilberto Igrejas, Patricia Poeta
Summary: The study conducted in wild rodents living in port areas in Portugal revealed the presence of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA), with some MRSA isolates carrying the mecC gene, indicating a high genetic lineage diversity.
Article
Food Science & Technology
Yangli Wan, Xiaowen Wang, Tianyi Bai, Xuting Zheng, Liu Yang, Qianhong Li, Xin Wang
Summary: This study discovered that lysine can inhibit the exotoxin alpha-hemolysin of Staphylococcus aureus and has no significant effect on the sensory score of food. Additionally, lysine has good biocompatibility and can be used as an anti-Staphylococcus aureus preparation in the food industry.
Article
Pharmacology & Pharmacy
Xin Wang, Qiang Ma, Xiaohao Niu, Zhu Liu, Xinyun Kang, Yanni Mao, Na Li, Guiqin Wang
Summary: We investigated the effect of andrographolide on the hemolytic capacity of Staphylococcus aureus isolated from our region. The results showed that andrographolide inhibits the hemolytic activity of S. aureus and downregulates the expression of key genes. This study provides a molecular basis for the use of andrographolide as an antivirulence drug and offers new ideas for developing drugs against S. aureus infection.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ye Tao, Dazhong Sun, Xinran Ren, Yicheng Zhao, Hengjian Zhang, Tao Jiang, Jiyu Guan, Yong Tang, Wu Song, Shuqiang Li, Li Wang
Summary: Bavachin was found to efficiently inhibit the activity of the important virulence factor alpha-hemolysin (hla) in Staphylococcus aureus infection, both transcriptionally and translationally. It also reduced the damage to A549 cells caused by S. aureus. In a mouse model, bavachin decreased the lethality, bacterial load, and lung inflammation of pneumonia infection, suggesting its potential as a candidate hla inhibitor against S. aureus.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Infectious Diseases
Javier Campanini-Salinas, Juan Andrades-Lagos, Nicolas Hinojosa, Fabian Moreno, Pedro Alarcon, Gerardo Gonzalez-Rocha, Ian E. Burbulis, David Vasquez-Velasquez
Summary: New quinone compounds show promising inhibitory activity against methicillin-resistant and methicillin-sensitive Staphylococcus aureus, including clinical isolates. The compounds did not induce resistance in the clinical strains and were as effective as vancomycin in protecting larvae from MRSA infection. These quinone derivatives have potential as drug candidates for further development.
Article
Immunology
Ning Yin, Xin Yang, Li Wang, Chi Zhang, Jiyu Guan, Ye Tao, Xuerui Guo, Yicheng Zhao, Wu Song, Bingmei Wang, Yong Tang
Summary: Kaempferol was found to downregulate the expression of the staphylococcal virulence factor Hla, thereby providing protection against MRSA-induced pneumonia in mice.
MICROBIAL PATHOGENESIS
(2022)
Article
Biotechnology & Applied Microbiology
Anna Cacilia Ingham, Tinna Ravnholt Urth, Raphael Niklaus Sieber, Marc Stegger, Sofie Marie Edslev, Oystein Angen, Anders Rhod Larsen
Summary: The study revealed that the nasal microbiota of pig truck drivers undergoes drastic changes during workdays and differs significantly from that of nonexposed individuals. MRSA-carrying drivers may introduce the pathogen into the community and healthcare facilities, but most drivers quickly lose the CC398 MRSA and rarely transmit it to spouses.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Microbiology
Yan Qian, Li Xia, Lai Wei, Di Li, Weiwei Jiang
Summary: The study found that artesunate can dose-dependently inhibit the formation of Staphylococcus aureus biofilms, as well as inhibit bacterial adhesion and the expression of virulence genes.
ARCHIVES OF MICROBIOLOGY
(2021)
Review
Immunology
Sunita Keshari, Manish Kumar, Arun Balasubramaniam, Ting-Wei Chang, Yun Tong, Chun-Ming Huang
EXPERT REVIEW OF VACCINES
(2019)
Article
Biotechnology & Applied Microbiology
M. T. Pham, C-M Huang, R. Kirschner
JOURNAL OF APPLIED MICROBIOLOGY
(2019)
Article
Food Science & Technology
Supitchaya Traisaeng, Deron Raymond Herr, Hsin-Jou Kao, Tsung-Hsien Chuang, Chun-Ming Huang
Article
Biochemistry & Molecular Biology
Sunita Keshari, Arun Balasubramaniam, Binderiya Myagmardoloonjin, Deron Raymond Herr, Indira Putri Negari, Chun-Ming Huang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Microbiology
Manish Kumar, Binderiya Myagmardoloonjin, Sunita Keshari, Indira Putri Negari, Chun-Ming Huang
Article
Biotechnology & Applied Microbiology
M. T. Pham, C. -M. Huang, R. Kirschner
LETTERS IN APPLIED MICROBIOLOGY
(2020)
Article
Microbiology
John Jackson Yang, Yung-Chi Huang, Tsung-Hsien Chuang, Deron Raymond Herr, Ming-Fa Hsieh, Chun-Jen Huang, Chun-Ming Huang
Article
Ecology
Minh Tan Pham, Chun-Ming Huang, Roland Kirschner
Article
Multidisciplinary Sciences
Supitchaya Traisaeng, Anir Batsukh, Tsung-Hsien Chuang, Deron Raymond Herr, Yu-Fen Huang, Battogtokh Chimeddorj, Chun-Ming Huang
SCIENTIFIC REPORTS
(2020)
Article
Chemistry, Multidisciplinary
Kuang-Hung Hsiao, Chun-Ming Huang, Yu-Hsiang Lee
Review
Immunology
Yu-Chen Chuang, Jen-Chih Tseng, Li-Rung Huang, Chun-Ming Huang, Chi-Ying F. Huang, Tsung-Hsien Chuang
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Shinta Marito, Sunita Keshari, Chun-Ming Huang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Microbiology
Arun Balasubramaniam, Prakoso Adi, Tra My Do Thi, Jen-Ho Yang, Asy Syifa Labibah, Chun-Ming Huang
Article
Microbiology
John Jackson Yang, Minh Tan Pham, Adelia Riezka Rahim, Tsung-Hsien Chuang, Ming-Fa Hsieh, Chun-Ming Huang
Article
Microbiology
Tristan Yusho Huang, Deron Raymond Herr, Chun-Ming Huang, Yong Jiang
MICROBIOLOGY AUSTRALIA
(2020)