Molecular Understanding of the Activation of CB1 and Blockade of TRPV1 Receptors: Implications for Novel Treatment Strategies in Osteoarthritis

Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice

(2018) Xin Luo et al.   BRAIN BEHAVIOR AND IMMUNITY

Stimulating TRPV1 externalization and synthesis in dorsal root ganglion neurons contributes to PGE2 potentiation of TRPV1 activity and nociceptor sensitization

(2016) W. Ma et al.   EUROPEAN JOURNAL OF PAIN

Sensitization of TRPV1 by protein kinase C in rats with mono-iodoacetate-induced joint pain

(2016) K. Koda et al.   OSTEOARTHRITIS AND CARTILAGE

The Molecular Basis for Dual Fatty Acid Amide Hydrolase (FAAH)/Cyclooxygenase (COX) Inhibition

(2015) Giulia Palermo et al.   ChemMedChem

The importance of TRPV1-sensitisation factors for the development of neuropathic pain

(2015) Natalia Malek et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A multi-target approach for pain treatment

(2015) Natalia Malek et al.   PAIN

Protein kinase C gamma-mediated phosphorylation of GluA1 in the postsynaptic density of spinal dorsal horn neurons accompanies neuropathic pain, and dephosphorylation by calcineurin is associated with prolonged analgesia

(2015) Gordana Miletic et al.   PAIN

Relative benefit-risk comparing diclofenac to other traditional non-steroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors in patients with osteoarthritis or rheumatoid arthritis: a network meta-analysis

(2015) Anneloes van Walsem et al.   ARTHRITIS RESEARCH & THERAPY

Evidence for central sensitization in patients with osteoarthritis pain: A systematic literature review

(2014) E. Lluch et al.   EUROPEAN JOURNAL OF PAIN

Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain

(2013) S Kelly et al.   ANNALS OF THE RHEUMATIC DISEASES

The transition from acute to chronic pain: understanding how different biological systems interact

(2013) Katherine A. Mifflin et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Immunopathogenesis of osteoarthritis

(2013) Abdul Haseeb et al.   CLINICAL IMMUNOLOGY

Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism

(2013) Katarzyna Starowicz et al.   PLoS One

Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint

(2013) James J. Burston et al.   PLoS One

“Redundancy” of Endocannabinoid Inactivation: New Challenges and Opportunities for Pain Control

(2012) Fabiana Piscitelli et al.   ACS Chemical Neuroscience

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats

(2012) Anne K. Schreiber et al.   NEUROPHARMACOLOGY

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

(2012) B.J.E. de Lange-Brokaar et al.   OSTEOARTHRITIS AND CARTILAGE

Why do cannabinoid receptors have more than one endogenous ligand?

(2012) V. Di Marzo et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Discovery of Prostamide F2α and Its Role in Inflammatory Pain and Dorsal Horn Nociceptive Neuron Hyperexcitability

(2012) Luisa Gatta et al.   PLoS One

Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain

(2010) Devi Rani Sagar et al.   ARTHRITIS AND RHEUMATISM

Effects of COX-2 inhibition on spinal nociception: the role of endocannabinoids

(2010) LE Staniaszek et al.   BRITISH JOURNAL OF PHARMACOLOGY

Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis

(2010) Niklas Schuelert et al.   PAIN

Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands

(2009) Enrico Morera et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Prostaglandin F2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β

(2009) Toru Oga et al.   NATURE MEDICINE

Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids

(2009) Alejandro Telleria-Diaz et al.   PAIN

Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons

(2008) Uma Anand et al.   PAIN