Article
Allergy
Laura Maintz, Thomas Welchowski, Nadine Herrmann, Juliette Brauer, Claudia Traidl-Hoffmann, Regina Havenith, Svenja Mueller, Claudio Rhyner, Anita Dreher, Matthias Schmid, Thomas Bieber
Summary: This study found that many patients with mild-to-moderate atopic dermatitis have elevated levels of biomarkers, suggesting a systemic impact of skin inflammation. Identifying different patient subtypes can better predict their response to specific treatments.
Review
Biochemistry & Molecular Biology
Gaku Tsuji, Kazuhiko Yamamura, Koji Kawamura, Makiko Kido-Nakahara, Takamichi Ito, Takeshi Nakahara
Summary: IL-33 and IL-37 co-regulate the balance between inflammation and anti-inflammation, and are involved in the pathogenesis of inflammatory skin diseases such as AD and psoriasis. AHR-mediated regulation of their expression may offer new therapeutic strategies for these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Wei-Yu Chen, Shao-Chuan Chen, Shou-Yi Hsu, Yu-An Lin, Chun-Ming Shih, Chun-Yao Huang, Kuo-Hsien Wang, Ai-Wei Lee
Summary: Skin diseases have a significant impact on individuals and society, and there is a need for high attention and effective treatment methods in the medical field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Georgia Pappa, Dimitrios Sgouros, Konstantinos Theodoropoulos, Antonios Kanelleas, Evangelia Bozi, Stamatios Gregoriou, Konstantinos Krasagakis, Alexander C. Katoulis
Summary: Atopic dermatitis is a complex inflammatory skin disease with multiple underlying factors. Recent studies have highlighted the important roles of interleukins-4 and -13 in the pathogenesis of atopic dermatitis. Novel therapeutic approaches targeting Th2 cytokines and their pathways offer potential for optimizing the treatment of atopic dermatitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Laura Bonzano, Francesco Borgia, Rossella Casella, Andrea Miniello, Eustachio Nettis, Sebastiano Gangemi
Summary: Microbiome dysbiosis and cytokine alternations play crucial roles in the development of atopic dermatitis (AD) and psoriasis (PsO), two highly prevalent and burdensome pruritic skin conditions worldwide. Interleukin (IL)-33 and IL-31 are major drivers in the pathogenesis and maintenance of AD and PsO, and their potential as therapeutic targets is under extensive investigation. The relationship between dysbiosis and immunological changes has been studied extensively, with ongoing debate on the primary causative factor behind AD and PsO. This literature review aims to support the hypothesis that dysbiosis is the origin of IL-33/IL-31 dysregulation in AD and PsO, and discusses current therapeutic options targeting IL-31, IL-33, and/or the microbiome.
Article
Chemistry, Medicinal
Hyeong Rok Yun, Sang Woo Ahn, Bomin Seol, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Jin Han, Kyung Soo Ko, Byoung Doo Rhee, Jung Eun Seol, Hyoung Kyu Kim
Summary: The study demonstrated the anti-inflammatory effects of Echinochrome A (Ech A) extracted from sea urchins in alleviating atopic dermatitis (AD) like skin lesions in an NC/Nga mouse model. Ech A treatment improved clinical symptoms of AD, reduced water loss, enhanced stratum corneum hydration, and suppressed inflammatory response and cytokine expression in skin lesions.
Article
Immunology
Song Xiao, Zhiping Lu, Martin Steinhoff, Yanqing Li, Timo Buhl, Michael Fischer, Weiwei Chen, Wenke Cheng, Renkai Zhu, Xinrong Yan, Hua Yang, Yang Liu, Yu Dou, Wanzhi Wang, Jiafu Wang, Jianghui Meng
Summary: The study revealed an upregulated expression of IL-13Rα-2 in the skin of AD patients, but not in psoriasis patients, in a disease activity-dependent manner. IL-13 was found to regulate keratinocyte-derived IL-13Rα-2 and TLR2 to modulate neuronal IL-13Rα-2, promoting neurogenic inflammation and exacerbating AD and itch. Hence, the IL-13-IL-13Rα-2 pathway and the neuronal TLR2-IL-13Rα-2 pathway are potential targets for treating AD and itch.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Allergy
Yusef Eamon Badi, Ana B. Pavel, Stelios Pavlidis, John H. Riley, Stewart Bates, Nazanin Zounemat Kermani, Richard Knowles, Johan Kolmert, Craig E. Wheelock, Sally Worsley, Mohib Uddin, Kjell Alving, Per S. Bakke, Annelie Behndig, Massimo Caruso, Pascal Chanez, Louise J. Fleming, Stephen J. Fowler, Urs Frey, Peter Howarth, Ildiko Horvath, Norbert Krug, Anke H. Maitland-van der Zee, Paolo Montuschi, Graham Roberts, Marek Sanak, Dominick E. Shaw, Florian Singer, Peter J. Sterk, Ratko Djukanovic, Sven-Eric Dahlen, Yi-Ke Guo, Kian Fan Chung, Emma Guttman-Yassky, Ian M. Adcock
Summary: The disease signature identified in atopic dermatitis (AD) can also be seen in adults with severe asthma, and the transcriptomic signature of AD patients who respond to anti-IL-22 therapy is enriched in severe asthma. The AD disease signature is enriched in the blood and sputum of patients with asthma and is correlated with the severity of asthma. The FZ-response signature is enriched in the blood and sputum of asthmatic patients and is correlated with the presence of neutrophils and mixed granulocytes in the sputum.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Celina Dubin, Ester Del Duca, Emma Guttman-Yassky
Summary: Atopic dermatitis is a common inflammatory skin disease with a complex pathophysiology involving immune dysregulation and barrier defects. The IL-4, IL-13, and IL-31 pathways play key roles in the disease's pathogenesis, and novel therapeutics targeting these pathways are being developed for potential treatments.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ya-Chu Tsai, Tsen-Fang Tsai
Summary: Psoriasis and atopic dermatitis are now considered to be a spectrum of disease, with overlapping genetic loci and immunopathogenesis. The clinical presentations also have similarities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Min Jee Park, So-Yeon Lee, Si Hyeon Lee, Mi-Jin Kang, Kun Baek Song, Sungsu Jung, Ji-Sun Yoon, Dong In Suh, Youn Ho Shin, Kyung Won Kim, Kangmo Ahn, Soo-Jong Hong
Summary: Exposure to antibiotics within 6 months of age was associated with an increased risk of developing early-persistent atopic dermatitis (AD) within 3 years of life, with the risk being dose-dependent. There was a weak interaction between genetic polymorphisms and environmental factors in the development of AD. Children with specific genetic variations had a higher risk of developing early-persistent AD when exposed to antibiotics multiple times compared to those without such exposure.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Sul-Hee Lee, Youin Bae, Young-Lip Park
Summary: This study found a negative correlation between serum adiponectin levels and disease severity and pruritus in AD patients. However, no significant effects were observed with biologic treatment for AD. Therefore, adiponectin may serve as a potential biomarker for severity assessment in AD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dermatology
Qiuju Li, Xiuying Li, Wenyu Li, Runge Fan, Qing Ma, Xiaomei Luo, Huahui Jian, Xiaozhi Chen, Cunwei Cao, Wenjun Zheng
Summary: Cases of atopic dermatitis-like rash induced by IL-17A inhibitor secukinumab treatment have been reported in psoriasis patients. Abnormal expression of multiple immune and inflammatory factors suggests a shift from Th17 towards Th2 in SI-AD.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Cell Biology
Alicja Mesjasz, Magdalena Trzeciak, Jolanta Glen, Marta Jaskulak
Summary: Interleukin 37 is a member of the IL-1 cytokine family with anti-inflammatory and immunosuppressive effects. It acts both extracellularly and intracellularly, and is linked to IL-18 and regulates Th2 inflammation in atopic dermatitis.
Article
Biochemistry & Molecular Biology
Kyunghee Kim, Hyeju Kim, Gun Yong Sung
Summary: The study indicates that short-term use of I3LA for approximately one week can effectively suppress the progression of atopic dermatitis and impact the expression of major constituent proteins of the skin barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Chie Morimoto, Hisako Matsumoto, Tomoko Tajiri, Yasuhiro Gon, Reiko Ito, Shu Hashimoto, Maho Suzukawa, Ken Ohta, Kenji Izuhara, Junya Ono, Shoichiro Ohta, Isao Ito, Tsuyoshi Oguma, Yoshihiro Kanemitsu, Tadao Nagasaki, Yumi Izuhara, Akio Niimi, Toyohiro Hirai
Summary: The study aimed to investigate the association between IL-18 and inadequate response to omalizumab treatment in severe allergic asthma patients. It was found that patients with high baseline serum free IL-18 levels may predict reduced efficacy of omalizumab in treating exacerbations.
Article
Biochemistry & Molecular Biology
Satoshi Nunomura, Yasuhiro Nanri, Veronique Lefebvre, Kenji Izuhara
Summary: SOX11 deficiency in epithelial cells impairs the extension of the leading edge of eyelids, resulting in embryonic eyelid closure failure. The transcription factor c-Jun downstream of FGF10 is required for this extension and its levels are decreased in SOX11-deficient embryos.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Letter
Allergy
Hironobu Sunadome, Hisako Matsumoto, Yuji Tohda, Takahiko Horiguchi, Hideo Kita, Kazunobu Kuwabara, Keisuke Tomii, Kojiro Otsuka, Masaki Fujimura, Noriyuki Ohkura, Takashi Iwanaga, Soichiro Hozawa, Akio Niimi, Yoshihiro Kanemitsu, Tadao Nagasaki, Noriyuki Tashima, Yumi Ishiyama, Chie Morimoto, Tsuyoshi Oguma, Tomoko Tajiri, Isao Ito, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Toyohiro Hirai
ALLERGOLOGY INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Junya Ono, Masayuki Takai, Ayami Kamei, Yoshinori Azuma, Kenji Izuhara
Summary: This article discusses the importance of Periostin as a biomarker in allergic diseases and pulmonary fibrosis, highlighting its correlation with disease severity, prognosis, and treatment response. It also summarizes recent developments in Periostin detection methods and describes factors influencing Periostin concentration under healthy conditions.
Article
Allergy
Satoshi Nunomura, Isao Kitajima, Yasuhiro Nanri, Midori Kitajima, Naoko Ejiri, I-Shuan Lai, Naoko Okada, Kenji Izuhara
Summary: The FADS mouse model, generated by specifically deleting Ikk2 in facial skin fibroblasts, exhibits similar ocular lesions to AKC in patients and can be used to examine the therapeutic effects of anti-AKC agents. Tear periostin, a novel biomarker for allergic conjunctival disease, is valuable for evaluating the efficacy of such treatments.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Letter
Dermatology
Yasuhiro Nanri, Satoshi Nunomura, Tomoya Watanabe, Shoichiro Ohta, Yukie Yamaguchi, Kenji Izuhara
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Pediatrics
Hayato Go, Junya Ono, Hitoshi Ohto, Kenneth E. Nollet, Kenichi Sato, Yohei Kume, Hajime Maeda, Mina Chishiki, Kentaro Haneda, Hirotaka Ichikawa, Nozomi Kashiwabara, Yuji Kanai, Kei Ogasawara, Maki Sato, Koichi Hashimoto, Satoshi Nunomura, Kenji Izuhara, Mitsuaki Hosoya
Summary: This study found higher serum periostin levels at birth in preterm infants subsequently diagnosed with bronchopulmonary dysplasia, and the serum periostin levels at birth significantly correlated with gestational age and birth weight.
PEDIATRIC RESEARCH
(2022)
Article
Respiratory System
Takashi Yoshida, Tetsutaro Nagaoka, Yuichi Nagata, Yoshifumi Suzuki, Takeo Tsutsumi, Sachiko Kuriyama, Junko Watanabe, Shinsaku Togo, Fumiyuki Takahashi, Masakazu Matsushita, Yusuke Joki, Hakuoh Konishi, Satoshi Nunomura, Kenji Izuhara, Simon J. Conway, Kazuhisa Takahashi
Summary: Periostin plays an important role in the development of pulmonary hypertension (PH) and is involved in the pathogenesis of both experimental PH and human PH.
Article
Medical Laboratory Technology
Masayuki Takai, Junya Ono, Masaki Okamoto, Kiminori Fujimoto, Ayami Kamei, Satoshi Nunomura, Yasuhiro Nanri, Shoichiro Ohta, Tomoaki Hoshino, Arata Azuma, Kenji Izuhara
Summary: The formation of an IgA complex affects the measurement of periostin. The EMI and R1 domains of periostin contribute to the formation of the complex with IgA. A novel ELISA system that combines the R3 and R4 domains allows for independent measurement of periostin.
ANNALS OF CLINICAL BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Ming-Hsiu Hsieh, Yukie Yamaguchi
Summary: This article reviews the structure of SARS-CoV-2 and discusses the safety profiles of vaccines such as BNT162b2, mRNA-1273, and AZD1222. It aims to provide an understanding of the possible immune mechanisms behind hypersensitivity reactions related to COVID-19 vaccination.
Letter
Allergy
Naoko Okada, Hiroyuki Yazu, Eisuke Shimizu, Kazumi Fukagawa, Satoshi Nunomura, Hirohisa Saito, Kenji Matsumoto, Atsushi Kawaguchi, Kenji Izuhara, Hiroshi Fujishima
Letter
Allergy
Takeshi Nakahara, Kenji Izuhara, Daisuke Onozuka, Hidehisa Saeki, Satoshi Nunomura, Motoi Takenaka, Mai Matsumoto, Yoko Kataoka, Rai Fujimoto, Sakae Kaneko, Eishin Morita, Akio Tanaka, Michihiro Hide, Tatsuro Okano, Tomomitsu Miyagaki, Natsuko Aoki, Kimiko Nakajima, Susumu Ichiyama, Makiko Kido-Nakahara, Kyoko Tonomura, Yukinobu Nakagawa, Risa Tamagawa-Mineoka, Koji Masuda, Takuya Takeichi, Masashi Akiyama, Yozo Ishiuji, Michie Katsuta, Yuki Kinoshita, Chiharu Tateishi, Aya Yamamoto, Akimichi Morita, Haruna Matsuda-Hirose, Yutaka Hatano, Hiroshi Kawasaki, Keiji Tanese, Mamitaro Ohtsuki, Koji Kamiya, Yudai Kabata, Riichiro Abe, Hiroshi Mitsui, Tatsuyoshi Kawamura, Gaku Tsuji, Norito Katoh, Masutaka Furue
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Allergy
Junya Hirayama, Takao Fujisawa, Mizuho Nagao, Yu Kuwabara, Keigo Kainuma, Yoshinori Azuma, Junya Ono, Shoichiro Ohta, Masahiro Hirayama, Kenji Izuhara
Summary: The study found that SCCAs, especially SCCA2, are sensitive biomarkers for detecting AD in children and adolescents, as well as for assessing the severity and response to treatment of severe AD.
ASIA PACIFIC ALLERGY
(2021)