Oligodendroglioma Cells Lack Glutamine Synthetase and Are Auxotrophic for Glutamine, but Do not Depend on Glutamine Anaplerosis for Growth

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models

(2018) Michael L Schulte et al.   NATURE MEDICINE

Glutamine Synthetase: Localization Dictates Outcome

(2018) Alessandra Castegna et al.   Genes

Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target

(2016) M. Bolzoni et al.   BLOOD

Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells

(2016) Angelika Bröer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon

(2016) Thang Van Nguyen et al.   MOLECULAR CELL

Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism

(2016) A Cacace et al.   ONCOGENE

Inhibition of glucose metabolism prevents glycosylation of the glutamine transporter ASCT2 and promotes compensatory LAT1 upregulation in leukemia cells

(2016) Florence Polet et al.   Oncotarget

Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine

(2016) Naniye Mallı Cetinbas et al.   Scientific Reports

D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures

(2016) Alan C. Foster et al.   PLoS One

N-linked Glycosylation of human SLC1A5 (ASCT2) transporter is critical for trafficking to membrane

(2015) Lara Console et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Amino Acid Transporters in Cancer and Their Relevance to "Glutamine Addiction": Novel Targets for the Design of a New Class of Anticancer Drugs

(2015) Y. D. Bhutia et al.   CANCER RESEARCH

Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation

(2015) Alex J. Bott et al.   Cell Metabolism

Tumor-specific mutations in low-frequency genes affect their functional properties

(2015) Lale Erdem-Eraslan et al.   JOURNAL OF NEURO-ONCOLOGY

Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development

(2015) Qian Wang et al.   JOURNAL OF PATHOLOGY

Glutaminase activity determines cytotoxicity of l-asparaginases on most leukemia cell lines

(2015) Jean Hugues Parmentier et al.   LEUKEMIA RESEARCH

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

(2015) M van Geldermalsen et al.   ONCOGENE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Glutamate and asparagine cataplerosis underlie glutamine addiction in melanoma

(2015) Boris Ratnikov et al.   Oncotarget

Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity

(2015) Suganthi Chittaranjan et al.   Oncotarget

Long-term Temozolomide Treatment Induces Marked Amino Metabolism Modifications and an Increase in TMZ Sensitivity in Hs683 Oligodendroglioma Cells

(2015) Delphine Lamoral-Theys et al.   NEOPLASIA

Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts

(2014) M Chiu et al.   BRITISH JOURNAL OF CANCER

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer

(2014) L. Yang et al.   Molecular Systems Biology

Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia

(2013) L. Willems et al.   BLOOD

Modulation of the Wnt/beta-catenin pathway in human oligodendroglioma cells by Sox17 regulates proliferation and differentiation

(2013) Hui-Ling Chen et al.   CANCER LETTERS

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Glutamine stimulates mTORC1 independent of the cell content of essential amino acids

(2012) Martina Chiu et al.   AMINO ACIDS

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

(2012) Anne Le et al.   Cell Metabolism

A HILIC–MS/MS method for the simultaneous determination of seven organic acids in rat urine as biomarkers of exposure to realgar

(2012) Yin Huang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

Valproic acid induces the glutamate transporter excitatory amino acid transporter-3 in human oligodendroglioma cells

(2012) M.G. Bianchi et al.   NEUROSCIENCE

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

(2012) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

L-Asparaginase and Inhibitors of Glutamine Synthetase Disclose Glutamine Addiction of β-Catenin-Mutated Human Hepatocellular Carcinoma Cells

(2011)   CURRENT CANCER DRUG TARGETS

Glutamine: pleiotropic roles in tumor growth and stress resistance

(2011) Naval P. Shanware et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Proteomic identification of glutamine synthetase as a differential marker for oligodendrogliomas and astrocytomas

(2011) Zhengping Zhuang et al.   JOURNAL OF NEUROSURGERY

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

(2011) Z. J. Reitman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

SNAT2 Amino Acid Transporter Is Regulated by Amino Acids of the SLC6 γ-Aminobutyric Acid Transporter Subfamily in Neocortical Neurons and May Play No Role in Delivering Glutamine for Glutamatergic Transmission

(2009) Sukhjeevan Grewal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA