Review
Psychology, Multidisciplinary
Paloma E. Fava-Felix, Silvia R. C. Bonome-Vanzelli, Fabiana S. Ribeiro, Flavia H. Santos
Summary: This review investigates the cognitive, functional, and behavioral effects of computerized rehabilitation in stroke patients and considers cognitive reserve proxies. The findings suggest that combining computerized cognitive training with education as a cognitive reserve proxy can improve cognitive abilities in patients.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Regina Silva Paradela, Brenno Cabella, Mariana Penteado Nucci, Naomi Vidal Ferreira, Laura Alo Torres, Luiza Menoni Martino, Fernanda Marciano Consolim-Colombo, Luiz Aparecido Bortolotto, Danielle Irigoyen da Costa, Maria Claudia Irigoyen
Summary: This study aimed to evaluate the effects of Cogmed WM training on the memory performance of hypertensive individuals. The results showed that Cogmed had no significant effects on memory performance, but functional magnetic resonance imaging revealed activation decreases in the frontal and parietal lobes after training.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Cell Biology
Hanna M. Gavelin, Magdalena E. Domellof, Isabella Leung, Anna Stigsdotter Neely, Nathalie H. Launder, Leila Nategh, Carsten Finke, Amit Lampit
Summary: Cognitive impairment is a common symptom in Parkinson's disease (PD) patients, and computerized cognitive training (CCT) may have beneficial effects on their cognitive and psychosocial functioning. This study found that CCT had a significant positive effect on overall cognitive function and clinical measures of global cognition in PD patients, especially those with mild cognitive impairment. The dose of CCT and the presence of mild cognitive impairment in PD patients were associated with larger effect sizes. There was no significant difference in efficacy between home-based and supervised training.
AGEING RESEARCH REVIEWS
(2022)
Article
Psychiatry
Frances Louise Dark, Victoria Gore-Jones, Ellie Newman, Maddison Wheeler, Veronica Demonte, Korinne Northwood
Summary: This study compared the relative effectiveness of Cognitive Compensatory Training (CCT) and Computerized Interactive Remediation of Cognition-Training for Schizophrenia (CIRCuiTs). The results showed no significant difference between the two approaches in terms of cognitive and functional outcomes. This finding has implications for addressing cognitive deficits in schizophrenia spectrum disorders.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Multidisciplinary
Jingsong Wu, Juan Peng, Zhaoying Li, Haiyin Deng, Zhenming Huang, Youze He, Jingnan Tu, Lei Cao, Jia Huang
Summary: The study aimed to investigate the effects of multi-domain computerized cognitive training on intellectual function and adaptive functioning in children with intellectual developmental disorder (IDD). Participants were randomly assigned to a multi-domain computerized cognitive training group or a control group and underwent a 5-week training program. Results showed significant improvements in intellectual function and adaptive functioning in the multi-domain computerized cognitive training group, indicating positive effects of the intervention on children with IDD.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Health Care Sciences & Services
Meg E. Morris, Victor McConvey, Joanne E. Wittwer, Susan C. Slade, Irene Blackberry, Madeleine E. Hackney, Simon Haines, Lydia Brown, Emma Collin
Summary: Dancing is a feasible and engaging physical activity for people living with early PD, as shown in the process evaluation of an online dance trial conducted by a multidisciplinary team. The online dance program was well-received, with no attrition or adverse events, and high program fidelity.
Review
Rehabilitation
Pei-Ling Wong, Shih-Jung Cheng, Yea-Ru Yang, Ray-Yau Wang
Summary: This study aimed to explore the effects of dual task training on gait performance and cognitive function in individuals with Parkinson's disease. The meta-analysis of ten randomized controlled trials showed that dual task training had positive effects on dual task gait speed, step and stride length, attention, and executive function. Moreover, participants with slower initial single task gait speed showed greater improvement in dual task step and stride length after dual task training.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Clinical Neurology
Elena Gambella, Arianna Margaritini, Marco Benadduci, Lorena Rossi, Paola D'Ascoli, Giovanni R. R. Riccardi, Sara Pasquini, Patrizia Civerchia, Giuseppe Pelliccioni, Roberta Bevilacqua, Elvira Maranesi
Summary: This study aims to evaluate the effectiveness of a treatment approach that combines cognitive training and physical exercise with virtual reality and reminiscence elements for patients with mild Alzheimer's disease. The study recruited 78 patients and conducted treatment sessions and evaluations. The ultimate goal is to improve the patients' cognitive status and quality of life.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Antonino Naro, Loris Pignolo, Daniele Bruschetta, Rocco Salvatore Calabro
Summary: Rhythmic Auditory Stimulation (RAS) has been shown to be effective in improving gait performance in patients with Parkinson's disease (PD) by reshaping the functional connectivity between specific brain areas and gait-cycle phases, with the cerebellum playing a crucial role in mediating this process.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Rehabilitation
Nicola Marotta, Dario Calafiore, Claudio Curci, Lorenzo Lippi, Valerio Ammendolia, Francesco Ferraro, Marco Invernizzi, Alessandro de Sire
Summary: In recent years, there has been increasing attention on the use of virtual reality and exergaming in the rehabilitation management of Parkinson's disease patients. However, there is currently no strong evidence supporting the effectiveness of these cutting-edge technologies on cognitive function, and integrating these promising tools into the rehabilitation framework of PD patients remains challenging.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Neurosciences
Xin Wang, LanLan Chen, Hongyu Zhou, Yao Xu, Hongying Zhang, Wenrui Yang, XiaoJia Tang, Junya Wang, Yichen Lv, Ping Yan, Yuan Peng
Summary: The study demonstrated that enriched rehabilitation can effectively improve gait performance and cognitive function in early-stage Parkinson's disease patients. This improvement is achieved through strengthening the functional connectivity between the left dorsolateral prefrontal cortex and other brain areas.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
John P. Seibyl
Summary: Diseases of the central nervous system, such as Alzheimer's and Parkinson's, are common and chronic conditions with significant morbidity. Abnormal protein accumulation and spread in the brain are found to be the primary factors in neurotoxicity and disruption of functional networks. Clinical trials are currently investigating various therapies to target these proteinopathies, although they face challenges in accurate diagnosis, variable rates of progression, and efficacy measures.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Review
Rehabilitation
Irene Battel, Irene Calvo, Margaret Walshe
Summary: The use of biofeedback in the treatment of dysphagia in patients with PD shows potential positive effects on swallowing-related quality of life. However, existing studies have low methodological quality and high risk of bias, future research should be rigorously designed to determine the optimal types, schedules, and timing of biofeedback treatment.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Clinical Neurology
Nancy D. Chiaravalloti, Silvana L. Costa, Nancy B. Moore, Kristen Costanza, John DeLuca
Summary: This study demonstrates the effectiveness of speed of processing training in improving processing speed deficits in individuals with multiple sclerosis. The training showed significant effects on the useful field of view and neuropsychological evaluation, with the number of completed training levels correlating with greater benefits.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Xiao Deng, Yilin Ning, Seyed Ehsan Saffari, Bin Xiao, Chenglin Niu, Samuel Yong Ern Ng, Nicole Chia, Xinyi Choi, Dede Liana Heng, Yi Jayne Tan, Ebonne Ng, Zheyu Xu, Kay-Yaw Tay, Wing-Lok Au, Adeline Ng, Eng-King Tan, Nan Liu, Louis C. S. Tan
Summary: Using a machine learning approach, this study found a strong association between high triglyceride and apolipoprotein A1 levels and Parkinson's disease mild cognitive impairment (PD-MCI), while SNCA rs6826785 may be a novel therapeutic target for PD-MCI. ShapleyVIC-assisted variable selection is a novel and robust alternative for prioritizing variables of interest in future clinical studies.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Malvina Hoxha, Calogero C. Tedesco, Silvana Quaglin, Visar Malaj, Linda Pustina, Valerie Capra, Jilly F. Evans, Angelo Sala, G. Enrico Rovati
Summary: The observational retrospective study suggests that the use of montelukast may be protective against incident cardiac ischemic events in older asthmatic patients. Analyses indicate that exposure to montelukast remains a significant protective factor for incident ischemic events, leading to a considerable risk reduction. The event-free Kaplan-Meier survival curves confirm the lower cardiovascular event incidence in patients exposed to montelukast.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Sara Bernini, Fabrizio Stasolla, Silvia Panzarasa, Silvana Quaglini, Elena Sinforiani, Giorgio Sandrini, Tomaso Vecchi, Cristina Tassorelli, Sara Bottiroli
Summary: The global COVID-19 pandemic has led to significant changes in healthcare organizations, with remote communication technologies emerging as effective solutions. HomeCoRe, an innovative home cognitive rehabilitation software, offers support for patients with neurodegenerative diseases, such as mild cognitive impairment and early dementia.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Federica Melazzini, Margherita Reduzzi, Silvana Quaglini, Federica Fumoso, Marco Vincenzo Lenti, Antonio Di Sabatino
Summary: This study aimed to assess the diagnostic delay of PE in COVID-19 patients and found a significant correlation between overall diagnostic delay and physician-related delay. Factors such as fever, respiratory symptoms, and high levels of lactate dehydrogenase were related to the delay in diagnosis.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Garifallia Sakellariou, Silvana Quaglini, Serena Bugatti, Francesca Bobbio-Pallavicini, Vittorio Gabba, Carlomaurizio Montecucco
Summary: This retrospective study identified predictors of access to targeted synthetic and biologic disease-modifying anti-rheumatic drugs (ts/bDMARDs) for patients with psoriatic arthritis (PsA). C-reactive protein, Visual Analogue Scale (VAS) pain, and synovial power Doppler (PD) were found to be significant predictors, providing evidence for the need for more intensive monitoring and treatment escalation in early peripheral PsA patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Enea Parimbelli, Federico Soldati, Lorry Duchoud, Gian Luca Armas, John de Almeida, Martina Broglie, Silvana Quaglini, Christian Simon
Summary: Cost-utility analysis was conducted to compare TORS and TLM for the treatment of oropharyngeal cancers. The findings indicate that non-robotic endoscopic surgery (TLM) is more cost-effective than robotic endoscopic surgery (TORS), although this advantage is sensitive to factors such as the number of re-operations and adjuvant treatments.
BMC HEALTH SERVICES RESEARCH
(2021)
Article
Physiology
Riccardo Cremascoli, Davide Sparasci, Gianluca Giusti, Stefania Cattaldo, Elisa Prina, Fausto Roveta, Francesco Bruno, Cristina Ghezzi, Silvia Cerri, Marta Picascia, Sara Bernini, Elena Sinforiani, Michele Terzaghi, Lorenzo Priano, Alessandro Mauro, Raffaele Manni
Summary: This study investigates the effects of light therapy on sleep quality, mood, and cognition in patients with mild/moderate Alzheimer's disease. It is shown that light therapy tailored to the individual's circadian phase can induce a circadian phase shift, improve subjective sleep quality and cognitive performance, and shorten the time between dim light melatonin onset and falling asleep.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Matteo Cotta Ramusino, Paolo Vitali, Nicoletta Anzalone, Luca Melazzini, Francesca Paola Lombardo, Lisa Maria Farina, Sara Bernini, Alfredo Costa
Summary: This study aims to investigate the distribution of vascular lesions in patients with Alzheimer's, vascular or mixed dementia and detect any distinctive neuroradiological profiles. The findings show that white and grey matter lesions predominate in vascular and mixed dementia, whereas deep and juxtacortical microbleeds predominate in mixed dementia.
CURRENT ALZHEIMER RESEARCH
(2022)
Article
Psychiatry
Elena Perdixi, Sara Bernini, Silvia Conti, Nithiya Jesuthasan, Matteo Cotta Ramusino, Alfredo Costa, Federica Prinelli
Summary: COVID-19 has resulted in a parallel epidemic of fear, anxiety, depression, stress, and frustration, particularly among vulnerable individuals such as older adults and those with pre-existing mental health disorders. This study investigated the association between depressive symptoms, mild cognitive impairment (MCI), and fear of COVID-19 among older adults. The results showed that older adults with MCI had a higher fear of being infected themselves, while those with depressive symptoms had a higher fear of contagion for family members. Impaired executive cognitive function was positively associated with increased fear. These findings highlight the importance of addressing the psychological effects of the COVID-19 outbreak, especially among vulnerable populations.
FRONTIERS IN PSYCHIATRY
(2022)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Cristiana Larizza, Silvana Quaglini, Michelangelo Chasseur, Valentina Bevolo, Gianvincenzo Zuccotti, Valeria Calcaterra
Summary: Childhood obesity is a growing concern, as it increases the risk of developing various diseases throughout life. This study aims to reduce childhood obesity through an educational program delivered via a mobile application. Unique aspects of this approach include involving families in the program and designing it based on psychological/behavioral change theories to maximize patient adherence. A pilot study evaluating usability and acceptability on a Likert scale from 1 to 5 yielded encouraging results, with mean scores above 3.
CARING IS SHARING-EXPLOITING THE VALUE IN DATA FOR HEALTH AND INNOVATION-PROCEEDINGS OF MIE 2023
(2023)
Article
Urology & Nephrology
Gabriella Moroni, Giulia Porata, Francesca Raffiotta, Silvana Quaglini, Giulia Frontini, Lucia Sacchi, Valentina Binda, Marta Calatroni, Francesco Reggiani, Giovanni Banfi, Claudio Ponticelli
Summary: This study aims to investigate whether the activity and chronicity indices can predict the development of kidney function impairment (KFI) in lupus nephritis (LN) patients, and to identify histologic features associated with KFI. The results showed that the chronicity index and its components were significantly correlated with kidney function impairment, while the activity index showed no significant correlation. Additionally, clinical and histologic features such as serum creatinine, arterial hypertension, chronic glomerular lesions, and delay in kidney biopsy were found to be independent predictors of KFI.
Article
Geriatrics & Gerontology
Claudia Rodella, Sara Bernini, Silvia Panzarasa, Elena Sinforiani, Marta Picascia, Silvana Quaglini, Elena Cavallini, Tomaso Vecchi, Cristina Tassorelli, Sara Bottiroli
Summary: The study evaluated the effectiveness of a combined treatment protocol involving computerized cognitive training and anodal transcranial direct current stimulation in patients with early cognitive impairment. Results showed improvements in working memory and attention/processing speed in the treatment group compared to the control group, with the treatment group maintaining stability at 6 months. Age, mood, and baseline scores were found to play a role in predicting treatment effects.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Hoxha, V. Malaj, C. C. Tedesco, S. Quaglini, V. Capra, A. Sala, G. E. Rovati
Article
Geriatrics & Gerontology
Sara Bernini, Silvia Panzarasa, Marica Barbieri, Elena Sinforiani, Silvana Quaglini, Cristina Tassorelli, Sara Bottiroli
Summary: This study aimed to evaluate the efficacy of computer-based cognitive training in patients with Parkinson's disease and mild cognitive impairment, showing that compared to traditional paper-and-pencil cognitive training, computer-based cognitive training led to significant improvements in cognitive performance, attention, and executive functions in patients. Further follow-up assessments are being conducted to verify the retention of these gains and the potential delay in progression to PD-dementia.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Review
Computer Science, Information Systems
Xinyi Chen, Xiang Liu, Yuke Wu, Zhenglei Wang, Shuo Hong Wang
Summary: The current research on the diagnosis and staging of prostate cancer using machine learning and deep learning is in its infancy, with low accuracy in diagnosis and classification. There is a lack of studies on CT images and ultrasound images.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2024)
Article
Computer Science, Information Systems
Jahanpour Alipour, Roxana Sharifian, Javid Dehghan Haghighi, Mehrnaz Hashemzehi, Afsaneh Karimi
Summary: This study investigated patients' perceptions of the e-prescribing system. The majority of patients were aware of e-prescribing, and preferred it over traditional prescriptions. Patients reported overall positive satisfaction and relatively positive perceptions and experiences with the e-prescribing system.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2024)
Review
Computer Science, Information Systems
Sarang Hashemi, Lu Bai, Shijia Gao, Frada Burstein, Kate Renzenbrink
Summary: This study demonstrates the value of the MINDSPACE framework in designing clinical decision support alerts and reminders. The framework addresses the challenges faced by designers in identifying behavioral effects relevant to alert and reminder designs.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2024)
Review
Computer Science, Information Systems
Ivan Otero-Gonzalez, Moises R. Pacheco-Lorenzo, Manuel J. Fernandez-Iglesias, Luis E. Anido-Rifon
Summary: This study explores the applications of conversational agents in detecting mental health disorders, specifically depression screening. The findings indicate that conversational agents are effective in detecting depression, and voice interaction is the future direction of development.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2024)
Article
Computer Science, Information Systems
Pedro A. Moreno-Sanchez, Ruben Arroyo-Fernandez, Elisabeth Bravo-Esteban, Asuncion Ferri-Morales, Mark van Gils
Summary: This study analyzed data from fibromyalgia patients to assess the impact of mental health factors on fibromyalgia severity compared to pain factors. The findings suggest that mental health factors are more relevant for fibromyalgia severity.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2024)
Article
Computer Science, Information Systems
Muhammad Asaduzzaman, Zeleke Mekonnen, Ernst Kristian Rodland, Sundeep Sahay, Andrea Sylvia Winkler, Christoph Gradmann
Summary: Our study explored the perspectives of stakeholders in Jimma, Ethiopia on the use of DHIS2 as a One Health Antimicrobial Resistance (AMR) surveillance platform. The findings suggest that DHIS2 has the potential to be a user-friendly and acceptable platform for OH-AMR surveillance. Despite some challenges, most participants perceived DHIS2 as suitable for OH-AMR surveillance and expressed their willingness to contribute in their current professional roles.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2024)
Article
Computer Science, Information Systems
Sari Kujala, Saija Simola, Bo Wang, Hedvig Soone, Josefin Hagstrom, Annika Barkas, Iiris Horhammer, Asa Cajander, Asbjorn Johansen Fagerlund, Bridget Kane, Anna Kharko, Eli Kristiansen, Jonas Moll, Hanife Rexphepi, Maria Hagglund, Monika A. Johansen
Summary: This study benchmarks the usability of national patient portals in Estonia, Finland, Norway, and Sweden using a mixed-methods survey approach. The results indicate variations in usability across countries and highlight the influence of very positive and very negative experiences on usability ratings. The survey approach proves effective in evaluating user experiences and identifying areas for improvement and desirable features.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2024)
Article
Computer Science, Information Systems
R. F. Willemsen, J. J. Aardoom, O. P. van der Galien, S. van de Vijver, N. H. Chavannes, A. Versluis
Summary: This study evaluated healthcare usage and costs of patients using a digital platform, showing an increase in GP consultations and costs after implementation.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2024)
Article
Computer Science, Information Systems
Danya Arif Siddiqi, Fatima Miraj, Humdiya Raza, Owais Ahmed Hussain, Mehr Munir, Vijay Kumar Dharma, Mubarak Taighoon Shah, Ali Habib, Subhash Chandir
Summary: This study developed and evaluated an AI chatbot in local language for providing immunization information in low-resource, low-literacy settings in Pakistan. The results showed that the chatbot was feasible and acceptable, meeting the needs of caregivers and reducing the workload of helpline operators.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2024)
Article
Computer Science, Information Systems
Liss Hernandez, Estefania Estevez-Priego, Laura Lopez-Perez, Maria Fernanda Cabrera-Umpierrez, Maria Teresa Arredondo, Giuseppe Fico
Summary: HeNeCOn is a reusable, extendible and standardized ontology that provides a clinically reliable data model for Head and Neck Cancer. It consists of 502 classes and 283 medical terms with detailed relations between them, allowing for information extraction and knowledge management.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2024)
Article
Computer Science, Information Systems
Savina Mannarino, Valeria Calcaterra, Giulia Fini, Andrea Foppiani, Antonio Sanzo, Martina Pisarra, Gabriele Infante, Marta Marsilio, Irene Raso, Sara Santacesaria, Gianvincenzo Zuccotti
Summary: This study introduces an innovative pediatric telecardiology system, seamlessly integrated with a hospital telemedicine platform, which enhances patient management in the community. The results demonstrate the system's value as a diagnostic tool to facilitate the execution, transmission, and reporting of ECG data between primary care pediatrician clinics and the hospital.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2024)
Article
Computer Science, Information Systems
Matthew Ho, Todd J. Levy, Ioannis Koulas, Kyriaki Founta, Kevin Coppa, Jamie S. Hirsch, Karina W. Davidson, Alex C. Spyropoulos, Theodoros P. Zanos
Summary: This study identified clinical phenotypes of hospitalized COVID-19 patients and investigated their longitudinal dynamics throughout the pandemic. Four distinct clinical phenotypes were associated with different mortality rates and showed variability across different viral variants. Factors such as sex, race/ethnicity, and treatment modalities revealed significant differences between the observed phenotypes. This methodology has the potential to guide evidence-based treatment strategies in a dynamic fashion.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2024)
Review
Computer Science, Information Systems
Louis Agha-Mir-Salim, Lucas McCullum, Enrico Dahnert, Yanick-Daniel Scheel, Ainsley Wilson, Marianne Carpio, Carmen Chan, Claudia Lo, Lindsay Maher, Corinna Dressler, Felix Balzer, Leo Anthony Celi, Akira-Sebastian Poncette, Michele M. Pelter
Summary: Alarm fatigue is a significant issue in the intensive care unit, and collaboration between nurses and engineers is crucial for finding solutions. However, the current research lacks sufficient involvement of nurses, leading to a lack of successful real-world solutions.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2024)
Review
Computer Science, Information Systems
Ana Raquel Costa-Brito, Antonio Bovolini, Maria Rua-Alonso, Claudia Vaz, Juan Francisco Ortega-Moran, J. Blas Pagador, Carolina Vila-Cha
Summary: This scoping review investigates the use of home-based technological tools to improve physical function in older adults. The majority of studies suggest high levels of technology usage and positive health outcomes. However, the lack of international consensus on technology usage measures and the exclusion of older adults without technology ownership or experience may limit the findings.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2024)