Slow AAV2 clearance from the brain of nonhuman primates and anti-capsid immune response

AAV9-mediated Expression of a Non-self Protein in Nonhuman Primate Central Nervous System Triggers Widespread Neuroinflammation Driven by Antigen-presenting Cell Transduction

(2013) Lluis Samaranch et al.   MOLECULAR THERAPY

Immune-mediated Loss of Transgene Expression From Virally Transduced Brain Cells Is Irreversible, Mediated by IFNγ, Perforin, and TNFα, and due to the Elimination of Transduced Cells

(2012) Jeffrey M Zirger et al.   MOLECULAR THERAPY

Cerebral Infusion of AAV9 Vector-encoding Non-self Proteins Can Elicit Cell-mediated Immune Responses

(2012) Agnieszka Ciesielska et al.   MOLECULAR THERAPY

Structure of adeno-associated virus-2 in complex with neutralizing monoclonal antibody A20

(2012) Dustin M. McCraw et al.   VIROLOGY

Adeno-Associated Virus Antibody Profiles in Newborns, Children, and Adolescents

(2011) Roberto Calcedo et al.   Clinical and Vaccine Immunology

Safety and Tolerability of Magnetic Resonance Imaging-Guided Convection-Enhanced Delivery of AAV2-hAADC with a Novel Delivery Platform in Nonhuman Primate Striatum

(2011) Waldy San Sebastian et al.   HUMAN GENE THERAPY

Real-time MR Imaging With Gadoteridol Predicts Distribution of Transgenes After Convection-enhanced Delivery of AAV2 Vectors

(2010) Xiaomin Su et al.   MOLECULAR THERAPY

Eight Years of Clinical Improvement in MPTP-Lesioned Primates After Gene Therapy With AAV2-hAADC

(2010) Piotr Hadaczek et al.   MOLECULAR THERAPY

Worldwide Epidemiology of Neutralizing Antibodies to Adeno‐Associated Viruses

(2009) Roberto Calcedo et al.   JOURNAL OF INFECTIOUS DISEASES

Striatal Readministration of rAAV Vectors Reveals an Immune Response Against AAV2 Capsids That Can Be Circumvented

(2009) Carmen S Peden et al.   MOLECULAR THERAPY

A Preclinical Animal Model to Assess the Effect of Pre-existing Immunity on AAV-mediated Gene Transfer

(2009) Hua Li et al.   MOLECULAR THERAPY

Detection of Intact rAAV Particles up to 6 Years After Successful Gene Transfer in the Retina of Dogs and Primates

(2008) Knut Stieger et al.   MOLECULAR THERAPY

Real-time MR imaging of adeno-associated viral vector delivery to the primate brain

(2008) Massimo S. Fiandaca et al.   NEUROIMAGE

Image-guided convection-enhanced delivery platform in the treatment of neurological diseases

(2008) Massimo S. Fiandaca et al.   Neurotherapeutics