Article
Pharmacology & Pharmacy
Caroline De Souza Pereira, Helenita Costa Quadros, Samuel Yaw Aboagye, Diana Fontinha, Sarah D'Alessandro, Margaret Elizabeth Byrne, Mathieu Gendrot, Isabelle Fonta, Joel Mosnier, Diogo Rodrigo M. Moreira, Nicoletta Basilico, David. L. L. Williams, Miguel Prudencio, Bruno Pradines, Maribel Navarro
Summary: Hybrid-based drugs linked through a transition metal, such as the novel compound [AuAQPQ]PF6, show strong and effective antiplasmodial activity against multiple stages of the Plasmodium life cycle. The compound's mechanism involves inhibiting beta-hematin formation and enzymatic activity of thioredoxin reductases.
Article
Infectious Diseases
John Oludele Olanlokun, Mercy Toluwase Ekundayo, Oluwakemi Ebenezer, Neil Anthony Koorbanally, Olufunso Olabode Olorunsogo
Summary: The African Mistletoe plant has anti-malarial properties, with its hexane fraction showing excellent efficacy against both susceptible and resistant strains of malaria parasites. It reduces parasite load, improves hematological parameters, increases heme, and decreases hemozoin content in infected mice. Friedelan-3-one, a major component, may be responsible for this activity.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Chemistry, Medicinal
Caroline C. Sousa, Godwin Akpeko Dziwornu, Helenita C. Quadros, Joao Honorato Araujo-Neto, Kelly Chibale, Diogo R. M. Moreira
Summary: This study examines the cellular uptake and antiplasmodium activity of Pyrido[1,2-a]benzimidazoles (PBIs), synthetic antiplasmodium agents. The results show that PBIs have potent antiparasitic effects against both chloroquine-susceptible and chloroquine-resistant Plasmodium strains, with a high rate of uptake by parasite cells but limited uptake by host cells. The mechanism of cellular uptake differs from other 4-aminoquinolines.
ACS INFECTIOUS DISEASES
(2022)
Article
Chemistry, Medicinal
Helenita C. Quadros, Aysun Capci, Lars Herrmann, Sarah D'Alessandro, Diana Fontinha, Raquel Azevedo, Wilmer Villarreal, Nicoletta Basilico, Miguel Prudencio, Svetlana B. Tsogoeva, Diogo R. M. Moreira
Summary: The artemisinin-quinoline hybrid compound 163A shows potent activity against the asexual blood stage of Plasmodium, with low cytotoxicity and high selectivity for mammalian cells. It suppresses hepatic infection and decreases gametocyte viability, potentially blocking malaria transmission. The bitopic ligand property of the hybrid enhances inhibition of beta-hematin and is essential for arresting the growth of asexual blood parasites.
Article
Biology
Mohd Asad, Yoshiki Yamaryo-Botte, Mohammad E. Hossain, Vandana Thakur, Shaifali Jain, Gaurav Datta, Cyrille Y. Botte, Asif Mohmmed
Summary: The study demonstrates that a parasite phospholipase, PfLPL1, plays a critical role in lipid homeostasis associated with haemoglobin degradation and heme conversion pathways. PfLPL1 has enzymatic activity to catabolize phospholipids, and its transient downregulation in the parasite resulted in a significant reduction of neutral lipids in the food vacuole-associated lipid bodies.
Article
Chemistry, Medicinal
Helenita C. Quadros, Mariana C. B. Silva, Diogo R. M. Moreira
Summary: Plasmodium has evolved the ability to regulate the levels and oxidative states of iron protoporphyrin IX. Antimalarial drugs may cause an imbalance in iron homeostasis by alkylating heme and forming hematin-drug adducts, which exhibit powerful cytocidal effects and can be potential antiplasmodial agents.
Article
Biology
Abhinay Ramaprasad, Severina Klaus, Olga Douvropoulou, Richard Culleton, Arnab Pain
Summary: Through extensive genetic and phenotype analysis of P. vinckei, it was found that the five subspecies have diverged widely and undergone large-scale genome rearrangements. Region-specific selection pressures were observed particularly on genes involved in mosquito transmission. The highland forest subspecies P. v. vinckei has a smaller genome and reduced multigene family repertoire, making it suitable for transfection and ideal for reverse genetics research. Amenable to genetic crosses, P. vinckei isolates show a large degree of phenotypic and genotypic diversity. Their inclusion in studies provides new insights into the evolution of RMPs and multigene families, making them valuable resources for research on parasite virulence and immunogenicity.
Article
Chemistry, Medicinal
Rahul Singh, Rashmi Singh, Velaga Srihari, Ravindra D. Makde
Summary: Malaria parasites produce toxic heme during hemoglobin digestion, which is neutralized by crystallizing into inert hemozoin. Chloroquine inhibits this detoxification process, but its exact mechanism of action is unknown. This study found that chloroquine slows down the transformation of heme into hemozoin, but does not affect the availability of the substrate or the formation of hemozoin. The presence of chloroquine increases the size of hemozoin crystals, suggesting that it delays hemozoin production by interfering with crystal nucleation or stability.
ACS INFECTIOUS DISEASES
(2023)
Article
Immunology
Adriano Franco, Yevel Flores-Garcia, Fidel Zavala, David J. Sullivan
Summary: In the acidic lysosome-like digestive vacuole, Plasmodium parasites crystallize heme from hemoglobin into hemozoin, or malaria pigment. Upon release of progeny merozoites, the residual hemozoin is phagocytized by macrophages principally in the liver and spleen where the heme crystals can persist for months to years, as heme oxygenase does not readily degrade the crystal. Hemozoin modulation of monocytes and macrophages has been demonstrated in previous studies. This study shows that purified washed hemozoin decreases P. berghei liver levels and provides innate immune protection against Plasmodium liver stages.
INFECTION AND IMMUNITY
(2023)
Review
Immunology
Abhijit A. Ambegaonkartk, Prasida Holla, Brian Lp Dizon, Haewon Sohn, Susan K. Pierce
Summary: The study highlights the importance of understanding atypical B cells (ABCs) in the defense against infectious diseases. ABCs in chronic infectious diseases and autoimmune diseases have common drivers of differentiation and expansion, with disease-specific features. Comparing ABC populations in malaria-endemic areas and SLE patients can provide insights into developing vaccines that induce pathogen-specific antibody responses and prevent autoimmunity.
CURRENT OPINION IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rahul Singh, Ravindra D. Makde
Summary: Most antimalarial therapeutics induce cytotoxicity in Plasmodium through the production of free heme, which can be detoxified by the highly conserved plasmodial protein HDP. In this study, a modified pyridine hemochrome assay was used to study the catalysis of HDP and the transformation of heme into hemozoin. The kinetics of hemozoin production mediated by HDP were found to be dependent on substrate concentration and a small fraction of substrate remained untransformed over time. The combination of HDP and the pyridine hemochrome assay can facilitate the screening of future antimalarials.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2022)
Article
Microbiology
Shivang S. Shah, David A. Fidock, Alice S. Prince
Summary: Hemozoin from severe malaria plays a direct role in stimulating lung epithelial activation and promoting lung inflammation by inducing global transcriptional reprogramming, upregulating proinflammatory signaling and cytoadherence molecules, and altering epithelial and extracellular matrix remodeling pathways. These findings provide new insights into the molecular pathogenesis of respiratory distress associated with severe malaria.
Article
Microbiology
Aditya Anand, Manjunatha Chandana, Sourav Ghosh, Rahul Das, Nalini Singh, Pradeep Mini Vaishalli, Nagavara Prasad Gantasala, Govindarajan Padmanaban, Viswanathan Arun Nagaraj
Summary: Food vacuoles of the malaria parasite play a central role in the degradation of red blood cell hemoglobin and detoxification of heme. The deletion of amino acid transporter 1 in Plasmodium berghei leads to swollen food vacuoles, reduced hemozoin production, and resistance to antimalarials. Mice infected with transporter-deleted parasites are protected from cerebral malaria and show delayed transmission.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Wenchuan Ma, Victoria A. Balta, Rachel West, Katy N. Newlin, Ognjen S. Miljanic, David J. Sullivan, Peter G. Vekilov, Jeffrey D. Rimer
Summary: The study reveals a new mechanism employed by artemisinin-class drugs in subduing the erythrocytic phase of the malaria parasite life cycle, involving heme-drug adducts produced after artemisinin activation, which potently kills Plasmodium falciparum at low concentrations.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Integrative & Complementary Medicine
Wiwied Ekasari, Dewi Resty Basuki, Heny Arwati, Tutik Sri Wahyuni
Summary: Extract from Cassia spectabilis DC leaf has potent antiplasmodial activity, offering potential for effective and affordable antimalarial phytomedicine.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Environmental Sciences
Riadh Badraoui, Mohamed Allouche, Dhia El Ouaer, Arif J. Siddiqui, Sahar Ishak, Amor Hedfi, Hamouda Beyrem, Octavian Pacioglu, Hassan A. Rudayni, Fehmi Boufahja
Summary: The study evaluated the impact of PAHs on the migratory behavior of meiobenthic nematodes from the Bizerte lagoon in Tunisia. The results showed a significant decrease in diversity and abundance in the contaminated compartments compared to the uncontaminated zones. Moreover, exposure to PAHs led to increased biochemical biomarker activity in males and gravid females of T. longicaudata, lower fertility in females, and an imbalanced sex ratio in favor of males.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Riadh Badraoui, Ghofrane Mannai, Arif J. Siddiqui, Octavian Pacioglu, Hassan A. Rudayni, Fehmi Boufahja, Naceur Essid
Summary: This study assessed the impact of azithromycin, a COVID-19 drug, on benthic marine nematodes, and found that the drug may have accumulated in marine sediments for three years. The study also explored the toxic impact of azithromycin on meiobenthic nematodes in the presence of a common macrophyte from the Mediterranean Sea. The results showed that the abundance and taxonomic diversity of nematode communities were significantly decreased by azithromycin, but the toxicity could be partially reduced or completely eliminated in the presence of a low mass of the macrophyte.
ENVIRONMENTAL POLLUTION
(2023)
Article
Chemistry, Medicinal
Mohd Kamil Hussain, Shaista Ahmed, Andleeb Khan, Arif Jamal Siddiqui, Shahnaaz Khatoon, Sadaf Jahan
Summary: Mucormycosis is a fungal infection that worsens over time if left undiagnosed and untreated. It is specifically associated with the current COVID-19 pandemic. Immuno-compromised patients are particularly vulnerable to both COVID-19 and mucormycosis. Risk factors for this infection include diabetes, corticosteroid medicines, and a weakened immune system. Treatments for mucormycosis are available but less effective, so researchers are focusing on promising agents such as liposomal amphotericin B, manogepix, echino-candins, isavuconazole, and posacanazole.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Arif Jamal Siddiqui, Mitesh Patel, Mohd Adnan, Sadaf Jahan, Juhi Saxena, Mohammed Merae Alshahrani, Abdelmushin Abdelgadir, Fevzi Bardakci, Manojkumar Sachidanandan, Riadh Badraoui, Mejdi Snoussi, Allal Ouhtit
Summary: The objective of this study was to synthesize bacteriocin-derived silver nanoparticles (Bac10307-AgNPs) from Lactobacillus acidophilus (L. acidophilus) to enhance the bioactivity of bacteriocins and overcome their commercial limitations. The synthesized Bac10307-AgNPs showed strong antibacterial activity, promising antioxidant activity, and cytotoxicity against human liver cancer cells.
Article
Biochemistry & Molecular Biology
Mejdi Snoussi, Ramzi Hadj Lajimi, Riadh Badraoui, Mousa Al-Reshidi, Mohammad A. A. Abdulhakeem, Mitesh Patel, Arif Jamal Siddiqui, Mohd Adnan, Karim Hosni, Vincenzo De Feo, Flavio Polito, Adel Kadri, Emira Noumi
Summary: This study investigated the chemical composition and medicinal properties of Ducrosia flabellifolia Boiss., a rare desert plant species. The major compounds in the volatile oil were identified as decanal and dodecanal, while the methanolic extract contained phenolic compounds. The extract showed antimicrobial and antioxidant activities, and exhibited anticancer activity against various cancer cell lines. Computational analysis revealed strong binding affinities between the identified compounds and certain proteins. These findings highlight the ethnopharmacological properties of D. flabellifolia and its potential applications in medicine.
Article
Infectious Diseases
Mohd Adnan, Arif Jamal Siddiqui, Emira Noumi, Sami Hannachi, Syed Amir Ashraf, Amir Mahgoub Awadelkareem, Mejdi Snoussi, Riadh Badraoui, Fevzi Bardakci, Manojkumar Sachidanandan, Mirav Patel, Mitesh Patel
Summary: This study used a network pharmacology approach to investigate the anti-listeriosis properties of biosurfactants and their mechanisms of action. It identified certain biosurfactants with potential therapeutic effects against L. monocytogenes infection and explored their pharmacological mechanisms, providing a foundation for further research and development.
Article
Biology
Nouha Bouali, Walid Sabri Hamadou, Riadh Badraoui, Ramzi Hadj Lajimi, Assia Hamdi, Mousa Alreshidi, Mohd Adnan, Zohra Soua, Arif Jamal Siddiqui, Emira Noumi, Mejdi Snoussi
Summary: Cancer is a leading cause of death globally, and attention is shifting towards natural products like honey for the development of new cancer therapies. This study evaluated the phytochemical profiling, antioxidant properties, drug-likeness, and anticancer activity of Ziziphus honey (ZH) from Saudi Arabia. The results showed that ZH contains various compounds with antioxidant and anticancer effects, making it a potential source for bioactive compounds.
Article
Biochemistry & Molecular Biology
Nouha Bouali, Iqrar Ahmad, Harun Patel, Elham Bader Alhejaili, Walid Sabri Hamadou, Riadh Badraoui, Ramzi Hadj Lajimi, Mousa Alreshidi, Arif Jamal Siddiqui, Mohd Adnan, Mohammad A. Abdulhakeem, Abdulrahman S. Bazaid, Mitesh Patel, Mohd Saeed, Mejdi Snoussi, Emira Noumi
Summary: This study aimed to investigate the antimicrobial potential of Ziziphus honey (ZH) against clinical bacterial strains and yeasts and molds. The results showed that ZH was able to inhibit the growth of both Gram-positive and Gram-negative bacteria. Computational simulations revealed that certain compounds in ZH had good affinity for targeted receptors. These findings highlight the potential pharmacological applications of ZH and its identified compounds.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Arif Jamal Siddiqui, Sadaf Jahan, Mitesh Patel, Abdelmushin Abdelgadir, Wael Alturaiki, Fevzi Bardakci, Manojkumar Sachidanandan, Riadh Badraoui, Mejdi Snoussi, Mohd Adnan
Summary: This study identifies six new inhibitors against the EGFR protein using computational approaches. These molecules show high docking scores and FEC values, as well as stable RMSD plots and strong hydrogen interactions. These findings have potential implications for developing new drugs to treat breast cancer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Cell Biology
Chinmoy Banerjee, Shiladitya Nag, Manish Goyal, Debanjan Saha, Asim Azhar Siddiqui, Somnath Mazumder, Subhashis Debsharma, Saikat Pramanik, Uday Bandyopadhyay
Summary: This study reveals the nuclease activity of PfAlba3 in response to DNA damage and its potential role in Plasmodium pathogenicity.
Article
Polymer Science
Mohd Adnan, Arif Jamal Siddiqui, Syed Amir Ashraf, Mejdi Snoussi, Riadh Badraoui, Angum M. M. Ibrahim, Mousa Alreshidi, Manojkumar Sachidanandan, Mitesh Patel
Summary: In recent years, there has been an increasing interest in bio-based degradable plastics as a substitute for synthetic plastics. Polyhyroxybutyrate (PHB), a macromolecule produced by bacteria, has fast degradation properties, making it a potential alternative for biodegradable plastics. This study isolated PHB-producing bacteria from soil samples collected from a solid waste landfill site in Saudi Arabia. Bacillus flexus was found to accumulate the highest amount of PHB among all the isolated bacteria. The production of PHB using agro-residues as carbon sources was evaluated, and the optimal conditions for PHB synthesis were determined using response surface methodology (RSM). This research demonstrates that B. flexus has the potential to produce industrial-scale quantities of PHB from agricultural wastes, providing a solution to the environmental concerns associated with synthetic plastics.
Article
Chemistry, Physical
Mohd Adnan, Debarati DasGupta, Saleha Anwar, Mitesh Patel, Arif Jamal Siddiqui, Fevzi Bardakci, Mejdi Snoussi, Md. Imtaiyaz Hassan
Summary: MARK4 is associated with the progression of various life-threatening conditions. In this study, the natural compound PBG was evaluated as an inhibitor of MARK4. Computational and spectroscopic methods were used to assess its binding affinity and inhibitory potential, showing promising results.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Khouloud Hchicha, Elena Cambiotti, Hmed Ben-Nasr, Daniel Chappard, Matti Haukka, Loredana Latterini, Salem Elkahoui, Arif J. Siddiqui, Mejdi Snoussi, Mohd Adnan, Houcine Naili, Riadh Badraoui
Summary: A sulfate-bridged copper complex with high thermal stability and therapeutic properties against skeletal metastases in breast cancer cells was synthesized. The structure analysis revealed a 1D chain-like structure interconnected by covalent sulfate linkages and a 2D network formed through hydrogen bonding. Optical studies demonstrated a hypsochromic effect in the absorption and photoluminescence spectra of the compound.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Infectious Diseases
Mohd Adnan, Arif Jamal Siddiqui, Syed Amir Ashraf, Mohammad Saquib Ashraf, Sarah Owdah Alomrani, Mousa Alreshidi, Bektas Tepe, Manojkumar Sachidanandan, Corina Danciu, Mitesh Patel
Summary: The saponin-derived silver nanoparticles obtained from Ajwa dates showed strong antibacterial, antibiofilm, and anti-quorum-sensing activities. They inhibited bacterial growth by disrupting the bacterial cell membranes and leakage of nucleic acid and protein contents, and prevented biofilm formation and quorum-sensing activity by interfering with signaling molecules. Additionally, the nanoparticles exhibited antioxidant activity and cytotoxicity against lung cancer cells.
Article
Biology
Fevzi Bardakci, Sarah Hilan Mohammed Al-Subaie, Riadh Badraoui, Mohd Adnan, Arif Jamal Siddiqui
Summary: The present study used the mitochondrial barcoding gene COI to identify and characterize hard ticks infesting camels in Ha'il province, Saudi Arabia. Nine haplotypes were found, with six being newly described. Phylogenetic analysis revealed two distinct clades corresponding to H. dromedarii and H. impeltatum. The presence of H. scupense together with H. impeltatum suggests possible asymmetrical hybridization and mitochondrial introgression between these species.
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.