Article
Rheumatology
Priyanka Iyer, Yubo Gao, Diana Jalal, Saket Girotra, Namrata Singh, Mary Vaughan-Sarrazin
Summary: This study shows that the use of hydroxychloroquine is associated with a lower risk of mortality in older patients with rheumatoid arthritis, but not with the incidence of major adverse cardiovascular events.
CLINICAL RHEUMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Edmond Atallah, Jane I. Grove, Colin Crooks, Esther Burden-Teh, Abhishek Abhishek, Sulleman Moreea, Kelsey M. Jordan, Aftab Ala, David Hutchinson, Richard J. Aspinall, Ruth Murphy, Guruprasad P. Aithal
Summary: This study evaluated the risk of long-term methotrexate (MTX) therapy on liver fibrosis using non-invasive markers and found that the risk attributed to MTX itself may have been overestimated, suggesting a need to modify current monitoring guidelines.
JOURNAL OF HEPATOLOGY
(2023)
Article
Rheumatology
Kirsi Paalanen, Kari Puolakka, Elena Nikiphorou, Pekka Hannonen, Tuulikki Sokka
Summary: This study found that 10.4% of seronegative RA patients had their diagnosis changed to SpA within 15 years, particularly with a higher proportion related to PsA and axial SpA. It highlights the importance of vigilance in diagnosing RA and considering the possibility of SpA diagnosis, especially in cases with atypical presentations.
Article
Medicine, General & Internal
Takahiro Mizuuchi, Tetsuji Sawada, Susumu Nishiyama, Koichiro Tahara, Haeru Hayashi, Hiroaki Mori, Eri Kato, Mayu Tago, Toshihiro Matsui, Shigeto Tohma
Summary: The involvement of distal interphalangeal (DIP) joints in adult-onset rheumatoid arthritis (RA) is associated with disease activity, particularly affecting small-sized and upper-extremity joints.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Zhibo Zhang, Xin Ma, Yu-Hsun Wang, Xiaofei Shi, James Cheng-Chung Wei
Summary: A retrospective cohort study was conducted to investigate whether hydroxychloroquine (HCQ) therapy increases the risks of cataracts in patients with rheumatoid arthritis (RA). The study included 2821 treatment-naive RA patients from 2000 to 2012, who were followed up until secondary cataracts were detected. The results showed that HCQ usage was not associated with the risk of cataracts in RA patients.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Li Lian, Jian-Xiong Wang, Yue-Chen Xu, He-Xiang Zong, Yu-Zhu Teng, Sheng-Qian Xu
Summary: The study highlighted the high prevalence of osteoporosis and sarcopenia in patients with rheumatoid arthritis, with sarcopenia potentially being a risk factor for osteoporosis occurrence in this population.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Biophysics
Tais Monteiro Magne, Edward Helal-Neto, Luana Barbosa Correa, Luciana Magalhaes Rebelo Alencar, Sara Gemini Piperni, Surtaj H. Iram, Prapanna Bhattarai, Lin Zhu, Eduardo Ricci-Junior, Maria das Gracas Muller de Oliveira Henriques, Elaine Cruz Rosas, Ralph Santos-Oliveira
Summary: Rheumatoid arthritis is a common autoimmune disease affecting joints causing inflammation and swelling, significantly impacting quality of life and mortality. The use of drug-loaded nanomicelles showed a 2-fold higher therapeutic effect in modulating the inflammatory process of RA.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Rheumatology
Else Helene Ibfelt, Rikke Kart Jacobsen, Tine Iskov Kopp, Rene Lindholm Cordtz, Anna Svarre Jakobsen, Niels Seersholm, Saher Burhan Shaker, Lene Dreyer
Summary: Patients with rheumatoid arthritis have a higher risk of ILD compared to the general population, but there is no additional risk associated with MTX treatment.
Article
Pharmacology & Pharmacy
Bayram Ali Uysal, Mevlut Serdar Kuyumcu
Summary: The study found that serum irisin and adropin levels were lower in the CAE group compared to the NCA group. Low levels of adropin and irisin were identified as independent risk factors for CAE. Receiver operating characteristic curve analysis demonstrated that serum adropin and irisin levels were significant predictors of CAE.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Elvira D'Andrea, Rishi J. Desai, Mengdong He, Robert J. Glynn, Hemin Lee, Michael E. Weinblatt, Seoyoung C. Kim
Summary: In older patients with rheumatoid arthritis, hydroxychloroquine and methotrexate showed similar risks of sudden cardiac arrest or ventricular arrhythmia (SCA/VA) and major adverse cardiovascular events (MACE). However, hydroxychloroquine initiators with a history of heart failure (HF) had higher risks of MACE, cardiovascular mortality, all-cause mortality, and myocardial infarction. An increased risk of hospitalized HF was observed among hydroxychloroquine initiators regardless of an HF history.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Health Care Sciences & Services
Bo Young Kim, HyeSung Moon, Sung-Soo Kim, Hyun-Sook Kim
Summary: This study aimed to evaluate the clinical outcomes of elderly patients with and without rheumatoid arthritis (RA) who underwent percutaneous coronary intervention (PCI). The study found that patients with RA had a lower overall survival rate compared to those without RA, especially elderly patients with RA.
Article
Gastroenterology & Hepatology
David Bergman, Bjorn Roelstraete, Jiangwei Sun, Fahim Ebrahimi, Johan Askling, Jonas F. Ludvigsson
Summary: A study found that there is an association between microscopic colitis (MC) and rheumatoid arthritis (RA), with MC patients being nearly twice as likely to develop RA compared to the general population. This study is important as it highlights the need for expedited evaluation for RA in MC patients presenting with joint symptoms and/or arthralgia, thus preventing delay in RA diagnosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Rheumatology
Liam J. O'Neil, Christopher B. Oliveira, Xinghao Wang, Mario Navarrete, Ana Barrera-Vargas, Javier Merayo-Chalico, Rwan Aljahdali, Eduardo Aguirre-Aguilar, Philip Carlucci, Mariana J. Kaplan, Carmelo Carmona-Rivera
Summary: Neutrophil infiltration into the synovial joint is a hallmark of rheumatoid arthritis (RA). This study found that carbamylation, a posttranslational modification, is linked to increased bone erosion in RA. The researchers demonstrated that neutrophil extracellular traps (NETs) and their carbamylated protein cargo directly promote bone destruction by inducing osteoclast formation.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Anthony James Ocon, George Reed, Dimitrios A. Pappas, Jeffrey R. Curtis, Joel M. Kremer
Summary: The study found that initiating glucocorticoids in steroid-naive RA patients is associated with an increased risk of cardiovascular events, especially at daily doses of >= 5mg, cumulative doses exceeding 1100mg, and durations longer than 81 days. No increased risk was found at lower doses or shorter durations.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Kevin L. Winthrop, Peter Nash, Kunihiro Yamaoka, Eduardo Mysler, Nasser Khan, Heidi S. Camp, Yanna Song, Jessica L. Suboticki, Jeffrey R. Curtis
Summary: In patients with RA, treatment with Upadacitinib (UPA) was associated with higher incidence and event rates of herpes zoster (HZ) compared to treatment with methotrexate (MTX) monotherapy or adalimumab (ADA) + MTX. The risk of HZ was also higher with the 30 mg dose of UPA compared to the 15 mg dose. Patients from Asia and those with a history of HZ may have an increased risk of HZ while receiving UPA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Letter
Rheumatology
Xiao-Huan Chen, James Cheng Chung Wei, Han-You Mo, Hsin-Hua Chen
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Xiao-Huan Chen, Fang-Xiao Zhu, Hsin-Hua Chen, James Cheng-Chung Wei
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
James Cheng-Chung Wei, Tae-Hwan Kim, Mitsumasa Kishimoto, Naoki Ogusu, Haeyoun Jeong, Shigeto Kobayashi
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Kevin Sheng-Kai Ma, Eshwar Thota, Jing-Yang Huang, Yu-Feng Huang, James Cheng-Chung Wei
Summary: This study found no significant association between dental restorations and the development of oral lichen planus (OLP). However, root canal therapy and tooth extraction were associated with significantly lower odds of OLP.
Letter
Psychology, Clinical
Hui-Yuan Chen, Renin Chang, James Cheng-Chung Wei
PSYCHOLOGICAL MEDICINE
(2023)
Editorial Material
Rheumatology
Jin-Xian Huang, Yung-Heng Lee, Meng-Yu Ko, James Cheng-Chung Wei
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Editorial Material
Rheumatology
Chiao-Hsin Ku, Yung-Heng Lee, James Cheng-Chung Wei, Juergen Braun
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Editorial Material
Rheumatology
Kevin Sheng-Kai Ma, Yung-Heng Lee, Chia-Jen Lin, Po-Cheng Shih, James Cheng-Chung Wei
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Editorial Material
Rheumatology
Weijie Wang, Yung-Heng Lee, James Cheng-Chung Wei, Philip Mease
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Review
Immunology
Jin-Xian Huang, Yung-Heng Lee, James Cheng-Chung Wei
Summary: Tumor necrosis factor inhibitors are widely used for axial spondyloarthritis, and current guidelines recommend dose reduction instead of withdrawal. This study reviewed and updated the evidence on dose reduction strategies based on prospective and retrospective studies. The core issues and solutions concerning timing, intensity, maintenance, and monitoring of dose reduction were discussed. Remission/relapse and extra-articular manifestations should be considered in individualized dose reduction plans.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Virology
Kevin Sheng-Kai Ma, Ning-Chien Chin, Ting-Yu Tu, Yao-Cheng Wu, Hei-Tung Yip, James Cheng-Chung Wei, Ren-in Chang
Summary: This cohort study investigated the correlation between HPV infections and the risk of osteoporosis. It found that patients with HPV infections had a significantly higher risk of osteoporosis. Subgroup analysis revealed that females, those aged between 60 and 80 years, and patients with long-term use of glucocorticoids were at greater risk. Furthermore, treatments for HPV infections attenuated the risk of HPV-associated osteoporosis.
Article
Rheumatology
Kai-Jun Zhu, Wei Feng, Xiao-Na Ma, Pei-Lun Liao, Chang-Song Lin, Jing-Yang Huang, James Cheng-Chung Wei, Qiang Xu
Summary: Previous studies have shown that the use of proton pump inhibitors (PPIs) increases the risk of gout, but there is a lack of epidemiological research investigating this association. This population-based case-control study from Taiwan aimed to explore the potential impact of PPI treatment on the risk of developing gout. The results indicated that Esomeprazole increased the risk of gout, particularly within 30 days of PPI treatment, and the risk was higher among female and middle-aged users compared to others.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Man Li, Zong-Han Lin, Ying-Cheng Chen, Pan Lin, Yong Xin Xie, James Cheng-Chung Wei
Summary: A 35-year-old male patient presented with bilateral lower extremity weakness for 3 years. Physical examination showed muscle weakness in both lower extremities. Laboratory data revealed elevated levels of creatine kinase, triglycerides, and cholesterol. Muscle pathology showed lipid droplet deposition under the sarcolemma. Next-generation sequencing revealed a pathogenic mutation in the ETFDH gene. The patient was diagnosed with late-onset multiple acyl-CoA dehydrogenase deficiency. After riboflavin treatment, the patient experienced relief of symptoms, improved physical endurance, and increased bone mineral density.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Editorial Material
Rheumatology
Jin-Xian Huang, Yung-Heng Lee, James Cheng-Chung Wei
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Editorial Material
Rheumatology
Po-Cheng Shih, Shu-Hao Chang, An-Ping Huo, James Cheng-Chung Wei
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)