Article
Anesthesiology
Lihai Chen, Liang Hong, Aixia Ma, Yanfei Chen, Yue Xiao, Feng Jiang, Ruijian Huang, Cui Zhang, Xinyi Bu, Yali Ge, Jifang Zhou
Summary: This study found that venous congestion is associated with acute kidney injury and disease in patients undergoing cardiac surgery, while intraoperative hypotension is not associated with the development of acute kidney disease.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Cardiac & Cardiovascular Systems
Patrick M. Wanner, Dirk U. Wulff, Mirjana Djurdjevic, Wolfgang Korte, Thomas W. Schnider, Miodrag Filipovic
Summary: This study found that targeting higher intraoperative mean arterial blood pressures (75 mm Hg) in cardiovascular risk patients undergoing major noncardiac surgery did not significantly reduce the incidence of postoperative major adverse cardiovascular events. Despite a shorter duration of hypotensive time during surgery, there were no significant differences in outcomes such as acute myocardial injury and 30-day MACE/AKI between the higher and lower blood pressure target groups.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Eero Pesonen, Hanna Vlasov, Raili Suojaranta, Seppo Hiippala, Alexey Schramko, Erika Wilkman, Tiina Eranen, Kaapo Arvonen, Maxim Mazanikov, Ulla-Stina Salminen, Mihkel Meinberg, Tommi Vahasilta, Liisa Petaja, Peter Raivio, Tatu Juvonen, Ville Pettila
Summary: Albumin solution may be better than crystalloids in maintaining hemodynamics in cardiac surgery, but it does not significantly reduce the risk of major adverse events compared to Ringer acetate.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Surgery
Daniel V. Lazzareschi, Nicholas Fong, Orestes Mavrothalassitis, Elizabeth L. Whitlock, Catherine L. Chen, Catherine Chiu, Dieter Adelmann, Michael P. Bokoch, Lee-Lynn Chen, Kathleen D. Liu, Romain Pirracchio, Michael R. Mathis, Matthieu Legrand, MPOG Collaborators
Summary: This study investigates the variation in albumin use among medical centers in the United States during major noncardiac surgery and finds that albumin administration is associated with an increased risk of postoperative complications.
Article
Anesthesiology
W. Brenton French, Pranav R. Shah, Yahya I. Fatani, Megan M. Rashid, Spencer T. Liebman, Brian J. Cocchiola, Kenneth F. Potter, Salem Rustom, Michael J. Scott
Summary: The study found that postoperative AKI is associated with increased length of hospital stay, higher surgical hospitalization costs, in-hospital mortality, and 1-year mortality, indicating that even patients with mild AKI are at higher risk for complications in both short and long term.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Review
Medicine, General & Internal
Jingtao Zhao, Maowei Li, Chen Tan
Summary: This meta-analysis and trial sequential analysis evaluated the efficacy of N-acetylcysteine (NAC) in preventing adverse events after cardiac surgery. The results showed that intravenous administration of NAC can reduce the incidence of acute kidney injury (AKI) and arrhythmia, but has no significant effect on mortality, acute myocardial infarction (AMI), cardiac insufficiency, and the use of renal replacement therapy. Oral NAC does not significantly affect the outcomes of patients after cardiac surgery.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
Benjamin Anderson, Muhammad Qasim, Felicity Evison, Suzy Gallier, Jonathan N. Townend, Charles J. Ferro, Adnan Sharif
Summary: This retrospective study of kidney transplant procedures in England found a MACE rate of 2.6% in the first year after transplantation. The occurrence of MACE was significantly associated with long-term mortality risk.
KIDNEY INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Lorenz M. Pammer, Claudia Lamina, Ulla T. Schultheiss, Fruzsina Kotsis, Barbara Kollerits, Helena Stockmann, Jan Lipovsek, Heike Meiselbach, Martin Busch, Kai-Uwe Eckardt, Florian Kronenberg
Summary: The study found a high prevalence of metabolic syndrome among patients with moderate CKD, which increases the risk of all-cause mortality and cardiovascular events. The glucose and lipid components appear to be the main drivers for the association with outcomes.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Medical Laboratory Technology
Hong Lang, Hang Zhang, Mengqing Ma, Xin Wan, Yuyang Chen, Qing Sun, Changchun Cao
Summary: A novel serum biomarker, Fstl1, was identified using protein array technology to assist in the early prediction of AKI after cardiac surgery. Higher levels of serum Fstl1 at 4 h post-surgery were associated with increased odds of AKI. Adding postoperative serum Fstl1 to the clinical model significantly improved predictive performance.
CLINICA CHIMICA ACTA
(2023)
Article
Anesthesiology
Esther M. Wesselink, Sjors H. Wagemakers, Judith A. R. Van Waes, Jonathan P. Wanderer, Wilton A. Van Klei, Teus H. Kappen
Summary: Intraoperative hypotension appears to have a continuous association with postoperative myocardial injury and mortality, with depth of hypotension contributing more than duration.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Anesthesiology
Nicholas L. McKenzie, R. Parker Ward, Peter Nagele, Daniel S. Rubin
Summary: This study investigated the association between preoperative initiation of beta-blockers within 60 days of surgery or chronic beta-blocker therapy and the risk of stroke in patients undergoing major abdominal surgery. The results showed no association between the use of beta-blockers and the risk of stroke in this patient population.
Article
Medicine, General & Internal
Emaad Siddiqui, Darcy Banco, Jeffrey S. Berger, Nathaniel R. Smilowitz
Summary: This study aims to estimate the prevalence of frailty and the association with major adverse cardiovascular events (MACE) among adults hospitalized for noncardiac surgery. The results showed that patients with higher frailty risk had a higher incidence of MACE, especially among younger individuals aged 45-64.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Paolo Murabito, Marinella Astuto, Filippo Sanfilippo, Luigi La Via, Francesco Vasile, Francesco Basile, Alessandro Cappellani, Lucia Longhitano, Alfio Distefano, Giovanni Li Volti
Summary: This study demonstrates that the use of an early warning system coupled with a hemodynamic algorithm can reduce intraoperative hypotension and decrease levels of neuronal specific enolase and oxidative stress.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Gustavo Romero-Velez, Jerry Dang, Juan S. Barajas-Gamboa, Terrence Lee-St John, Andrew T. Strong, Salvador Navarrete, Ricard Corcelles, John Rodriguez, Maan Fares, Matthew Kroh
Summary: This study evaluated and compared prediction models for MACE in bariatric surgery using traditional statistical methods and machine learning. The machine learning models showed good discriminant function and can assist clinicians in patient selection and identification of individuals at elevated risk of MACE after bariatric surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Critical Care Medicine
Dingxin Zhou, Jun Jiang, Jing Zhang, Fengsheng Cao, Zhiyong Peng
Summary: This study aimed to investigate the association between hyperchloremia and/or the increase of blood chloride levels at ICU admission and the incidence of major adverse kidney events within 30 days (MAKE30) in critically ill adults. The results showed that an increase in chloride levels ≥5 mmol/L within 48 hours of ICU admission was associated with an increased incidence of MAKE30, while hyperchloremia at ICU admission was not associated with the incidence of MAKE30.
Article
Oncology
Jun-Peng Pei, Zhe-Ming Zhao, Zhe Sun, Wan-Jie Gu, Jiang Zhu, Ji Zhu, Si-Ping Ma, Yu Liang, Rui Guo, Rui Zhang, Chun-Dong Zhang
Summary: This study developed a novel TLODDS classification for colon and rectal cancers, which showed better discriminatory ability, model-fitting, and net benefits compared to the existing TNM classification.
Review
Infectious Diseases
Wan-Jie Gu, Jiao Huang, Hai-Yin Jiang
Summary: This review assessed the effects of antiviral therapy on critically ill patients undergoing mechanical ventilation. The results showed that antiviral therapy reduced the risk of viral reactivation without an association with mortality and increased risk of renal insufficiency.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Surgery
Wan-Jie Gu, Jian-Xin Zhou, Run-Qing Ji, Lu-Yang Zhou, Chun-Mei Wang
Summary: The study investigated the occurrence of emergence delirium in adults after elective brain tumor resection, finding a high incidence rate and association with poor outcomes, suggesting the need for enhanced screening and prevention strategies for delirium in the perioperative period for this population.
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
(2022)
Review
Gastroenterology & Hepatology
Wan-Jie Gu, Hao-Tian Wang, Jiao Huang, Jun-Peng Pei, Kazuhiro Nishiyama, Masanobu Abe, Zhe-Ming Zhao, Chun-Dong Zhang
Summary: High flow nasal oxygen can reduce the risk of hypoxemia and improve the lowest oxygen saturation in gastrointestinal endoscopy with conscious sedation. However, caution should be exercised in interpreting the results due to substantial heterogeneity and limited evidence, and further research is needed to confirm the preliminary findings.
DIGESTIVE ENDOSCOPY
(2022)
Article
Multidisciplinary Sciences
Fei-Long Ning, Jun Lyu, Jun-Peng Pei, Wan-Jie Gu, Nan-Nan Zhang, Shi-Yi Cao, Yong-Ji Zeng, Masanobu Abe, Kazuhiro Nishiyama, Chun-Dong Zhang
Summary: This study analyzed the burden and trends of gastric cancer in five Asian countries, examining incidence, death, and potential risk factors. It found that despite an increase in cases and deaths over time, the age-standardized incidence and death rates decreased with improved sociodemographic index and increased with age.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Wan-Jie Gu, Fei-Long Ning, Hao-Ran Jin, Zhe-Ming Zhao, Jun Lyu, Jun-Peng Pei, Shi-Yi Cao, Yong-Ji Zeng, Masanobu Abe, Kazuhiro Nishiyama, Chun-Dong Zhang
Summary: This study examined the burden and trends of IBD in 5 Asian countries, the United States, and the United Kingdom, and found significant variations in incidence and death rates between these countries over the past 3 decades.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Anesthesiology
Luming Zhang, Wan-Jie Gu, Tao Huang, Jun Lyu, Haiyan Yin
Summary: This study retrospectively evaluated the association between the timing of hydrocortisone initiation and mortality in septic shock. The results showed that initiating hydrocortisone within 12 hours of vasopressor use was associated with lower mortality risk.
ANESTHESIA AND ANALGESIA
(2023)
Article
Infectious Diseases
Dan He, Hai Hu, Liang Hong, Luming Zhang, Xuehao Lu, Wan-jie Gu, Jun Lyu, Haiyan Yin
Summary: This retrospective study found that the combination of NE and PE in patients with septic shock was associated with a higher hospital mortality rate compared to the use of NE alone.
BMC INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao
Summary: Temporal lobe epilepsy (TLE) is a common and severe form of epilepsy, and the underlying mechanisms are not well understood. This study found that KCTD13 protein, which plays a role in ubiquitin degradation, is down-regulated in the brain tissue of TLE patients. In a TLE mouse model, changes in KCTD13 expression were observed during epileptogenesis. Knockdown of KCTD13 increased seizure susceptibility and severity, while overexpression of KCTD13 had the opposite effect. KCTD13 was found to facilitate degradation of the NMDAR subunit GluN1, and dysregulation of KCTD13 affected glutamate receptor expression and synaptic transmission. Memantine, an NMDAR inhibitor, partially rescued the epileptic phenotype caused by KCTD13 knockdown. These findings suggest that KCTD13 could be a potential therapeutic target for epilepsy.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Surgery
Fei-Long Ning, Wan-Jie Gu, Zhe-Ming Zhao, Wan-Ying Du, Min Sun, Shi-Yi Cao, Yong-Ji Zeng, Masanobu Abe, Chun-Dong Zhang
Summary: This study found that the risk of postoperative mortality after gastric cancer surgery is influenced by the hospital surgical case volume. Hospitals with higher surgical case volumes have lower postgastrectomy mortality rates. The postgastrectomy mortality rate remains stable or decreases after the hospital volume reaches a plateau of 100 gastrectomy cases per year.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Psychiatry
Wan-Jie Gu, Lu-Ming Zhang, Chun-Mei Wang, Feng-Zhi Zhao, Hai-Yan Yin, Jun Lyu
Summary: We conducted a retrospective cohort study to investigate the association between pre-ICU use of SSRIs and mortality in critically ill adults with mental disorders. The results show that the use of SSRIs before ICU admission is associated with an increased risk of in-hospital mortality in critically ill adults with mental disorders.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Emergency Medicine
Dan He, Luming Zhang, Hai Hu, Wan-jie Gu, Xuehao Lu, Minshang Qiu, Chao Li, Haiyan Yin, Jun Lyu
Summary: This retrospective cohort study aimed to compare the effects of early initiation of vasopressin combined with norepinephrine (NE) versus nonearly initiation of vasopressin with NE in patients with septic shock. The results showed that there was no significant difference in short-term mortality between the two groups.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Anesthesiology
Wan-Jie Gu, Xiang-Jie Duan, Xiao-Zhu Liu, Yun Cen, Li-Yuan Tao, Jun Lyu, Hai-Yan Yin
Summary: This retrospective cohort study found that the use of magnesium sulfate in critically ill patients with sepsis was associated with lower mortality rates. This association was observed regardless of the baseline serum magnesium status. The use of magnesium sulfate was also associated with lower ICU mortality, in-hospital mortality, and the need for renal replacement therapy.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Biochemistry & Molecular Biology
Xiaogang Zhang, Yixue Gu, Yuanlin Ma, Junhong Wu, Yuanyuan Chen, Kaiyan Tao, Houchao Sun, Zhao Liu, Xuefeng Wang, Xin Tian
Summary: Activation of the apelin/APJ system in the central nervous system has neuroprotective effects and protects against excitotoxicity mediated by NMDA receptors. This study investigated the localization and expression of APJ in the brains of mice with seizures and found that APJ activation reduced seizure activity, while APJ inhibition aggravated it. The findings suggest that the apelin/APJ system modulates seizure activity and may be a potential therapeutic target for epilepsy.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Letter
Medicine, General & Internal
Wan-Jie Gu, Jun Lyu, Hai-Yan Yin
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)