Article
Cardiac & Cardiovascular Systems
Hyung Oh Kim, Bo Jiang, Eric K. W. Poon, Vikas Thondapu, Chong-Jin Kim, Osamu Kurihara, Makoto Araki, Akihiro Nakajima, Chris Mamon, Jouke Dijkstra, Hang Lee, Andrew Ooi, Peter Barlis, Ik-Kyung Jang
Summary: This study investigated the evolution of hemodynamic parameters at the plaque erosion site in conservatively treated patients. The results showed that the erosion site had higher values of endothelial shear stress (ESS) and ESS gradient (ESSG), which persisted up to 12 months.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tom Adriaenssens, Marc P. Allard-Ratick, Vikas Thondapu, Tomoyo Sugiyama, O. Christopher Raffel, Peter Barlis, Eric K. W. Poon, Makoto Araki, Akihiro Nakajima, Yoshiyasu Minami, Masamichi Takano, Osamu Kurihara, Valentin Fuster, Tsunekazu Kakuta, Ik-Kyung Jang
Summary: The development of optical coherence tomography (OCT) technology has significantly impacted our understanding of coronary artery disease by revealing unique mechanisms of plaque growth and stability through the study of different hemodynamic factors. Recent research has introduced a new concept of plaque healing, changing the way we perceive coronary artery disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nieves Gonzalo, Carlos H. Salazar, Maria Jose Perez-Vizcayno, Juan Carlos Gomez-Polo, Pilar Jimenez-Quevedo, Santiago Jimenez-Valero, Monica Masotti, Rafael Romaguera, Antonio Fernandez-Ortiz, Javier Escaned, Fernando Alfonso, Carlos Macaya
Summary: This study aimed to evaluate the influence of neoatherosclerosis on the prognosis and treatment response in patients with in-stent restenosis. The results showed that in patients treated with paclitaxel-coated balloon or everolimus-eluting stents, neoatherosclerosis did not seem to affect acute and long-term outcomes.
REVISTA ESPANOLA DE CARDIOLOGIA
(2021)
Article
Cardiac & Cardiovascular Systems
Juhwan Lee, Gabriel T. R. Pereira, Issam Motairek, Justin N. N. Kim, Vladislav N. N. Zimin, Luis A. P. Dallan, Ammar Hoori, Sadeer Al-Kindi, Giulio Guagliumi, David L. L. Wilson
Summary: This study investigated the ability of quantitative plaque characteristics from intravascular optical coherence tomography (IVOCT) images taken just prior to stent implantation to predict neoatherosclerosis after implantation. The results showed that the surface area of the fibrous cap was the strongest predictor of neoatherosclerosis development after stent implantation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Chemistry, Analytical
Yuqian Zhao, Zhibo Zhu, Huiwen Jiang, Yao Yu, Jian Liu, Jingmin Luan, Yi Wang, Zhenhe Ma
Summary: This article proposes a novel method for measuring the stress phase angle (SPA) using spectral domain optical coherence tomography (SD-OCT). The method is validated by measuring SPA in the outflow tract (OFT) of chick embryonic hearts and the common carotid artery of mice. This is the first time that OCT has been used for SPA measurement.
Article
Cardiac & Cardiovascular Systems
Daisuke Nakamura, Tomoharu Dohi, Takayuki Ishihara, Atsushi Kikuchi, Naoki Mori, Kensuke Yokoi, Tatsuya Shiraki, Isamu Mizote, Toshiaki Mano, Yoshiharu Higuchi, Takahisa Yamada, Masami Nishino, Yasushi Sakata
Summary: In this multicentre ISR registry, OCT imaging revealed that eGFR, the time from PCI to ISR, and DES-ISR were independent predictors for neoatherosclerosis, which had a negative impact on the CD-TLR rate in ISR lesions.
Article
Biochemical Research Methods
Shan Ling, Brecken J. Blackburn, Michael W. Jenkins, Michiko Watanabe, Stephanie M. Ford, Maryse Lapierre-Landry, Andrew M. Rollins
Summary: Optical coherence tomography (OCT) is used to investigate heart development and can image both structure and function. An automatic image-processing pipeline was developed to segment beating embryonic heart structures from a 4-D OCT dataset, reducing segmentation time and labor. This method allows for cohort studies to quantify complex cardiac motion and function.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Cardiac & Cardiovascular Systems
Chongying Jin, Ryo Torii, Anantharaman Ramasamy, Vincenzo Tufaro, Callum D. Little, Klio Konstantinou, Yi Ying Tan, Nathan A. L. Yap, Jackie Cooper, Tom Crake, Constantinos O'Mahony, Roby Rakhit, Mohaned Egred, Javed Ahmed, Grigoris Karamasis, Lorenz Raeber, Andreas Baumbach, Anthony Mathur, Christos V. Bourantas
Summary: This study revealed significant morphological and physiological differences between culprit ruptured plaques in native and stented segments, highlighting the need for further research to better understand the causes of these differences and the mechanisms regulating neoatherosclerotic lesion destabilization.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Engineering, Biomedical
Parastou Eslami, Eline M. J. Hartman, Mazen Albaghadai, Julia Karady, Zexi Jin, Vikas Thondapu, Nicholas Cefalo, Michael T. Lu, Ahmet Coskun, Peter H. Stone, Alison Marsden, Udo Hoffmann, Jolanda J. Wentzel
Summary: This study developed an optimized methodology using computational fluid dynamics to derive ESS, pressure drop, and oscillatory shear index in 3D models of coronary arteries derived from non-invasive coronary CTA. The results showed that this methodology can accurately assess the distribution of TAESS non-invasively from CTA and demonstrated a good correlation with TAESS calculated using IVUS/OCT 3D reconstructed models.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Cardiac & Cardiovascular Systems
Yohei Sumino, Taishi Yonetsu, Hiroki Ueno, Kai Nogami, Toru Misawa, Masahiro Hada, Masao Yamaguchi, Masahiro Hoshino, Yoshihisa Kanaji, Tomoyo Sugiyama, Tetsuo Sasano, Tsunekazu Kakuta
Summary: Neoatherosclerosis observed by optical coherence tomography (OCT) at 3-7 years after stenting is associated with worse subsequent clinical outcomes, serving as an independent predictor for major adverse cardiac events (MACE) and stent failure.
JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lei Xing, Yongpeng Zou, Chao Fu, Xiaoying Fan, Xuedong Wang, Qi Liu, Mengyue Yang, Dandan Liu, Linxing Feng, Jingbo Hou, Xingtao Huang
Summary: The study found that patients with in-stent neoatherosclerosis (ISNA) had smaller minimum lumen area, greater decrease, and more plaques with lipid core length increase in non-culprit lesions, suggesting a possible link between ISNA formation and delayed plaque stabilization in non-culprit lesions.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Optics
Jianan Fang, Kun Huang, E. Wu, Ming Yan, Heping Zeng
Summary: This article introduces an infrared 3D imaging system capable of detecting three-dimensional structure and reflectivity information. The system operates at single-photon sensitivity and femtosecond timing resolution, enabling imaging under low-light conditions. By nonlinear frequency upconversion and recording with a silicon camera, the presented system achieves high lateral and depth resolutions for 3D reconstruction. Additionally, a numerical denoiser based on spatiotemporal correlation allows the retrieval of object profile and reflectivity even with a detected flux below 0.05 photons/pixel/second. This infrared 3D imager features high detection sensitivity, precise timing resolution, and wide-field operation, offering new possibilities in life and material sciences.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Review
Cardiac & Cardiovascular Systems
Heng Wang, Qian Wang, Jie Hu, Ruijing Zhang, Tingting Gao, Shuling Rong, Honglin Dong
Summary: This article analyzes the current state and development trends of in-stent neoatherosclerosis (ISNA/NA) research using bibliometric methods. The results show that topics such as optical coherence tomography, thrombosis, and restenosis have gained increasing attention in this field. The article points out that reducing the incidence of ISNA and improving the late patency rate of coronary stents remain hot topics for future research.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Vikas Thondapu, Chris Mamon, Eric K. W. Poon, Osamu Kurihara, Hyung Oh Kim, Michele Russo, Makoto Araki, Hiroki Shinohara, Erika Yamamoto, Jouke Dijkstra, Mark Tacey, Hang Lee, Andrew Ooi, Peter Barlis, Ik-Kyung Jang
Summary: The study found that high ESSG is independently associated with plaque rupture, while high ESSG, ESS, and OSI are associated with plaque erosion. Furthermore, ESSG is higher at rupture sites, OSI is higher at erosion sites, and ESS is similar between the two.
CARDIOVASCULAR RESEARCH
(2021)
Article
Optics
Zunyue Zhang, Yi Wang, Jiarui Wang, Dan Yi, David Weng U. Chan, Wu Yuan, Hon Ki Tsang
Summary: In this study, a compact integrated scanning spectrometer is proposed, which utilizes a tunable micro-ring resonator and a single arrayed waveguide grating to achieve wide optical bandwidths and high spectral resolutions. The integrated spectrometer with germanium photodetectors demonstrates excellent performance.
PHOTONICS RESEARCH
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
James Muller, Patrick Serruys, Niel Grubb, John Pastore
EUROPEAN HEART JOURNAL
(2023)
Article
Health Care Sciences & Services
Rayyan Hemetsberger, Serdar Farhan, Dominika Lukovic, Katrin Zlabinger, Judit Hajagos-Toth, Judit Bota, Hector M. Garcia-Garcia, Cihan Ay, Eslam Samaha, Robert Gaspar, Rita Garamvoelgyi, Kurt Huber, Andreas Spannbauer, Mariann Gyoengyoesi
Summary: Peri-interventional triple therapy with dabigatran in a pig model of coronary artery stenting has been found to ameliorate local inflammation and disturb vasomotion, without reducing neointimal formation.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Murat Cap, Ryo Torii, Yoshinobu Onuma, Rob Krams, Martin R. Bennett, Peter H. Stone, Patrick W. Serruys, Christos V. Bourantas
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Kamil Bujak, Pablo Vidal-Cales, Rami Gabani, Riccardo Rinaldi, Josep Gomez-Lara, Luis Ortega-Paz, Victor Jimenez-Diaz, Marcelo Jimenez-Kockar, Pilar Jimenez-Quevedo, Roberto Diletti, Gianluca Campo, Antonio Silvestro, Jaume Maristany, Xacobe Flores, Loreto Oyarzabal, Antonio De Miguel-Castro, Andres Iniguez, Luis Nombela-Franco, Alfonso Ielasi, Maurizio Tespili, Mattie Lenzen, Simone Biscaglia, Soheil Al-Shaiban, Rafael Romaguera, Joan Antoni Gomez-Hospital, Mariusz Gasior, Patrick W. Serruys, Manel Sabate, Salvatore Brugaletta
Summary: This study aims to analyze the relationship between total stent length (TSL) and 10-year target-lesion failure (TLF) in patients with ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention. The results show that there is a direct relationship between TSL and the risk of TLF at 10 years, mainly driven by target lesion revascularization (TLR).
AMERICAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Felice Gragnano, Roxana Mehran, Mattia Branca, Anna Franzone, Usman Baber, Yangsoo Jang, Takeshi Kimura, Joo-Yong Hahn, Qiang Zhao, Stephan Windecker, Charles M. Gibson, Byeong-Keuk Kim, Hirotoshi Watanabe, Young Bin Song, Yunpeng Zhu, Pascal Vranckx, Shamir Mehta, Sung-Jin Hong, Kenji Ando, Hyeon-Cheol Gwon, Paolo Calabro, Patrick W. Serruys, George D. Dangas, Eugene P. McFadden, Dominick J. Angiolillo, Dik Heg, Marco Valgimigli
Summary: This study suggests that P2Y12 inhibitor monotherapy after complex percutaneous coronary intervention (PCI) can preserve ischemic protection while limiting bleeding risk. Compared with dual antiplatelet therapy (DAPT), P2Y12 inhibitor monotherapy after 1-month to 3-month DAPT can reduce the major bleeding risk in complex PCI patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Biology
Maria Emfietzoglou, Michail C. Mavrogiannis, Hector M. Garcia-Garcia, Kimon Stamatelopoulos, Ioannis Kanakakis, Michail I. Papafaklis
Summary: Despite advances in treatment, coronary artery disease (CAD) remains a major cause of illness and death worldwide. Invasive and non-invasive imaging techniques have been used to identify high-risk plaques and the vulnerable state of patients with CAD. However, the predictive value of the invasive-only approach is limited, and a more interdisciplinary approach is needed to identify both the vulnerable plaque and patient. This review summarizes and critically evaluates the modalities used for detecting high-risk plaques in patients with CAD and discusses the challenges of the vulnerable plaque concept.
Article
Medicine, Research & Experimental
Samuel D. J. Spears, Yusuf F. Abdulle, Dionisios Korovilas, Ryo Torii, Deepak M. Kalaskar, Nikhil Sharma
Summary: Most people with MND reject neck collars due to their restrictiveness, which exacerbates problems with daily activities. Current standardized outcome measures for neck collars are summarized to assess their suitability for a bespoke collar designed for people with MND.
INTERACTIVE JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Hesham Elzomor, Timotheus J. Neumann, Linus Boas, Philipp Ruile, Mahmoud Abdelshafy, Ahmed Elkoumy, Pruthvi C. Revaiah, Tsung-Ying Tsai, Klaus Kaier, Osama Soliman, Miroslaw Ferenc, Dirk Westermann, Franz-Josef Neumann, Patrick Serruys, Simon Schoechlin
Summary: Background estimation of regurgitant fraction using videodensitometry (VD-AR) is a new objective grading tool for paravalvular regurgitation (PVR) after transcatheter aortic valve implantation (TAVI). This study found that VD-AR > 17% was independently associated with 3-year mortality. Compared to subjective visual evaluation, VD-AR resulted in a smaller proportion of patients classified as prognostically relevant for PVR.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Pruthvi C. Revaiah, Patrick W. Serruys, Denise P. Yates, Yoshinobu Onuma, Jose Luis Zamorano
Summary: This article reports on the use of CCTA to non-invasively risk stratify and guide further management of patients with non-obstructive CAD. In the case presented, CCTA showed lipid-rich plaques in the left main stem and left anterior descending arteries, and the patient remained asymptomatic after treatment. The discussion highlights the value of CCTA as a diagnostic tool for assisting in the diagnosis and treatment of patients with non-obstructive CAD.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Nozomi Kotoku, Patrick W. Serruys, Kai Ninomiya, Alan Soo, Shinichiro Masuda, Shigetaka Kageyama, Pruthvi C. Revaiah, Michael J. Mack, David R. Holmes, Marie -Claude Morice, Piroze M. Davierwala, Friedrich W. Mohr, Milan Milojevic, Arie Pieter Kappetein, Scot Garg, Yoshinobu Onuma
Summary: This study aimed to evaluate the impact of non-fatal periprocedural major adverse events (PMAE) on 10-year mortality and investigate whether PMAE affect mortality predicted by SYNTAX score II 2020 (SSII-2020) and whether optimal medical therapy (OMT) has a positive effect on the prognosis of patients with non-fatal PMAE. The results show that non-fatal PMAE are more common following CABG than PCI, but their prognostic impact is similar, being significant in the first year and then diminishing out to 10 years. Therefore, patients with non-fatal PMAE may require more careful follow-up and additional preventive treatment in the first year post-procedure.
Meeting Abstract
Cardiac & Cardiovascular Systems
Kai Ninomiya, Shigetaka Kageyama, Hiroki Shiomi, Nozomi Kotoku, Shinichiro Masuda, Pruthvi Revaiah, Scot Garg, Neil O'leary, Takeshi Kimura, Yoshinobu Onuma, Patrick Serruys, Patrick Serruys
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Pruthvi Chenniganahosahalli Revaiah, Asishkumar Mandalay, Gunasekaran Sengottuvelu, Ahmed Elkoumy, Hesham Elzomor, Mahmoud Abdelshafy, Sanjeev Bhatt, Yoshinobu Onuma, Osama Soliman, Patrick W. Serruys
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Patrick Serruys, Kai Ninomiya, Jinying Zhou, Nozomi Kotoku, Shigetaka Kageyama, Shinichiro Masuda, Yoshinobu Onuma
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
TsungYing Tsai, Shigetaka Kageyama, Yoshinobu Onuma, Giulio Pompilio, Daniele Andreini, Saima Mushtaq, Gianluca Pontone, Gianluca Pontone, Mark La Meir, Johan De Mey, Kaoru Tanaka, Torsten Doenst, Ulf Teichgraeber, Ulf Teichgraeber, Ulrich Schneider, John Puskas, Jagat Narula, Patrick W. Serruys
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Bo Wang, Randall Lee, Yoshinobu Onuma, Patrick W. J. C. Serruys, Ling Tao
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)