Article
Medicine, General & Internal
Alberto Braghiroli, David Kuller, Massimo Godio, Fabio Rossato, Carlo Sacco, Elisa Morrone
Summary: This study compared a novel sleep respiratory monitoring device (Airgo (TM)) with a standard home respiratory monitoring system (Nox T3). The results showed that Airgo (TM) had excellent agreement with the gold standard results and exhibited high levels of sensitivity, specificity, predicted value, and accuracy. Therefore, Airgo (TM) is a reliable and well-tolerated tool for screening patients with suspected sleep respiratory disorders, leading to more efficient use of healthcare resources.
FRONTIERS IN MEDICINE
(2022)
Article
Chemistry, Analytical
Hyunjun Jung, Dongyeop Kim, Jongmin Choi, Eun Yeon Joo
Summary: This study assessed the accuracy of wrist-based respiratory rate estimation during sleep using the Samsung Galaxy Watch series based on the severity of obstructive sleep apnea. The results showed that the GW accurately estimated respiratory rate, although accuracy may be compromised in patients with severe OSA.
Article
Engineering, Multidisciplinary
Alessandra Galli, Giada Giorgi, Claudio Narduzzi
Summary: Wearable cardiac monitors play a positive role in the early detection of cardiovascular pathologies, but wireless transmission of ECG trace data faces challenges due to the large amount of data. This study proposes a signal analysis approach based on a Gaussian dictionary to compress ECG traces, achieving effective compression for wireless data transmission and accurate reconstruction of ECG traces.
Article
Instruments & Instrumentation
Marco Chu, Hani E. Naguib
Summary: This study assessed the performance of various conductive composite polymers in collecting electrical signals from the heart, and found that adding 5% carbon nanotubes significantly increased the elastic modulus and conductivity of the composites. SBS-CNT composites at 5% and 10% showed the best performance in detecting ECG waves from the heart.
SMART MATERIALS AND STRUCTURES
(2021)
Article
Computer Science, Information Systems
Qiwei Chen, Sanja Kastratovic, Mohamad Eid, Sohmyung Ha
Summary: Cardiovascular diseases are deadly and early detection of cardiac abnormalities is crucial. A small-sized, non-contact, real-time ECG recording system has been developed for mobile long-term monitoring, providing clear ECG recording, low cost, and good wearability.
Article
Engineering, Electrical & Electronic
Chaehyun Kim, Ahram Jang, Sebin Kim, Sungbo Cho, Donghun Lee, Young-Joon Kim
Summary: In this study, a simple and minimally invasive ECG measurement system for mice was developed. It consists of a miniaturized wearable ECG monitoring device and a smartphone application that displays real-time ECG waveform and heart rate. The system proved to be feasible through validation experiments.
IEEE SENSORS JOURNAL
(2023)
Article
Computer Science, Information Systems
Shuenn-Yuh Lee, Yi-Wen Hung, Po-Han Su, I-Pei Lee, Ju-Yi Chen
Summary: This paper introduces a complete wearable system with smart clothing for long-term monitoring of lead-I ECG and respiratory signals. The proposed system overcomes challenges in integrating ECG electrodes and respiration transducers in clothing and provides high-quality signals for clinical use. Moreover, real-time monitoring and health information analysis are enabled through a software platform.
Article
Engineering, Electrical & Electronic
Jiahao Lu, Dongsheng Liu, Xuan Cheng, Lai Wei, Ang Hu, Xuecheng Zou
Summary: This paper proposes an efficient unstructured sparse CNN accelerator for ECG classification. The new accelerator adopts a tile-first dataflow and compressed data storage format to skip zero weight multiplications and improve computing efficiency. Experimental results show that the proposed accelerator performs well in ECG classification, especially in situations with limited hardware resources and sparse weight distribution.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS
(2022)
Article
Engineering, Electrical & Electronic
Shuaiju Yin, Gang Li, Yongshun Luo, Shuqiang Yang, Han Tain, Ling Lin
Summary: This study designed a single-channel amplifier circuit that can simultaneously acquire ECG and impedance respiratory signals to improve the measuring precision of physiological signals. Experimental results show that the circuit can obtain high-quality ECG and respiratory waveforms.
CIRCUITS SYSTEMS AND SIGNAL PROCESSING
(2021)
Article
Chemistry, Analytical
Shaokui Wang, Weipeng Xuan, Ding Chen, Yexin Gu, Fuhai Liu, Jinkai Chen, Shudong Xia, Shurong Dong, Jikui Luo
Summary: Sleep apnea syndrome (SAS) is a common health problem that is often undiagnosed, affecting quality of life and increasing cardiovascular risks. To address the complicated and expensive clinical diagnosis procedures for sleep apnea, a small and low-cost wearable apnea diagnostic system is proposed. The system utilizes a photoplethysmography (PPG) optical sensor to collect pulse wave signals and blood oxygen saturation synchronously, and uses algorithms to process the signals for analysis and diagnosis with a high accuracy of over 85%.
Article
Medicine, Research & Experimental
Qin Shen, Jianqing Li, Chang Cui, Xingyao Wang, Hongxiang Gao, Chengyu Liu, Minglong Chen
Summary: Arrhythmias, including atrial fibrillation and malignant ventricular arrhythmias, are common and early diagnosis is crucial. Holter monitoring is the gold standard for noninvasive detection, but has limitations such as fixed detection timings. A new wearable ECG device with remote cloud-based platform and expert-supporting system showed high sensitivity and specificity for detecting arrhythmias.
JOURNAL OF BIOMEDICAL RESEARCH
(2021)
Article
Computer Science, Information Systems
Zhiya Wang, Caijing Peng, Baozhu Li, Thomas Penzel, Ran Liu, Yuan Zhang, Xinge Yu
Summary: This study presents a multiscale neural network URNet model for OSA detection, achieving high accuracy and sensitivity on the ECG dataset. Our approach provides significant improvements compared to current state-of-the-art methods.
INTERNET OF THINGS
(2022)
Article
Clinical Neurology
Jesper Jeppesen, Jakob Christensen, Peter Johansen, Sandor Beniczky
Summary: This study developed a patient-adaptive logistic regression machine learning algorithm for detecting focal epileptic seizures based on heart rate variability. The algorithm showed improved performance compared to previous methods and can be implemented in a wearable device to alert patients and caregivers, optimizing medical treatment.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Article
Electrochemistry
Josue Ferri, Raul Llinares, Izan Segarra, Antonio Cebrian, Eduardo Garcia-Breijo, Jose Millet
Summary: This paper presents a new manufacturing process for a dry ECG electrode printed on a textile substrate. The electrode is made by screen printing a conductive silver ink coated with a biocompatible carbon layer. The impedance measurements and comparison with a conventional wet electrode show promising results for the dry electrode's performance in ECG monitoring.
ELECTROCHEMISTRY COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Xue Wang, Xiao Xiao, Zhiping Feng, Yufen Wu, Jin Yang, Jun Chen
Summary: A soft bioelectronic patch has been developed to monitor respiration and cardiovascular activities during sleep in a wearable and non-invasive manner. The patch exhibits high sensitivity and low-frequency response, making it suitable for sleep monitoring and diagnosis of obstructive sleep apnea-hypopnea syndrome.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Rehabilitation
Barbara Bernardo Figueiredo, Cyda Reinaux, Helen Fuzari, Antonio Sarmento, Juliana Fernandes, Armele Dornelas de Andrade
Summary: This study investigated various physiological indicators of MPS patients and compared them with healthy individuals. The results showed significant reductions in body composition, lung function, respiratory muscle strength, and functional capacity among MPS patients.
DISABILITY AND REHABILITATION
(2023)
Article
Cardiac & Cardiovascular Systems
Federica Toto, Elisabetta Salvioni, Damiano Magri, Susanna Sciomer, Massimo Piepoli, Roberto Badagliacca, Arianna Galotta, Nikita Baracchini, Stefania Paolillo, Ugo Corra, Rosa Raimondo, Rocco Lagioia, Pasquale Perrone Filardi, Annamaria Iorio, Michele Senni, Michele Correale, Mariantonietta Cicoira, Enrico Perna, Marco Metra, Marco Guazzi, Giuseppe Limongelli, Gianfranco Sinagra, Gianfranco Parati, Gaia Cattadori, Francesco Bandera, Maurizio Bussotti, Massimo Mapelli, Manlio Cipriani, Alice Bonomi, Goncalo Cunha, Federica Re, Carlo Vignati, Andrea Garascia, Carlo Lombardi, Angela B. Scardovi, Andrea Passantino, Michele Emdin, Claudio Passino, Caterina Santolamazza, Davide Girola, Denise Zaffalon, Dario Vizza, Fabiana De Martino, Piergiuseppe Agostoni
Summary: This study aimed to assess the prognostic impact of moderate hyperkalemia in chronic HFrEF patients and found that it does not influence patients' outcome.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Massimo Mapelli
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Massimo Mapelli, Valentina Mantegazza, Cristina Ferrari, Roberto Cimino, Riccardo Maragna, Gianluca Pontone, Mauro Pepi, Piergiuseppe Agostoni
Summary: This case report presents a dramatic reversal of remodeling and regression of disease in a young woman with HFrEF on hemodialysis treated with sacubitril/valsartan and SGLT2i. After 10 months of follow-up, the patient showed normalization of left ventricular and atrial volumes and improved ejection fraction within the normal range. Cardiac biomarkers and exercise performance also improved simultaneously. The hemodialysis protocol and loop diuretic dose remained unchanged throughout.
Article
Biochemistry & Molecular Biology
Maura Brioschi, Yuri D'Alessandra, Massimo Mapelli, Irene Mattavelli, Elisabetta Salvioni, Sonia Eligini, Alice Mallia, Veronica Ricci, Erica Gianazza, Stefania Ghilardi, Piergiuseppe Agostoni, Cristina Banfi
Summary: Sacubitril/Valsartan, a combination drug for heart failure treatment, reduces the levels of miR-29b-3p, miR-221-3p, and miR-503-5p in the plasma of patients with stable HF. These miRNAs have potential roles in HFrEF pathophysiology.
Editorial Material
Pediatrics
Massimo Mapelli, Paola Zagni
Article
Pharmacology & Pharmacy
Massimo Mapelli, Irene Mattavelli, Stefania Paolillo, Elisabetta Salvioni, Damiano Magri, Arianna Galotta, Fabiana De Martino, Valentina Mantegazza, Carlo Vignati, Immacolata Esposito, Simona Dell'Aversana, Roberta Paolillo, Teresa Capovilla, Gloria Tamborini, Alessandro Alberto Nepitella, Pasquale Perrone Filardi, Piergiuseppe Agostoni
Summary: Our study aimed to evaluate the effects of different doses of sacubitril/valsartan on exercise parameters, echocardiographic changes, and biomarker levels. The results showed that sacubitril/valsartan improved functional capacity, induced left ventricle reverse remodeling, reduced NT-proBNP levels, and improved quality of life.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Piergiuseppe Agostoni, Francesca Romana Pluchinotta, Elisabetta Salvioni, Massimo Mapelli, Arianna Galotta, Alice Bonomi, Damiano Magri, Enrico Perna, Stefania Paolillo, Ugo Corra, Rosa Raimondo, Rocco Lagioia, Roberto Badagliacca, Pasquale Perrone Filardi, Anna Apostolo, Michele Senni, Annamaria Iorio, Michele Correale, Jeness Campodonico, Pietro Palermo, Mariantonietta Cicoira, Marco Metra, Marco Guazzi, Giuseppe Limongelli, Mauro Contini, Beatrice Pezzuto, Gianfranco Sinagra, Gianfranco Parati, Gaia Cattadori, Cosimo Carriere, Marco Cittar, Maria Vittoria Matassini, Andrea Salzano, Antonio Cittadini, Marco Mase, Francesco Bandera, Maurizio Bussotti, Irene Mattavelli, Federica Re, Carlo Vignati, Carlo Lombardi, Angela B. Scardovi, Susanna Sciomer, Andrea Passantino, Michele Emdin, Andrea Di Lenarda, Claudio Passino, Caterina Santolamazza, Federica Moscucci, Denise Zaffalon, Massimo Piepoli, MECKI Score Res Grp
Summary: The study found that heart failure patients with improved ejection fraction have distinct clinical characteristics, biology, and prognosis compared to patients with persistently reduced ejection fraction. Despite having milder symptoms, HFimpEF patients still face risks of adverse outcomes.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Letter
Cardiac & Cardiovascular Systems
Charles Fauvel, Clara Ines Saldarriaga Giraldo, Anders Barassa, Anastasia Shchendrygina, Massimo Mapelli, Nina Jakus, Antoine Jobbe-Duval, Anja Zupan Meznar, Brahim Harbaoui, Emmanuelle Berthelot, Francois Roubille, Giuseppe Rosano, Nathan Mewton
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Jeness Campodonico, Mauro Contini, Marina Alimento, Massimo Mapelli, Elisabetta Salvioni, Irene Mattavelli, Alice Bonomi, Piergiuseppe Agostoni
Summary: The pharmacological treatment of heart failure has become more complex in recent decades due to the availability of new effective drugs. This study aims to evaluate the effects of different drugs on cardiopulmonary function in patients with heart failure, both at rest and during exercise, in order to guide the choice of appropriate treatment protocols for individual patients and promote precision medicine.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Massimo Mapelli, Elisabetta Salvioni, Irene Mattavelli, Paola Gugliandolo, Alice Bonomi, Pietro Palermo, Maddalena Rossi, Davide Stolfo, Finn Gustafsson, Massimo Piepoli, Piergiuseppe Agostoni
Summary: Heart failure patients often experience dyspnea during daily activities that may represent maximal or supramaximal exercises for them. New-generation portable metabolimeters can measure task-related oxygen intake in different scenarios. By studying the metabolic behaviors of heart failure patients and healthy subjects during activities of daily living (ADLs), we can better understand the relationship between metabolic variables and CPET parameters.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Damiano Magri, Giovanna Gallo, Massimo Piepoli, Elisabetta Salvioni, Massimo Mapelli, Carlo Vignati, Emiliano Fiori, Melwyn Luis Muthukkattil, Ugo Corra, Marco Metra, Stefania Paolillo, Antonello Maruotti, Pierfrancesco Alaimo Di Loro, Michele Senni, Rocco Lagioia, Domenico Scrutinio, Michele Emdin, Claudio Passino, Gianfranco Parati, Gianfranco Sinagra, Michele Correale, Roberto Badagliacca, Susanna Sciomer, Andrea Di Lenarda, Piergiuseppe Agostoni, Pasquale Perrone Filardi
Summary: This study found an association between chronotropic incompetence, exercise capacity, and cardiovascular death risk in patients with HFmrEF. Larger prospective studies are needed to determine the potential use of chronotropic incompetence in HFmrEF management.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Elisabetta Salvioni, Alice Bonomi, Damiano Magri, Marco Merlo, Beatrice Pezzuto, Mattia Chiesa, Massimo Mapelli, Nikita Baracchini, Gianfranco Sinagra, Massimo Piepoli, Piergiuseppe Agostoni
Summary: Cardiopulmonary exercise tests (CPET) are crucial for evaluating the functional capacity of chronic heart failure (HF) patients. The MECKI score, developed by a group of Italian centers skilled in HF management and CPET analysis, has been extensively validated and shown to be effective in risk stratification for HF. The MECKI score research group has grown over time and is now investigating other areas such as cardiomyopathy.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Carlo Vignati, Mauro Contini, Elisabetta Salvioni, Carolina Lombardi, Sergio Caravita, Grzegorz Bilo, Erik R. Swenson, Gianfranco Parati, Piergiuseppe Agostoni
Summary: Patients with chronic heart failure may safely spend time at altitudes <3500 m, but may experience decreased exercise capacity proportional to the severity of heart failure and altitude. Specialized 'hypoxic-tailored treatment' is necessary to avoid pharmacological interference with altitude adaptation mechanisms.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Irene Mattavelli, Carlo Vignati, Stefania Farina, Anna Apostolo, Gaia Cattadori, Fabiana De Martino, Beatrice Pezzuto, Denise Zaffalon, Piergiuseppe Agostoni
Summary: Cardiopulmonary exercise test (CPET) is a valuable diagnostic tool in heart failure (HF) due to its strong prognostic value. The peak oxygen uptake (peak VO2) is the most important parameter provided by CPET, indicating the maximum rate of oxygen consumption during physical exertion. However, standard CPET cannot distinguish between impairments in oxygen delivery or extraction, necessitating the use of more complex technologies.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)