4.7 Article

Rotating night shift work and colorectal cancer risk in the nurses' health studies

Journal

INTERNATIONAL JOURNAL OF CANCER
Volume 143, Issue 11, Pages 2709-2717

Publisher

WILEY
DOI: 10.1002/ijc.31655

Keywords

rotating night work; shift work; colorectal cancer; colon cancer; rectum cancer

Categories

Funding

  1. National Institutes of Health [UM1CA186107, UM1CA176726]
  2. Center for Disease Control and Prevention/The National Institute for Occupational Safety and Health [R01OH009803]
  3. NATIONAL CANCER INSTITUTE [UM1CA176726, UM1CA186107] Funding Source: NIH RePORTER
  4. NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH [R01OH009803] Funding Source: NIH RePORTER

Ask authors/readers for more resources

Animal and human data have suggested that shift work involving circadian disruption may be carcinogenic for humans, but epidemiological evidence for colorectal cancer remains limited. We investigated the association of rotating night shift work and colorectal cancer risk in two prospective female cohorts, the Nurses' Health Study (NHS) and NHS2, with 24 years of follow-up. In total, 190,810 women (NHS = 77,439; NHS2 = 113,371) were included in this analysis, and 1,965 incident colorectal cancer cases (NHS = 1,527; NHS2 = 438) were reported during followup (NHS: 1988-2012, NHS2: 1989-2013). We used Cox proportional hazards models adjusted for a wide range of potential confounders. We did not observe an association between rotating night work duration and colorectal cancer risk in these cohorts (NHS: 1-14 years: Hazard Ratio (HR) 1.04, 95% CI: 0.94, 1.16; 15+ years: HR 1.15, 95% CI: 0.95, 1.39; P-trend = 0.14 and NHS2: 1-14 years: HR 0.81, 95% CI: 0.66, 0.99; 15+ years: HR 0.96, 95% CI: 0.56, 1.64 and P-trend = 0.88). In subsite analysis in NHS, rectal cancer risk increased after long-term (15+ years) rotating night shift work (proximal colon cancer: HR 1.00, 95% CI: 0.75, 1.34, P-trend = 0.90; distal colon cancer: HR 1.27, 95% CI: 0.87, 1.85, P-trend = 0.32; rectal cancer: HR 1.60, 95% CI: 1.09, 2.34, P-trend = 0.02). We found no overall evidence of an association between rotating night shift work and colorectal cancer risk in these two large cohorts of nurses. Risk for rectal cancer significantly increased with shift work duration, suggesting that long-term circadian disruption may play a role in rectal cancer development.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available