Article
Oncology
Shih-Min Pai, Kuo-Hung Huang, Ming-Huang Chen, Wen-Liang Fang, Yee Chao, Su-Shun Lo, Anna Fen-Yau Li, Chew-Wun Wu, Yi-Ming Shyr
Summary: The study found that cardia gastric cancer is not an independent prognostic factor. Cardia gastric cancer patients with intestinal-type tumors had more common PIK3CA amplification, while those with diffuse-type tumors had more common HER2 expression. Targeted therapy may be beneficial for these specific patient subgroups.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yan Zheng, Mengyu Xie, Nasha Zhang, Jiandong Liu, Yemei Song, Liqing Zhou, Ming Yang
Summary: The study found that the expression of the miR-1262 gene is significantly decreased in GCA patients, while carriers of the CT or TT alleles of the rs12740674 gene have a lower risk of developing GCA. MiR-1262 can suppress the development of GCA by regulating the oncogene ULK1.
Article
Multidisciplinary Sciences
Xue-Ke Zhao, Pengwei Xing, Xin Song, Miao Zhao, Linxuan Zhao, Yonglong Dang, Ling-Ling Lei, Rui-Hua Xu, Wen-Li Han, Pan-Pan Wang, Miao-Miao Yang, Jing-Feng Hu, Kan Zhong, Fu-You Zhou, Xue-Na Han, Chao-Long Meng, Jia-Jia Ji, Xingqi Chen, Li-Dong Wang
Summary: Frequent focal amplifications and ecDNAs were identified in Chinese GCA patients, with associations to chromothripsis process and dietary habits. The presence of oncogene focal amplifications in GCA patients showed diverse correlations with prognosis, highlighting ERBB2 focal amplifications as a potential prognostic marker in this population.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Rui Hua Xu, Xue Ke Zhao, Xin Song, Ling Ling Lei, Kan Zhong, Wen Li Han, Ran Wang, Qi De Bao, Jing Feng Hu, Meng Xia Wei, Jia Jia Ji, Liu Yu Li, Zong Min Fan, Xue Na Han, Bei Li, Yuan Ze Yang, Lin Sun, Jia Li, Miao Miao Yang, Xing Song Li, Duo You, He Lin Bai, Jia Xin Qiao, Ye Zhen Xie, Fu You Zhou, Xue Min Li, Ai Li Li, Li Dong Wang
Summary: Gender is an independent prognostic factor for patients with gastric cardia adenocarcinoma (GCA). Women have a significantly better outcome than men, regardless of menopausal status. Female patients have longer survival than male patients in different stages.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Merel J. M. van Velzen, Michelle Braemer, Grard A. P. Nieuwenhuijzen, Johanna W. van Sandick, Peter D. Siersema, Jelle P. Ruurda, Marcel Verheij, Manon C. W. Spaander, Laurens V. Beerepoot, Nadia Haj Mohammad, Hanneke W. M. van Laarhoven, Rob H. A. Verhoeven
Summary: This study aimed to analyze the trends in incidence, staging, and treatment of gastric cancer. The results showed a decrease in incidence, more accurate staging, a shift in treatment modalities, and improved patient survival.
Article
Multidisciplinary Sciences
Tianyu Zhu, Zhuoyin Wang, Guojun Wang, Zhihao Hu, Hengxuan Ding, Ruixin Li, Junfeng Sun
Summary: The study found that LncRNA ZFAS1 is up-regulated in gastric cardia adenocarcinoma (GCA) tissues and closely associated with metastasis and cancer recurrence, serving as an independent prognostic indicator for disease-free survival and overall survival in GCA patients. Targeting ZFAS1 and EPAS1 may provide an alternative therapeutic option for GCA.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Nutrition & Dietetics
Shailja C. Shah, Xiangzhu Zhu, Qi Dai, Richard M. Peek, Martha J. Shrubsole
Summary: The study found that higher magnesium intake is independently associated with a lower risk of primary liver cancer, especially among moderate and heavy alcohol users. Robust experimental and mechanistic data support these findings.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Oncology
John D. Murphy, Andrew F. Olshan, Feng-Chang Lin, Melissa A. Troester, Hazel B. Nichols, Julia Butt, You-Lin Qiao, Christian C. Abnet, Manami Inoue, Shoichiro Tsugane, Meira Epplein
Summary: This study developed a predictive model for noncardia gastric adenocarcinoma risk using serum data on pepsinogen, antibody response to 13 H. pylori antigens, demographic, and lifestyle factors. The model showed higher accuracy and sensitivity compared to the ABC Method, and could assist in targeting screening resources to individuals at high risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Andrea Ghezzi, Jessica Rossi, Francesco Cavallieri, Manuela Napoli, Rosario Pascarella, Romana Rizzi, Marco Russo, Gaetano Salomone, Antonio Romano, Corrado Iaccarino, Elisabetta Froio, Silvia Serra, Salvatore Cozzi, Lucia Giaccherini, Franco Valzania, Anna Pisanello
Summary: A rare case of pituitary metastasis from gastric cardia adenocarcinoma is reported in this article. The patient presented with symptoms of diabetes insipidus and visual deterioration. Surgical removal of the pituitary mass revealed adenocarcinoma of uncertain origin. This case highlights the importance of considering pituitary metastasis as a potential cause for diabetes insipidus and visual impairment, especially without evidence of other metastatic sites.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Zhangding Wang, Qiang Wang, Chen Chen, Xiaoya Zhao, Honggang Wang, Lei Xu, Yao Fu, Guang Huang, Mengmeng Li, Jiawen Xu, Qianyi Zhang, Bo Wang, Guifang Xu, Lei Wang, Xiaoping Zou, Shouyu Wang
Summary: This study used single-cell RNA sequencing to explore the cellular and molecular heterogeneity in early gastric cardia adenocarcinoma. The results showed that certain cell populations were predominant during malignant progression, and NNMT-mediated nicotinamide metabolism played a role in tumor initiation and inflammation-induced angiogenesis.
Article
Gastroenterology & Hepatology
Joel H. Rubenstein, Simon Fontaine, Peter W. MacDonald, Jennifer A. Burns, Richard R. Evans, Maria E. Arasim, Joy W. Chang, Elizabeth M. Firsht, Sarah T. Hawley, Sameer D. Saini, Lauren P. Wallner, Ji Zhu, Akbar K. Waljee
Summary: The K-ECAN tool was developed to predict the occurrence of esophageal adenocarcinoma and gastric cardia adenocarcinoma using electronic health records data, and it showed better discrimination than other validated models. However, further validation and implementation in electronic health records are needed.
Article
Gastroenterology & Hepatology
Dan Li, Sheng-Fang Jiang, Nan Ye Lei, Shailja C. Shah, Douglas A. Corley
Summary: This large-scale retrospective cohort study in the United States investigated the incidence of noncardia gastric adenocarcinoma (NCGA) after Helicobacter pylori eradication therapy. The findings showed a significantly reduced risk of NCGA after 8 years of treatment compared to no treatment. This study highlights the potential for substantial gastric cancer prevention through H pylori eradication. Evaluation: 8 out of 10.
Article
Oncology
Jianhua Gu, Shuanghua Xie, Shaoming Wang, Liyan Xue, Jiachen Zhou, Minjuan Li, Zhiyuan Fan, Ru Chen, Daniel R. S. Middleton, Changqing Hao, Jinwu Wang, Bianyun Li, Xinqing Li, Wenqiang Wei
Summary: The study found that the incidence and cancer risk of GCA varied among patients with different histological cardia lesions, increasing monotonically with each step in Correa's cascade. The results suggest a postponed starting age of 50 years for GCA screening, immediate treatment for patients with CHGD, a 3-year surveillance interval for patients with CLGD, and a lengthened surveillance interval of 5 years for patients with AC/CIM.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Qian Xiao, Rena R. Jones, Peter James, Rachael Z. Stolzenberg-Solomon
Summary: Research suggests that circadian disruption caused by light at night (LAN) may increase the risk of pancreatic cancer. The study found that higher LAN exposure was associated with elevated PDAC risk, with stronger associations in normal and overweight groups compared to the obese group.
Article
Oncology
Liting Lv, Xiao Liang, Dan Wu, Feng Wang, Yan Zhang, Hui Cang, Xiongwei Deng, Mei Li
Summary: The study showed that early cardia cancer is more common in males and White individuals, while signet ring cell carcinoma is more common in non-cardia cancer with worse differentiation. Early cardia cancer had a worse prognosis compared to non-cardia cancer and was identified as an independent prognostic factor for poor prognosis.
Article
Oncology
Hamideh Rashidian, Maryam Hadji, Mahin Gholipour, Ahmad Naghibzadeh-Tahami, Maryam Marzban, Elham Mohebbi, Roya Safari-Faramani, Mahdieh Bakhshi, Monireh Sadat Seyyedsalehi, Bayan Hosseini, Reza Alizadeh-Navaei, Habib Emami, Ali Akbar Haghdoost, Abbas Rezaianzadeh, Abdolvahab Moradi, Alireza Ansari-Moghaddam, Azim Nejatizadeh, Soodabeh ShahidSales, Alireza Rezvani, Mohammad Hasan Larizadeh, Farid Najafi, Hossein Poustchi, Mohammad Ali Mohagheghi, Paul Brennan, Elisabete Weiderpass, Joachim Schuz, Eero Pukkala, Neal D. Freedman, Paolo Boffetta, Reza Malekzadeh, Arash Etemadi, Afarin Rahimi-Movaghar, Farin Kamangar, Kazem Zendehdel
Summary: Opium use is strongly associated with an increased risk of lung cancer, particularly small cell carcinoma. Regular opium users have a 3.6-fold higher risk of developing lung cancer compared to non-users, with a dose-response relationship observed. Female opium users have a higher risk than male users. The risk is further increased for individuals who use both opium and tobacco.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Hilary A. Robbins, Karine Alcala, Elham Khodayari Moez, Florence Guida, Sera Thomas, Hana Zahed, Matthew T. Warkentin, Karl Smith-Byrne, Yonathan Brhane, David Muller, Xiaoshuang Feng, Demetrius Albanes, Melinda C. Aldrich, Alan A. Arslan, Julie Bassett, Christine D. Berg, Qiuyin Cai, Chu Chen, Michael P. A. Davies, Brenda Diergaarde, John K. Field, Neal D. Freedman, Wen-Yi Huang, Mikael Johansson, Michael Jones, Woon-Puay Koh, Stephen Lam, Qing Lan, Arnulf Langhammer, Linda M. Liao, Geoffrey Liu, Reza Malekzadeh, Roger L. Milne, Luis M. Montuenga, Thomas Rohan, Howard D. Sesso, Gianluca Severi, Mahdi Sheikh, Rashmi Sinha, Xiao-Ou Shu, Victoria L. Stevens, Martin C. Tammemaegi, Lesley F. Tinker, Kala Visvanathan, Ying Wang, Renwei Wang, Stephanie J. Weinstein, Emily White, David Wilson, Jian-Min Yuan, Xuehong Zhang, Wei Zheng, Christopher I. Amos, Paul Brennan, Mattias Johansson, Rayjean J. Hung
Summary: The INTEGRAL program aims to develop tools for optimizing LDCT lung cancer screening. It includes the Risk Biomarker and Nodule Malignancy projects, which investigate circulating protein markers for identifying individuals likely to benefit from screening and distinguishing benign versus malignant nodules. A total of 1161 and 1078 proteins were measured, and 21 proteins were selected for performance evaluation in the Risk Biomarker and Nodule Malignancy projects.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Mitchell J. Machiela, Wen-Yi Huang, Wendy Wong, Sonja I. Berndt, Joshua Sampson, Jonas De Almeida, Mustapha Abubakar, Jada Hislop, Kai-Ling Chen, Casey Dagnall, Norma Diaz-Mayoral, Mary Ferrell, Michael Furr, Alex Gonzalez, Belynda Hicks, Aubrey K. Hubbard, Amy Hutchinson, Kevin Jiang, Kristine Jones, Jia Liu, Erikka Loftfield, Jennifer Loukissas, Jerome Mabie, Shannon Merkle, Eric Miller, Lori M. Minasian, Ellen Nordgren, Brian Park, Paul Pinsky, Thomas Riley, Lorena Sandoval, Neeraj Saxena, Aurelie Vogt, Jiahui Wang, Craig Williams, Patrick Wright, Meredith Yeager, Bin Zhu, Claire Zhu, Stephen J. Chanock, Montserrat Garcia-Closas, Neal D. Freedman
Summary: The PLCO Cancer Screening Trial is a prospective cohort study that developed the PLCO Atlas Project, a large resource for GWAS. Genotyping was performed on participants with available DNA, and GWAS were conducted using a custom pipeline. The PLCO Atlas GWAS Explorer website, with APIs and SDKs, allows for exploration, visualization, and open data access. It currently hosts association data for 90 traits and >78 million genomic markers, focusing on cancer-related phenotypes. The PLCO Atlas is a FAIR resource for cancer research and genetic epidemiology.
Article
Public, Environmental & Occupational Health
Jihyoun Jeon, Maki Inoue -Choi, Yoonseo Mok, Timothy S. McNeel, Jamie Tam, Neal D. Freedman, Rafael Meza
Summary: The study examines the age-specific mortality rates associated with cigarette smoking among different sociodemographic groups in the U.S. It finds that the impact of smoking on mortality varies significantly by factors such as race/ethnicity, gender, and educational attainment.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Letter
Medicine, General & Internal
Maki Inoue-Choi, Yesenia Ramirez, Neal D. Freedman, Erikka Loftfield
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Oncology
Arash Etemadi, Christian C. Abnet, Sanford M. Dawsey, Neal D. Freedman
Summary: Biomarkers can provide unique information about cancer risk factors by measuring the internal dose of carcinogens. Smoke-related biomarkers, including tobacco-specific biomarkers and those from exposure to tobacco and non-tobacco pollutants, are commonly studied in relation to cancer. Biomonitoring is superior to self-reported exposure assessment and will continue to be essential to cancer research.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Wayne R. Lawrence, Jasmine A. McDonald, Faustine Williams, Meredith S. Shiels, Neal D. Freedman, Ziqiang Lin, Jared W. Magnani
Summary: Chronic stress is hypothesized to be associated with breast cancer, but previous studies have shown mixed results. This study examined the association between self-reported stressful life events and incident breast cancer in postmenopausal women, taking into account estrogen receptor (ER) status and social support. The results showed that there was no relationship between stressful life events and ER-positive breast cancer, but there was an increased risk of ER-negative breast cancer in women with higher levels of stressful life events. This association was stronger in widowed women. Social support did not modify the relationship between stressful life events and ER-negative breast cancer.
CANCER PREVENTION RESEARCH
(2023)
Article
Oncology
Vicky C. C. Chang, Jongeun Rhee, Sonja I. I. Berndt, Steven C. C. Moore, Neal D. D. Freedman, Rena R. R. Jones, Debra T. T. Silverman, Gretchen L. L. Gierach, Jonathan N. N. Hofmann, Mark P. P. Purdue
Summary: In this nested case-control study, prediagnostic serum levels of PFOS and PFOA were found to be associated with breast cancer risk, particularly for hormone receptor-positive tumors, providing evidence of a possible positive association.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Anika T. Haque, Amy Berrington de Gonzalez, Yingxi Chen, Emily A. Haozous, Maki Inoue-Choi, Wayne R. Lawrence, Jennifer K. McGee-Avila, Anna M. Napoles, Eliseo J. Perez-Stable, Kekoa Taparra, Jacqueline B. Vo, Neal D. Freedman, Meredith S. Shiels
Summary: The study estimated cancer death rates among different racial and ethnic groups in the United States from 2018 to 2020. The results found significant disparities in cancer death rates, with the highest rates observed among Black individuals and Native Hawaiian and Pacific Islander (NHPI) individuals. Separating NHPI and Asian individuals revealed large differences in cancer mortality between the two groups that were previously combined in vital statistics data.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Xianhui Ran, Rongshou Zheng, Hongmei Zeng, Siwei Zhang, Kexin Sun, Bingfeng Han, Shaoming Wang, Ru Chen, Li Li, Wenqiang Wei, Jie He
Summary: This study investigated the geographic variability in esophageal cancer-related mortality among Chinese counties and found an association between county-level socioeconomic status and this variation. China has made progress in reducing esophageal cancer-related mortality and disparities, but intercounty differences remain large.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Environmental Sciences
Jongeun Rhee, Erikka Loftfield, Demetrius Albanes, Tracy M. Layne, Rachael Stolzenberg-Solomon, Linda M. Liao, Mary C. Playdon, Sonja I. Berndt, Joshua N. Sampson, Neal D. Freedman, Steven C. Moore, Mark P. Purdue
Summary: This study aimed to investigate the biological effects of PFOS and PFOA on the human body. Through metabolomic analysis, several metabolites associated with PFOS and PFOA were identified, with lipids and xenobiotics being the most common types. These findings provide insights into the potential hazards of PFOS and PFOA.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Oncology
Xianhui Ran, Hongmei Zeng, Rongshou Zheng, Kexin Sun, Bingfeng Han, Shaoming Wang, Ru Chen, Li Li, Wenqiang Wei, Jie He
Summary: This study investigated the geographic and sex disparities in esophageal cancer incidence among various counties in China and found significant differences. The incidence was higher in the north-central region, and males had a 2.9 times higher incidence rate compared to females. County-level socioeconomic status was associated with esophageal cancer incidence. These findings are important for reducing disparities in esophageal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Meeting Abstract
Oncology
Courtney D. Dill, Dontray Trump, Rebecca Landy, Li Cheung, Wen-Yi Huang, Sonja Berndt, Neal Freedman, Hormuzd Katki
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Meeting Abstract
Oncology
Courtney D. Dill, Dontray Trump, Rebecca Landy, Li Cheung, Wen-Yi Huang, Sonja Berndt, Neal Freedman, Hormuzd Katki
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)