Article
Nutrition & Dietetics
Sen Zou, Jiangman Liu, Hongli Si, Duliurui Huang, Di Qi, Xiaoting Pei, Dingli Lu, Shenzhen Huang, Zhijie Li
Summary: This study investigates the effects of diet on the rhythmic transcriptome and metabolism of meibomian glands. The results show that a high-fat diet significantly alters the circadian transcriptome profile and lipid component oscillations in meibomian glands, revealing the high sensitivity of meibomian gland clocks to lipid composition in food.
FRONTIERS IN NUTRITION
(2023)
Article
Veterinary Sciences
Zhaohong Geng, Yuchan Yuan, Dan He, Hewang Lee, Hongyan Wang, Nan Niu, Zhigang Ni, Shopit Abdullah, Zeyao Tang, Peng Qu
Summary: This study found a close relationship between Pdha1 and obesity and revealed possible downstream pathways and target genes involved, laying a good foundation for further research on the function of Pdha1 in the future.
EXPERIMENTAL ANIMALS
(2023)
Article
Genetics & Heredity
Xiangqi Zhong, Jiaze Gu, Siying Zhang, Xiangning Chen, Jingjing Zhang, Jintao Miao, Zhujin Ding, Jianhe Xu, Hanliang Cheng
Summary: In this study, a diet-induced obesity model was developed in zebrafish to investigate the impact of peripheral 5-HT on muscle tissue transcription characteristics. The results demonstrated that peripheral 5-HT affected body weight and gene expression in metabolic pathways related to muscle metabolism in zebrafish.
Article
Pharmacology & Pharmacy
Hua Yang, Ronghua Pan, Jing Wang, Lizhong Zheng, Zhenjing Li, Qingbin Guo, Changlu Wang
Summary: Red yeast rice and pigments can effectively reduce lipid levels in hyperlipidemia model rats, regulate intestinal flora and liver transcriptome, and improve lipid metabolism pathways, demonstrating lipid-lowering effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Wenya Gao, Junyi Zhou, Xinru Gu, Yanyan Zhou, Linna Wang, Nan Si, Xiaorui Fan, Baolin Bian, Hongjie Wang, Haiyu Zhao
Summary: This study systematically revealed the transcriptional regulation mechanism of high-fat diet on Alzheimer's disease mice through whole-transcriptome sequencing and ribosome footprints profiling. The results showed that HFD might affect the occurrence and development of Alzheimer's disease by regulating the expression of miRNAs and genes.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Yao Li, Juan Huang, Silu Zhang, Fan Yang, Haolin Zhou, Yang Song, Bing Wang, Huajun Li
Summary: The study found that sodium alginate (SA) and galactooligosaccharides (GOS) can delay diet-induced obesity, improve lipid profiles, and modulate gut microbial composition to ameliorate obesity and associated metabolic disorders in mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nutrition & Dietetics
Tengda Huang, Lin Yu, Hongyuan Pan, Zeqiang Ma, Tian Wu, Lifang Zhang, Kang Liu, Qi Qi, Weiwei Miao, Ziyi Song, Haojie Zhang, Lei Zhou, Yixing Li
Summary: The study demonstrated that betaine alleviates hepatic lipid metabolic disorders induced by a high-fat diet by up-regulating fatty acid beta oxidation and lipid oxidation processes, reducing liver steatosis. Transcriptome and translatome analysis showed that betaine had a greater impact on NAFLD at the translational level, decreasing translational efficiency for genes related to lipid biosynthesis.
FRONTIERS IN NUTRITION
(2021)
Article
Food Science & Technology
Shishuai Sun, Chunyu Cao, Jibo Li, Qingwei Meng, Baojing Cheng, Baoming Shi, Anshan Shan
Summary: Lycopene plays a vital role in improving immunity, enhancing antioxidant capacity, and regulating fat metabolism. The study found that under a high-fat diet, lycopene can reduce oxidative stress, inflammation, and fat deposition in the placenta, promoting fetal development. Lycopene supplementation decreases levels of IL-17, IL-6, and TNF-alpha, increases expression of Glrx gene and protein, and enhances antioxidant capacity in the placenta.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Cell Biology
Miyeko D. Mana, Amanda M. Hussey, Constantine N. Tzouanas, Shinya Imada, Yesenia Barrera Millan, Dorukhan Bahceci, Dominic R. Saiz, Anna T. Webb, Caroline A. Lewis, Peter Carmeliet, Maria M. Mihaylova, Alex K. Shalek, Omer H. Yilmaz
Summary: Obesity is a known risk factor for cancer in many tissues, and a high-fat diet can promote the regeneration and tumorigenesis of intestinal stem cells. PPAR alpha and PPAR delta contribute to the response to a high-fat diet in ISCs by inducing a downstream fatty acid oxidation metabolic program. Inhibiting the activated FAO program may provide a therapeutic opportunity to counteract the effects of a high-fat diet on ISCs and intestinal tumorigenesis.
Article
Agriculture, Dairy & Animal Science
Xiao-Hui Su, Hai-Ying He, Chao Fang, Ling-Ling Liu, Wu-Jun Liu
Summary: This study identified LncRNAs involved in the regulation of sheep fat deposition through whole transcriptome sequencing of tail tissues from different tail types of sheep populations. The tissue expression profiles and relative expression differences of these LncRNAs were analyzed, and their relationships with target genes were examined. The findings provide insights into the molecular mechanisms of fat tail deposition from a transcriptomic perspective.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Immunology
Yawei Fu, Hu Gao, Xiaohong Hou, Yue Chen, Kang Xu
Summary: The study showed that IPA has preventive effects on DSS-induced colitis in mice, alleviating growth performance decrease and intestinal damage while enhancing immunity. This effect is achieved by regulating inflammatory cytokines, balancing colonic microbiota, and modulating gene expression related to inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Mizuki Honda, Shinya Oki, Ryuichi Kimura, Akihito Harada, Kazumitsu Maehara, Kaori Tanaka, Chikara Meno, Yasuyuki Ohkawa
Summary: This study introduces a transcriptome profiling method utilizing photo-isolation chemistry to analyze gene expression specifically from photo-irradiated regions in mouse embryos, demonstrating its potential in elucidating cell interactions and functions at subcellular resolutions.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Xu Shi, Xiao Wang, Andrew F. Neuwald, Leena Halakivi-Clarke, Robert Clarke, Jianhua Xuan
Summary: BayesDenovo addresses the challenge of de novo transcriptome assembly by accurately reconstructing splicing graphs using a read-guided and Bayesian strategy, achieving higher accuracy and reducing false positives, especially for alternatively spliced genes and highly/lowly expressed transcripts. Additionally, it is more robust on multiple replicates and can identify phenotype-specific transcripts associated with breast cancer recurrence.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Chunyan Yang, Zhixiu Wang, Qianqian Song, Bingqiang Dong, Yulin Bi, Hao Bai, Yong Jiang, Guobin Chang, Guohong Chen
Summary: This study identified genes and lncRNAs affecting abdominal fat deposition in ducks through RNA sequencing, revealing their important roles in fat synthesis, metabolism, and cell differentiation processes.
Article
Multidisciplinary Sciences
August Guang, Mark Howison, Felipe Zapata, Charles Lawrence, Casey W. Dunn
Summary: treeinform is a method that utilizes phylogenetic information across species to improve transcriptome assemblies within species. It helps identify and correct the error of mistaking different transcripts of the same gene as transcripts from multiple closely related genes.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)