Article
Food Science & Technology
Ziying Yang, Yajie Hu, Panpan Yue, Rui Tian, Huiling Li, Baozhong Lu, Gegu Chen, Feng Peng
Summary: In this study, amorphous selenium nanoparticles were prepared by decorating them with lichenan, and their potential anticancer efficacy was demonstrated through ROS-triggered selenium release.
Article
Biochemistry & Molecular Biology
Liuming Xie, Zhibing Huang, Hui Meng, Zhibing Fan, Xiaoyi Shi, Jianhua Xie
Summary: The addition of genistein during fermentation increased the yield of EPS produced by M. purpureus and improved its physicochemical properties, as well as enhanced its immunomodulatory activity. The genistein-treated M. purpureus EPS stimulated higher levels of nitric oxide and cytokine secretion in RAW264.7 macrophages, indicating its potential for improving the EPS yield of M. purpureus.
Article
Oncology
Wei Shi, Mackenzie Fijardo, Jeff P. Bruce, Jie Su, Wei Xu, Rachel Bell, Pierre-Antoine Bissey, Angela B. Y. Hui, John Waldron, Trevor J. Pugh, Kenneth W. Yip, Fei-Fei Liu
Summary: This study reveals the prognostic significance of CD8+ tumor-infiltrating lymphocytes (TILs) in naso-pharyngeal cancer (NPC) and suggests the potential of utilizing CD8+ lymphocytes for immunotherapy.
CLINICAL CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Aleksander Roszczyk, Jadwiga Turlo, Radoslaw Zagozdzon, Beata Kaleta
Summary: Shiitake mushroom, also known as Lentinula edodes, is a popular edible fungus that contains valuable polysaccharides with anticancer, antioxidant, antimicrobial, and immunomodulatory properties. The biological activity of these polysaccharides depends on the extraction method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jiawei Lv, Yuan Wei, Jian-Hua Yin, Yu-Pei Chen, Guan-Qun Zhou, Chen Wei, Xiao-Yu Liang, Yuan Zhang, Cui-Juan Zhang, Shi-Wei He, Qing-Mei He, Zhuo-Li Huang, Jia-Li Guan, Jia-Yi Shen, Xiao-Min Li, Jun-Yan Li, Wen-Fei Li, Ling-Long Tang, Yan-Ping Mao, Rui Guo, Rui Sun, Yu-Hui Zheng, Wen-Wen Zhou, Ke-Xu Xiong, Si-Qi Wang, Xin Jin, Na Liu, Gui-Bo Li, Dong-Ming Kuang, Ying Sun, Jun Ma
Summary: By using single-cell RNA sequencing and T cell and B cell receptor sequencing, this study reveals that Gemcitabine plus cisplatin (GP) chemotherapy activates an innate-like B cell (ILB)-dominant antitumor immune response, which enhances cytotoxic T cells and improves the treatment outcome for patients with nasopharyngeal carcinoma (NPC). ILB frequency serves as a potential biomarker for predicting favorable outcomes in patients receiving GP-based treatment and immunotherapy combined treatment.
Article
Immunology
Han-cheng Wu, Qi-rui Hu, Ting Luo, Wen-cheng Wei, Hui-juan Wu, Jing Li, Liu-feng Zheng, Qun-ying Xu, Ze-yuan Deng, Fang Chen
Summary: The study showed that Rh2-O enhanced the activity of splenic lymphocytes in H22 tumor-bearing mice, with the partial involvement of Tlr4, thus exerting immunomodulatory effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Genoveffa Nuzzo, Giuseppina Senese, Carmela Gallo, Federica Albiani, Lucia Romano, Giuliana d'Ippolito, Emiliano Manzo, Angelo Fontana
Summary: Cancer, one of the leading causes of death globally, can be combated through the use of anticancer drugs and cancer immunotherapy. Natural products, with their diverse structures and pharmacological potential, have shown promise in the development of modern anticancer drugs. These natural products not only possess antitumor properties but also exhibit immunomodulatory activity, making them suitable for use alone or in combination with conventional cancer therapies.
Article
Biochemistry & Molecular Biology
Di Wu, Xuemei Yuan, Ruijie Zhou, Wanchao Chen, Wen Li, Zhengpeng Li, Xueyin Li, Rui Zhu, Hualin Wang, Yan Yang
Summary: An aqueous extract of Sanghuangporus baumii (SHWE) was found to inhibit cervical cancer growth by inducing autophagy in tumors and disturbing glucose metabolism. Additionally, SHWE administration also modulated the gut microbiota by promoting the proliferation of the probiotic Akkermansia, leading to the inhibition of cervical carcinoma development.
Article
Biochemistry & Molecular Biology
Haitao Fan, Meng Sun, Jie Li, Shuofeng Zhang, Guangzhong Tu, Kechun Liu, Qing Xia, Yanyan Jiang, Bin Liu
Summary: A new polysaccharide, named SP800201, was isolated from Saposhnikoviae Radix. The polysaccharide consisted of monosaccharides including Gal, GalA, Ara, and Rha. Both cell and zebrafish experiments demonstrated the immunomodulatory activity of SP800201.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Shasha Yu, Xiaodan Dong, Haiyu Ji, Juan Yu, Anjun Liu
Summary: The polysaccharide PTP from Polygala tenuifolia Willd. was found to induce apoptosis in human lung cancer cells through the FAS/FAS-L pathway. Furthermore, PTP demonstrated antitumor activity and immunoregulation for S180 sarcoma cells in vitro and in vivo experiments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Mengran Guo, Xing Duan, Xingchen Peng, Zhaohui Jin, Hai Huang, Wen Xiao, Qian Zheng, Yongqi Deng, Na Fan, Kepan Chen, Xiangrong Song
Summary: In this study, a lipid-based LMP2-mRNA vaccine was developed and shown to effectively express LMP2 and stimulate antigen-specific T-cell responses in cell assays. It significantly inhibited tumor growth in an LMP2-expressing tumor model after three doses of vaccination.
Article
Biochemistry & Molecular Biology
Hai-Qiang Mai, Qiu-Yan Chen, Dongping Chen, Chaosu Hu, Kunyu Yang, Jiyu Wen, Jingao Li, Ying-Rui Shi, Feng Jin, Ruilian Xu, Jianji Pan, Shenhong Qu, Ping Li, Chunhong Hu, Yi-Chun Liu, Yi Jiang, Xia He, Hung-Ming Wang, Wan-Teck Lim, Wangjun Liao, Xiaohui He, Xiaozhong Chen, Zhigang Liu, Xianglin Yuan, Qi Li, Xiaoyan Lin, Shanghua Jing, Yanju Chen, Yin Lu, Ching-Yun Hsieh, Muh-Hwa Yang, Chia-Jui Yen, Jens Samol, Hui Feng, Sheng Yao, Patricia Keegan, Rui-Hua Xu
Summary: The study is a double-blind phase 3 trial that shows the combination of toripalimab with GP chemotherapy for RM-NPC patients provides a superior PFS compared to GP alone. Most adverse events were similar between the two arms, but immune-related AEs were more frequent in the toripalimab arm.
Article
Immunology
Rui Sang, Fuliang Sun, Hongyuan Zhou, Meng Wang, Haitao Li, Chunting Li, Xinhui Sun, Xin Zhao, Xuemei Zhang
Summary: This study found that Inonotus obliquus polysaccharide can inhibit the excessive inflammatory response caused by T. gondii infection by modulating NF-kappa B, p38, and JNK signaling pathways.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Food Science & Technology
Jiankuan Li, Yan Wang, Jiaojiao Ji, Lingya Cao, Yune Bai, Jianping Gao
Summary: The research identified a glucan named CPC from the roots of Codonopsis pilosula, with a structure of 1,4-linked alpha-D-glucose backbone and 1,6-linked beta-D-glucose branched chains. Additionally, CPC exhibited significant induction on immune-related indicators, indicating its potential benefits for regulating human immune health.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Chemistry, Applied
Zhijun Xiao, Changyang Yan, Chunxue Jia, Ying Li, Yuanlin Li, Jie Li, Xinxin Yang, Xueyan Zhan, Changhua Ma
Summary: This study aims to extract and purify an active heteropolysaccharide called Chia seed polysaccharide (CSP-A), characterize its structure, and evaluate its antioxidant and immunomodulatory activities. The results showed that CSP-A had moderate antioxidant activity and immune regulation effect. This study provides scientific basis for further utilization and development of Chia seeds as a functional food.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)