4.7 Article

Carboxymethyl cellulose-rosin gum hybrid nanoparticles: An efficient drug carrier

Journal

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 112, Issue -, Pages 390-398

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.01.184

Keywords

Carboxymethyl cellulose; Gum rosin; 5-Aminosalicylic acid

Funding

  1. University Grants Commission India Under Junior Research Fellowship (NET-UGC-JRF) Scheme [2121510345]
  2. Department of Science and Technology, New Delhi, India [SB/FT/CS-119/2012]

Ask authors/readers for more resources

Adequate release of 5-ASA in colon is challenging as it easily permeates at the acidic pH of the upper gastrointestinal tract. Targeting delayed release of 5-ASA at acidic pH, Carboxymethyl cellulose-rosin gum hybrid nanopartides (CRNP3) with an average size of 267 nm have been crafted through nanoprecipitation method. CRNP3 was extensively characterized using Fourier Transform Spectroscopy (FFIR), X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and particle size analysis based on dynamic light scattering. Colon specific targeted in vitro release of 5 Aminosalicylic acid from CRNPs was monitored in simulated gastric (SGF) and intestinal (SIF) fluids. The release rate was very slow in first 2 h in SGF, while in SIF, it was greater and 72% drug was released in a controlled manner during the time span of 12 h in contrast to native carboxymethyl cellulose or rosin gum for which 100% release was accomplished within 5 h or 8 h respectively. The delayed release from CRNPs is attractive for enhancing the bioavailability of drug in colon. The drug release followed zero-order kinetics and non-Fickian diffusion mechanism. (C) 2018 Elsevier B.V. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Biochemistry & Molecular Biology

Grafting of vinyl acetate-ethylacrylate binary monomer mixture onto guar gum

Vandana Singh, Angela Singh, Sneha Joshi, Tulika Malviya

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2016)

Review Polymer Science

Polysaccharide-Silica Hybrids: Design and Applications

Vandana Singh, Preeti Srivastava, Angela Singh, Devendra Singh, Tulika Malviya

POLYMER REVIEWS (2016)

Article Chemistry, Multidisciplinary

Gum acacia-CuNp-silica hybrid: an effective, stable and recyclable catalyst for reduction of nitroarenes

V. Singh, A. K. Pandey, Preeti, J. Singh, T. Malviya

RSC ADVANCES (2016)

Article Biochemistry & Molecular Biology

Synthesis of Aloevera/Acrylonitrile based Nanoparticles for targeted drug delivery of 5-Aminosalicylic acid

Tulika Malviya, Sneha Joshi, Lalit Mohan Dwivedi, Kirti Baranwal, Shehala, Arvind Kumar Pandey, Vandana Singh

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Article Chemistry, Applied

An Escherichia coli antimicrobial effect of arabinoglucomannan from fruit of Bryonia lacinosa

Vandana Singh, Tulika Malviya, Devendra Narayan Tripathi, Upma Naraian

CARBOHYDRATE POLYMERS (2009)

Article Polymer Science

Persulfate/Ascorbic Acid Initiated Synthesis of Poly(acrylonitrile)-Grafted Tamarind Seed Gum: A Potential Commercial Gum

Vandana Singh, Devendra Narayan Tripathi, Tulika Malviya, Rashmi Sanghi

JOURNAL OF APPLIED POLYMER SCIENCE (2009)

Article Biochemistry & Molecular Biology

Efficient sensing of saccharin through interference synthesis of gum ghatti capped silver nanoparticles

Shehala, Kirti Baranwal, Tulika Malviya, Lalit Mohan Dwivedi, Mani Prabha, Vandana Singh

Summary: The presence of saccharin (SH) was efficiently detected through the interference synthesis of gum ghatti (GG) capped silver nanoparticles (GGAgNps), with the detection further enhanced by combo capping with chitosan (Ch). The method successfully detected SH in commercially available real juice samples.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Chemistry, Multidisciplinary

Simple nanoprecipitation method for size-restricted synthesis of aloevera nanoparticles: Characteristic analysis and its application as an adsorbent

Tulika Malviya, Praveen Kumar Tandon, Mahesh Kumar Gupta, Vandana Singh, Devendra Narayan Tripathi

Summary: The Nanoprecipitation method is effective in synthesizing size-restricted Aloevera nanoparticles in a simple and single step. The amount of ethanol used plays a significant role in determining the shape and size of the nanoparticles. The synthesis of the nanoparticles has been confirmed through various tests, and their potential as adsorbents for wastewater treatment has been discovered.

JOURNAL OF THE INDIAN CHEMICAL SOCIETY (2022)

Article Chemistry, Multidisciplinary

Carboxymethyl cellulose-NiO nanoparticles as peroxidase mimic for sensitive colorimetric detection of hydrogen peroxide

Shehala, Kirti Baranwal, Mani Prabha, Tulika Malviya, Anand Gaurav, Vandana Singh

Summary: A simple co-precipitation method was used to prepare an excellent peroxidase-like material, which exhibited excellent sensitivity and selectivity in the oxidation reaction of H2O2.

CHEMICAL PAPERS (2022)

Article Chemistry, Multidisciplinary

Montmorillonite based copper oxide nanoparticles for the efficient remediation of phosphate and anti-bacterial activity against gram-negative bacteria

Mahesh Kumar Gupta, Praveen Kumar Tandon, Vijay Pandey, Mubashra Afroz, Tulika Malviya

Summary: This study successfully prepared a montmorillonite-based nanocomposite that efficiently removes phosphate ions from water and also exhibits antibacterial potential. The adsorption kinetics followed a pseudo-second-order model, and the adsorption isotherms fit well with the Langmuir isotherm, indicating chemical adsorption. These findings suggest that the MMT-CuONC nanocomposite has promising applications as an adsorbent for phosphate removal in wastewater.

SEPARATION SCIENCE AND TECHNOLOGY (2023)

Article Chemistry, Applied

A non-ionic glucomannan from the seeds of an indigenous medicinal plant:: Bryonia lacinosa

V Singh, T Malviya

CARBOHYDRATE POLYMERS (2006)

Article Chemistry, Organic

Microwave promoted methylation of plant polysaccharides

V Singh, A Tiwari, DN Tripathi, T Malviya

TETRAHEDRON LETTERS (2003)

Article Biochemistry & Molecular Biology

Effects of aging and diabetes on the deformation mechanisms and molecular structural characteristics of collagen fibrils under daily activity

Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang

Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Tea polyphenols protect against Flavobacterium columnare-induced gill injury via suppression of oxidative stress, inflammation, and apoptosis in grass carp

Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng

Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Neddylation-dependent LSD1 destabilization inhibits the stemness and chemoresistance of gastric cancer

Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng

Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Review Biochemistry & Molecular Biology

Cellular and physiological roles of sigma factors in Vibrio spp.: A comprehensive review

Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim

Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

An eco-friendly composite hydrogel based on covalently crosslinked cellulose/poly (glycerol citrate) for thallium (І) removal from aqueous solutions

Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati

Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Enzyme-triggered approach to reduce water bodies' contamination using peroxidase-immobilized ZnO/SnO2/alginate nanocomposite

Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal

Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Bacterial cellulose microfiber reinforced hollow chitosan beads decorated with cross-linked melamine plates for the removal of the Congo red

Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri

Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Necrotic activity of ExhC from Mammaliicoccus sciuri is mediated by specific amino acid residues

Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti

Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Silk-hydrogel functionalized with human decellularized Wharton's jelly extracellular matrix as a minimally invasive injectable hydrogel system for potential nucleus pulposus tissue replacement therapy

Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal

Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

A uniform-unsaturated crosslinking strategy to construct injectable alginate hydrogel

Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma

Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

α-Tocopherol-loaded multi-layer nanoemulsion using chitosan, and dextran sulfate: Cellular uptake, antioxidant activity, and in vitro bioaccessibility

Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee

Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Stabilization of oil-in-water high internal phase emulsions with octenyl succinic acid starch and beeswax oleogel

Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao

Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Review Biochemistry & Molecular Biology

A review for the correlation between optic atrophy 1-dependent mitochondrial fusion and cardiovascular disorders

Bi-Feng Yao, Xiu-Ju Luo, Jun Peng

Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Review Biochemistry & Molecular Biology

Nanomaterials for detection of biomolecules and delivering therapeutic agents in theragnosis: A review

Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park

Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Article Biochemistry & Molecular Biology

Preparation and characterization of hemicellulose films reinforced with amino polyhedral oligomeric silsesquioxane for biodegradable packaging

Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan

Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)