Article
Multidisciplinary Sciences
Mohamad Malik Al-adil Baharudin, Mohamad Syazwan Ngalimat, Fairolniza Mohd Shariff, Zetty Norhana Balia Yusof, Murni Karim, Syarul Nataqain Baharum, Suriana Sabri
Summary: This study identified five strains of Bacillus velezensis that exhibited broad inhibitory activities against Gram-negative, Gram-positive, and MRSA strains, with PD9 strain showing the largest inhibitory zone. The antimicrobial peptide produced by the PD9 strain showed bactericidal activity and stability under various conditions.
Article
Microbiology
Sylvia Ighem Chi, Sandra Ramirez-Arcos
Summary: Biofilm formation and slow growth of Staphylococcus aureus in platelet concentrates lead to missed detection and an increased risk of sepsis. Comparative RNAseq analyses and CRISPR mutagenesis of SE genes reveal that SEs play a role in biofilm development by providing a scaffold, mediating aggregation, and ensuring survival. The study uncovers new roles for SEs and explains the failed detection of S. aureus in platelet concentrates by automated culture systems.
Article
Agriculture, Dairy & Animal Science
Zhu Qiao, Jiaxin Chen, Qiaqia Zhou, Xin Wang, Yuanyuan Shan, Yanglei Yi, Bianfang Liu, Yuan Zhou, Xin Lu
Summary: Bacteriocin BM173 was successfully expressed and purified, showing broad-spectrum antibacterial activity, high thermal and pH stability, as well as efficacy in disrupting cell membrane integrity and inhibiting biofilm formation. These findings suggest that BM173 has promising potential as a preservative in the dairy industry.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Microbiology
Shakilur Rahman, Amit Kumar Das
Summary: Staphylococcus aureus is a highly infectious pathogen that forms biofilms, reducing susceptibility to antibiotics and immune defenses. A study has identified a novel function of staphylococcal superantigen-like protein 10 (SSL10) in enhancing biofilm formation, through amyloid aggregation.
Review
Microbiology
Hala O. Eltwisy, Howida Omar Twisy, Mahmoud Hr Hafez, Ibrahim M. Sayed, Mohamed A. El-Mokhtar
Summary: Staphylococcus haemolyticus is a common microbe on human skin and an emerging microbe causing nosocomial infections. It is resistant to antibiotics and can transfer resistance genes to other Staphylococcus species. Severe infections, especially in immunocompromised patients, are associated with S. haemolyticus. It forms biofilms and secretes factors for bacterial invasion.
Article
Infectious Diseases
Mariana Andrade, Ketlyn Oliveira, Catarina Morais, Patricia Abrantes, Constanca Pomba, Adriana E. Rosato, Isabel Couto, Sofia Santos Costa
Summary: This study reveals the frequent biofilm production by antimicrobial-resistant coagulase-positive staphylococci in companion animals, which is associated with a higher virulence potential and persistent or recurrent infections.
Article
Food Science & Technology
Ji Hyeon Kim, Hyunwoo Ahn, Daehyeop Lee, Hyunjun Lee, Wang June Kim
Summary: This study investigated the potential of the JM01 bacteriocin produced by Pediococcus acidilactici JM01 as an effective antibiofilm agent for MRSA. Results showed that JM01 bacteriocin significantly reduced MRSA biofilm formation by inhibiting its growth and adhesion. Therefore, JM01 bacteriocin could be a potential candidate for regulating biofilm formation by MRSA.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Microbiology
Runa Wolden, Kirill V. Ovchinnikov, Hermoine J. Venter, Thomas F. Oftedal, Dzung B. Diep, Jorunn Pauline Cavanagh
Summary: Staphylococcus haemolyticus is an increasingly relevant nosocomial pathogen. Researchers have discovered a new bacteriocin called romsacin, which is effective against a wide range of Gram-positive bacteria, including antibiotic-resistant strains.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Margarita Trobos, Rininta Firdaus, Karin Svensson Malchau, Jonatan Tillander, Dimitrios Arnellos, Ola Rolfson, Peter Thomsen, Inigo Lasah
Summary: This study investigates the presence and frequency of specific genetic variants and virulence factors in staphylococcal bacteria causing periprosthetic joint infection (PJI) of the hip and knee, and evaluates their clinical relevance as predictors of treatment failure. The study characterizes the genetic virulence traits of a large collection of clinical staphylococci isolated from PJI patients and assesses their association with the patient's infection outcome. The results show that S. aureus strains producing strong biofilms and S. epidermidis strains with resistance to several antibiotics are significantly associated with unresolved infection. Specific genetic variants associated with biofilm formation and multidrug resistance are considered important risk factors for the diagnosis and treatment guidance in PJI.
MICROBIOLOGY SPECTRUM
(2022)
Article
Multidisciplinary Sciences
Walter Dehority, Valerie J. Morley, Daryl B. Domman, Seth M. Daly, Kathleen D. Triplett, Kylie Disch, Rebekkah Varjabedian, Aimee Yousey, Parisa Mortaji, Deirdre Hill, Olufunmilola Oyebamiji, Yan Guo, Kurt Schwalm, Pamela R. Hall, Darrell Dinwiddie, Jon Femling
Summary: Pediatric osteoarticular infections caused by Staphylococcus aureus are genetically heterogeneous, with a higher prevalence of genes involved in immune evasion. However, overall virulence gene carriage is similar with infrequent mutations, suggesting that pathogenesis of these infections may be primarily regulated at transcriptional and/or translational levels.
Review
Pharmacology & Pharmacy
Nikki N. Tran, Taylor Morrisette, Sarah C. J. Jorgensen, Jose M. Orench-Benvenutti, Razieh Kebriaei
Summary: Staphylococcus aureus is a significant cause of healthcare-associated and community-acquired infections, especially when associated with medical devices and in biofilm form. Biofilm structure allows for the enrichment of resistant and persistent phenotypes, leading to relapse and recurrence of infection. Minimal diffusion of antibiotics within biofilms leads to heterogeneity and distinct physiological activity. Horizontal gene transfer between cells in proximity adds to the challenges of eradicating biofilms. This review focuses on biofilm-associated infections caused by S. aureus, the impact of environmental conditions on biofilm formation, interactions within biofilm communities, and the clinical challenges they pose. Potential solutions, novel treatment strategies, combination therapies, and reported alternatives are also discussed.
Article
Microbiology
Veronica Folliero, Federica Dell'Annunziata, Biagio Santella, Emanuela Roscetto, Carla Zannella, Nicoletta Capuano, Alessandro Perrella, Anna De Filippis, Giovanni Boccia, Maria Rosaria Catania, Massimiliano Galdiero, Gianluigi Franci
Summary: The emergence of multidrug-resistant strains requires the urgent discovery of new antibacterial drugs. In this study, the anthelmintic avermectins were screened for antibacterial activity against gram-positive and gram-negative strains. Selamectin, a subset of avermectins, showed potent antibacterial activity against gram-positive strains, particularly Staphylococcus aureus. Further studies demonstrated its ability to inhibit bacterial growth, alter cell surface, and reduce biofilm biomass. Synergistic effects were also observed with other antibiotics. These findings suggest that selamectin may be a promising candidate for the treatment of S. aureus infections.
Review
Infectious Diseases
Narayan Pant, Damon P. Eisen
Summary: Staphylococcus aureus biofilms play a significant role in chronic infections by protecting bacteria from antimicrobials and the immune system. The complexity of biofilm biology, particularly in S. aureus, highlights the need for novel treatment approaches targeting vulnerable genetic and biochemical processes. Successful treatment strategies in animal models provide potential insights for the prevention and eradication of biofilm-related S. aureus infections.
Article
Microbiology
Khulood Fahad Alabbosh, Tarek Zmantar, Abdulrahman S. Bazaid, Mejdi Snoussi, Emira Noumi
Summary: This study investigated the adhesive properties and antibiotic resistance of clinical S. aureus isolated from Hail Hospital Province, Kingdom of Saudi Arabia using molecular approaches. The findings suggest that antibiotic resistance and adhesion play important roles in the pathogenesis of clinical S. aureus isolates.
Review
Infectious Diseases
Victoria Heath, Elaine Cloutman-Green, Samuel Watkin, Magdalena Karlikowska, Derren Ready, James Hatcher, Nicola Pearce-Smith, Colin Brown, Alicia Demirjian
Summary: A national incident team was formed in June 2021 to address the increased detection of Staphylococcus capitis in hospitalized infants. The team conducted a literature review and found that S. capitis outbreaks have often been associated with the NRCS-A clone and environmental sources. The clone exhibits multidrug resistance and poses challenges in outbreak management.
Article
Food Science & Technology
Patricia Carlin Fagundes, Felipe Miceli de Farias, Olinda Cabral da Silva Santos, Juliana Aparecida Souza da Paz, Hilana Ceotto-Vigoder, Daniela Sales Alviano, Maria Teresa Villela Romanos, Maria do Carmo de Freire Bastos
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2016)
Article
Biotechnology & Applied Microbiology
H. Ceotto-Vigoder, S. L. S. Marques, I. N. S. Santos, M. D. B. Alves, E. S. Barrias, A. Potter, D. S. Alviano, M. C. F. Bastos
JOURNAL OF APPLIED MICROBIOLOGY
(2016)
Article
Biotechnology & Applied Microbiology
P. C. Fagundes, F. M. Farias, O. C. S. Santos, N. E. M. de Oliveira, J. A. S. da Paz, H. Ceotto-Vigoder, D. S. Alviano, M. T. V. Romanos, M. C. F. Bastos
JOURNAL OF APPLIED MICROBIOLOGY
(2016)
Article
Food Science & Technology
Andreza Freitas de Souza Duarte, Hilana Ceotto, Marcus Livio Varella Coelho, Maria Aparecida Vasconcelos de Paiva Brito, Maria do Carmo de Freire Bastos
Article
Food Science & Technology
Hilana Ceotto, Dag Brede, Zhian Salehian, Janaina dos Santos Nascimento, Patricia Carlin Fagundes, Ingolf F. Nes, Maria do Carmo de Freire Bastos
FOODBORNE PATHOGENS AND DISEASE
(2010)
Article
Microbiology
Janaina dos Santos Nascimento, Marcus Livio Varella Coelho, Hilana Ceotto, Amina Potter, Luana Rocha Fleming, Zhian Salehian, Ingolf F. Nes, Maria do Carmo de Freire Bastos
JOURNAL OF BACTERIOLOGY
(2012)
Article
Microbiology
E. M. Barros, H. Ceotto, M. C. F. Bastos, K. R. N. dos Santos, M. Giambiagi-deMarval
JOURNAL OF CLINICAL MICROBIOLOGY
(2012)
Article
Microbiology
Amina Potter, Hilana Ceotto, Marcia Giambiagi-deMarval, Katia Regina Netto dos Santos, Ingolf F. Nes, Maria do Carmo de Freire Bastos
JOURNAL OF MICROBIOLOGY
(2009)
Article
Biotechnology & Applied Microbiology
Bruna Goncalves Coutinho, Marcus Livio Varella Coelho, Hilana Ceotto, Maria do Carmo de Freire Bastos
JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY
(2011)
Article
Biotechnology & Applied Microbiology
H. Ceotto, R. C. da Silva Dias, J. dos Santos Nascimento, M. A. V. de Paiva Brito, M. Giambiagi-deMarval, M. do Carmo de Freire Bastos
LETTERS IN APPLIED MICROBIOLOGY
(2012)
Article
Microbiology
Amina Potter, Hilana Ceotto, Marcus Livio Varella Coelho, Allan J. Guimaraes, Maria do Carmo de Freire Bastos
Article
Microbiology
Patricia Carlin Fagundes, Hilana Ceotto, Amina Potter, Maria Aparecida Vasconcelos de Paiva Brito, Dag Brede, Ingolf F. Nes, Maria do Carmo de Freire Bastos
RESEARCH IN MICROBIOLOGY
(2011)
Article
Microbiology
Hilana Ceotto, Helge Holo, Karlla Fernanda Silva da Costa, Janaina dos Santos Nascimento, Zhian Salehian, Ingolf F. Nes, Maria do Carmo de Freire Bastos
VETERINARY MICROBIOLOGY
(2010)
Review
Food Science & Technology
Victoria Gabrielle Pires Martins, Janaina Dos Santos Nascimento, Flavia Myllena Da Silva Martins, Hilana Ceotto Vigoder
Summary: Infections caused by Vibrio bacteria, particularly from contaminated water and raw seafood consumption, are often underreported. Vibrio cholerae, Vibrio parahaemolyticus, and Vibrio vulnificus are the main pathogenic species for humans, causing a range of illnesses from gastroenteritis to sepsis. The presence of these bacteria in marine foods, especially raw fish and shellfish, is an important risk factor for human health. However, the new legislation in Brazil no longer requires the investigation of V. parahaemolyticus in ready-to-eat food based on raw fish. Therefore, it is crucial to implement preventive measures and monitor the microbiological quality of water and marine foods, including research on Vibrio bacteria.
FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)