Journal
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
Volume 34, Issue 6, Pages -Publisher
WILEY
DOI: 10.1002/cnm.2975
Keywords
baroreflex; hemodynamics; hemorrhage; hypertension
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Funding
- U.S. Army Medical Research Acquisition Activity [W81XWH-15-1-0147]
- U.S. Office of Naval Research [N00014-13-C-0357]
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A computational tool is developed for simulating the dynamic response of the human cardiovascular system to various stressors and injuries. The tool couples 0-dimensional models of the heart, pulmonary vasculature, and peripheral vasculature to 1-dimensional models of the major systemic arteries. To simulate autonomic response, this multiscale circulatory model is integrated with a feedback model of the baroreflex, allowing control of heart rate, cardiac contractility, and peripheral impedance. The performance of the tool is demonstrated in 2 scenarios: neurogenic hypertension by sustained stimulation of the sympathetic nervous system and an acute 10%hemorrhage from the left femoral artery.
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