Article
Immunology
Felix Kohle, Robin Ackfeld, Franziska Hommen, Ines Klein, Martin K. R. Svacina, Christian Schneider, Gereon R. R. Fink, Mohammed Barham, David Vilchez, Helmar C. C. Lehmann
Summary: This study evaluated the neuro-regenerative effects of the small molecule kinesin-5 inhibitor monastrol in a rodent model of acute autoimmune neuropathies. The results showed that treatment with monastrol improved the functional and histological recovery of neuropathies and promoted the regeneration of nerve terminals, possibly through accelerated motor neurite outgrowth.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Immunology
Takafumi Uchi, Shingo Konno, Hideo Kihara, Toshiki Fujioka
Summary: The S1PR1 agonist siponimod may alleviate the severity of symptoms in an animal model of autoimmune peripheral neuropathy, reducing the expression of interferon-gamma and IL-10 in lymph nodes and cauda equina. Siponimod also reduces demyelinating lesions and inflammatory cell invasion. Shh, Gdnf, and C-Jun play significant roles in the recovery of injured nerves.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Pharmacology & Pharmacy
Ehsan Elahi, Mohamed Ehab Ali, Julian Zimmermann, Daniel R. Getts, Marcus Mueller, Alf Lamprecht
Summary: This study found that cargo-free nanoparticles (NPs) prepared from poly-lactic co-glycolic acid (PLGA) can significantly alleviate the clinical symptoms of experimental autoimmune neuritis (EAN), reduce the trafficking of inflammatory cells, and divert them towards the spleen. Therapeutic treatment with NPs also reduced the expression of proinflammatory markers and elevated the expression levels of anti-inflammatory markers.
Review
Immunology
Pamela A. A. McCombe, Todd A. A. Hardy, Robert J. J. Nona, Judith M. M. Greer
Summary: Guillain Barre syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are immune mediated neuropathies that are more common in males. There are reported sex differences in immune system elements, which may contribute to the male predominance of these diseases and warrant further study in peripheral nerves.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Li-Juan Wang, Jie Zhu, Xiu-Juan Wu, Ting Li, Chun-Jiao Yang, Xi-Xiong Kang, Hong-Liang Zhang, Guo-Jun Zhang
Summary: This study aimed to observe the effect of Toll-like receptor 4 (TLR4) deficiency on clinical severity and expression of Th1/Th2/Th17-associated cytokines in experimental autoimmune neuritis (EAN). It was found that TLR4 deficiency could attenuate the clinical severity and delay the onset of EAN. Additionally, the production of IL-17A was significantly lower in the TLR4 KO mice with EAN compared to their WT counterparts.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Clinical Neurology
Chunrong Li, Shan Liu, Qiaolifan Aerqin, Donghui Shen, Xiujuan Wu, Kangding Liu
Summary: The study showed that ginkgolides improved the disease score in experimental autoimmune neuritis (EAN) mice and reduced the proportion of Th17 cells in the spleen of EAN mice. Additionally, in Guillain-Barre syndrome (GBS) patients, ginkgolides significantly decreased the levels of interferon and interleukin, indicating potential therapeutic effects in the future for both GBS and EAN.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Immunology
Fabian Szepanowski, Maximilian Winkelhausen, Rebecca D. Steubing, Anne K. Mausberg, Christoph Kleinschnitz, Mark Stettner
Summary: LPA(1) signaling may be a novel therapeutic target for treating inflammatory neuropathies, potentially affecting regenerative responses in the peripheral nerve by modulating Schwann cell differentiation.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Felix Kohle, Alina Sprenger, Ines Klein, Gereon R. Fink, Helmar C. Lehmann
Summary: Nerve conduction studies are crucial for assessing peripheral nerve fiber function in immune-mediated neuritis research models, but the lack of standard protocols hinders data comparability. A systematic review and meta-analysis of Lewis rats' NCS over the past 30 years revealed significant heterogeneity in recorded parameters, emphasizing the need for standardization in conducting and reporting NCS.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Review
Cell Biology
Shirin Sarejloo, Shokoufeh Khanzadeh, Samaneh Hosseini, Morad Kohandel Gargari, Brandon Lucke-Wold, Seyedarad Mosalamiaghili, Pouria Azami, Sanaz Oftadehbalani, Shahram Sadeghvand
Summary: This study conducted a systematic review and meta-analysis on the role of NLR in GBS, finding significantly increased NLR levels in GBS patients compared to healthy controls. High NLR predicted poor outcomes, especially in patients requiring mechanical ventilation. However, NLR levels could not differentiate among different GBS subtypes.
MEDIATORS OF INFLAMMATION
(2022)
Editorial Material
Clinical Neurology
Jonah P. Zuflacht, Aimee K. Boegle
Summary: CIDP may present acutely, resembling GBS.
Editorial Material
Clinical Neurology
Sina Marzoughi, Laura Marulanda, Dian Ngo, Tychicus Chen
Summary: This case presents an atypical motor axonal neuropathy with asymmetric paralysis, initially preserved reflexes, rapid progression, and cardiac dysfunction independent of dysautonomia.
Article
Clinical Neurology
Johanna I. Hamel, Eric L. Logigian
Summary: This study retrospectively reviewed cases from 1999 to 2020 to describe the clinical, micronutrient, and electrophysiologic spectra and prognosis of acute nutritional axonal neuropathy (ANAN). The results showed that ANAN has a wide spectrum of manifestations and specific micronutrient deficiencies or risk factors do not predict neuropathy subtype. The prognosis of ANAN is guarded due to slow recovery of independent ambulation and residual neuropathic pain.
Article
Immunology
Kaixi Ren, Sanzhong Li, Shiqian Liang, Fan Fan, Jiarui Lu, Tiaoxia Wei, Xiuli Cao, Li Gong, Hongzeng Li, Junlong Zhao, Hongyan Qin, Jun Guo
Summary: The conversion of monocytes modulated by Notch signaling plays a crucial role in the mouse model of experimental autoimmune neuritis.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Multidisciplinary Sciences
Shujun Sun, Yiyong Wen, Shu Li, Zhihua Huang, Jianming Zhu, Yandeng Li
Summary: This retrospective study analyzed the data of 136 GBS patients and 211 controls from January 2010 to December 2020. The results showed that neutrophil-to-lymphocyte ratio (NLR) is associated with the occurrence, severity, and prognosis of GBS. NLR was found to be an independent risk factor for GBS and a predictor of severe functional disability, severe weakness, and short-term prognosis. The association between NLR and GBS risk was stronger in older or male patients.
Editorial Material
Clinical Neurology
Jeffrey A. Allen
Summary: With every influenza vaccination, the question of previous Guillain-Barre syndrome (GBS) history is asked, and vaccination is typically advised against for those with GBS. The topic is widely discussed with strong opinions for or against vaccination within patient and physician networks. The COVID-19 pandemic has heightened concerns among the inflammatory neuropathy community and clinicians caring for GBS and CIDP patients, given the global scale of SARS-CoV-2 vaccinations.
Article
Chemistry, Multidisciplinary
Lu Zhang, Xian-meng Li, Xu-he Shi, Kai Ye, Xue-li Fu, Xue Wang, Shi-man Guo, Jia-qi Ma, Fei-fei Xu, Hui-min Sun, Qian-qian Li, Wei-ying Zhang, Li-hong Ye
Summary: HBXIP prevents sorafenib-induced cell death in hepatocellular carcinoma and attenuates ferroptosis.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Rheumatology
Jun Li, Suli Wang, Jiayi Zheng, Qianqian Li, Jia Li, Liangjing Lu
Summary: This study investigated the risk of PJP in newly diagnosed MDA5 + DM patients within 6 months and found a high incidence and mortality rate in these patients, with certain treatment methods being associated with a higher risk.
CLINICAL RHEUMATOLOGY
(2023)
Article
Chemistry, Organic
Siyuan Wang, Yunpeng Sun, Yaqi Li, Wenjun Xu, Qianqian Li, Yanbing Mu, Lingyi Kong, Jun Luo
Summary: In this study, seven lindenane-type sesquiterpenoid trimers were isolated from Chloranthus fortunei. Four of them were new compounds, while the other three were known analogues. Their structures and absolute configurations were determined using various analytical techniques. Compound 1 exhibited a unique feature of two lindenane units connected by a C-15-C-15' bond. Compound 2 had a 5/7/5-fused ring system, which was believed to be formed through keto-enol tautomerism and Cope rearrangement. Compounds 3-6 were derived from trishizukaol A (7) via vinylcyclopropane rearrangement. The biomimetic conversion from 7 to 3-6 was successfully achieved. Compound 1-7 showed anti-inflammatory activity with IC50 values ranging from 2.90 to 22.80 nmol/L.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Yang Zhou, Qianqian Li, Ye Wu, Xinyu Li, Ya Zhou, Zhu Wang, Hui Liang, Feiqing Ding, Sheng Hong, Nicole F. Steinmetz, Hui Cai
Summary: Self-assembly is a widely used method for constructing biomaterials, and peptides have been extensively investigated due to their desirable properties. Stimuli-responsive peptide nanoparticles, capable of conformational and chemical changes in response to stimuli, have emerged as a promising class of materials with diverse biomedical applications.
Article
Polymer Science
Li-Ying Ren, Qian-Qian Li, Yu-Xia Zhang
Summary: EDOT-based conjugated microporous polymers (CMPs) were efficiently synthesized via one-step direct arylation polymerization using simple EDOT as a linker and commercially available aryl bromides as the knots. This strategy allows the use of simple thiophene derivatives as building blocks for synthesizing thiophene-based CMPs of different structures, avoiding the synthesis of complex thiophene derivatives. The resulting EDOT-based CMPs exhibited high quenching constants and were successfully applied as fluorescent sensors for various compounds.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Engineering, Multidisciplinary
Peng Wang, YiCheng Lin, Yu Cao, HaoRan Zhao, QianQian Li, HongTao Wang
Summary: In this work, the complete martensitic transformation of non-equiatomic HEA is reproduced via atomic simulations with a novel interatomic potential. The physical parameters of interatomic potential are verified to agree well with experimental measurements and first-principles calculations. The study reveals two basic transition models for martensitic transformation in TRIP-DP-HEA and elucidates the pathway with the gliding of Shockley partial dislocations.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2023)
Article
Forestry
Wenyi Zhang, Yanrong Yang, Cheng Hu, Leying Zhang, Bo Hou, Weifeng Wang, Qianqian Li, Yansong Li
Summary: With climate change, forest fires are becoming more frequent worldwide, resulting in increased carbon emissions and affecting the carbon cycle of forest ecosystems. However, the impact of forest fires on carbon cycles varies by region, and there is a lack of comparative studies. This research examines the carbon loss under forest fire disturbances in northeast and southwest natural forest areas of China, using NPP data as an important parameter of forest carbon absorption. The study reveals differences in forest fire characteristics, carbon emissions, and the impact on forest NPP between the two regions.
Article
Pharmacology & Pharmacy
Yu-Ting Xiong, Jian-Fei Wang, Xiao-Xia Niu, Yi-Ming Fu, Ke-Xin Wang, Chun-Yan Wang, Qian-Qian Li, Jian-Jun Wang, Jun Zhao, Dong Ji
Summary: Clinical characteristics and risk factors associated with the severity of drug-induced liver injury (DILI) in elderly patients were identified. The presence of autoimmunity was found to be associated with a more serious state of DILI.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qianqian Li, Wenyi He, Weiran Li, Shulu Luo, Minghong Zhou, Dingcai Wu, Yan Li, Shuyi Wu
Summary: In guided bone regeneration surgery, a new class of local double-layered adhesive barrier membranes (ABMs) has been developed to immobilize bone graft materials. These ABMs have suction-adhesion properties and can firmly adhere to wet bone surfaces, effectively preventing displacement and leakage. This versatile strategy may open up new avenues for designing next-generation barrier membranes.
Article
Immunology
Ruixin Song, Chao Yang, Qianqian Li, Jiayin Wang, Jing Chen, Kai Sun, Hongmin Lv, Yankai Yang, Jing Liang, Qing Ye, YanYing Gao, Jun Li, Ying Li, Junqing Yan, Ying Liu, Tao Wang, Changen Liu, Ping Zhu, Fei Wang, Weili Yin, Huiling Xiang
Summary: The aim of this study was to evaluate the durability of immune response after basic and booster immunization with SARS-CoV-2 vaccines in patients with chronic liver disease (CLD). The results showed that the positive rates of antibodies decreased rapidly with the extension of vaccination time after basic immunization, while the positive rates increased rapidly and remained high after booster immunization. Thus, booster immunization improved the immune response and significantly prolonged the durability of SARS-CoV-2 antibodies in patients with CLD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Qingran Yan, Mei Zhang, Fang Du, Yuening Kang, Ping Ye, Qianqian Li, Bei Liu, Min Dai, Chunde Bao
Summary: This prospective study evaluated the efficacy and safety of IGU as an add-on therapy for patients with refractory lupus nephritis. The results showed that IGU, as a component of combination therapy, can effectively reduce urine protein and is well tolerated.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Rong Wang, Jingkun Qu, Xueping Tang, Jiaxin Zhang, Ante Ou, Qianqian Li, Guihua Chen, Caihong Zheng, Bahtiyor Muhitdinov, Yongzhuo Huang
Summary: A lactoferrin-modified gambogic acid liposomal delivery system was developed to enhance the treatment efficacy of colorectal cancer by improving tumor delivery and drug solubility.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Shuoshuo Li, Wenyu Hu, Shenghui Gong, Ping Zhang, Jinbo Cheng, Shukun Wang, Yingyi Wang, Wenjun Shi, Qianqian Li, Fengchao Wang, Zengqiang Yuan
Summary: High altitude exposure leads to cognitive impairments by affecting the cerebral vasculature system and reducing oxygen and nutrition supply to the brain. The study investigates the molecular mechanism of vascular system remodeling under acute hypoxia and identifies a novel m6A reader protein, PRRC2B, in endothelial cells. Knockdown of PRRC2B promotes hypoxia-induced endothelial cell migration and vascular remodeling, alleviating hypoxia-induced cognitive decline. These findings provide a new potential therapeutic target for hypoxia-induced cognitive impairments.
Article
Computer Science, Interdisciplinary Applications
Qianqian Li, Jingqi Zeng, Lijuan Ma, Jinyuan Zhu, Fangyu Zhang, Yunan Wei, Mingshuang Li, Lu Yao, Jing Du, Zhisheng Wu
Summary: In this study, an industrial information integrated strategy was proposed to address the OQC evaluation issue of Chinese meteria medica (CMM) from multi-batch in the complex system of big honeyed pill. The strategy consisted of a two-step digital process control and an OQC diagnosis strategy. The two-step digital control utilized online near infrared (NIR) monitoring to acquire critical quality attributes (CQAs) and control consistency from honey refining to He-Tuo procedure. The OQC diagnosis strategy utilized data fusion approach to determine multi-batch OQC from different perspectives. The information integrated strategy successfully identified three abnormal samples out of 30 batches with weights of 27.82%, 44.60%, and 27.58% for NIR, mid-infrared (MIR), and texture technologies, respectively. The diagnosed samples were also tested using zebrafish efficacy as an in vivo test, which demonstrated the effectiveness of the OQC diagnosis strategy. Overall, the proposed information integrated strategy provides important theoretical and practical foundations for ensuring the overall quality of multi-batch CMM, especially for digital and intelligent industrialization.
JOURNAL OF INDUSTRIAL INFORMATION INTEGRATION
(2023)
Article
Chemistry, Physical
Hailin Shen, Yueling Cai, Zhongtao Ma, Peng Wang, Bingkun Guo, Jipeng Cheng, Qianqian Li, Hongtao Wang, Zhongyuan Liu, Anmin Nie, Jinsong Wu
Summary: The researchers report a metal phosphorous trichalcogenide of MnPS3 as a reliable and high-capacity anode material for lithium-ion batteries. It has a unique layered van der Waals structure and can enable fast insertion/extraction of ions.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)