Article
Immunology
Hadar Edelman-Klapper, Keren Masha Rabinowitz, Eran Zittan, Ariella Bar-Gil Shitrit, Idan Goren, Irit Avni-Biron, Jacob E. Ollech, Lev Lichtenstein, Hagar Banai-Eran, Henit Yanai, Yifat Snir, Maor H. Pauker, Adi Friedenberg, Adva Levy-Barda, Yelena Broitman, Haim Ben Zvi, Tsachi-Tsadok Perets, Rami Eliakim, Revital Barkan, Sophy Goren, Dani Cohen, Iris Dotan
Summary: Vaccination plays a crucial role in controlling the COVID-19 pandemic, but patients with inflammatory bowel diseases (IBDs) treated with anti-TNF-alpha may have lower serologic response after a third vaccine dose. This study suggests that a fourth vaccine dose may be needed for this patient population.
Article
Gastroenterology & Hepatology
Shannon Linda Kanis, Sanne Modderman, Johanna C. Escher, Nicole Erler, Ruud Beukers, Nanne de Boer, Alexander Bodelier, Annekatrien C. T. M. Depla, Gerard Dijkstra, Anne-Baue Ruth Margaretha van Dijk, Lennard Gilissen, Frank Hoentjen, Jeroen M. Jansen, Johan Kuyvenhoven, Nofel Mahmmod, Rosalie C. Mallant-Hent, Andrea E. Van der Meulen-de Jong, Anahita Noruzi, Bas Oldenburg, Liekele E. Oostenbrug, Pieter C. J. Ter Borg, Marieke Pierik, Marielle Romberg-Camps, Willem Thijs, Rachel West, Alison de Lima, C. Janneke van der Woude
Summary: This study aimed to describe the long-term health outcomes of children born to mothers with inflammatory bowel disease (IBD) and assess the impact of maternal IBD medication use on these outcomes. The results showed no association between in utero exposure to anti-TNF-alpha and/or thiopurine and long-term health outcomes, but an increased rate of intrahepatic cholestasis of pregnancy (ICP) was found when thiopurine was used during pregnancy.
Article
Gastroenterology & Hepatology
Tung On Yau, Jayakumar Vadakekolathu, Gemma Ann Foulds, Guodong Du, Benjamin Dickins, Christos Polytarchou, Sergio Rutella
Summary: This study collected transcriptomic data from inflammatory bowel disease patients receiving anti-TNF-alpha therapy and found that hyperactive neutrophil chemotaxis influenced the response to anti-TNF-alpha treatment. IL13RA2 was identified as a potential biomarker to predict the response to anti-TNF-alpha treatment.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Piotr Eder, Aleksandra Zielinska, Jacek Karczewski, Agnieszka Dobrowolska, Ryszard Slomski, Eliana B. Souto
Summary: Despite significant advancements in the treatment of inflammatory bowel disease in recent years, there is still a large room for improvement. Oral anti-TNF-alpha antibody therapy is hypothesized to provide targeted anti-inflammatory effects without significant systemic exposure, potentially improving long-term treatment outcomes and safety. Various attempts have been made to design oral formulations of these molecules, aiming to enter a new era of treatment for IBD.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Irene Soleto, Samuel Fernandez-Tome, Irene Mora-Gutierrez, Montserrat Baldan-Martin, Cristina Ramirez, Cecilio Santander, Jose Andres Moreno-Monteagudo, Maria Jose Casanova, Fernando Casals, Sergio Casabona, Irene Becerro, Maria Chaparro, David Bernardo, Javier P. Gisbert
Summary: Inflammatory bowel disease (IBD) is a chronic condition characterized by uncontrolled intestinal immune response. This study focuses on the role of dendritic cells (DCs) in IBD and explores the mechanisms governing their migration. The results suggest that DC migration towards the intestinal mucosa plays a key role in IBD and may have potential diagnostic and immunomodulatory implications.
Review
Chemistry, Medicinal
Ines Ben Ghezala, Maeva Charkaoui, Christophe Michiels, Marc Bardou, Maxime Luu
Summary: Inflammatory bowel diseases (IBDs), such as Crohn's disease (CD) and Ulcerative Colitis (UC), are chronic disorders with an unclear pathogenesis. While tumor necrosis factor (TNF)-alpha inhibitors and other compounds have significantly improved the clinical management of IBDs, approximately one third of patients still have insufficient efficacy. Therefore, orally administered Small Molecules Drugs (SMDs) are being developed to address these issues.
Review
Gastroenterology & Hepatology
Max N. Brondfield, Uma Mahadevan
Summary: This review provides an update on the management of inflammatory bowel disease (IBD) during pregnancy and breastfeeding. Effective disease management, including pre-conception counseling and therapeutic agents, can improve pregnancy outcomes for women with IBD.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Matheus Freitas Cardoso de Azevedo, Luisa Leite Barros, Filipe Fernandes Justus, Jane Oba, Karoline Soares Garcia, Camilla de Almeida Martins, Alexandre de Sousa Carlos, Andre Zonetti Arruda Leite, Aytan Miranda Sipahi, Natalia Sousa Freitas Queiroz, Aderson Omar Mourao Cintra Damiao
Summary: This study aimed to identify risk factors for active tuberculosis (TB) development in inflammatory bowel disease (IBD) patients and describe their clinical characteristics and outcomes in a tertiary referral center in Brazil. Results showed that active TB was significantly associated with IBD diagnosis older than 17 years and anti-TNF therapy. Reintroduction of anti-TNFs after TB treatment appears to be safe.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Simeng Lin, Nicholas A. Kennedy, Aamir Saifuddin, Diana Munoz Sandoval, Catherine J. Reynolds, Rocio Castro Seoane, Sherine H. Kottoor, Franziska P. Pieper, Kai-Min Lin, David K. Butler, Neil Chanchlani, Rachel Nice, Desmond Chee, Claire Bewshea, Malik Janjua, Timothy J. McDonald, Shaji Sebastian, James L. Alexander, Laura Constable, James C. Lee, Charles D. Murray, Ailsa L. Hart, Peter M. Irving, Gareth-Rhys Jones, Klaartje B. Kok, Christopher A. Lamb, Charlie W. Lees, Daniel M. Altmann, Rosemary J. Boyton, James R. Goodhand, Nick Powell, Tariq Ahmad
Summary: This study reports immune responses and breakthrough infections in patients with inflammatory bowel disease receiving anti-TNF treatments after receiving COVID-19 vaccination, and suggests the need for adapted vaccination schedules for these patients.
NATURE COMMUNICATIONS
(2022)
Review
Medicine, General & Internal
Eduard Brunet Mas, Xavier Calvet Calvo
Summary: Combination of two biological therapies (CoT) appears to be a safe and effective treatment option for refractory and severely ill patients with inflammatory bowel disease (IBD). Ustekinumab plus vedolizumab and vedolizumab plus anti-TNF are the most commonly used CoTs for Crohn's disease. For ulcerative colitis, vedolizumab plus anti-TNF and vedolizumab plus tofacitinib are the most commonly used CoTs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Patricia Richi, Jose Yuste, Teresa Navio, Laura Gonzalez-Hombrado, Marina Salido, Israel Thuissard-Vasallo, Ana Jimenez-Diaz, Jesus Llorente, Laura Cebrian, Leticia Lojo, Martina Steiner, Tatiana Cobo, Maria Dolores Martin, Marta Garcia-Castro, Patricia Castro, Santiago Munoz-Fernandez
Summary: Patients with different autoimmune inflammatory diseases on biological therapy are at risk of pneumococcal disease. The study showed that a protocol combining PCV13 and PPV23 vaccines can help achieve functional antibodies against pneumococcal serotypes. Among the different biological therapies used, etanercept was associated with achieving higher OPKA titers, while rituximab did not lead to a worse immune response compared to other agents.
Article
Medicine, General & Internal
Giorgia Colombo, Gian Paolo Caviglia, Alberto Ravera, Elisa Tribocco, Simone Frara, Chiara Rosso, Cristina Travelli, Armando A. Genazzani, Davide Giuseppe Ribaldone
Summary: This study investigated the levels of eNAMPT and eNAPRT in the serum and stools of IBD patients and found that both factors were significantly increased in IBD patients and correlated with disease severity and inflammatory markers. Furthermore, serum NAMPT levels were associated with treatment failure in patients starting adalimumab therapy. Therefore, a prospective clinical trial evaluating the relationship between eNAMPT and eNAPRT levels and response to biologics in IBD patients is recommended.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xiangli Zhao, Ronghan Liu, Yuehong Chen, Aubryanna Hettinghouse, Chuanju Liu
Summary: Fexofenadine, a commonly used antihistamine, has been found to be therapeutic in murine models of chemically-induced IBD, with its anti-inflammatory effects depending on cPLA2 rather than histamine H1 receptor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Yiwei Chen, Qiongdan Mai, Zixu Chen, Tao Lin, Yongjie Cai, Jing Han, Ying Wang, Mudan Zhang, Shimin Tan, Zhiying Wu, Lingming Chen, Zhiyi Zhang, Yi Yang, Taimei Cui, Beiyin Ouyang, Yue Sun, Lijia Yang, Lin Xu, Sien Zhang, Jian Li, Hongbo Shen, Linna Liu, Lingchan Zeng, Shenghong Zhang, Gucheng Zeng
Summary: The magnitude and diversity of gut microbiota and metabolic systems are essential in maintaining human health. This study demonstrates that intestinal dysbacteriosis, inflammation, and abnormal lipid metabolism contribute to the failure of anti-TNF-a therapy in inflammatory bowel disease (IBD) patients. Dietary supplementation of palmitoleic acid (POA) repairs the gut mucosal barriers, reduces inflammation, and improves the efficacy of anti-TNF-a therapy in mouse models. Mechanistically, POA selectively promotes the growth of Akkermansia muciniphila in the gut microbiota and reprograms its composition and structures.
Article
Pharmacology & Pharmacy
Alberto Signore, Rita Bonfiglio, Michela Varani, Filippo Galli, Giuseppe Campagna, Manuel Desco, Lorena Cusso, Maurizio Mattei, Andreas Wunder, Filippo Borri, Maria T. Lupo, Elena Bonanno
Summary: Imaging using radiolabelled monoclonal antibodies can provide molecular information for treatment planning and monitoring therapeutic response in cancer and chronic inflammatory diseases. The study aimed to evaluate if a pre-therapy scan with radiolabelled anti-alpha(4)beta(7) integrin or anti-TNF alpha mAb could predict therapeutic outcome with unlabelled counterparts.
Letter
Gastroenterology & Hepatology
Cristina Bezzio, Gianpiero Manes, Francesco Bini, Lucienne Pellegrini, Simone Saibeni
Article
Gastroenterology & Hepatology
Mario Schettino, Lucienne Pellegrini, Desiree Picascia, Simone Saibeni, Cristina Bezzio, Francesco Bini, Barbara F. Omazzi, Massimo Devani, Ilaria Arena, Marco Bongiovanni, Gianpiero Manes, Cristina Maria Rita Della Corte
Summary: Gastrointestinal symptoms are common in patients with COVID-19 and may be associated with a better prognosis. These data suggest that the gastrointestinal tract may be more involved than the respiratory system in severe acute respiratory syndrome coronavirus 2 infection, potentially explaining the less severe course of the disease.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Cristina Bezzio, Gianpiero Manes, Mario Schettino, Ilaria Arena, Germana de Nucci, Cristina Della Corte, Massimo Devani, Enzo Mandelli, Daniela Morganti, Barbara Omazzi, Lucienne Pellegrini, Desiree Picascia, Davide Redaelli, Raffaella Reati, Simone Saibeni
Summary: IBD prevalence in asymptomatic adults is low, with majority having mild disease, though some may require biologic therapy.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
Gianpiero Manes, Simone Saibeni, Lucienne Pellegrini, Desiree Picascia, Fabio Pace, Mario Schettino, Cristina Bezzio, Germana de Nucci, Cesare Hassan, Alessandro Repici
Summary: During the COVID-19 outbreak in Italy, there was a 53.6% reduction in the number of fast-track endoscopic procedures compared with 2019. However, both appropriate referral and diagnostic yield increased in 2020 for both upper and lower endoscopy. A higher rate of cancer was diagnosed in 2020 by upper endoscopy.
Article
Gastroenterology & Hepatology
Cristina Bezzio, Alessandro Armuzzi, Federica Furfaro, Sandro Ardizzone, Monica Milla, Sonia Carparelli, Ambrogio Orlando, Flavio Andrea Caprioli, Fabiana Castiglione, Chiara Vigano, Davide Giuseppe Ribaldone, Fabiana Zingone, Rita Monterubbianesi, Nicola Imperatore, Stefano Festa, Marco Daperno, Ludovica Scucchi, Antonio Ferronato, Luca Pastorelli, Paola Balestrieri, Chiara Ricci, Maria Cappello, Carla Felice, Gionata Fiorino, Simone Saibeni
Summary: This study found that IBD patients with higher risk factors, such as obesity, active disease, and comorbidities, are at greater risk of adverse COVID-19 outcomes. However, IBD medications do not appear to pose additional risks.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Maria Lia Scribano, Annalisa Aratari, Benedetto Neri, Cristina Bezzio, Paola Balestrieri, Valentina Baccolini, Giuliano Falasco, Caterina Camastra, Paolo Pantanella, Rita Monterubbianesi, Alessandro Tullio, Simone Saibeni, Claudio Papi, Livia Biancone, Rocco Cosintino, Roberto Faggiani
Summary: This study assessed the effectiveness of ustekinumab in a large cohort of Italian patients with refractory Crohn's disease. The results showed that ustekinumab can achieve corticosteroid-free clinical remission in most patients, with significant decreases in HBI and CRP values. The normalization rate of CRP values also increased over time.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Gaetano Bergamaschi, Fabiana Castiglione, Renata D'Inca, Marco Astegiano, Walter Fries, Monica Milla, Carolina Ciacci, Fernando Rizzello, Simone Saibeni, Rachele Ciccocioppo, Ambrogio Orlando, Fabrizio Bossa, Mariabeatrice Principi, Piero Vernia, Chiara Ricci, Maria L. Scribano, Giorgia Bodini, Dario Mazzucco, Gabrio Bassotti, Gabriele Riegler, Andrea Buda, Matteo Neri, Flavio Caprioli, Fabio Monica, Aldo Manca, Erica Villa, Gionata Fiorino, Michele Comberlato, Nicola Aronico, Cristina Della Corte, Roberta Caccaro, Paolo Gionchetti, Paolo Giuffrida, Paola Iovino, Marco Lenti, Caterina Mengoli, Lucienne Pellegrini, Alberto Pieraccini, Davide Ribaldone, Anna Testa, Cristina Ubezio, Anna Viola, Maurizio Vecchi, Catherine Klersy, Antonio Di Sabatino
Summary: The prevalence of anemia in Italian IBD patients is lower than previously reported, with the majority being caused by iron deficiency and leading to fatigue and decreased quality of life. However, a large proportion of patients with iron and/or vitamin deficiencies remain untreated.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Oncology
Cristina Bezzio, Marta Vernero, Davide Giuseppe Ribaldone, Eleonora Alimenti, Gianpiero Manes, Simone Saibeni
Summary: Tofacitinib is a novel therapy for immune-mediated inflammatory diseases, but safety concerns regarding cardiovascular side effects and cancer risk have been raised. This meta-analysis compared the cancer risk of tofacitinib with a placebo and other therapies and found no significant difference in overall cancer risk. However, a slightly higher risk of cancer was observed in patients treated with tofacitinib compared to those treated with tumor necrosis factor inhibitors. Further studies are needed to better understand the cancer risk of tofacitinib therapy.
Article
Medicine, General & Internal
Marta Vernero, Cristina Bezzio, Davide G. Ribaldone, Stefania Costa, Davide Scalvini, Elisa Tribocco, Gianpiero Manes, Simone Saibeni
Summary: This study evaluated the effectiveness and safety of GP2017, a biosimilar drug, in the treatment of inflammatory bowel disease (IBD). The results showed that GP2017 is an effective and safe therapy for IBD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
F. S. Macaluso, M. Principi, F. Facciotti, A. Contaldo, A. Todeschini, S. Saibeni, C. Bezzio, F. Castiglione, O. M. Nardone, R. Spagnuolo, P. Doldo, M. C. Fantini, S. Paba, G. Riguccio, F. S. Conforti, C. Vigano, M. Ascolani, G. Bodini, M. Milla, G. Scardina, M. Vernero, F. Desideri, M. Mannino, G. Rizzo, F. A. Caprioli, A. Orlando
DIGESTIVE AND LIVER DISEASE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
S. Saibeni, C. Bezzio, A. Armuzzi, M. Daperno, M. Zanetti, M. Vernero, G. M. Giorgetti
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
S. Saibeni, C. Bezzio, A. Armuzzi, M. Daperno, M. Zanetti, M. Vernero, G. M. Giorgetti
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
C. Bezzio, A. D. Guarino, G. Fiorino, A. Armuzzi, D. G. Ribaldone, F. Furfaro, D. Pugliese, M. Vernero, A. Variola, V. Gerardi, L. Scucchi, C. Vigano, F. A. Caprioli, J. Roselli, F. Coppini, S. Ardizzone, S. Onali, F. Zingone, M. Daperno, C. Cortellezzi, S. Carparelli, A. Soriano, G. Manes, S. Saibeni
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
C. Bezzio, A. D. Guarino, I. Arena, C. Della Corte, M. Devani, G. Manes, M. Schettino, E. Sablich, M. Vernero, S. Saibeni
JOURNAL OF CROHNS & COLITIS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
C. Bezzio, S. Costa, A. Armuzzi, F. Furfaro, S. Ardizzone, M. Milla, F. Bossa, A. Orlando, F. A. Caprioli, F. Castiglione, C. Vigano, D. G. Ribaldone, F. Zingone, R. Monterubbianesi, N. Imperatore, S. Festa, M. Daperno, L. Scucchi, A. Ferronato, L. Pastorelli, P. Balestrieri, C. Ricci, M. Cappello, C. Felice, F. Coppini, P. Alvisi, V. Gerardi, A. Variola, S. Mazzuoli, M. V. Lenti, S. Alessandro, A. Buda, F. Micheli, V. Ciardo, G. Casella, A. Viscido, G. Bodini, G. Fiorino, M. Vernero, S. Saibeni
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)