Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Review
Immunology
Tewodros Shibabaw, Banchamlak Teferi, Birhanu Ayelign
Summary: Metastatic breast cancer is a common cause of death for women worldwide. Th-17, a pro-inflammatory infiltrative cell, plays a significant role in the proliferation, invasiveness, and metastasis of breast cancer. IL-17, a cytokine generated by Th-17, is upregulated in metastatic breast cancer. IL-17 and its downstream signaling molecules are potential targets for the prevention and treatment of breast cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Nan Li, Shulin Chen, Weiqing Deng, Zhaohui Gong, Yu Guo, Shan Zeng, Qiang Xu
Summary: This study explored the potential mechanisms by which kaempferol regulates gouty arthritis (GA) through network pharmacology and experimental validation. The results showed that kaempferol exerts therapeutic effects on GA by regulating the IL-17, AGE-RAGE, p53, TNF, and FoxO signaling pathways. Experimental validation supported the clinical use of kaempferol for GA treatment.
Review
Medicine, General & Internal
Feliciano Chanana Paquissi, Hugo Abensur
Summary: Systemic lupus erythematosus (SLE) is a disease characterized by dysregulation and hyperreactivity of the immune response, with lupus nephritis (LN) being a worrying manifestation. The Th17/IL-17 axis plays a significant role in kidney diseases, promoting inflammation and fibrotic pathways that lead to organ damage.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Hetal Bhadricha, Vainav Patel, Amit Kumar Singh, Lalita Savardekar, Anushree Patil, Suchitra Surve, Meena Desai
Summary: The study indicates that the increase in Th17 cell frequency and IL-17 levels in postmenopausal women may be associated with decreased bone density, possibly due to estrogen deficiency. Th17 cells and IL-17 could be potential targets for immunotherapy in the treatment of osteoporosis.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Chiara Della Bella, Antonio Antico, Maria Piera Panozzo, Nagaja Capitani, Luisa Petrone, Marisa Benagiano, Sofia D'Elios, Clotilde Sparano, Annalisa Azzurri, Sara Pratesi, Fabio Cianchi, Diana Ortiz-Princz, Mathijs Bergman, Nicola Bizzaro, Mario Milco D'Elios
Summary: This study investigated the gastric H+/K+-ATPase-specific Th17 responses and serum IL-17 cytokine subfamily in AIG patients, showing that gastric LPMCs from AIG patients are activated by H+/K+-ATPase and produce high levels of IL-17A and IL-17F, while serum IL-17A, IL-17F, IL-21, and IL-17E levels are significantly elevated in AIG patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Michael Crawford, Nicholas Borcherding, Nitin Karandikar
Summary: CD4(+) T-helper 17 (Th17) T cells play a crucial role in promoting inflammation through the secretion of IL-17 and are a major therapeutic target for autoimmune disorders. Recent studies have shown that IL-17 family cytokines can directly act on CD4(+) T cells, specifically naive cells, leading to functional changes. The differences in downstream signaling and functional consequences suggest that IL-17AF heterodimer is the most influential cytokine.
Review
Biochemistry & Molecular Biology
Liping Liu, Renli Liu, Chaojie Wei, Dong Li, Xiuzhu Gao
Summary: Interleukin 17 (IL-17) is an inflammatory cytokine that plays multiple roles in immune protection, immunopathology, and inflammation-related tumors. Lung cancer is a type of cancer related to inflammation, and studies have shown conflicting results regarding the role of IL-17 in the occurrence and development of lung cancer. This review aims to introduce the basic characteristics of IL-17 and focus on its role in lung cancer, providing a theoretical basis for the prevention, diagnosis, and treatment of lung cancer.
Article
Rheumatology
Anella Saviano, Adel Abo Manosour, Federica Raucci, Francesco Merlino, Noemi Marigliano, Anna Schettino, Mussarat Wahid, Jenefa Begum, Andrew Filer, Julia E. Manning, Gian Marco Casillo, Marialuisa Piccolo, Maria Grazia Ferraro, Simona Marzano, Pasquale Russomanno, Rosa Bellavita, Carlo Irace, Jussara Amato, Mohammed Alfaifi, Peter Rimmer, Tariq Iqbal, Stefano Pieretti, Valentina Vellecco, Francesco Caso, Luisa Costa, Roberto Giacomelli, Raffaele Scarpa, Giuseppe Cirino, Mariarosaria Bucci, Helen M. McGettrick, Paolo Grieco, Asif Jilani Iqbal, Francesco Maione
Summary: This study identified a novel IL-17A/F-derived peptide and generated a new anti-IL-17 antibody that can effectively reverse the pro-inflammatory actions of IL-17A/F. The antibody showed less off-target effects compared to the current gold-standard biologic. Preclinical and clinical evidence demonstrated the high efficacy and therapeutic potency of the antibody in patients with IMIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Multidisciplinary Sciences
Manik Chandra Shill, Bisshojit Biswas, Sadia Kamal, Moriam Islam, Sharmin Sultana Rima, Farhana Afrin Ferdausi, Qamruzzaman Chowdhury, Hasan Mahmud Reza, Asim Kumar Bepari
Summary: Lung cancer is a major cause of cancer deaths, and environmental contaminants are believed to be a risk factor in addition to smoking. This study investigated the use of IL-6 and IL-17 as diagnostic markers for lung cancer. The results showed significantly elevated levels of IL-6 in lung cancer patients, while IL-17 levels were slightly higher. Furthermore, IL-6 and IL-17 levels were higher in patients with adenocarcinoma compared to other subtypes of lung cancer.
Article
Immunology
Sun-Hee Hwang, Jin Seok Woo, Jeonghyeon Moon, SeungCheon Yang, Jin-Sil Park, JaeSeon Lee, JeongWon Choi, Kun Hee Lee, Seung-Ki Kwok, Sung-Hwan Park, Mi-La Cho
Summary: The study found that the increase of IL-17 is associated with aging and metabolic abnormalities, and may play a key role in the onset and progression of SS.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Jia-Lu Shi, Zi-Meng Zheng, Min Chen, Hui-Hui Shen, Ming-Qing Li, Jun Shao
Summary: Interleukin-17 (IL-17) is a proinflammatory cytokine derived from Th17 cells, which plays a pivotal role in inflammatory and autoimmune diseases. It is also linked to endometriosis, where IL-17 expression is up-regulated. IL-17 is involved in the regulation of immune microenvironment and the growth and invasion of ectopic lesions, suggesting its therapeutic value in endometriosis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Oncology
Gang Liu, Xiang-Ting Chen, Hao Zhang, Xin Chen
Summary: This study investigated the relationship between changes in peripheral blood VEGF, IL-5, IL-6, IL-8, and IL-17 concentrations in breast cancer patients and their significance in breast cancer staging and invasive metastasis. The results showed that IL-6, IL-17, and VEGF were strongly associated with breast cancer development and could be used as reference indicators for diagnosis and postoperative follow-up.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Laura Soriano-Romani, Fayaz A. Mir, Niharika Singh, Ian Chin, Ali Hafezi-Moghadam, Sharmila Masli
Summary: This study investigates the role of thrombospondin (TSP)-1 in regulating leukocyte recruitment and VCAM-1 expression in mouse models of uveitis. The results show that TSP-1 deficiency can reduce retinal leukocyte adhesion in LPS-mediated acute uveitis, while TSP-1-derived CD47-binding peptide can reduce the clinical disease course and retinal leukocyte adhesion in chronic uveitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Marina Popovic, Natalija Dedic Plavetic, Damir Vrbanec, Zlatko Marusic, Davor Mijatovic, Ana Kulic
Summary: This study found that breast cancer patients have higher serum concentrations of IL-17 compared to healthy controls, both before and after treatment. However, there was no significant correlation between IL-17 concentration and IL-17 expression in tumor tissue. After surgery, IL-17 concentration decreases but remains elevated compared to healthy controls.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)