Article
Gastroenterology & Hepatology
Quinn S. Solfisburg, Sarmed S. Sami, Joel Gabre, Ali Soroush, Lovekirat Dhaliwal, Claire Beveridge, Zhezhen Jin, John M. Poneros, Gary W. Falk, Gregory G. Ginsberg, Kenneth K. Wang, Charles J. Lightdale, Prasad G. Iyer, Julian A. Abrams
Summary: Recurrence of intestinal metaplasia at the gastroesophageal junction (GEJIM) after endoscopic eradication of Barrett's esophagus (BE) is common, but not associated with an increased risk of subsequent dysplasia. Older age and longer initial BE length are independently associated with recurrence.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Tony He, Vijaya Sundararajan, Nicholas J. Clark, John Slavin, Edward H. Tsoi, Alexander J. Thompson, Bronte A. Holt, Paul V. Desmond, Andrew C. F. Taylor
Summary: Routine surveillance biopsy sampling of normal-appearing tubular esophageal neosquamous epithelium has no yield for detecting recurrent nondysplastic BE or dysplasia after CRIM. Dysplastic recurrences are predominantly visible and located in BE islands, while dysplastic recurrences at the gastroesophageal junction are less visible. Endoscopic features can help identify recurrent advanced dysplasia or neoplasia.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Linda S. Yang, Bronte A. Holt, Richard Williams, Richard Norris, Edward Tsoi, Georgina Cameron, Paul Desmond, Andrew C. F. Taylor
Summary: This study retrospectively analyzed patients with dysplastic Barrett's esophagus and found that buried Barrett's mucosa was identified in 7% of cases, even in treatment-naive patients. The proposed endoscopic features showed a diagnostic accuracy of 79% in patients with histologically confirmed disease. These features may predict the presence of buried Barrett's mucosa, which could contain dysplasia or neoplasia.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Cary C. Cotton, Nicholas J. Shaheen, Aaron P. Thrift
Summary: Endoscopic surveillance after successful ablation of baseline high-grade dysplasia or intramucosal cancer is much more effective than surveillance after successful treatment of baseline low-grade dysplasia in preventing invasive adenocarcinoma.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Oncology
Lu Zhang, Binyu Sun, Xi Zhou, QiongQiong Wei, Sicheng Liang, Gang Luo, Tao Li, Muhan Lu
Summary: This article briefly describes the etiology and clinical significance of intestinal metaplasia in Barrett's esophagus, as well as its impact on diagnosis, monitoring, and treatment according to different guidelines. The basis for endoscopic diagnosis and identification techniques of goblet cells in Barrett's esophagus are explored, along with current treatment methods related to the condition.
FRONTIERS IN ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Shashank Garg, Jesse Xie, Sumant Inamdar, Sheila L. Thomas, Arvind J. Trindade
Summary: Dysplasia in Barrett's esophagus is predominantly located in the right half of the esophagus before ablation therapy. Post-ablation recurrence of dysplasia is more commonly found at the top of the gastric folds and is non-visible compared to the tubular esophagus.
Review
Gastroenterology & Hepatology
John J. McGoran, Krish Ragunath
Summary: Barrett's esophagus is a precursor to esophageal adenocarcinoma, and endoscopic surveillance followed by endoscopic eradication therapy is the current practice. The mantra of 'Detect-Resect-Ablate' guides the therapeutic approach, emphasizing the importance of high-quality endoscopy in identifying associated pathology and preventing dysplasia recurrence. The review discusses current practices, pitfalls, complications, and future perspectives in this field, with a focus on bridging clinical practice differences between Western and Asian nations.
DIGESTIVE ENDOSCOPY
(2021)
Review
Medicine, General & Internal
Francesco Maione, Alessia Chini, Rosa Maione, Michele Manigrasso, Alessandra Marello, Gianluca Cassese, Nicola Gennarelli, Marco Milone, Giovanni Domenico De Palma
Summary: Barrett's Esophagus is a common condition associated with chronic gastroesophageal reflux disease and has a higher risk of developing esophageal adenocarcinoma. Low and high-grade dysplasia precede neoplastic transformation in this condition. The evaluation of low-grade dysplastic esophageal mucosa is still controversial, but endoscopic surveillance and minimally invasive endoscopic treatments such as endoscopic mucosal resection and radiofrequency ablation are available options. Cryotherapy ablation and argon plasma coagulation are novel endoscopic treatments with high eradication rates and fewer complications and post-procedural pain.
Article
Multidisciplinary Sciences
Arvind J. Trindade, Jianying Zhang, Kara L. Raphael, Jiejing Qiu, John Hauschild, Petros C. Benias
Summary: This retrospective observational study examined the utilization of endoscopic ablation therapy and esophagectomy in patients with Barrett's esophagus. The study found an increasing trend in the utilization of ablation therapy, while esophagectomy showed a decreasing trend. These findings suggest that endoscopic ablation therapy has become the predominant method of treatment for Barrett's esophagus with dysplasia.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Esther A. Nieuwenhuis, Sanne N. van Munster, Wouter L. Curvers, Bas L. A. M. Weusten, Lorenza Alvarez Herrero, Auke Bogte, Alaa Alkhalaf, B. Ed Schenk, Arjun D. Koch, Manon C. W. Spaander, Thjon J. Tang, Wouter B. Nagengast, Jessie Westerhof, Martin H. M. G. Houben, Jacques J. G. H. M. Bergman, Erik J. Schoon, Roos E. Pouw
Summary: One quarter of patients with confirmed low grade dysplasia (LGD) in Barrett's esophagus (BE) diagnosed in a community hospital had high grade dysplasia (HGD) or cancer after re-staging at an expert center. Referral of patients with confirmed LGD, even without visible lesions, for re-staging endoscopy at an expert center is necessary.
Article
Gastroenterology & Hepatology
Anouk Overwater, Sjoerd G. Elias, Erik J. Schoon, Jacques J. G. H. M. Bergman, Roos E. Pouw, Bas L. A. M. Weusten
Summary: This study aimed to describe the course of pain and dysphagia after radiofrequency ablation (RFA) treatment for Barrett's esophagus (BE) neoplasia and identify associated risk factors. The results showed that 95% of patients reported post-RFA pain, with 64% experiencing major pain. Dysphagia was present in 83% of patients.
Review
Medicine, General & Internal
Peter M. M. Stawinski, Karolina N. N. Dziadkowiec, Lily A. A. Kuo, Juan Echavarria, Shreyas Saligram
Summary: Barrett's esophagus (BE) is a premalignant mucosal transformation characterized by the replacement of esophageal squamous epithelium with metaplastic columnar epithelium. It is associated with an increased risk of esophageal adenocarcinoma and is often caused by gastroesophageal reflux disease. Screening for BE is selective based on risk factors and is not recommended for the general population. Diagnosis involves endoscopic recognition, targeted biopsies, and histologic confirmation of columnar metaplasia. This review provides a comprehensive overview of the epidemiology, pathogenesis, screening, and advanced techniques for detecting and eradicating Barrett's esophagus.
Review
Oncology
Leonardo Henry Eusebi, Andrea Telese, Chiara Castellana, Rengin Melis Engin, Benjamin Norton, Apostolis Papaefthymiou, Rocco Maurizio Zagari, Rehan Haidry
Summary: Barrett's oesophagus is a pathological condition characterized by the replacement of normal oesophageal squamous mucosa with specialised, intestinal-type metaplasia, which is strongly associated with chronic gastro-oesophageal reflux. Accurate diagnosis is crucial for managing Barrett's oesophagus to identify patients at high risk of developing neoplasia and guide appropriate endoscopic therapy.
Article
Gastroenterology & Hepatology
Chanakyaram A. Reddy, Anna Tavakkoli, Vincent L. Chen, Sheryl Korsnes, Aarti Oza Bedi, Philip W. Carrott, Andrew C. Chang, Kiran H. Lagisetty, Richard S. Kwon, B. Joseph Elmunzer, Mark B. Orringer, Cyrus Piraka, Anoop Prabhul, Rishindra M. Reddy, Erik Wamsteker, Joel H. Rubenstein
Summary: This study compared long-term quality of life between patients undergoing endoscopic therapy and esophagectomy for Barrett's esophagus with high-grade dysplasia or T1a esophageal adenocarcinoma. While patients who underwent endoscopic therapy had worse physical and role functioning, they had significantly lower odds of experiencing symptoms such as diarrhea, trouble eating, choking, coughing, and speech difficulty compared to esophagectomy patients.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Nicholas J. Shaheen, Gary W. Falk, Prasad G. Iyer, Rhonda F. Souza, Rena H. Yadlapati, Bryan G. Sauer, Sachin Wani
Summary: Barrett's esophagus is a common condition associated with chronic gastroesophageal reflux disease and is a precursor to esophageal adenocarcinoma. The revised guidelines propose recommendations for the definition, diagnosis, screening, surveillance, and treatment of Barrett's esophagus, including important changes such as expanding acceptable screening methods and volume criteria for treatment centers.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Cary C. Cotton, Yash A. Choksi
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
S. Ryanne Corder, Manaswita Tappata, Olivia Shaheen, Cary C. Cotton, Elizabeth T. Jensen, Evan S. Dellon
DIGESTIVE DISEASES AND SCIENCES
(2020)
Editorial Material
Gastroenterology & Hepatology
Cary C. Cotton, Nicholas J. Shaheen
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Oncology
Dongyu Zhang, Yilin Feng, Nan Li, Xuezheng Sun
Summary: The study found that moderate fruit and vegetable consumption was significantly inversely associated with frequent mental distress (FMD) among breast cancer survivors. No significant association was found between fruit juice consumption and FMD. There was no interaction between adverse lifestyle behaviors and the outcomes.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Gastroenterology & Hepatology
Cary C. Cotton, Renee Betancourt, Cara Randall, Irina Perjar, Christine Bookhout, John T. Woosley, Nicholas J. Shaheen, Evan S. Dellon
Summary: A predictive model was developed based on the updated EoE diagnostic guidelines to identify patients with EoE without a PPI trial. Clinical features and endoscopic findings effectively identified patients with EoE, and the addition of histologic data further improved diagnostic accuracy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ekaterina Safroneeva, Cary C. Cotton, Alain M. Schoepfer, Marcel Zwahlen, John T. Woosley, Evan S. Dellon
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Engineering, Environmental
Yun Liu, Nan Li, George D. Papandonatos, Antonia M. Calafat, Charles B. Eaton, Karl T. Kelsey, Aimin Chen, Bruce P. Lanphear, Kim M. Cecil, Heidi J. Kalkwarf, Kimberly Yolton, Joseph M. Braun
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2020)
Article
Multidisciplinary Sciences
Marisa A. Patti, Nan Li, Melissa Eliot, Craig Newschaffer, Kimberly Yolton, Jane Khoury, Aimin Chen, Bruce P. Lanphear, Kristen Lyall, Irva Hertz-Picciotto, Margaret Daniele Fallin, Lisa A. Croen, Joseph M. Braun
Summary: Maternal caffeine intake during pregnancy is positively associated with child ASD-related behaviors, particularly among women with higher pre-pregnancy BMI. Further studies are needed to confirm these findings.
Article
Gastroenterology & Hepatology
Charles E. Gaber, Swathi Eluri, Cary C. Cotton, Paula D. Strassle, Timothy M. Farrell, Jennifer L. Lund, Evan S. Dellon
Summary: This study estimated the incidence, prevalence, and direct medical costs of achalasia in the United States. The results showed that achalasia has a higher epidemiologic and economic burden in the US than previously suggested, with a particularly increasing diagnosis in older patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Environmental Sciences
Nan Li, Yun Liu, George D. Papandonatos, Antonia M. Calafat, Charles B. Eaton, Karl T. Kelsey, Kim M. Cecil, Heidi J. Kalkwarf, Kimberly Yolton, Bruce P. Lanphear, Aimin Chen, Joseph M. Braun
Summary: The study revealed that children with higher gestational exposure to PFOA and PFHxS were associated with unfavorable cardiometabolic risk in adolescence, primarily driven by insulin resistance and adiponectin to leptin ratio. Other individual cardiometabolic risk factors associated with gestational PFOA included insulin and waist circumference.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Shweta Bhatia, Cary C. Cotton, Erin Kim, Hannah Angle, Ariel E. Watts, Swathi Eluri, Nicholas J. Shaheen
Summary: This study found that the proportion of female authors in high-impact gastroenterology journals has significantly increased over the past 20 years, especially in the role of first authors. However, the growth rate of female last authors is slower, indicating that gender disparities still exist. Future interventions should focus on the transition from first to last authorship to reduce gender inequality in GI research.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
D. Nance, K. M. Rappazzo, E. T. Jensen, K. Hoffman, C. C. Cotton, A. K. Krajewski, K. O. Turner, R. M. Genta, D. T. Lobdell, E. S. Dellon
Summary: This study investigated the association between environmental quality and the risk of eosinophilic esophagitis (EoE) using the Environmental Quality Index. The findings showed that poor environmental quality, particularly in terms of water quality, was associated with an increased risk of EoE, while better air and land quality were inversely associated with EoE. Further research to identify specific water pollutants that may play a role in EoE etiology may be necessary.
DISEASES OF THE ESOPHAGUS
(2021)
Article
Gastroenterology & Hepatology
Charles E. Gaber, Cary C. Cotton, Swathi Eluri, Jennifer L. Lund, Timothy M. Farrell, Evan S. Dellon
Summary: This study suggests that achalasia may be associated with autoimmune conditions and viral infections. Autoimmune diseases and certain viral infections may increase the risk of achalasia.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Public, Environmental & Occupational Health
Blanche C. Ip, Nan Li, Medina Jackson-Browne, Melissa Eliot, Yingying Xu, Aimin Chen, Bruce P. Lanphear, Adam J. Spanier, Joseph M. Braun
Summary: The study found that cord blood leptin and adiponectin concentrations can affect children's lung development and function, with higher cord blood adiponectin concentrations associated with higher %FEV1 in girls, and higher leptin concentrations associated with lower risk of wheeze in girls. However, higher adiponectin concentrations were associated with a lower risk of wheeze in both boys and girls.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2021)
Article
Environmental Sciences
Nan Li, George D. Papandonatos, Antonia M. Calafat, Kimberly Yolton, Bruce P. Lanphear, Aimin Chen, Joseph M. Braun
ENVIRONMENT INTERNATIONAL
(2020)