Review
Microbiology
Rana Abdelqader, Hanan Hasan, Lo'ai Alanagreh
Summary: This systematic review examined the prevalence and circulating genotypes of Human bocavirus (HBoV) in respiratory and stool samples from patients of all age groups in the Middle East and North Africa from 2005 to February 2021. The study included 65 articles and found HBoV to be common in children and adults in the MENA region, highlighting the need for more data on coinfection of HBoV and other viruses such as SARS-CoV-2 in children with acute bronchiolitis.
Article
Virology
Juan Carlos Munoz-Escalante, Gabriel Mata-Moreno, Gerardo Rivera-Alfaro, Daniel E. Noyola
Summary: Analysis of HMPV G gene ectodomain sequences reveals that viruses with 111-nt or 180-nt duplications have become the most frequent HMPV A strains globally, replacing other HMPV A viruses in Asia, Europe, and South America. Continued surveillance of HMPV is necessary to track the emergence and spread of epidemiologically relevant variants.
Article
Virology
Rachel L. Tulloch, Jen Kok, Ian Carter, Dominic E. Dwyer, John-Sebastian Eden
Summary: This study aimed to develop a simple and robust method for HMPV whole-genome sequencing for genomic epidemiological studies. By designing primer sets specific to all known HMPV subtypes and examining these sequences using a phylogenetic approach, the utility of this method was demonstrated.
Article
Pediatrics
Xifeng Tang, Ge Dai, Ting Wang, Huiming Sun, Wujun Jiang, Zhengrong Chen, Yongdong Yan
Summary: In this study, the clinical data of hospitalized children with lower respiratory tract infections caused by human bocavirus (HBoV) and human metapneumovirus (hMPV) were compared. The detection rate of HBoV was significantly higher than that of hMPV. Compared to hMPV, HBoV is more likely to cause severe infection and has a greater impact on children.
FRONTIERS IN PEDIATRICS
(2023)
Article
Infectious Diseases
Maria Pinana, Alejandra Gonzalez-Sanchez, Cristina Andres, Michel Abanto, Jorgina Vila, Juliana Esperalba, Noelia Moral, Elena Espartosa, Narcis Saubi, Anna Creus, Maria Gema Codina, Dolores Folgueira, Jaime Martinez-Urtaza, Tomas Pumarola, Andres Anton
Summary: This study aimed to describe the prevalence, genetic diversity, and evolutionary dynamics of HMPV. The findings showed that HMPV had a prevalence of 2.5% and peaked in February-April, circulating alternately between HMPV-A and -B until the emergence of SARS-CoV-2. HMPV re-emerged in summer and autumn 2021 with a higher prevalence and the almost exclusive circulation of A2c111dup. The F protein exhibited a highly conserved nature, supporting the need for steric shielding. The mutation rate of the HMPV genome was 6.95 x 10-4 substitutions/site/year. The study highlights the importance of effective viral surveillance and maintenance of viral epidemiological characteristics.
JOURNAL OF INFECTION
(2023)
Article
Pediatrics
Elina Oldhoff, Rutger Bennet, Margareta Eriksson, Tobias Allander
Summary: In this study, the characteristics, seasonality, pre-existing medical conditions, codetections, clinical manifestations, and complications of HBoV1 infection in children in Stockholm were retrospectively described. The results showed that HBoV1 mainly occurred from December to March and was often co-detected with other viruses. However, the viral load was associated with patient age, single detection of HBoV1, and early season. There were few differences in clinical manifestations between different subgroups of HBoV1.
Article
Immunology
Meghana Nadiger, Prithvi Sendi, Paul A. Martinez, Balagangadhar R. Totapally
Summary: In hospitalized children in the United States, HMPV infection is less common than RSV infection. Complex chronic conditions are more prevalent in children hospitalized with HMPV infection. Hospitalization with HMPV is associated with longer length of stay and higher hospital charges. The adjusted mortality is similar with both infections.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Infectious Diseases
Shanshan Cong, Chao Wang, Tianli Wei, Zhiping Xie, Yiman Huang, Jingjing Tan, Aijun Chen, Fenlian Ma, Lishu Zheng
Summary: This study investigated the epidemiology and genotypic diversity of HMPV in hospitalized children with ARTIs in Beijing, China. It found that HMPV is an important cause of ARTIs in children under 5 years old, with the peak occurring in winter and spring and the A2b subtype being the most common. The study also showed a significant decrease in HMPV infection among hospitalized children with ARTIs during the COVID-19 pandemic.
INFECTION GENETICS AND EVOLUTION
(2022)
Review
Infectious Diseases
Lei Guo, Li Li, Li Liu, Tiesong Zhang, Ming Sun
Summary: This article provides an overview of the progress and future directions in the research of potent F-specific nMAbs against hMPV, and discusses the strategy for vaccine research and development.
Article
Virology
Mengxiao Luo, Mario Mietzsch, Paul Chipman, Kangkang Song, Chen Xu, John Spear, Duncan Sousa, Robert McKenna, Maria Soderlund-Venermo, Mavis Agbandje-McKenna
Summary: Human bocaviruses (HBoVs) infect children and immunocompromised individuals, resulting in respiratory and gastrointestinal infections. This study compared the capsid structures of HBoV2 with previously determined HBoV1, HBoV3, and HBoV4, revealing strain and genus-specific features contributing to tissue tropism and antigenicity. Additionally, analyzing HBoV1 and HBoV2 structures under acidic conditions provided insights into capsid changes associated with endosomal and gastrointestinal acidification, unraveling the molecular mechanism of HBoV infection.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Chao Wang, Tianli Wei, Fenlian Ma, Hao Wang, Jianqiang Guo, Aijun Chen, Yiman Huang, Zhiping Xie, Lishu Zheng
Summary: This study investigated the epidemiology and genotypic diversity of HMPV in children hospitalized with ARTIs in Beijing, China. The main findings include a higher susceptibility of 4-year-old children to HMPV infection during the winter and early spring season, and the common co-infection of HMPV with influenza and respiratory syncytial virus.
Article
Virology
Brunno Camara Lopes Costa, Nathania Alves Silva Dabilla, Tamera Nunes Almeida, Fabiola Souza Fiaccadori, Teresinha Teixeira de Souza, Divina das Dores de Paula Cardoso, Adriano de Moraes Arantes, Menira Souza
Summary: The aim of this study was to evaluate the occurrence and viral loads of human bocavirus (HBoV) in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). The study found a high frequency and viral loads of HBoV in fecal samples of the patients, and positivity in fecal samples was an early predictor of HBoV presence.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Ching-Lin Hsieh, Scott A. Rush, Concepcion Palomo, Chia-Wei Chou, Whitney Pickens, Vicente Mas, Jason S. McLellan
Summary: This study engineered stabilized variants of the human metapneumovirus fusion (F) protein in the prefusion state, which elicited higher neutralizing antibody titers in mice. The findings contribute to the development of hMPV vaccines and therapeutic antibodies.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Avik Banerjee, Jiachen Huang, Scott A. Rush, Jackelyn Murray, Aaron D. Gingerich, Fredejah Royer, Ching-Lin Hsieh, Ralph A. Tripp, Jason S. McLellan, Jarrod J. Mousa
Summary: This study identified immunodominant antigenic epitopes on the hMPV F protein and identified a monoclonal antibody (mAb) therapy for hMPV F disease prevention and treatment. Additionally, a prefusion-specific epitope on the hMPV F protein was discovered.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Virology
Manita Aryal, Guangliang Liu
Summary: Porcine bocavirus (PBoV) is a single-stranded DNA virus that has been reported worldwide, mainly in weaning piglets, but its pathogenic nature remains unclear. Current research faces limitations, including the lack of available cell lines for study and animal models.