Journal
INFLAMMATION
Volume 41, Issue 3, Pages 751-759Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-018-0729-3
Keywords
FGF-21; THP-1 cells; IL-10; LPS
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Funding
- Young Talents Project of Northeast Agricultural University [16QC27]
- Natural Science Foundation of Heilongjiang Province of China [C2017023]
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Fibroblast growth factor 21 (FGF-21) has been previously judged as a major metabolic regulator. In this paper, we show that FGF-21 has a potential role in anti-inflammation and immunoregulation. In vivo, treatment with exogenous FGF-21 can alleviate LPS-induced inflammation. In vitro, FGF-21 inhibited LPS-induced IL-1 beta expression in THP-1 cells. Furthermore, besides the NF-kappa B pathway, the mechanism of action of FGF-21 was observed to involve the elevation of IL-10 in the ERK1/2 pathway. This study clearly indicates that FGF21 can be used as an attractive target for the management of inflammatory disorders. This piece of research indicates that FGF-21 could have much value in the management of inflammatory disorders.
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