Article
Critical Care Medicine
Jad Malas, Qiudong Chen, Tao Shen, Dominic Emerson, Tyler Gunn, Dominick Megna, Pedro Catarino, Michael Nurok, Michael Bowdish, Joanna Chikwe, Susan Cheng, Joseph Ebinger, Abirami Kumaresan
Summary: This study aimed to describe the institutional experience with extremely prolonged venovenous extracorporeal membrane oxygenation (ECMO) support for patients with acute respiratory failure. The study found that most patients in this cohort had adult respiratory distress syndrome (ARDS) secondary to COVID-19. Prolonged ECMO support was successful in weaning patients off and enabling their recovery, with a high rate of survival.
CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Ryan M. Rivosecchi, Aris R. Arakelians, John Ryan, Holt Murray, Raj Ramanan, Hernando Gomez, Dennis Phillips, Christopher Sciortino, Peter Arlia, Danielle Freeman, Penny L. Sappington, Pablo G. Sanchez
Summary: Comparison of patients receiving unfractionated heparin or bivalirudin for anticoagulation on venovenous extracorporeal membrane oxygenation revealed that those receiving bivalirudin experienced a decrease in extracorporeal membrane oxygenation circuit-related thrombotic events and reduced volume of blood products administered.
CRITICAL CARE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
J. W. Awori Hayanga, Subhasis Chatterjee, Bo Soo Kim, HelenMari Merritt-Genore, Rita Carrie Karianna Milewski, Jonathan W. Haft, Rakesh C. Arora
Summary: The high transmissibility of SARS-CoV-2 and severity of COVID-19 have created a global health emergency. The virus enters host cells through the spike membrane protein, with angiotensin-converting enzyme 2 as the receptor. The pandemic has tested the global health infrastructure and led to the exploration of new strategies. ECMO has been used as a rescue option, but there is no consensus on a specific scoring system for its severity assessment.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Engineering, Biomedical
Francesco Vasques, Barnaby Sanderson, Genex Correa, Patrick Collins, Valentina Camarda, Lorenzo Giosa, Andrew Retter, Chris Meadows, Nicholas A. Barrett, Luigi Camporota
Summary: The aim of this study was to investigate the frequency of circuit change, associated risk factors, and their relationship with outcomes in VV ECMO patients. The results showed that circuit change was associated with lower ICU survival and longer ICU stay. Hematological abnormalities and increased lung pressure were the main indications for circuit change. Changes in transmembrane lung resistance were better predictors of circuit change, and low postoxygenator PO2 was a common reason for circuit change. However, ECMO oxygen transfer was higher in cases of circuit change with low postoxygenator PO2.
Article
Critical Care Medicine
Nina Buchtele, Christian Schoergenhofer, Michael Schwameis, Bernd Jilma, Peter Schellongowski, Harald Herkner, Katharina Riss, Monika Schmid, Alexander Hermann, Oliver Robak, Bernhard Nagler, Ludwig Traby, Andja Bojic, Thomas Staudinger
Summary: This study investigated the safety and efficacy of PGE(1) in adults receiving venovenous extracorporeal membrane oxygenation (ECMO). The results showed that PGE(1) can reduce thromboembolic events and clinically overt bleeding events, as well as prolong the time without bleeding and thromboembolism.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Critical Care Medicine
Ricardo Teijeiro-Paradis, Whitney D. Gannon, Eddy Fan
Summary: This narrative review discusses the various complications that can occur during treatment with venovenous extracorporeal membrane oxygenation (V-V ECMO), including both short-term and long-term complications. Patient selection, timing of initiation, and management decisions greatly influence the presence and severity of these potential harms.
CRITICAL CARE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Boris Kuzmin, Arevik Movsisyan, Florian Praetsch, Thomas Schilling, Anke Lux, Mohammad Fadel, Faranak Azizzadeh, Julia Crackau, Olaf Keyser, George Awad, Thomas Hachenberg, Jens Wippermann, Maximilian Scherner
Summary: This study retrospectively analyzed data from 85 patients with severe acute respiratory distress syndrome (ARDS) who required extracorporeal membrane oxygenation (ECMO) support. The COVID-19 group (52 patients) had a significantly lower survival rate compared to the non-COVID-19 group (33 patients) at 60 days, and the COVID-19 group had higher risks of superinfection, intracerebral bleeding, and pre-existing ischemic heart disease.
Article
Critical Care Medicine
Akram Zaaqoq, Matthew Griffee, Thu-Lan Kelly, Jonathon Fanning, Silver Heinsar, Jacky Suen, Silvia Mariani, Gianluigi Li Bassi, Jeffrey Jacobs, Nicole White, John Fraser, Roberto Lorusso, Giles Peek, Sung-Min Cho
Summary: This study aims to characterize the prevalence and risk factors of stroke secondary to COVID-19 in patients on venovenous ECMO. The results showed that obesity and pre-ECMO vasopressor use were associated with an increased risk of stroke. In addition, stroke patients had a more significant relative decrease in Paco(2) and relative increase in Pao(2) within 48 hours after ECMO initiation compared to non-stroke patients, and they also had a higher in-hospital mortality rate.
CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Whitney D. Gannon, John W. Stokes, Sarah Bloom, Wren Sherrill, Matthew Bacchetta, Todd W. Rice, Matthew W. Semler, Jonathan D. Casey
Summary: The protocol for daily assessment of readiness to liberate from ECMO is safe and feasible, and may help identify patients for decannulation earlier than gradual weaning approaches.
Article
Critical Care Medicine
Senta Jorinde Raasveld, Mina Karami, Walter M. van den Bergh, Annemieke Oude Lansink-Hartgring, Franciska van der Velde, Jacinta J. Maas, Pablo van de Berg, Maarten de Haan, Roberto Lorusso, Thijs S. R. Delnoij, Dinis Dos Reis Miranda, Loes Mandigers, Erik Scholten, Martijn Overmars, Fabio Silvio Taccone, Alexandre Brasseur, Dieter F. Dauwe, Erwin De Troy, Greet Hermans, Philippe Meersseman, Federico Pappalardo, Evgeny Fominskiy, Visnja Ivancan, Robert Bojcic, Jesse de Metz, Bas van den Bogaard, Dirk W. Donker, Christiaan L. Meuwese, Martin de Bakker, Benjamin Reddi, Sanne de Bruin, Wim K. Lagrand, Jose P. S. Henriques, Lars M. Broman, Alexander P. J. Vlaar
Summary: This study aims to provide an overview of red blood cell transfusion in patients on venovenous extracorporeal membrane oxygenation. The study found that red blood cell transfusion has a high occurrence rate even in non-bleeding patients on extracorporeal membrane oxygenation.
CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Michael Kouch, Adam Green, Emily Damuth, Christopher Noel, Jason Bartock, Michael Rosenbloom, Christa Schorr, Robert Rios, Nancy Loperfido, Nitin Puri
Summary: This study compared the effectiveness of cardiothoracic surgeons and medical intensivists in performing extracorporeal membrane oxygenation cannulation. The results showed that there was no difference in success and complication rates between the two groups in an established extracorporeal membrane oxygenation program. A rapidly deployed cannulation program led by intensivists for venovenous extracorporeal membrane oxygenation can be performed with high success and low complication rates.
CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Oliver Hunsicker, Lukas Beck, Alexander Krannich, Tobias Finger, Vincent Prinz, Claudia Spies, Steffen Weber-Carstens, Stefan Wolf, Jan Adriaan Graw, Mario Menk
Summary: Intracranial hemorrhage is a serious complication in patients receiving venovenous extracorporeal membrane oxygenation during treatment of the acute respiratory distress syndrome. The study found that early occurrence of intracranial hemorrhage is associated with higher 60-day mortality, and adjusting modifiable risk factors may lower the prevalence of this complication.
CRITICAL CARE MEDICINE
(2021)
Article
Oncology
Jenny C. Potratz, Sarah Guddorf, Martina Ahlmann, Maria Tekaat, Claudia Rossig, Heymut Omran, Katja Masjosthusmann, Andreas H. Groll
Summary: The study showed that there is a chance of survival for pediatric patients with cancer and/or hematopoietic cell transplantation who undergo ECMO treatment, providing valuable insights for clinicians and families when deciding on ECMO therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Biomedical
Satoshi Watanabe, Chitaru Kurihara, Adwaiy Manerikar, Sanket Thakkar, Mark Saine, Ankit Bharat
Summary: MELD score can be used complementarily to the RESP score to predict outcomes in patients with ARDS undergoing VV ECMO. Higher MELD score was associated with increased post-ECMO mortality but reduced risk of dialysis and tracheostomy.
Article
Critical Care Medicine
Marco Giani, Emanuele Rezoagli, Christophe Guervilly, Jonathan Rilinger, Thibault Duburcq, Matthieu Petit, Laura Textoris, Bruno Garcia, Tobias Wengenmayer, Giacomo Bellani, Giacomo Grasselli, Antonio Pesenti, Alain Combes, Giuseppe Foti, Matthieu Schmidt
Summary: This study assesses the association of the timing of prone positioning (PP) during venovenous extracorporeal membrane oxygenation (V-V ECMO) with the probability of being discharged alive from ICU and improvement of respiratory system compliance. The results show that delayed PP during V-V ECMO is associated with lower ICU discharge probability and less improvement in respiratory system compliance. Early PP is beneficial for ARDS patients on ECMO.
CRITICAL CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Juwon Kim, Danbee Kang, Hyejeong Park, Minwoong Kang, Ki Hong Choi, Taek Kyu Park, Joo Myung Lee, Jeong Hoon Yang, Young Bin Song, Jin-Ho Choi, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Eliseo Guallar, Juhee Cho, Joo-Yong Hahn
Summary: This study compared the risk of adverse cardiovascular events between patients receiving moderate-intensity statins plus ezetimibe and those receiving high-intensity statins after a coronary revascularization procedure. The results showed that patients receiving moderate-intensity statins plus ezetimibe had similar rates of major adverse cardiovascular events as patients receiving high-intensity statins.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Hongseok Oh, Young Joon Hong, Gyu-Chul Yi, Hyeonjun Baek, Dong Ryeol Lee, Hyun Hwi Lee
Summary: In this study, synchrotron radiation X-ray diffraction analysis is used to analyze the initial growth dynamics of ZnO nanorods on c-Al2O3 substrates. The relationship between ZnO and Al2O3 in heteroepitaxy is revealed through reciprocal space mapping and diffraction image transformation. The growth rate is estimated through atomic force microscopy and Scherrer equation analysis.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Cardiac & Cardiovascular Systems
Joo Myung Lee, Hyun Kuk Kim, Keun Ho Park, Eun Ho Choo, Chan Joon Kim, Seung Hun Lee, Min Chul Kim, Young Joon Hong, Sung Gyun Ahn, Joon-Hyung Doh, Sang Yeub Lee, Sang Don Park, Hyun-Jong Lee, Min Gyu Kang, Jin-Sin Koh, Yun-Kyeong Cho, Chang-Wook Nam, Bon-Kwon Koo, Bong-Ki Lee, Kyeong Ho Yun, David Hong, Hyun Sung Joh, Ki Hong Choi, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo-Yong Hahn, FRAME AMI Invest
Summary: For patients with acute myocardial infarction and multivessel coronary artery disease, FFR-guided PCI is superior to angiography-guided PCI in reducing the risk of death or myocardial infarction.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
David Hong, Doosup Shin, Seung Hun Lee, Hyun Sung Joh, Ki Hong Choi, Hyun Kuk Kim, Sang Jin Ha, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo Myung Lee
Summary: The study aimed to compare the prognosis of coronary microvascular dysfunction according to different patterns of CFR and IMR. The results showed that decreased CFR was associated with an increased risk of heart failure and cardiovascular death, while elevated IMR alone with preserved CFR did not show significant prognostic value.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Biochemistry & Molecular Biology
Hayoung Choi, Jin Young Lee, Hongseok Yoo, Kyeongman Jeon
Summary: This study aimed to compare gene expression profiles between patients with sepsis and healthy volunteers to determine the accuracy of these profiles in diagnosing sepsis and predicting sepsis outcomes. Certain upregulated genes showed high accuracy in diagnosing sepsis and predicting in-hospital mortality, while downregulated genes showed high accuracy in predicting mortality of patients with sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Woo Jin Jang, Ki Hong Choi, Jihoon Kim, Jeong Hoon Yang, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Yang Hyun Cho, Kiick Sung, Wook Sung Kim, Dong Seop Jeong, Young Bin Song
Summary: This study evaluated the impact of sex on mid-term prognosis in patients who underwent coronary artery bypass grafting (CABG). The results showed that there was no significant difference in the incidence of cardiovascular death or myocardia infarction at 5 years between female and male groups.
Article
Cell & Tissue Engineering
Dae Sung Park, Myung Ho Jeong, Yu Jeong Jin, Mi Hyang Na, Doo Sun Sim, Munki Kim, Kyung Hoon Cho, Dae Young Hyun, Seok Oh, Jeong Ha Kim, Kyung Seob Lim, Jun-Kyu Park, Han Ki Kim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Jeong Hun Kim
Summary: The mechanical properties, safety, and efficacy of drug-eluting metal-based stents (MBS) and bioresorbable vascular scaffolds (BVS) were evaluated. The BVS showed better mechanical properties and lower restenosis rate than the MBS. Thinner and completely absorbed BVSs should be developed and evaluated for long-term safety and efficacy.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Infectious Diseases
Bo-Guen Kim, Danbee Kang, Kyung Hoon Min, Juhee Cho, Kyeongman Jeon
Summary: The comparative analysis of clinical outcomes in patients with hospital-acquired pneumonia treated with cefepime and piperacillin/tazobactam showed that the treatment effects were comparable between the two groups.
Article
Materials Science, Multidisciplinary
Namjung Kim, Dongseok Lee, Youngjoon Hong
Summary: The rapid advancement of additive manufacturing technologies allows for the creation of pixelated or voxelated structures known as digital materials in 2D or 3D, respectively. These digital materials offer maximum design flexibility without constraints on geometry and material, resulting in unique physical properties and functionalities that cannot be achieved through conventional manufacturing processes. However, the vast design space of digital materials presents a significant challenge in maximizing their availability. In this study, a novel deep generative model with discrete representations of the latent space was developed for designing digital materials. The proposed model, inspired by the discrete nature of digital materials, achieves comparable reconstruction and prediction accuracies with only one-third of the data usage compared to conventional generative models. The physical insights provided by the discrete representations of the latent space demonstrate a strong correlation between certain discrete representations and the mechanical behavior of digital materials, such as auxeticity. Furthermore, the proposed model is proven to be an excellent tool for generating functionally graded structures and previously unseen auxetic structures.
ACS MATERIALS LETTERS
(2023)
Article
Critical Care Medicine
Beomsu Shin, Jin Young Lee, Yunjoo Im, Hongseok Yoo, Junseon Park, Joo Sang Lee, Ki-Young Lee, Kyeongman Jeon
Summary: This study examined the differential expression of exosomal miRNAs in plasma samples from sepsis patients and healthy controls. Four downregulated miRNAs (hsa-let-7f-5p, miR-331-3p, miR-301a-3p, and miR-335-5p) were identified as independent prognostic factors for in-hospital and 90-day mortalities among sepsis patients. Bioinformatics analysis suggested that these miRNAs may contribute to sepsis pathogenesis through PI3K-Akt and MAPK signaling pathway.
JOURNAL OF INTENSIVE CARE
(2023)
Correction
Medicine, General & Internal
Hye Ju Yeo, Dong Kyu Oh, Woo Sik Yu, Sun Mi Choi, Kyeongman Jeon, Mihyang Ha, Jin Gu Lee, Woo Hyun Cho, Young Tae Kim
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Correction
Cardiac & Cardiovascular Systems
Sang Jun Lee, Se-Eun Kim, Tae-Hwa Go, Dae Ryong Kang, Ho-Seong Jeon, Young-In Kim, Dong-Hyuk Cho, Young Jun Park, Jung-Hee Lee, Jun-Won Lee, Young-Jin Youn, Sang-Hyun Kim, Jang Young Kim, Sung Gyun Ahn
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Minjung Bak, Minyeong Kim, Boram Lee, Eun Kyoung Kim, Taek Kyu Park, Jeong Hoon Yang, Duk-Kyung Kim, Sung -A Chang
Summary: This study aimed to understand the nature of rapid RV failure syndrome with a suspected diagnosis of PTTM for better clinical management. The study found that rapid RV failure syndrome showed a progressive course from symptom onset to death, and chemotherapy had limited impact on patient survival. Other treatment methods did not improve the patient's prognosis.
KOREAN CIRCULATION JOURNAL
(2023)
Article
Computer Science, Information Systems
Junho Choi, Namjung Kim, Youngjoon Hong
Summary: In recent years, machine learning methods have been applied to solve partial differential equations (PDEs) and dynamical systems, leading to the emergence of a new research field known as scientific machine learning that combines deep neural networks, statistical learning and classical problems in applied mathematics. This paper proposes a novel numerical algorithm that utilizes machine learning and artificial intelligence to solve PDEs. Based on the Legendre-Galerkin framework, an unsupervised machine learning algorithm is proposed to learn multiple instances of solutions for various types of PDEs. The proposed neural network is applied to general 1D and 2D PDEs with different boundary conditions, as well as convection-dominated singularly perturbed PDEs exhibiting strong boundary layer behavior.
Article
Medicine, General & Internal
Soo Jin Na, Dong Kyu Oh, Sunghoon Park, Yeon Joo Lee, Sang-Bum Hong, Mi Hyeon Park, Ryoung-Eun Ko, Chae-Man Lim, Kyeongman Jeon
Summary: This study evaluated the effect of tachycardia on mortality in patients with septic shock and found that tachycardia was associated with improved survival in patients with elevated lactate levels, but not in patients with normal lactate levels.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
