Do immune checkpoint inhibitors perform identically in patients with weight extremes?

Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis

(2018) Jennifer L McQuade et al.   LANCET ONCOLOGY

Sarcopenic overweight is associated with early acute limiting toxicity of anti-PD1 checkpoint inhibitors in melanoma patients

(2017) Valentine Heidelberger et al.   INVESTIGATIONAL NEW DRUGS

Deubiquitination and Stabilization of PD-L1 by CSN5

(2016) Seung-Oe Lim et al.   CANCER CELL

Obesity and cancer immunotherapy toxicity

(2015) Annie Mirsoian et al.   Immunotherapy

Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients

(2015) Isabelle Magalhaes et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered Distribution and Increased IL-17 Production by Mucosal-Associated Invariant T Cells in Adult and Childhood Obesity

(2015) Eirin Carolan et al.   JOURNAL OF IMMUNOLOGY

Obesity-associated cancer: an immunological perspective

(2015) Melissa J. Conroy et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Breast Cancer Cell Colonization of the Human Bone Marrow Adipose Tissue Niche

(2015) Zach S. Templeton et al.   NEOPLASIA

Obesity Impairs γδ T Cell Homeostasis and Antiviral Function in Humans

(2015) Anne E. Costanzo et al.   PLoS One

Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice

(2014) Annie Mirsoian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults

(2014) Krishnan Bhaskaran et al.   LANCET

Using macrophage activation to augment immunotherapy of established tumours

(2013) Z G Fridlender et al.   BRITISH JOURNAL OF CANCER

Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy

(2013) Myriam N. Bouchlaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines

(2013) A Q Butt et al.   ONCOGENE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Caloric restriction leads to high marrow adiposity and low bone mass in growing mice

(2010) Maureen J Devlin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

(2009) Olaia Naveiras et al.   NATURE

Are Natural Killer Cells Protecting the Metabolically Healthy Obese Patient?

(2009) Lydia A. Lynch et al.   Obesity