Differential signaling pathways are initiated in macrophages during infection depending on the intracellular fate of Chlamydia spp.

Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection

(2017) Yutao Wang et al.   IMMUNITY

Guanylate Binding Proteins Enable Rapid Activation of Canonical and Noncanonical Inflammasomes in Chlamydia-Infected Macrophages

(2015) Ryan Finethy et al.   INFECTION AND IMMUNITY

The DNA Sensor, Cyclic GMP–AMP Synthase, Is Essential for Induction of IFN-β duringChlamydia trachomatisInfection

(2014) Yugen Zhang et al.   JOURNAL OF IMMUNOLOGY

Perforin-2 Restricts Growth of Chlamydia trachomatis in Macrophages

(2013) K. A. Fields et al.   INFECTION AND IMMUNITY

STING-Dependent Recognition of Cyclic di-AMP Mediates Type I Interferon Responses during Chlamydia trachomatis Infection

(2013) J. R. Barker et al.   mBio

B Cells Enhance Antigen-Specific CD4 T Cell Priming and Prevent Bacteria Dissemination following Chlamydia muridarum Genital Tract Infection

(2013) Lin-Xi Li et al.   PLoS Pathogens

Autophagy restrictsChlamydia trachomatisgrowth in human macrophages via IFNG-inducible guanylate binding proteins

(2012) Munir A. Al-Zeer et al.   Autophagy

Significant Role of IL-1 Signaling, but Limited Role of Inflammasome Activation, in Oviduct Pathology during Chlamydia muridarum Genital Infection

(2012) U. M. Nagarajan et al.   JOURNAL OF IMMUNOLOGY

Plasmid-Cured Chlamydia caviae Activates TLR2-Dependent Signaling and Retains Virulence in the Guinea Pig Model of Genital Tract Infection

(2012) Lauren C. Frazer et al.   PLoS One

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Interferon Regulatory Transcription Factor 3 Protects Mice from Uterine Horn Pathology during Chlamydia muridarum Genital Infection

(2011) Daniel Prantner et al.   INFECTION AND IMMUNITY

The pathogenic role of Chlamydia in spondyloarthritis

(2010) Hervé C Gérard et al.   CURRENT OPINION IN RHEUMATOLOGY

Induction of IFN-αβ enablesListeria monocytogenesto suppress macrophage activation by IFN-γ

(2010) Manira Rayamajhi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stimulator of IFN Gene Is Critical for Induction of IFN-β during Chlamydia muridarum Infection

(2010) Daniel Prantner et al.   JOURNAL OF IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Critical Role for Interleukin-1  (IL-1 ) during Chlamydia muridarum Genital Infection and Bacterial Replication-Independent Secretion of IL-1  in Mouse Macrophages

(2009) D. Prantner et al.   INFECTION AND IMMUNITY

Role for the Chlamydial Type III Secretion Apparatus in Host Cytokine Expression

(2008) D. Prantner et al.   INFECTION AND IMMUNITY

Type I Interferon Signaling Exacerbates Chlamydia muridarum Genital Infection in a Murine Model

(2008) U. M. Nagarajan et al.   INFECTION AND IMMUNITY