Journal
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
Volume 38, Issue 1, Pages 89-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2017.09.008
Keywords
Food allergy; Adjuvants; Probiotics; Bacterial adjuvants; Omalizumab; Interferon gamma
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Finding an effective curative treatment for food allergy is a research priority. Although oral immunotherapy (OIT) is effective at inducing desensitization, the temporary nature of this effect and high rates of adverse reactions have highlighted a need for novel strategies to improve tolerance induction and safety. One such strategy is the use of an adjuvant together with food immunotherapy to either suppress allergic reactions and/or modulate the underlying allergic immune response. In particular, the use of bacterial adjuvants seems to be a promising means of enhancing OIT-induced sustained unresponsiveness and warrants further investigation.
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