TCR tuning of T cell subsets

CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1

(2016) BAOXIA DONG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

CD6 modulates thymocyte selection and peripheral T cell homeostasis

(2016) Marc Orta-Mascaró et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Constitutive Lck Activity Drives Sensitivity Differences between CD8+Memory T Cell Subsets

(2016) Duane Moogk et al.   JOURNAL OF IMMUNOLOGY

CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells

(2016) Jae-Ho Cho et al.   Nature Communications

Dynamic Tuning of Lymphocytes: Physiological Basis, Mechanisms, and Function

(2015) Zvi Grossman et al.   Annual Review of Immunology

Small molecule inhibition of Csk alters affinity recognition by T cells

(2015) Boryana N Manz et al.   eLife

Memory CD8+T cells exhibit increased antigen threshold requirements for recall proliferation

(2014) Erin R. Mehlhop-Williams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The TCR's sensitivity to self peptide–MHC dictates the ability of naive CD8+ T cells to respond to foreign antigens

(2014) Ross B Fulton et al.   NATURE IMMUNOLOGY

Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC

(2014) Stephen P Persaud et al.   NATURE IMMUNOLOGY

T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens

(2013) Judith N. Mandl et al.   IMMUNITY

Control of inflammation by integration of environmental cues by regulatory T cells

(2013) Ashutosh Chaudhry et al.   JOURNAL OF CLINICAL INVESTIGATION

Themis sets the signal threshold for positive and negative selection in T-cell development

(2013) Guo Fu et al.   NATURE

Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling

(2013) Ying Xim Tan et al.   NATURE IMMUNOLOGY

Selection of Self-Reactive T Cells in the Thymus

(2012) Gretta L. Stritesky et al.   Annual Review of Immunology

Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity

(2012) Stephanie M. Stanford et al.   IMMUNOLOGY

Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold

(2012) T. L. Stephen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD8 T cell quiescence revisited

(2012) Sara E. Hamilton et al.   TRENDS IN IMMUNOLOGY

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

(2011) Florian Wiede et al.   JOURNAL OF CLINICAL INVESTIGATION

Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells

(2011) Jonathan Sprent et al.   NATURE IMMUNOLOGY

Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival

(2011) J. Zikherman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Receptor-Dependent Regulation of Lipid Rafts Controls Naive CD8+ T Cell Homeostasis

(2010) Jae-Ho Cho et al.   IMMUNITY

CD45-Csk Phosphatase-Kinase Titration Uncouples Basal and Inducible T Cell Receptor Signaling during Thymic Development

(2010) Julie Zikherman et al.   IMMUNITY

Thymoproteasome Shapes Immunocompetent Repertoire of CD8+ T Cells

(2010) Takeshi Nitta et al.   IMMUNITY

The Phosphatase PTP-PEST Promotes Secondary T Cell Responses by Dephosphorylating the Protein Tyrosine Kinase Pyk2

(2010) Dominique Davidson et al.   IMMUNITY

Dendritic cells control T cell tonic signaling required for responsiveness to foreign antigen

(2010) K. Hochweller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self–class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels

(2009) Kensuke Takada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Activation Threshold of CD4+ T Cells Is Defined by TCR/Peptide-MHC Class II Interactions in the Thymic Medulla

(2009) T. L. Stephen et al.   JOURNAL OF IMMUNOLOGY

An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells

(2009) Wan-Lin Lo et al.   NATURE IMMUNOLOGY

Themis controls thymocyte selection through regulation of T cell antigen receptor–mediated signaling

(2009) Guo Fu et al.   NATURE IMMUNOLOGY

An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

(2009) Peter J R Ebert et al.   NATURE IMMUNOLOGY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY

CD45 Glycosylation controls T-cell life and death

(2008) L A Earl et al.   IMMUNOLOGY AND CELL BIOLOGY

CD4+ T cell hyper-responsiveness in CD45 transgenic mice is independent of isoform

(2008) Robert J. Salmond et al.   INTERNATIONAL IMMUNOLOGY