Article
Gastroenterology & Hepatology
Arthur I. Kooyker, Esther Toes-Zoutendijk, Annemieke W. J. Opstal-van Winden, Maaike Buskermolen, Hanneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, Chris Ramakers, Evelien Dekker, Iris D. Nagtegaal, Harry J. de Koning, Manon C. W. Spaander, Iris Lansdorp-Vogelaar, Monique E. van Leerdam
Summary: The colonoscopy-related mortality within the Dutch FIT-based CRC screening program was estimated to range from 0.23 to 0.91 per 10,000 FIT-positive participants undergoing colonoscopy, with 50% of likely colonoscopy-related causes of death being cardiovascular events.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Tareq El Menabawey, Raymond McCrudden, Dushyant Shetty, Andrew D. Hopper, Matthew T. Huggett, Noor Bekkali, Nicholas R. Carroll, Elaine Henry, Gavin J. Johnson, Margaret G. Keane, Mark Love, Colin J. McKay, Sally Norton, Kofi Oppong, Ian Penman, Jayapal Ramesh, Barbara Ryan, Keith Siau, Manu Nayar
Summary: The international approach to credentialing individuals in endoscopic ultrasound (EUS) varies, but there is no consensus on this or its implementation. In 2019, the Joint Advisory Group on GI Endoscopy (JAG) commissioned a working group to develop evidence-based recommendations for EUS training and certification. The key recommendations include a minimum of 250 hands-on cases, attendance at a basic EUS course, formative DOPS assessment every 10 cases, competent performance in summative DOPS assessments, and a minimum 12-month mentorship period.
Article
Gastroenterology & Hepatology
Kai Man Alexander Ho, Amitava Banerjee, Mark Lawler, Matthew D. Rutter, Laurence B. Lovat
Summary: This study analyzed the impact of the COVID-19 pandemic on endoscopy services in England, revealing a significant backlog of procedures that may take a considerable amount of time to clear even with increased capacity. Urgent action is required to address the backlog and prevent delays in patient management.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Marten A. Lantinga, Felix Theunissen, Pieter C. J. ter Borg, Marco J. Bruno, Rob J. T. Ouwendijk, Peter D. Siersema
Summary: The COVID-19 lockdown led to a significant reduction in the number of endoscopies performed in Dutch hospitals, with a higher likelihood of detecting cancer during endoscopy. After the lockdown was lifted, endoscopy volumes quickly returned to normal, except for colorectal cancer screening.
Article
Engineering, Chemical
Petr Travnicek, Petr Junga, Lubos Kotek, Tomas Vitez
Summary: The article addresses the issue of process safety in municipal wastewater treatment plants, creating a database of 232 accidents and analyzing their causes, consequences, and prevention methods. The most common cause of accidents is device or structural failure, with environmental damage being the most frequent consequence. Extreme weather conditions account for 13% of all accidents at WWTPs, indicating a need for operators to prepare for an increase in such incidents.
JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES
(2022)
Review
Gastroenterology & Hepatology
Fang Xie, Keqiang Zhang, Feng Li, Guorong Ma, Yuanyuan Ni, Wei Zhang, Junchao Wang, Yuewei Li
Summary: This study evaluated the accuracy and effectiveness of the convolutional neural network (CNN) in diagnosing gastric cancer and predicting the invasion depth. The results showed that the CNN performed highly accurately in both diagnosing gastric cancer and predicting the invasion depth. Its performance was comparable to that of expert endoscopists.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Public, Environmental & Occupational Health
Hye Young Shin, Da Hun Jang, Jae Kwan Jun
Summary: The study showed that healthcare professionals who have participated in endoscope reprocessing training are more likely to adhere to the guidelines, and they are generally satisfied with the current training. National training programs can help ensure quality control for endoscopy, but further training is needed for half of the practitioners currently working in endoscopy units.
AMERICAN JOURNAL OF INFECTION CONTROL
(2021)
Article
Gastroenterology & Hepatology
Swati Pawa, Richard S. Kwon, Douglas S. Fishman, Nirav C. Thosani, Amandeep Shergill, Samir C. Grover, Mohammad Al-Haddad, Stuart K. Amateau, James L. Buxbaum, Audrey H. Calderwood, Jean M. Chalhoub, Nayantara Coelho-Prabhu, Madhav Desai, Sherif E. Elhanafi, Nauzer Forbes, Larissa L. Fujii-Lau, Divyanshoo R. Kohli, Jorge D. Machicado, Neil B. Marya, Wenly Ruan, Sunil G. Sheth, Andrew C. Storm, Nikhil R. Thiruvengadam, Bashar J. Qumseya
Summary: This clinical practice guideline provides an evidence based approach to prevent endoscopy-related injury (ERI) in GI endoscopists. It includes a detailed account of the methodology used for the evidence review and suggests various measures to decrease the risk of ERI.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Biochemical Research Methods
Di Xiao, Hani Jieun Kim, Ignatius Pang, Pengyi Yang
Summary: This study developed a statistical framework to identify stable phosphorylated sites in human phosphoproteomics datasets, which are evolutionarily conserved, functionally important, and enriched in core signaling and gene pathways. Particularly, SPSs in the RNA splicing pathway are frequent targets of cancer mutations, suggesting a potential link between dysregulated RNA splicing and cancer development through mutations on SPSs.
Article
Surgery
Shawn M. Purnell, Daniel J. Vargo, Michael Sarap, John J. Nguyen-Lee, Chelsea Allen, Brian J. Dunkin
Summary: The study surveyed rural surgeons on their requirements and preferences for a simulation model for rehearsing the endoscopic management of NVUGIB. Results showed that most rural surgeons lack experience with simulation models but are interested in further training.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Sohi Mistry, Omar Alaber, Apoorva Krishna Chandar, Lady Katherine Mejia Perez, John Dumot, Amit Bhatt, Amitabh Chak
Summary: The survey of ESD experts in the US showed that the majority work in university-based, community, or tertiary care hospitals, and most of them received formal supervised hands-on training before performing ESD independently. Many indicated that credentialing requirements should include attending weekend ESD courses, observing live procedures, practicing on explants, and advanced endoscopic training in interventional endoscopy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Biochemistry & Molecular Biology
Qi Xu, Jeanne Kowalski
Summary: Alternate forms of DNA, such as Z-DNA, G-quadruplex, and triplex, have shown potential roles in cancer development. Non-B DNA-forming sequences have been found to induce genetic instability in human cancer genomes, implicating their involvement in cancer and other genetic diseases. However, existing non-B prediction tools and databases lack the capability to analyze and visualize non-B data in a cancer context. In this study, we present NBBC, a non-B DNA burden explorer in cancer, which provides analysis and visualization for non-B DNA forming motifs. We introduce the concept of 'non-B burden' as a metric to summarize the prevalence of non-B DNA motifs at different levels. With the non-B burden metric, we develop two analysis modules within a cancer context, aiming to explore both gene- and motif-level heterogeneity of non-B DNA. NBBC is designed as a novel analysis and visualization platform guided by non-B burden as a marker.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Health Care Sciences & Services
Pei-Chin Chen, Yun-Ru Lu, Yi-No Kang, Chun-Chao Chang
Summary: This study evaluated the diagnostic accuracy of AI in the diagnosis of early gastric cancer from endoscopic images. The results showed that AI can support the diagnosis of early gastric cancer. However, the collocation of imaging techniques and optimal algorithms remains unclear.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Medicine, General & Internal
Silvia Calabria, Giulia Ronconi, Letizia Dondi, Carlo Piccinni, Enrico Cinconze, Antonella Pedrini, Immacolata Esposito, Alice Addesi, Nello Martini, Aldo Pietro Maggioni
Summary: This study analyzed healthcare consumption and costs of CAD patients eligible for secondary prevention in Italy in 2018, revealing a significant burden on patients with comorbidities and frequent hospitalizations. A multidisciplinary healthcare approach is recommended to improve patient outcomes and reduce costs for the Italian National Health Service.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Leonardo Frazzoni, Liboria Laterza, Marina La Marca, Rocco Maurizio Zagari, Franco Radaelli, Cesare Hassan, Alessandro Repici, Antonio Facciorusso, Paraskevas Gkolfakis, Cristiano Spada, Konstantinos Triantafyllou, Franco Bazzoli, Mario Dinis-Ribeiro, Lorenzo Fuccio
Summary: This study assessed the diagnostic performance of alarm features (rectal bleeding, anemia, change in bowel habit, and weight loss) for colorectal cancer (CRC) diagnosis through a systematic review and meta-analysis. The results showed variable accuracy for each alarm feature, and rectal bleeding and anemia were identified as the most practical features for selecting patients for colonoscopy.
Editorial Material
Gastroenterology & Hepatology
Cary C. Cotton, Yash A. Choksi
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
S. Ryanne Corder, Manaswita Tappata, Olivia Shaheen, Cary C. Cotton, Elizabeth T. Jensen, Evan S. Dellon
DIGESTIVE DISEASES AND SCIENCES
(2020)
Editorial Material
Gastroenterology & Hepatology
Cary C. Cotton, Nicholas J. Shaheen
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Oncology
Dongyu Zhang, Yilin Feng, Nan Li, Xuezheng Sun
Summary: The study found that moderate fruit and vegetable consumption was significantly inversely associated with frequent mental distress (FMD) among breast cancer survivors. No significant association was found between fruit juice consumption and FMD. There was no interaction between adverse lifestyle behaviors and the outcomes.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Gastroenterology & Hepatology
Cary C. Cotton, Renee Betancourt, Cara Randall, Irina Perjar, Christine Bookhout, John T. Woosley, Nicholas J. Shaheen, Evan S. Dellon
Summary: A predictive model was developed based on the updated EoE diagnostic guidelines to identify patients with EoE without a PPI trial. Clinical features and endoscopic findings effectively identified patients with EoE, and the addition of histologic data further improved diagnostic accuracy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ekaterina Safroneeva, Cary C. Cotton, Alain M. Schoepfer, Marcel Zwahlen, John T. Woosley, Evan S. Dellon
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Engineering, Environmental
Yun Liu, Nan Li, George D. Papandonatos, Antonia M. Calafat, Charles B. Eaton, Karl T. Kelsey, Aimin Chen, Bruce P. Lanphear, Kim M. Cecil, Heidi J. Kalkwarf, Kimberly Yolton, Joseph M. Braun
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2020)
Article
Multidisciplinary Sciences
Marisa A. Patti, Nan Li, Melissa Eliot, Craig Newschaffer, Kimberly Yolton, Jane Khoury, Aimin Chen, Bruce P. Lanphear, Kristen Lyall, Irva Hertz-Picciotto, Margaret Daniele Fallin, Lisa A. Croen, Joseph M. Braun
Summary: Maternal caffeine intake during pregnancy is positively associated with child ASD-related behaviors, particularly among women with higher pre-pregnancy BMI. Further studies are needed to confirm these findings.
Article
Gastroenterology & Hepatology
Charles E. Gaber, Swathi Eluri, Cary C. Cotton, Paula D. Strassle, Timothy M. Farrell, Jennifer L. Lund, Evan S. Dellon
Summary: This study estimated the incidence, prevalence, and direct medical costs of achalasia in the United States. The results showed that achalasia has a higher epidemiologic and economic burden in the US than previously suggested, with a particularly increasing diagnosis in older patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Environmental Sciences
Nan Li, Yun Liu, George D. Papandonatos, Antonia M. Calafat, Charles B. Eaton, Karl T. Kelsey, Kim M. Cecil, Heidi J. Kalkwarf, Kimberly Yolton, Bruce P. Lanphear, Aimin Chen, Joseph M. Braun
Summary: The study revealed that children with higher gestational exposure to PFOA and PFHxS were associated with unfavorable cardiometabolic risk in adolescence, primarily driven by insulin resistance and adiponectin to leptin ratio. Other individual cardiometabolic risk factors associated with gestational PFOA included insulin and waist circumference.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Shweta Bhatia, Cary C. Cotton, Erin Kim, Hannah Angle, Ariel E. Watts, Swathi Eluri, Nicholas J. Shaheen
Summary: This study found that the proportion of female authors in high-impact gastroenterology journals has significantly increased over the past 20 years, especially in the role of first authors. However, the growth rate of female last authors is slower, indicating that gender disparities still exist. Future interventions should focus on the transition from first to last authorship to reduce gender inequality in GI research.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
D. Nance, K. M. Rappazzo, E. T. Jensen, K. Hoffman, C. C. Cotton, A. K. Krajewski, K. O. Turner, R. M. Genta, D. T. Lobdell, E. S. Dellon
Summary: This study investigated the association between environmental quality and the risk of eosinophilic esophagitis (EoE) using the Environmental Quality Index. The findings showed that poor environmental quality, particularly in terms of water quality, was associated with an increased risk of EoE, while better air and land quality were inversely associated with EoE. Further research to identify specific water pollutants that may play a role in EoE etiology may be necessary.
DISEASES OF THE ESOPHAGUS
(2021)
Article
Gastroenterology & Hepatology
Charles E. Gaber, Cary C. Cotton, Swathi Eluri, Jennifer L. Lund, Timothy M. Farrell, Evan S. Dellon
Summary: This study suggests that achalasia may be associated with autoimmune conditions and viral infections. Autoimmune diseases and certain viral infections may increase the risk of achalasia.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Public, Environmental & Occupational Health
Blanche C. Ip, Nan Li, Medina Jackson-Browne, Melissa Eliot, Yingying Xu, Aimin Chen, Bruce P. Lanphear, Adam J. Spanier, Joseph M. Braun
Summary: The study found that cord blood leptin and adiponectin concentrations can affect children's lung development and function, with higher cord blood adiponectin concentrations associated with higher %FEV1 in girls, and higher leptin concentrations associated with lower risk of wheeze in girls. However, higher adiponectin concentrations were associated with a lower risk of wheeze in both boys and girls.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2021)
Article
Environmental Sciences
Nan Li, George D. Papandonatos, Antonia M. Calafat, Kimberly Yolton, Bruce P. Lanphear, Aimin Chen, Joseph M. Braun
ENVIRONMENT INTERNATIONAL
(2020)