Journal
IEEE TRANSACTIONS ON MEDICAL IMAGING
Volume 37, Issue 10, Pages 2322-2332Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMI.2018.2830381
Keywords
Positron emission tomography; super resolution; sinogram; deep residual learning; convolutional neural networks; transfer learning
Categories
Funding
- Center for HPC, Shanghai Jiao Tong University
Ask authors/readers for more resources
Increasing the image quality of positron emission tomography (PET) is an essential topic in the PET community. For instance, thin-pixelated crystals have been used to provide high spatial resolution images but at the cost of sensitivity and manufacture expense. In this paper, we proposed an approach to enhance the PET image resolution and noise property for PET scanners with large pixelated crystals. To address the problemof coarse blurred sinograms with large parallax errors associated with large crystals, we developed a data-driven, single-image superresolution (SISR) method for sinograms, based on the novel deep residual convolutional neural network (CNN). Unlike the CNN-based SISR on natural images, periodically padded sinogram data and dedicated network architecture were used to make it more efficient for PET imaging. Moreover, we included the transfer learning scheme in the approach to process cases with poor labeling and small training data set. The approach was validated via analytically simulated data (with and without noise), Monte Carlo simulated data, and pre-clinical data. Using the proposedmethod, we could achieve comparable image resolution and better noise property with large crystals of bin sizes 4 x of thin crystals with a bin size from 1 x 1 mm 2 to 1.6 x 1.6 mm 2. Our approach uses external PET data as the prior knowledge for training and does not require additional information during inference. Meanwhile, the method can be added into the normal PET imaging framework seamlessly, thus potentially finds its application in designing low-cost high-performance PET systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available