Article
Chemistry, Analytical
Ji-Eun Joo, Myung-Jae Lee, Sung Min Park
Summary: This paper introduces an optoelectronic receiver IC for home-monitoring LiDAR sensors, manufactured using CMOS process with high gain and wide bandwidth. By utilizing different circuit techniques, lower power consumption and cost, as well as higher reliability and efficiency, can be achieved.
Article
Optics
Dingyi Wu, Dong Wang, Daigao Chen, Jie Yan, Ziyue Dang, Jianchao Feng, Shiping Chen, Peng Feng, Hongguang Zhang, Yanfeng Fu, Lei Wang, Xiao Hu, Xi Xiao, Shaohua Yu
Summary: A high-performance 3D-integrated silicon photonics receiver is demonstrated using flip-chip bonding technology. It consists of a high-speed germanium-silicon photodetector and a commercial linear transimpedance amplifier. The receiver achieves a 3 dB bandwidth of approximately 38 GHz and demonstrates clear eye diagrams for various modulation schemes. The receiver also exhibits low power consumption, making it suitable for short-reach data center applications.
Article
Optics
Weizhong Li, Hongguang Zhang, Xiao Hu, Donglai Lu, Daigao Chen, Sikai Chen, Jian He, Lei Wang, Nan Qi, Xi Xiao, Shaohua Yu
Summary: This study demonstrates a co-designed optical receiver integrated with a silicon-photonic photodetector and silicon-germanium trans-impedance amplifier. By accurate equivalent circuit models and proposed EQ techniques, the bandwidth of the optical receiver is successfully extended to achieve high-speed data transmission.
Article
Engineering, Biomedical
Drew A. Hall, Nagaraj Ananthapadmanabhan, Chulmin Choi, Le Zheng, Paul P. P. Pan, Christoph Von Jutrzenka, Thuan Nguyen, Jose Rizo, Macklan Weinstein, Raymond Lobaton, Prem Sinha, Trevor Sauerbrey, Cruz Sigala, Kathryne Bailey, Paul J. Mudondo, Ashesh Ray Chaudhuri, Simone Severi, Carl W. Fuller, James M. Tour, Sungho Jin, Paul W. Mola, Barry Merriman
Summary: This work presents the first CMOS molecular electronics chip that allows direct, real-time observation of molecular interaction kinetics. It provides a new platform for applications in biological research, diagnostics, drug discovery, and more.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2022)
Article
Optics
Xiao Hu, Dingyi Wu, Ye Liu, Min Liu, Daigao Chen, Lei Wang, Xi Xiao, Shaohua Yu
Summary: Based on the commercial silicon photonics (SiPh) process platform, a germanium-silicon (Ge-Si) photodetector (PD) with a flat 3 dB bandwidth of 80 GHz is experimentally demonstrated, achieving an exceptional bandwidth performance by using the gain peaking technique. The peaked Ge-Si PD exhibits high-speed large signal reception capability and shows improved transmitter dispersion eye closure quaternary (TDECQ) penalties compared to the un-peaked PD. Additionally, it demonstrates comparable bit error rate (BER) performance to a 70 GHz Finisar PD, making it a potential solution for supporting high-speed optical receivers.
Article
Engineering, Electrical & Electronic
Ji-Eun Joo, Myung-Jae Lee, Sung Min Park
Summary: This article presents an optoelectronic receiver IC with on-chip avalanche photodiode (APD) for indoor-monitoring light detection and ranging (LiDAR) sensors. The integrated CMOS p+/n-well APD avoids signal distortion and unwanted effects. Various circuit techniques, such as DFD-TIA, ASD converter, CI-PA, and TDA-NIC, are utilized to achieve high performance. The measurement results show that the proposed receiver provides a potential solution for low-cost and low-power short-range LiDAR sensors.
IEEE SENSORS JOURNAL
(2023)
Review
Engineering, Electrical & Electronic
Da Ying, Drew A. Hall
Summary: This article reviews current-output sensors and current-sensing front-ends, providing comprehensive design guidance from both sensor and circuit perspectives. It discusses various types of sensors and their applications, circuit models, and nonidealities, as well as current-sensing front-ends such as TIAs, CCs, I-to-F converters, and I-Delta Sigma modulators, analyzing their characteristics and tradeoffs between different architectures.
IEEE SENSORS JOURNAL
(2021)
Article
Engineering, Electrical & Electronic
Farzad Khoeini, Bardia Pezeshki, Emad Afifi, Alex Tselikov, Robert F. Kalman, Bahareh Hadidian, Ehsan Afshari
Summary: This article compares the energy efficiency of serial and parallel optical links and proposes a design of an optical receiver integrated with blue photodetectors. The design achieves high energy efficiency and compact analog front-end, paving the way for dense and energy efficient parallel links.
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2023)
Article
Computer Science, Information Systems
Guido Di Patrizio Stanchieri, Andrea De Marcellis, Marco Faccio, Elia Palange, Graziano Battisti, Ulkuhan Guler
Summary: This paper presents a CMOS fully integrated optoelectronic sensing system for wearable/portable/implantable biomedical applications. It consists of a Si photodiode and a transimpedance amplifier as the electronic analog front-end, designed to be small, low power, and compatible with biological tissues. The system was implemented and fabricated in TSMC 180 nm integrated CMOS technology, achieving high performance in terms of transimpedance gain and bandwidth. Experimental measurements and case examples of optical detection for electrocardiography and photoplethysmography signals were provided.
Article
Engineering, Electrical & Electronic
Mohammad Khaleqi Qaleh Jooq, Fereshteh Behbahani, Mohammad Hossein Moaiyeri
Summary: This paper introduces an ultra-efficient recycling folded cascode operational transconductance amplifier, which utilizes two positive feedbacks to enhance input transconductance and output impedance, while reducing power consumption by operating near the threshold. Simulation results show low power consumption, reasonable slew rate response, and high gain. Additionally, a capacitive readout circuit and a transimpedance amplifier for MEMS/NEMS applications are proposed to evaluate performance.
AEU-INTERNATIONAL JOURNAL OF ELECTRONICS AND COMMUNICATIONS
(2021)
Article
Optics
Yu Hu, Ji-Eun Joo, Xinyue Zhang, Yeojin Chon, Shinhae Choi, Myung-Jae Lee, Sung-Min Park
Summary: This paper presents three different types of on-chip avalanche photodiodes (APDs) realized in a TSMC 180 nm 1P6M RF CMOS process. A P+/N-well (NW) APD is designed for high responsivity and large bandwidth. A P+/Deep N-well (DNW) APD is designed to improve near-infrared (NIR) sensitivity. A P+/NW/DNW APD is designed to prevent premature edge breakdown and improve NIR sensitivity. A current-mode optoelectronic receiver (C-OER) is proposed to extend the dynamic range for short-range LiDAR sensors. The optically measured results demonstrate large output pulses with low power consumption and small chip size.
Article
Engineering, Electrical & Electronic
Preeti Singh, Maneesha Gupta
Summary: This paper presents a new wideband inductorless CMOS transimpedance amplifier for 10Gb/s applications, utilizing novel feedback topology and techniques to extend bandwidth. The performance of the proposed amplifier is analyzed mathematically and verified through simulation.
INTERNATIONAL JOURNAL OF NUMERICAL MODELLING-ELECTRONIC NETWORKS DEVICES AND FIELDS
(2021)
Article
Chemistry, Multidisciplinary
Mookyoung Yoo, Kyeongsik Nam, Gyuri Choi, Sanggyun Kang, Byeongkwan Jin, Hyeoktae Son, Kyounghwan Kim, Hyoungho Ko
Summary: This paper presents an incremental second-order delta-sigma modulator with a coarse-fine input buffer in 180-nm CMOS, achieving high performance as demonstrated by experimental results.
APPLIED SCIENCES-BASEL
(2022)
Article
Engineering, Electrical & Electronic
Wenxin Yu, Lenian He, Jianxiong Xi
Summary: This paper presents an 18-bit 2-2 MASH delta-sigma modulator (DSM) for the isolated amplifier, which effectively reduces harmonic distortion. Techniques such as gain boost, slew rate (SR) boost, and chopper technique are utilized to enhance performance. The DSM achieves a Schreier figure-of-merit (FoMs) of 170.00 dB and simulation results show a signal-to-noise and distortion ratio (SNDR) of 108.71 dB and an effective number of bits (ENOB) of 17.77 in a 20 kHz bandwidth.
MICROELECTRONICS JOURNAL
(2023)
Article
Computer Science, Information Systems
Guido Di Patrizio Stanchieri, Andrea De Marcellis, Graziano Battisti, Marco Faccio, Elia Palange, Ulkuhan Guler
Summary: This paper presents a novel solution for a transimpedance amplifier (TIA) in biomedical applications. The proposed solution operates with nanoampere input pulsed currents and has been analyzed for its performance through accurate post-layout simulations.
Editorial Material
Clinical Neurology
Caroline Menard, Tabrez J. Siddiqui, Derya Sargin, Ashley Lawson, Yves De Koninck, Judy Illes
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Marc Lopez-Cano, Joan Font, Ester Aso, Kristoffer Sahlholm, Gisela Cabre, Jesus Giraldo, Yves De Koninck, Jordi Hernando, Amadeu Llebaria, Victor Fernandez-Duenas, Francisco Ciruela
Summary: Photopharmacology offers a promising approach to improve the benefit/risk profiles of opioid-based drugs. This study successfully developed a morphine photo-derivative that can be activated by light, providing effective analgesia without the occurrence of tolerance or associated opioid-related side effects.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Editorial Material
Clinical Neurology
Melissa L. Perreault, Malcolm King, Chelsea Gabel, Christopher J. Mushquash, Yves De Koninck, Ashley Lawson, Caterina Marra, Caroline Menard, Jennie Z. Young, Judy Illes
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Engineering, Electrical & Electronic
Mousa Karimi, Mohamed Ali, Ahmad Hassan, Mohamad Sawan, Benoit Gosselin
Summary: In this study, a dead-time control circuit is proposed to generate independent delays for the high and low sides of half-bridge converter switches, reducing losses and mitigating shoot-through current. Implemented in AMS 0.35 μm technology, the proposed circuit greatly decreases power losses in the half-bridge circuit.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS
(2022)
Article
Neurosciences
Candler Paige, Isabel Plasencia-Fernandez, Moeno Kume, Melina Papalampropoulou-Tsiridou, Louis-Etienne Lorenzo, Eric T. David, Lucy He, Galo L. Mejia, Christopher Driskill, Francesco Ferrini, Andrew L. Feldhaus, Leon F. Garcia-Martinez, Armen N. Akopian, Yves De Koninck, Gregory Dussor, Theodore J. Price
Summary: The findings suggest that CGRP promotes pain plasticity in female rodents but has a limited impact in males.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Noosha Yousefpour, Samantha Locke, Haley Deamond, Chengyang Wang, Lucas Marques, Manon St-Louis, Johanne Ouellette, Arkady Khoutorsky, Yves De Koninck, Alfredo Ribeiro-da-Silva
Summary: Neuropathic pain is a debilitating condition caused by nerve system damage, and the imbalance of spinal excitation and inhibition is believed to contribute to it. Little is known about the structural basis of this imbalance. Through a preclinical model of neuropathic pain, researchers have found that microglia selectively engulf spinal synapses of central neurons but not peripheral sensory neurons. They also discovered that the removal of inhibitory and excitatory synapses occurs in different temporal patterns, with microglia-mediated inhibitory synapse removal happening before excitatory synapse removal. Additionally, they observed a gradual increase in complement depositions on dorsal horn synapses, which corresponds to the temporal pattern of microglial synapse pruning activity and specific synapse loss.
Review
Clinical Neurology
Marco Battaglia, Cornelius B. Groenewald, Fiona Campbell, Simona Scaini, Yves De Koninck, Jennifer Stinson, Patrick D. Quinn
Summary: This article provides a multidisciplinary assessment of the relationships among mental health, chronic pain, prescribing patterns, and the opioid crisis. It highlights the impact of the crisis on young people and emphasizes the role of prescribing patterns as a modifiable hazard factor. It calls for psychiatrists to take a more active role in leading interdisciplinary conversations and addressing the crisis.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Ekaterina Martianova, Renata Sadretdinova, Alicia Pageau, Nikola Pausic, Tommy Doucet Gentiletti, Danahe Leblanc, Arturo Marroquin Rivera, Benoit Labonte, Christophe D. Proulx
Summary: The outputs of lateral hypothalamic neurons play a critical role in sensory integration and organizing behavior responses. This study demonstrates the significant coherent activity of three major neuronal outputs projecting to downstream targets during sensory-evoked or self-initiated motor responses in mice.
Article
Clinical Neurology
Melina Papalampropoulou-Tsiridou, Stephanie Shiers, Feng Wang, Antoine G. Godin, Theodore J. Price, Yves De Koninck
Summary: This study examined the expression pattern of ASIC1, ASIC2, and ASIC3 mRNA in human dorsal root ganglia neurons using an in situ hybridization approach. The results showed broad expression of ASIC1 and ASIC3 subunits in human primary sensory neurons, contrasting with the expression patterns in rodents. These differences should be considered when evaluating the translational potential of ASIC studies in rodents.
BRAIN COMMUNICATIONS
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
G. Gagnon-Turcotte, B. Gosselin
Summary: We present a small headstage that allows for multichannel neural recording and optogenetic stimulation in freely moving laboratory mice. The device is compact and lightweight, making it the smallest BLE electro-optic device for freely moving brain research. In vivo experiments conducted in the hippocampus of a mouse demonstrated successful results.
2022 20TH IEEE INTERREGIONAL NEWCAS CONFERENCE (NEWCAS)
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
S. Nazila Hosseini, V. K. Lazarjan, M. Makhdoumi Akram, Benoit Gosselin
Summary: This paper presents the design of a custom integrated CMOS lock-in amplifier (LIA) with an impedance sensor for microbial monitoring applications. The main building block of the lock-in amplifier is a fully differential switched-capacitor transimpedance amplifier, and chopper stabilization is used to improve the sensor's sensitivity.
2022 20TH IEEE INTERREGIONAL NEWCAS CONFERENCE (NEWCAS)
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Mousa Karimi, Amir Aghajani, Mohamed Ali, Mohamad Sawan, Benoit Gosselin
Summary: This work presents the design of an energy-efficient buck converter using a custom integrated reconfigurable Asymmetric Deadtime Generator (ADG). The design addresses the need for energy-efficient and high-power density power converters, providing a wide range of deadtime delays for different power conversion applications with various loads. Experimental results show that the presented ADG can significantly improve the converter's efficiency.
2022 20TH IEEE INTERREGIONAL NEWCAS CONFERENCE (NEWCAS)
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Magali Ozon, Antoine Frasie, Michelle Janusz, Gabriel Gagnon-Turcotte, Mourad Roudjane, Laurent Bouyer, Ghyslain Gagnon, Younes Messaddeq, Benoit Gosselin
Summary: The design of a motion analysis wearable sensor based on a flexible and stretchable fiber sensor is presented. The performance of the fiber is thoroughly characterized and benchmarked, and the system is validated using a robotic arm and utilized to measure motion on the knee joints of volunteers.
2022 20TH IEEE INTERREGIONAL NEWCAS CONFERENCE (NEWCAS)
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Saeed Ghaneei Aarani, MohammadReza Mehranpouy, Benoit Gosselin
Summary: This paper presents a novel circuit technique to extend the bandwidth of an ultra-wideband low-noise amplifier (LNA). The proposed circuit utilizes a symmetric center-tapped inductor and an RC series network to increase the headroom voltage of the LNA and enable larger S21. Experimental results show that the proposed approach can effectively operate in a frequency range of 4.33 GHz to 13.9 GHz.
2022 20TH IEEE INTERREGIONAL NEWCAS CONFERENCE (NEWCAS)
(2022)
Article
Medicine, Research & Experimental
Calvin Wong, Omer Barkai, Feng Wang, Carolina Thorn Perez, Shaya Lev, Weihua Cai, Shannon Tansley, Noosha Yousefpour, Mehdi Hooshmandi, Kevin C. Lister, Mariam Latif, A. Claudio Cuello, Masha Prager-Khoutorsky, Jeffrey S. Mogil, Philippe Seguela, Yves De Koninck, Alfredo Ribeiro-da-Silva, Alexander M. Binshtok, Arkady Khoutorsky
Summary: The activation of mTORC2 triggered by tissue inflammation causes structural changes in nociceptive free nerve endings, leading to inflammatory pain. Inhibiting the regulatory protein Rictor of mTORC2 can prevent the elongation and branching of nociceptive fibers, reducing inflammatory pain hypersensitivity.
JOURNAL OF CLINICAL INVESTIGATION
(2022)