Article
Biophysics
Ting-Wei Wang, Yen-Ling Sung, Hsiao-Wei Chu, Shien-Fong Lin
Summary: This study developed a low-cost, portable IPG-based sensor for real-time measurement of cardiomyocytes' response to optogenetic stimulation. The results demonstrated that the IPG sensor accurately measured the beating rhythm of cardiomyocytes and detected irregular fibrillating waveforms caused by arrhythmia. The study confirmed the feasibility of long-term electrophysiological sensing for optogenetic cardiomyocytes.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Bing-Syun Chen, Mon-Juan Lee, Wei Lee
Summary: This study utilizes the doping of a cationic surfactant into liquid crystals to enable the detection and quantification of bovine serum albumin. The use of DC voltage or dielectric analysis allows for label-free biosensing and multimode quantification.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Ran Liu, Yuansheng Hu, Ying He, Tian Lan, Jingjing Zhang
Summary: Home testing is an emerging strategy to combat the COVID-19 pandemic and prevent healthcare resource overload. Current diagnostic technologies for SARS-CoV-2 have drawbacks in terms of sensitivity, usability, and costs, making the tests unaffordable for most users at home. To address these limitations, a target-responsive CRISPR-PGM system has been proposed for translating SARS-CoV-2 detection into a glucose test, offering a potential single-device solution for monitoring multiple COVID-19 biomarkers at home.
Article
Food Science & Technology
Thierry Delatour, Aurelien Desmarchelier, Richard H. Stadler
Summary: Accurate quantification of acrylamide levels in food is crucial for consumer protection, but signal interference due to improper LC-MS/MS analytical conditions may lead to overestimation of acrylamide levels.
CURRENT OPINION IN FOOD SCIENCE
(2022)
Article
Microbiology
Merel Oeyen, Eef Meyen, Jordi Doijen, Dominique Scholsa
Summary: This study utilized ECIS technology to evaluate Zika virus infection in human cells and test the efficacy and mechanism of antiviral compounds. The results demonstrated that CEI can sensitively detect viral infection and provide useful information for the search for antiviral drugs.
MICROBIOLOGY SPECTRUM
(2022)
Review
Chemistry, Analytical
Ping Xu, Subhadeep Ghosh, Anam Rana Gul, Jigna R. Bhamore, Jong Pil Park, Tae Jung Park
Summary: Biosensors have seen rapid growth in the field of biological detection and biomedical diagnosis, with displayed peptides from phage display libraries being recognized as a promising alternative to antibodies. The advantages of displayed peptides include high affinity, low cost, ease of design and modification, mass production, and increased resistance to complex environments.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Liu Shi, Lin Wang, Xuemei Ma, Mohammed Jalalah, Saeed A. Alsareii, Tao Gao, Farid A. Harraz, Genxi Li
Summary: The study introduces a novel method called the electrochemical trans-channel assay for efficiently evaluating tumor cell invasiveness. By using a bioinspired extracellular matrix degradation model to construct the electrochemical apparatus, the invasive capability of tumor cells can be sensitively evaluated, providing a faster and more convenient alternative to traditional migration methods. This assay also allows for quantification of the invasion process, offering a promising approach for clinical assessment or prognostic applications of tumor metastasis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Environmental
Wejdene Gongi, Hassen Touzi, Idris Sadly, Hafedh Ben Ouada, Ollivier Tamarin, Hatem Ben Ouada
Summary: This study investigates the application of cyanobacterial extracellular polymeric substances (EPS) as a sensor coating material for microplastic detection. The EPS-based sensor deposited on a gold electrode was analyzed using electrochemical impedance spectroscopy. Surface properties of the sensor were examined using various techniques, including scanning electron microscopy, Fourier transforms infrared spectroscopy, and X-ray spectroscopy. The results show that the EPS-based sensor has a high homogenous structure and can detect low concentrations of four types of microplastics.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Chemistry, Analytical
Karen Y. P. S. Avelino, Leony S. Oliveira, Norma Lucena-Silva, Cesar A. S. Andrade, Maria D. L. Oliveira
Summary: A biosensor composed of PPy films and AuNPs was developed for specific detection of HPV genotypes, with modified oligonucleotides designed for strict recognition. The biosensor exhibited high sensitivity and specificity for HPV detection, as well as monitoring of the p53 gene biomarker. The flexible system showed a linear range for HPV detection with high sensitivity and accuracy.
Article
Biochemistry & Molecular Biology
Zhanzhi Liu, Shuhan Liu, Jingyi Jia, Liuxin Wang, Feng Wang, Xiaoyue Pan, Jing Wu, Sheng Chen
Summary: This study optimized an ultrahigh-throughput screening assay based on the transcription factor PsiR, and obtained a variant of D-allulose 3-epimerase with improved specific activity and thermal stability, providing a possibility for the industrial application of D-allulose.
Article
Multidisciplinary Sciences
Youjin Lee, Daeho Ryu, Saeyeong Jeon, Yena Lee, Yoon Kyung Cho, Chang-Hyeon Ji, Yong-Kweon Kim, Sang Beom Jun
Summary: Optogenetics is an essential tool for investigating neural signaling due to its unique capability of selective neural modulation or monitoring. The ability to genetically modify neuronal cells to express opsin proteins enables optical stimulation or inhibition of specific neurons. Recent advancements include combining optical waveguides for light delivery with electrophysiological recording to monitor neural responses to optogenetic stimuli simultaneously.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Environmental Sciences
Hessamaddin Sohrabi, Ehsan Dezhakam, Ehsan Nozohouri, Mir Reza Majidi, Yasin Orooji, Yeojoon Yoon, Alireza Khataee
Summary: This article provides an overview of different types and applications of glucose analysis methods, including traditional chromatography, spectroscopy, and electrochemical analysis. It also discusses the utilization of nanomaterials in sensor design. Additionally, the article highlights the current limitations and future challenges in glucose analysis.
Correction
Multidisciplinary Sciences
Hendrik Lapp, Tobias Bruegmann, Daniela Malan, Stephanie Friedrichs, Carsten Kilgus, Alexandra Heidsieck, Philipp Sasse
Summary: The paper has been amended and the updated version can be accessed through the link at the top of the paper.
SCIENTIFIC REPORTS
(2021)
Article
Biophysics
Ezat Ahamadzadeh, Keyvan Jaferzadeh, Seonghwan Park, Seungwoo Son, Inkyu Moon
Summary: This paper introduces a new non-invasive, low-cost platform for quantitative analysis of human-induced pluripotent stem cell-derived cardiomyocytes using holographic image tracking for cardiotoxicity screening. The reliability of the platform was demonstrated through characterization of single-cell motion and synchronization analysis, showing its applicability in pharmacological studies.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Hassanein Shaban, Mon-Juan Lee, Wei Lee
Summary: This study demonstrates the potential of LCLCs for spectrometrically quantitative biosensing, showing superior detection sensitivity for BSA and CA125 compared to thermotropic LC-based techniques, allowing for quantitation of concentration based on optical signals.
Article
Engineering, Electrical & Electronic
Amr Ahmed, Min-Yu Huang, David Munzer, Hua Wang
Summary: This article introduces a wideband millimeter-wave receiver front-end that covers the frequency range from 43 to 97 GHz, incorporating passive mixer-first topology and I/Q generation for high linearity and wideband performance. The front-end implements multi-gate gm3 cancellation at the IF amplifiers to preserve linearity and provide gain, while achieving image rejection capabilities for high-quality signal processing. The prototype demonstrates ultra-wideband performance across the frequency range with up to 32 dB image rejection, 1.6-5.2 dBm IIP3, and 15 dB gain, supporting high-speed modulated signals of up to 6 Gbps 64QAM modulation data.
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2021)
Article
Engineering, Electrical & Electronic
Min-Yu Huang, You-Wei Chen, Run-Kai Shiu, Hua Wang, Gee-Kung Chang
Summary: This research demonstrates an autonomous beamformer system for future extreme broadband and dynamic mm-Wave fronthaul applications operating in 5G NR frequencies. The experimental results show full FoV beamforming and enhanced mobile multi-Gb/s transmission with the ability to receive multi-band signals. A system testbed further achieves a mm-Wave bi-directional link in a fiber-wireless integrated network, making it the first of its kind for mm-Wave applications in a fiber-wireless integrated radio access network.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Moez Karim Aziz, Joerg Herrmann, Konstantinos Marmagkiolis, Dinu Valentin Balanescu, Teodora Donisan, Bala Pushparaji, Heather Y. Lin, Gerryross Tomakin, Taylor Hoyt, Martin Pham, Jouke Dijkstra, Mehmet Cilingiroglu, Juan Lopez-Mattei, Vlad Zaha, H. Vernon Anderson, Marc D. Feldman, Donald A. Molony, Cezar A. Iliescu
Summary: This study found that the stent healing patterns in cancer patients after DES placement were similar to those in non-cancer patients. Stent healing was not associated with overall survival (OS), while the underlying cancer and active chemotherapy determined the patients' survival outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Engineering, Electrical & Electronic
Jongseok Park, Sushil Subramanian, Lester Lampert, Todor Mladenov, Ilya Klotchkov, Dileep J. Kurian, Esdras Juarez-Hernandez, Brando Perez Esparza, Sirisha Rani Kale, Asma K. T. Beevi, Shavindra P. Premaratne, Thomas P. Watson, Satoshi Suzuki, Mustafijur Rahman, Jaykant B. Timbadiya, Saksham Soni, Stefano Pellerano
Summary: This article presents a fully integrated Cryo-CMOS system on chip (SoC) for quantum computing, which includes an RF pulse modulator, a signal generator, a coherent receiver, and DACs. The SoC also integrates a microcontroller for low latency signal processing and increased flexibility in implementing quantum instruction sets.
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2021)
Editorial Material
Engineering, Electrical & Electronic
Debabani Choudhury, Hua Wang, Jenshan Lin
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
(2022)
Article
Engineering, Electrical & Electronic
Naga Sasikanth Mannem, Tzu-Yuan Huang, Elham Erfani, Sensen Li, David Munzer, Matthieu R. Bloch, Hua Wang
Summary: Spatial selectivity of antenna arrays is widely used for various applications and this article focuses on exploiting and engineering this selectivity for secure wireless communication. Two schemes, constellation decomposition array (CDA) and spatial carrier aggregation (SCA), are proposed to achieve high throughput keyless physical layer security using antenna arrays.
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2022)
Article
Engineering, Electrical & Electronic
David Munzer, Naga Sasikanth Mannem, Edgar Felipe Garay, Hua Wang
Summary: This study proposes a quadrature coupler-based impedance/power detector for mm-Wave applications integrated with a power amplifier (PA). It successfully addresses the issue of driving impedance variation caused by undesired element couplings in phased arrays. The research provides design guidelines and performance evaluation based on a comprehensive comparison with traditional coupler sensors.
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
(2022)
Article
Engineering, Electrical & Electronic
Naga Sasikanth Mannem, Jeongsoo Park, Elham Erfani, Edward Liu, Jeongseok Lee, Hua Wang
Summary: This article introduces a reconfigurable phase-time array (PTA) TX that enables low-latency joint communication and sensing with high security in keyless wireless communication and fast multi-RX localization.
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2023)
Article
Engineering, Electrical & Electronic
Tzu-Yuan Huang, Boce Lin, Naga Sasikanth Mannem, Basem Abdelaziz, Hua Wang
Summary: This paper proposes a wideband MIMO receiver array that utilizes time-modulation operation to achieve concurrent steerable multibeam MIMOs with only one single beamformer. The proposed array supports concurrent SDMA communication and fast-beam scanning with low hardware complexity. In addition, it achieves good crossbeam isolation and supports wideband-16/64 QAM single carrier modulations on each beam.
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2023)
Article
Engineering, Electrical & Electronic
Tzu-Yuan Huang, Naga Sasikanth Mannem, Sensen Li, Doohwan Jung, Min-Yu Huang, Hua Wang
Summary: In this work, a 180° coupler balun structure is proposed as a wideband active load modulation network for broadband power backoff (PBO) efficiency enhancement. This structure, called coupler balun load-modulated PA (CBMA), supports natural single-ended-to-differential balun conversion, differential power cells, and wideband capacitive neutralization, making it ideal for integrated mm-Wave PAs. A continuous-mode CBMA operation with role exchanges is also proposed to achieve nearly 3:1 carrier bandwidth.
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
(2023)
Article
Engineering, Biomedical
Adam Y. Wang, Yuguo Sheng, Wanlu Li, Doohwan Jung, Gregory V. Junek, Hangxing Liu, Jongseok Park, Dongwon Lee, Mian Wang, Sushila Maharjan, Sagar Kumashi, Jin Hao, Yu S. Zhang, Kevin Eggan, Hua Wang
Summary: The article presents a fully integrated multimodal and multifunctional CMOS biosensing/actuating array chip and system for multi-dimensional cellular/tissue characterization. The chip supports high-throughput and single-cell resolution physiological measurements on living cells/tissues. The on-chip electrodes are designed and fabricated to ensure high biocompatibility and long-term measurement reliability.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2022)
Article
Engineering, Electrical & Electronic
Adam Wang, Doohwan Jung, Dongwon Lee, Hua Wang
Summary: This paper presents a systematic analysis of the interfacial electrochemical impedance spectroscopy of electrodes with different biocompatible materials. The study found that PEDOT:PSS-coated electrodes significantly reduce interfacial impedance at 1 kHz, making them promising candidates for bioelectrical interfaces with subcellular spatial resolution.
ACS APPLIED ELECTRONIC MATERIALS
(2021)
Article
Computer Science, Hardware & Architecture
Boce Lin, Amr Ahmed, Hua Wang
Summary: This work proposes a 26-32-GHz dual-polarization receiver with autonomous polarization alignment technique, ideal for mobile, dynamic, and ultrareliable low-latency communications. The system achieves up to 35 dB of polarization leakage suppression and ultrarapid mu-second polarization mismatch correction time in experiments.
IEEE SOLID-STATE CIRCUITS LETTERS
(2021)
Article
Medicine, General & Internal
Brittany Kirsch, Moez Aziz, Sungita Kumar, Michael Burke, Tyler Webster, Amrutha Immadi, Maurine Sam, Aditya Lal, Rosa M. Estrada-Y-Martin, Sujith Cherian, Gabriel Marcelo Aisenberg
Summary: This study investigated the ability of using the Wells score to predict the presence of pulmonary embolism in patients with COVID-19. The results showed that high Wells score, elevated D-dimer levels, and evidence of deep vein thrombosis were associated with pulmonary embolism.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Dinu Valentin Balanescu, Moez Karim Aziz, Teodora Donisan, Nicolas Palaskas, Juan Lopez-Mattei, Saamir Hassan, Peter Kim, Juhee Song, William Ntim, Mehmet Cilingiroglu, Konstantinos Marmagkiolis, Cezar Iliescu
Summary: Studies suggest that cancer patients can safely resume cancer treatment within 6 months after PCI, with no significant differences in overall survival among different DES types. Factors such as timing of DAPT discontinuation, age, and cancer stage may impact survival outcomes.
CORONARY ARTERY DISEASE
(2021)