Article
Public, Environmental & Occupational Health
Andre Moreira-Rosario, Shamila Ismael, Ines Barreiros-Mota, Juliana Morais, Catarina Rodrigues, Ines Castela, Ines Curvelo Mendes, Maria Ines Soares, Luis Soares da Costa, Catarina Batista Oliveira, Tiago Henriques, Patricia Pinto, Debora Pita, Catarina Marques de Oliveira, Janaina Maciel, Thaina Serafim, Joao Araujo, Julio Cesar Rocha, Diogo Pestana, Marta P. Silvestre, Claudia Marques, Ana Faria, Jorge Polonia, Conceicao Calhau
Summary: The study compared the effectiveness of salt reduction and healthy lifestyle empowerment programs in reducing blood pressure, with the salt reduction program proving to be more effective in lowering blood pressure.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Nutrition & Dietetics
Shinsuke Yamada, Masaaki Inaba
Summary: Potassium is the main intracellular cation that plays a vital role in maintaining cellular functions. Kidney function is crucial in regulating serum potassium levels, and tailored potassium management is necessary for individuals with impaired renal function. Abnormalities in potassium metabolism can lead to dangerous arrhythmias or sudden cardiac death, emphasizing the importance of monitoring and early intervention for high-risk patients.
Review
Peripheral Vascular Disease
Michael A. Razavi, Lydia A. Bazzano, Jovia Nierenberg, Zhijie Huang, Camilo Fernandez, Alexander C. Razavi, Seamus P. Whelton, Jiang He, Tanika N. Kelly
Summary: The majority of US adults develop hypertension by age 40, raising the risk of atherosclerotic cardiovascular disease. Dietary sodium and potassium play a crucial role in hypertension pathophysiology, with individual variation in salt and potassium sensitivity affecting disease risk. Genomic characterization of these traits may be key in precision lifestyle approaches for hypertension prevention.
Article
Peripheral Vascular Disease
Takashi Hisamatsu, Donald M. Lloyd-Jones, Laura A. Colangelo, Kiang Liu
Summary: The study revealed that individuals with high sodium and low potassium intake experienced significant increases in blood pressure levels and were at higher risk of developing hypertension during the follow-up period. The findings emphasize the importance of reducing sodium intake and increasing potassium intake for hypertension prevention among young adults.
JOURNAL OF HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Hiroyuki Takase, Naomi Kawakatsu, Kazusa Hayashi, Fumihiko Kin, Takeru Isogaki, Yasuaki Dohi
Summary: The study found a significant association between urinary Na/K ratio and the development of chronic kidney disease in the general Japanese population, especially after adjusting for important factors.
HYPERTENSION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lihua Zhou, Yiran Jiang, Cui Zhang, Tingwei Su, Lei Jiang, Weiwei Zhou, Xu Zhong, Luming Wu, Weiqing Wang
Summary: This study investigated the effect of a low-sodium diet on hemodynamic variables and disease biomarkers in IHA patients, and found that the low-sodium group had decreased blood pressure and increased serum potassium levels compared to the normal-sodium group. The low-sodium group also showed better control of both blood pressure and serum potassium. Therefore, a dietary sodium intake of 50 mmol/d is recommended for IHA patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Yishu Liu, Hongling Chu, Ke Peng, Xuejun Yin, Liping Huang, Yangfeng Wu, Sallie-Anne Pearson, Nicole Li, Paul Elliott, Lijing L. Yan, Darwin R. Labarthe, Zhixin Hao, Xiangxian Feng, Jianxin Zhang, Yuhong Zhang, Ruijuan Zhang, Bo Zhou, Zhifang Li, Jixin Sun, Yi Zhao, Yan Yu, Maoyi Tian, Bruce Neal, Hueiming Liu
Summary: Lowering sodium intake is essential for reducing blood pressure and cardiovascular disease risk. The use of salt substitutes in rural China faces challenges due to a lack of understanding of sodium reduction and salt substitutes, as well as habitual consumption of high-sodium foods.
Article
Medicine, General & Internal
B. Neal, Y. Wu, X. Feng, R. Zhang, Y. Zhang, J. Shi, J. Zhang, M. Tian, L. Huang, Z. Li, Y. Yu, Y. Zhao, B. Zhou, J. Sun, Y. Liu, X. Yin, Z. Hao, J. Yu, K. -C. Li, X. Zhang, P. Duan, F. Wang, B. Ma, W. Shi, G. L. Di Tanna, S. Stepien, S. Shan, S. -A. Pearson, N. Li, L. L. Yan, D. Labarthe, P. Elliott
Summary: The study found that among individuals with a history of stroke or aged 60 or older with high blood pressure, using a salt substitute can reduce the rates of stroke, major cardiovascular events, and death.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Justyna Kanclerska, Mieszko Wieckiewicz, Anna Szymanska-Chabowska, Rafal Poreba, Pawel Gac, Anna Wojakowska, Grzegorz Mazur, Helena Martynowicz
Summary: This study aimed to evaluate the plasma concentration of electrolytes and their impact on the intensity of sleep bruxism (SB) and blood pressure variability. The results showed a lower plasma sodium concentration in patients with SB, which was associated with increased blood pressure variability.
Article
Cardiac & Cardiovascular Systems
Tommaso Filippini, Marcella Malavolti, Paul K. Whelton, Androniki Naska, Nicola Orsini, Marco Vinceti
Summary: The study demonstrates an approximately linear relationship between dietary sodium intake and blood pressure, indicating that reducing sodium intake can lead to a decrease in blood pressure, with a more pronounced effect in individuals with hypertension.
Article
Peripheral Vascular Disease
Abu Mohd Naser, Feng J. He, Mahbubur Rahman, Norm R. C. Campbell
Summary: The study evaluated the relationship between estimated 24-hour urinary sodium excretion from different formulas and blood pressure, finding discrepancies between formula-estimated sodium levels and actual measurements. The formulas resulted in overestimation of sodium at lower levels and underestimation at higher levels, impacting the relationship with blood pressure.
Review
Physiology
Voravech Nissaisorakarn, George Ormseth, William Earle, Martha Catalina Morales-Alvarez, Swapnil Hiremath, Stephen P. P. Juraschek
Summary: Hypertension is a major worldwide medical condition that contributes to chronic kidney disease, cardiovascular disease, and death. Nonpharmacological, population-level interventions are crucial for prevention, but there is ongoing debate on which strategies to prioritize. The Salt Substitute and Stroke Study demonstrated the efficacy of substituting table salt with potassium salt, sparking discussions on whether sodium or potassium should be the focus in countries where salt substitution is less feasible. This commentary summarizes arguments for both reduced sodium and increased potassium intake strategies, and highlights the importance of considering cultural context in policy approaches.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Review
Nutrition & Dietetics
Rhoda N. Ndanuko, Rukayat Ibrahim, Retno A. Hapsari, Elizabeth P. Neale, David Raubenheimer, Karen E. Charlton
Summary: This study found that a lower 24-hour urinary sodium to potassium ratio is associated with lower blood pressure in adults. Dietary strategies aimed at increasing potassium intake while reducing sodium intake could be beneficial in lowering blood pressure.
ADVANCES IN NUTRITION
(2021)
Article
Medicine, Research & Experimental
Swapnil Hiremath, Dean Fergusson, Greg Knoll, Tim Ramsay, Jennifer Kong, Marcel Ruzicka
Summary: High blood pressure is the leading cause of cardiovascular disease globally, with a preference among patients for non-therapeutic methods to control blood pressure. Research suggests that increasing potassium intake can reduce blood pressure and cardiovascular risk, but medical professionals often advise patients to simply increase fruit and vegetable intake.
Review
Nutrition & Dietetics
David A. Jaques, Gregoire Wuerzner, Belen Ponte
Summary: Excessive salt intake can lead to high blood pressure and various adverse consequences. Reducing salt consumption presents a potential strategy to reduce the burden of cardiovascular disease.
Article
Peripheral Vascular Disease
Thirumagal Kanagasabai, Wuxiang Xie, Li Yan, Liancheng Zhao, Ellison Carter, Dongshuang Guo, Stella S. Daskalopoulou, Queenie Chan, Paul Elliott, Majid Ezzati, Xudong Yang, Gaoqiang Xie, Frank Kelly, Yangfeng Wu, Jill Baumgartner
Summary: The study suggests that household air pollution from cooking and heating with solid fuel may contribute to higher blood pressure, thicker intima-media in arteries, and larger plaque area.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Letter
Biochemistry & Molecular Biology
Ash Routen, Lauren O'Mahoney, Daniel Ayoubkhani, Amitava Banerjee, Chris Brightling, Melanie Calvert, Nishi Chaturvedi, Ian Diamond, Rosalind Eggo, Paul Elliott, Rachael A. Evans, Shamil Haroon, Emily Herret, Margaret E. O'Hara, Roz Shafran, Julie Stanborough, Terence Stephenson, Jonathan Sterne, Helen Ward, Kamlesh Khunti
Article
Multidisciplinary Sciences
Paul Elliott, Barbara Bodinier, Oliver Eales, Haowei Wang, David Haw, Joshua Elliott, Matthew Whitaker, Jakob Jonnerby, David Tang, Caroline E. Walters, Christina Atchison, Peter J. Diggle, Andrew J. Page, Alexander J. Trotter, Deborah Ashby, Wendy Barclay, Graham Taylor, Helen Ward, Ara Darzi, Graham S. Cooke, Marc Chadeau-Hyam, Christl A. Donnelly
Summary: The unprecedented increase in SARS-CoV-2 infections, particularly due to the Omicron variant, during December 2021 has been observed in England and globally. This study analyzed the prevalence and dynamics of SARS-CoV-2 in England from late November to mid-December 2021 among nearly 100,000 participants in the REACT-1 study. The results showed a high prevalence and rapid growth of infections, particularly in London, with an increasing proportion of Omicron cases. Vaccination and booster campaigns are crucial in controlling the spread of the virus, although additional measures have been necessary to control the rapid growth of the Omicron variant.
Article
Peripheral Vascular Disease
Yuichi Sawayama, Takashi Hisamatsu, Aya Kadota, Sayuki Torii, Keiko Kondo, Akira Fujiyoshi, Yosuke Higo, Akiko Harada, Yoshiyuki Watanabe, Yoshihisa Nakagawa, Katsuyuki Miura, Hirotsugu Ueshima
Summary: This study found that ambulatory blood pressure indices are associated with both aortic valve calcification (AVC) and coronary artery calcification (CAC), but with different effects on their presence.
JOURNAL OF HYPERTENSION
(2022)
Article
Endocrinology & Metabolism
Phap Tran Ngoc Hoang, Aya Kadota, Yuichiro Yano, Akiko Harada, Takehito Hayakawa, Shohei Okamoto, Naoko Miyagawa, Keiko Kondo, Nagako Okukda, Yoshiuni Kita, Akira Okayama, Yukihiro Fujita, Hiroshi Maegawa, Katsuyuki Miura, Tomonori Okamura, Hirotsugu Ueshima
Summary: In middle-aged Japanese adults, diabetes and prediabetes are associated with a higher risk of disability and mortality.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
Takashi Hisamatsu, Katsuyuki Miura, Yasuharu Tabara, Yuichi Sawayama, Takashi Kadowaki, Aya Kadota, Sayuki Torii, Keiko Kondo, Yuichiro Yano, Akira Fujiyoshi, Takashi Yamamoto, Yoshihisa Nakagawa, Minoru Horie, Takeshi Kimura, Tomonori Okamura, Hirotsugu Ueshima
Summary: Alcohol consumption is positively associated with coronary artery calcification burden, but inversely associated with clinical coronary heart disease, particularly acute coronary syndrome.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Environmental Sciences
Thirumagal Kanagasabai, Ellison Carter, Li Yan, Queenie Chan, Paul Elliott, Majid Ezzati, Frank Kelly, Gaoqiang Xie, Xudong Yang, Liancheng Zhao, Dongshuang Guo, Stella S. Daskalopoulou, Yangfeng Wu, Jill Baumgartner
Summary: In this cross-sectional study of peri-urban Chinese adults, we found inconsistent evidence linking household solid fuel use and renal function.
ENVIRONMENTAL RESEARCH
(2023)
Article
Peripheral Vascular Disease
Xuejun Yin, Ellie Paige, Maoyi Tian, Qiang Li, Liping Huang, Jie Yu, Anthony Rodgers, Paul Elliott, Yangfeng Wu, Bruce Neal
Summary: The SSaSS study found that potassium-enriched salt can have definitive effects on cardiovascular outcomes and death. By quantifying the amount of potassium-enriched salt used, researchers were able to estimate the impact on risk reduction and the potential for population-wide scale-up. The results showed that even a partial replacement of regular salt with potassium-enriched salt can deliver significant health gains.
Article
Pharmacology & Pharmacy
Naoko Miyagawa, Akira Sekikawa, Katsuyuki Miura, Rhobert W. Evans, Nagako Okuda, Akira Fujiyoshi, Katsushi Yoshita, Queenie Chan, Yukiko Okami, Aya Kadota, Bradley Willcox, Kamal Masaki, Beatriz Rodriguez, Kiyomi Sakata, Hideaki Nakagawa, Shigeyuki Saitoh, Akira Okayama, Lewis H. Kuller, Paul Elliott, Jeremiah Stamler, Hirotsugu Ueshima
Summary: This study examined the association between plasma phospholipid fatty acid levels and dietary intake of fatty acids. The results showed a correlation between intake and circulating fatty acid levels, especially for marine-derived fatty acids. Plasma phospholipid measurements of marine-derived fatty acids can be used as a reliable biomarker for assessing dietary intake.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Review
Peripheral Vascular Disease
Keiko Kondo, Katsuyuki Miura, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima
Summary: Dietary habits significantly impact healthy life expectancy by affecting cardiovascular disease risk and chronic diseases. The NIPPON DATA80/90 cohort study found that a dietary pattern characterized by high intake of fruits, vegetables, fish (n-3 polyunsaturated fatty acids), and dietary fiber, and low intake of salt and sodium-to-potassium ratio, is associated with a lower risk of cardiovascular disease mortality. These findings can inform effective strategies for cardiovascular disease prevention.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Public, Environmental & Occupational Health
Hideki Nagata, Katsuyuki Miura, Sachiko Tanaka, Aya Kadota, Takehito Hayakawa, Keiko Kondo, Akira Fujiyoshi, Naoyuki Takashima, Yoshikuni Kita, Akira Okayama, Tomonori Okamura, Hirotsugu Ueshima
Summary: This study investigated the relationship between functional capacity and mortality risk among a population-based cohort of older residents in Japan. Impaired functional capacity was associated with a higher risk of all-cause mortality, with different factors playing a role for men and women.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sandi L. Navarro, G. A. Nagana Gowda, Lisa F. Bettcher, Robert Pepin, Natalie Nguyen, Mathew Ellenberger, Cheng Zheng, Lesley F. Tinker, Ross L. Prentice, Ying Huang, Tao Yang, Fred K. Tabung, Queenie Chan, Ruey Leng Loo, Simin Liu, Jean Wactawski-Wende, Johanna W. Lampe, Marian L. Neuhouser, Daniel Raftery
Summary: Demographic and clinical factors have an influence on the metabolome. A study on 444 post-menopausal women found correlations between serum and urine metabolites and demographic and clinical parameters.
Article
Endocrinology & Metabolism
Yik Weng Yew, Theresia Mina, Hong Kiat Ng, Benjamin Chih Chiang Lam, Elio Riboli, Eng Sing Lee, Jimmy Lee, Joanne Ngeow, Paul Elliott, Steven Tien Guan Thng, John C. Chambers, Marie Loh
Summary: This study aims to establish the association between obesity and skin physiology measurements and investigates whether obesity may play a possible causal role on skin barrier dysfunction. The results show a strong association between BMI and TEWL and skin pH, with suggestive evidence of a possible causal relationship. It highlights the potential impact of obesity on skin barrier function and the opportunity for prevention.
INTERNATIONAL JOURNAL OF OBESITY
(2023)