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Medicine, Research & Experimental
Juan Gu, Shu Zhang, Xin He, Sufang Chen, Yan Wang
Summary: High expression of PIG11 is associated with unfavorable prognosis in patients with gastric cancer, serving as a potential diagnostic and prognostic biomarker for gastric cancer.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, General & Internal
Laura Sophie Tribian, Maximilian Lennartz, Doris Hoeflmayer, Noemi de Wispelaere, Sebastian Dwertmann Rico, Clara von Bargen, Simon Kind, Viktor Reiswich, Florian Viehweger, Florian Lutz, Veit Bertram, Christoph Fraune, Natalia Gorbokon, Soeren Weidemann, Claudia Hube-Magg, Anne Menz, Ria Uhlig, Till Krech, Andrea Hinsch, Eike Burandt, Guido Sauter, Ronald Simon, Martina Kluth, Stefan Steurer, Andreas H. Marx, Patrick Lebok, David Dum, Sarah Minner, Frank Jacobsen, Till S. Clauditz, Christian Bernreuther
Summary: Prostate-specific acid phosphatase (PSAP) is a marker for prostate cancer and its expression is limited in normal tissues but higher in prostate cancers. The expression level of PSAP is associated with clinical characteristics and prognosis of prostate cancer, making it a potential marker for prognostic evaluation.
Article
Biochemistry & Molecular Biology
Mourad Assidi, Fatimah M. Yahya, Maryam H. Al-Zahrani, Razan Elkhatib, Ali Zari, Aisha Elaimi, Jaudah Al-Maghrabi, Ashraf Dallol, Abdelbaset Buhmeida, Muhammad Abu-Elmagd
Summary: This study investigated the expression pattern and methylation profiles of leptin (LEP) in ovarian cancer (OC), and found that high LEP protein expression is associated with better survival outcomes. The results suggest that LEP expression in OC may be regulated by promoter hypermethylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Alexandros Lalos, Ornella Neri, Caner Ercan, Alexander Wilhelm, Sebastian Staubli, Alberto Posabella, Benjamin Weixler, Luigi Terracciano, Salvatore Piscuoglio, Sylvia Stadlmann, Giulio C. Spagnoli, Raoul A. Droeser, Gad Singer
Summary: Ovarian cancer is the most aggressive and fatal malignancy of the female reproductive system. The tumor microenvironment plays a critical role in tumorigenesis, progression, prognosis, and response to chemotherapy. High density of CD16-expressing tumor-infiltrating immune cells in recurrent ovarian cancer is associated with better recurrence-free survival and overall survival, indicating a potential interaction between standard chemotherapy and immune cell infiltration.
Article
Oncology
Mourad Assidi
Summary: This study investigates the expression patterns of N-CAD protein in ovarian cancer (OC) patients and its correlations with clinicopathological features. The study finds that N-CAD protein is often overexpressed in OC and its cytoplasmic overexpression is significantly correlated with tumor grade, subtype, necrosis, and age at menarche. Patients with cytoplasmic N-CAD overexpression have a shorter disease-free survival and higher recurrence rate. These findings highlight the poor prognostic role of N-CAD in OC and its involvement in EMT and distant metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Hyesung Kim, Jae Kyung Myung, Seung Sam Paik, Hyunsung Kim, Hosub Park, Yeon Ju Kim, Seung Bum Lee, Heung Up Kim, Hyun Joo Song, In Ho Jeong, Suji Hong, Chul Min Park, Cheol Lee, Younghoon Kim, Bogun Jang
Summary: EPHB2 is an upregulated protein tyrosine kinase in gastric cancer that is closely correlated with intestinal stem cell markers and CDX2 expression, and acts as a tumor suppressor in gastric cancer, serving as a prognostic marker in intestinal-type gastric cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Tingting Yang, Xuan Gu, Lizhou Jia, Jiaojiao Guo, Qi Tang, Jin Zhu, Wei Zhao, Zhenqing Feng
Summary: Immunohistochemical testing revealed lower DSG2 expression in colon cancer tissues compared to pericarcinomatous tissues, and this low expression is associated with poor survival in colon cancer patients. Bioinformatics analysis indicated that low DSG2 expression affects protein activation, regulates the P53-related pathway in colon cancer, and activates the EGFR pathway.
BMC GASTROENTEROLOGY
(2021)
Article
Reproductive Biology
Mina Sharbatoghli, Parisa Shamshiripour, Fahimeh Fattahi, Elham Kalantari, Zohre Habibi Shams, Mahshid Panahi, Mehdi Totonchi, Zeynab Asadi-Lari, Zahra Madjd, Leili Saeednejad Zanjani
Summary: The co-expression of SALL4/ALDH1A1 is significantly associated with clinicopathological parameters and prognosis in serous ovarian carcinoma patients, suggesting its potential as a prognostic biomarker for cancer progression.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Multidisciplinary Sciences
Konrad Lehr, Darja Nikitina, Ramiro Vilchez-Vargas, Ruta Steponaitiene, Cosima Thon, Jurgita Skieceviciene, Denny Schanze, Martin Zenker, Peter Malfertheiner, Juozas Kupcinskas, Alexander Link
Summary: The mucosal microbial community in the stomach is associated with worse overall survival in gastric cancer patients, with the genus Fusobacterium and Prevotella being significantly associated with poor prognosis. The abundance of Fusobacterium nucleatum in tumorous specimens has the strongest negative impact on prognosis.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Konrad Lehr, Darja Nikitina, Ramiro Vilchez-Vargas, Ruta Steponaitiene, Cosima Thon, Jurgita Skieceviciene, Denny Schanze, Martin Zenker, Peter Malfertheiner, Juozas Kupcinskas, Alexander Link
Summary: Helicobacter pylori (H. pylori) infection is the main cause of gastric cancer, but other bacterial species may also play a role. This study found that the mucosal microbial community in the stomach is associated with the prognosis of gastric cancer. The abundance of Fusobacterium and Prevotella is significantly associated with worse overall survival in gastric cancer patients.
SCIENTIFIC REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Su-Wen Zhu, Shuo Wang, Zhi-Zhong Wu, Qi-Chao Yang, De-Run Chen, Shu-Cheng Wan, Zhi-Jun Sun
Summary: This study revealed the overexpression of CD168 in oral squamous cell carcinoma (OSCC) tissues, which was associated with worse patient survival and pathological grade. Additionally, CD168 expression was positively correlated with other marker expression in OSCC.
Article
Oncology
Philipp Kohn, Alexandros Lalos, Alberto Posabella, Alexander Wilhelm, Athanasios Tampakis, Ercan Caner, Uwe Guth, Sylvia Stadlmann, Giulio C. Spagnoli, Salvatore Piscuoglio, Sabine Richarz, Tarik Delko, Raoul A. Droeser, Gad Singer
Summary: High expression of CXCL12 in immune cells is associated with better chemosensitivity, overall survival, and longer recurrence-free survival in patients with high-grade serous ovarian carcinoma. Additionally, combined high density of CXCL12 and CD66b immune cells is an independent favorable predictor of recurrence-free survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Cristian Carrasco, Andres Tittarelli, Natalia Paillaleve, Maeva Del Pozo, Daniel Rojas-Sepulveda, Omar Barria, Paula Fluxa, Melissa Hott, Carolina Martin, Claudia Quezada, Flavio Salazar-Onfray
Summary: Gallbladder cancer is a highly lethal disease with low global incidence, but a significant health problem in certain regions. New tumor-associated markers, such as MUC6, CK17, and CD10, show potential as prognosis markers for gallbladder cancer, with different expressions associated with different patient prognosis.strconv
Article
Oncology
Chang-An Guo, Xiao-Lu Su, Wen-Jie Wang, Tian-Hong Xia, Xiao-Meng Cao, Shao-Bin Yuan, Wen-An Wang, An Zhang, Hong-Bin Liu
Summary: NPM1 plays an important role in the occurrence and development of leukemia and various solid tumors. This study investigated the expression of NPM1 in gastric cancer (GC) and its association with clinicopathological characteristics. The results showed that NPM1 was lowly expressed in the majority of GC tissues and high expression was associated with better overall survival and disease-free survival. These findings suggest that NPM1 may be a valuable tool for the diagnosis and prognosis assessment of GC.
Article
Oncology
Katharina Moller, Martina Kluth, Malik Ahmed, Lia Burkhardt, Christina Moller-Koop, Franziska Buscheck, Soren Weidemann, Maria-Christina Tsourlakis, Sarah Minner, Hans Heinzer, Hartwig Huland, Markus Graefen, Guido Sauter, Thorsten Schlomm, David Dum, Ronald Simon
Summary: Deletion of chromosome 5q is common in prostate cancer, with separate deletions at 5q13 and 5q21 leading to aggressive disease. Cancers with co-deletion of 5q13 and 5q21 have worse prognosis compared to those with isolated deletions at either locus. 5q21 deletions are associated with ERG negativity, while 5q13 deletions are not related to ERG status.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Chemistry, Multidisciplinary
Jianfei Huang, Haijun Mei, Zhiyuan Tang, Jieying Li, Xiaojing Zhang, Yixiang Lu, Fang Huang, Qin Jin, Zhiwei Wang
JOURNAL OF CONTROLLED RELEASE
(2017)
Article
Medicine, General & Internal
Juan Yao, Qin Jin, Xu-dong Wang, Hui-jun Zhu, Qi-chao Ni
Article
Oncology
Youjun Mao, Yuqing Jia, Huijun Zhu, Wei Wang, Qin Jin, Fang Huang, Shu Zhang, Xiaoqiang Li
MOLECULAR MEDICINE REPORTS
(2017)
Article
Gastroenterology & Hepatology
Jieying Li, Qin Jin, Fang Huang, Zhiyuan Tang, Jianfei Huang
Article
Oncology
Qingqing Wang, Juan Yao, Qin Jin, Xudong Wang, Huijun Zhu, Fan Huang, Wei Wang, Jianfeng Qiang, Qichao Ni
Article
Oncology
Qin Jin, Fang Huang, Xudong Wang, Huijun Zhu, Yun Xian, Jieying Li, Shu Zhang, Qichao Ni
Article
Pathology
Chunyi Jiang, Jinhong Zhu, Pengcheng Zhou, Huijun Zhu, Wei Wang, Qin Jin, Peng Li
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2018)
Article
Multidisciplinary Sciences
Li Xing, Lu Zhongqian, Song Chunmei, Chen Pingfa, He Lei, Jin Qin, Mu Genhua, Deng Yijun
Article
Critical Care Medicine
Xing Li, Genhua Mu, Chunmei Song, Liangliang Zhou, Lei He, Qin Jin, Zhongqian Lu
Article
Oncology
Qin Jin, Gang Liu, Luri Bao, Yuzhen Ma, Huidong Qi, Zhizhong Yun, Yanfeng Dai, Shu Zhang
CANCER MANAGEMENT AND RESEARCH
(2018)
Article
Cell Biology
Qin Jin, Gang Liu, Shubin Li, Haihan Yuan, Zhizhong Yun, Wenqi Zhang, Shu Zhang, Yanfeng Dai, Yuzhen Ma
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Gang Liu, Biao Wang, Shubin Li, Qin Jin, Yanfeng Dai
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Pathology
Qin Jin, Yanfeng Dai, Yan Wang, Shu Zhang, Gang Liu
JOURNAL OF CLINICAL PATHOLOGY
(2019)
Article
Cell Biology
Shudong Gu, Jia Feng, Qin Jin, Wei Wang, Shu Zhang
HISTOLOGY AND HISTOPATHOLOGY
(2017)